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IID00598  Serine/threonine-protein kinase mTOR (Homo sapiens) P42345
  :order  :disorder  :conflict  :PDB cluster  :ProS  :SCOP Domain  :Pfam Domain
Networkxml
Experiment
2549
fasta
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1376-2549 Hetero trimer : IID00599Complex
 Evidence X-RAY 5wby B Reference
       Region 5wby B 1376-1384 disorder
       Region 5wby B 1385-1814 order
       Region 5wby B 1815-1866 disorder
       Region 5wby B 1867-2436 order
       Region 5wby B 2437-2491 disorder
       Region 5wby B 2492-2549 order
 Evidence X-RAY 5wby A Reference
       Region 5wby A 1376-1384 disorder
       Region 5wby A 1385-1605 order
       Region 5wby A 1606-1611 disorder
       Region 5wby A 1612-1814 order
       Region 5wby A 1815-1866 disorder
       Region 5wby A 1867-2436 order
       Region 5wby A 2437-2491 disorder
       Region 5wby A 2492-2549 order
Seq 1376-2549 Hetero trimer : IID00599Complex,Q96B36
 Evidence X-RAY 5wbu B Reference
       Region 5wbu B 1376-1384 disorder
       Region 5wbu B 1385-1814 order
       Region 5wbu B 1815-1866 disorder
       Region 5wbu B 1867-2436 order
       Region 5wbu B 2437-2491 disorder
       Region 5wbu B 2492-2549 order
 Evidence X-RAY 5wbu A Reference
       Region 5wbu A 1376-1384 disorder
       Region 5wbu A 1385-1605 order
       Region 5wbu A 1606-1611 disorder
       Region 5wbu A 1612-1814 order
       Region 5wbu A 1815-1866 disorder
       Region 5wbu A 1867-2436 order
       Region 5wbu A 2437-2491 disorder
       Region 5wbu A 2492-2549 order
Seq 1376-2549 Hetero dimer : IID00599Complex
 Evidence X-RAY 4jsn B Reference
       Region 4jsn B 1376-1384 disorder
       Region 4jsn B 1385-1814 order
       Region 4jsn B 1815-1866 disorder
       Region 4jsn B 1867-2436 order
       Region 4jsn B 2437-2491 disorder
       Region 4jsn B 2492-2549 order
 Evidence X-RAY 4jsn A Reference
       Region 4jsn A 1376-1384 disorder
       Region 4jsn A 1385-1606 order
       Region 4jsn A 1607-1610 disorder
       Region 4jsn A 1611-1814 order
       Region 4jsn A 1815-1866 disorder
       Region 4jsn A 1867-2436 order
       Region 4jsn A 2437-2491 disorder
       Region 4jsn A 2492-2549 order
 Evidence X-RAY 4jsp B Reference
       Region 4jsp B 1376-1384 disorder
       Region 4jsp B 1385-1814 order
       Region 4jsp B 1815-1866 disorder
       Region 4jsp B 1867-2436 order
       Region 4jsp B 2437-2491 disorder
       Region 4jsp B 2492-2549 order
 Evidence X-RAY 4jsp A Reference
       Region 4jsp A 1376-1384 disorder
       Region 4jsp A 1385-1814 order
       Region 4jsp A 1815-1866 disorder
       Region 4jsp A 1867-2436 order
       Region 4jsp A 2437-2491 disorder
       Region 4jsp A 2492-2549 order
 Evidence X-RAY 4jsv B Reference
       Region 4jsv B 1376-1384 disorder
       Region 4jsv B 1385-1814 order
       Region 4jsv B 1815-1866 disorder
       Region 4jsv B 1867-2436 order
       Region 4jsv B 2437-2491 disorder
       Region 4jsv B 2492-2549 order
 Evidence X-RAY 4jsv A Reference
       Region 4jsv A 1376-1384 disorder
       Region 4jsv A 1385-1814 order
       Region 4jsv A 1815-1866 disorder
       Region 4jsv A 1867-2436 order
       Region 4jsv A 2437-2491 disorder
       Region 4jsv A 2492-2549 order
 Evidence X-RAY 4jsx B Reference
       Region 4jsx B 1376-1384 disorder
       Region 4jsx B 1385-1814 order
       Region 4jsx B 1815-1866 disorder
       Region 4jsx B 1867-2436 order
       Region 4jsx B 2437-2491 disorder
       Region 4jsx B 2492-2549 order
 Evidence X-RAY 4jsx A Reference
       Region 4jsx A 1376-1384 disorder
       Region 4jsx A 1385-1606 order
       Region 4jsx A 1607-1610 disorder
       Region 4jsx A 1611-1814 order
       Region 4jsx A 1815-1866 disorder
       Region 4jsx A 1867-2436 order
       Region 4jsx A 2437-2491 disorder
       Region 4jsx A 2492-2549 order
 Evidence X-RAY 4jt5 B Reference
       Region 4jt5 B 1376-1384 disorder
       Region 4jt5 B 1385-1814 order
       Region 4jt5 B 1815-1866 disorder
       Region 4jt5 B 1867-2436 order
       Region 4jt5 B 2437-2491 disorder
       Region 4jt5 B 2492-2549 order
 Evidence X-RAY 4jt5 A Reference
       Region 4jt5 A 1376-1384 disorder
       Region 4jt5 A 1385-1606 order
       Region 4jt5 A 1607-1610 disorder
       Region 4jt5 A 1611-1814 order
       Region 4jt5 A 1815-1866 disorder
       Region 4jt5 A 1867-2436 order
       Region 4jt5 A 2437-2491 disorder
       Region 4jt5 A 2492-2549 order
 Evidence X-RAY 4jt6 B Reference
       Region 4jt6 B 1376-1384 disorder
       Region 4jt6 B 1385-1814 order
       Region 4jt6 B 1815-1866 disorder
       Region 4jt6 B 1867-2436 order
       Region 4jt6 B 2437-2491 disorder
       Region 4jt6 B 2492-2549 order
 Evidence X-RAY 4jt6 A Reference
       Region 4jt6 A 1376-1384 disorder
       Region 4jt6 A 1385-1606 order
       Region 4jt6 A 1607-1610 disorder
       Region 4jt6 A 1611-1814 order
       Region 4jt6 A 1815-1866 disorder
       Region 4jt6 A 1867-2436 order
       Region 4jt6 A 2437-2491 disorder
       Region 4jt6 A 2492-2549 order
Seq 2015-2114 Monomer :
 Evidence X-RAY 1aue A Reference
       Region 1aue A 2015-2021 disorder
       Region 1aue A 2022-2113 order
       Region 1aue A 2114-2114 disorder
 Evidence X-RAY 1aue B Reference
       Region 1aue B 2015-2020 disorder
       Region 1aue B 2021-2114 order
 Evidence NMR 2gaq A Reference
       Region 2gaq A 2015-2114 order
       Region 2gaq A 2015-2019 high_rmsd
 Evidence NMR 2npu A Reference
       Region 2npu A 2015-2114 order
       Region 2npu A 2015-2018 high_rmsd
Seq 2018-2112 Hetero dimer : P62942
 Evidence X-RAY 1fap B Reference
       Region 1fap B 2018-2112 order
 Evidence X-RAY 2fap B Reference
       Region 2fap B 2019-2112 order
 Evidence X-RAY 3fap B Reference
       Region 3fap B 2019-2112 order
 Evidence X-RAY 4fap B Reference
       Region 4fap B 2019-2112 order
 Evidence X-RAY 1nsg B Reference
       Region 1nsg B 2019-2112 order
 Evidence NMR 2rse B Reference
       Region 2rse B 2019-2112 order
Seq 2018-2114 Hetero hexamer : P23443
 Evidence X-RAY 5wbh A Reference
       Region 5wbh A 2018-2021 disorder
       Region 5wbh A 2022-2113 order
       Region 5wbh A 2114-2114 disorder
 Evidence X-RAY 5wbh B Reference
       Region 5wbh B 2018-2021 disorder
       Region 5wbh B 2022-2113 order
       Region 5wbh B 2114-2114 disorder
 Evidence X-RAY 5wbh C Reference
       Region 5wbh C 2018-2113 order
       Region 5wbh C 2114-2114 disorder
 Evidence X-RAY 5wbh D Reference
       Region 5wbh D 2018-2021 disorder
       Region 5wbh D 2022-2113 order
       Region 5wbh D 2114-2114 disorder
 Evidence X-RAY 5wbh E Reference
       Region 5wbh E 2018-2021 disorder
       Region 5wbh E 2022-2114 order
Seq 2021-2112 Hetero dimer : IID00063Complex
 Evidence X-RAY 5gpg B Reference
       Region 5gpg B 2021-2112 order
Seq 2025-2114 Hetero dimer : IID00068Complex
 Evidence X-RAY 4drj B Reference
       Region 4drj B 2025-2114 order
Seq 2025-2114 Hetero dimer : IID00073Complex
 Evidence X-RAY 4drh B Reference
       Region 4drh B 2025-2112 order
       Region 4drh B 2113-2114 disorder
 Evidence X-RAY 4drh E Reference
       Region 4drh E 2025-2059 order
       Region 4drh E 2060-2064 disorder
       Region 4drh E 2065-2112 order
       Region 4drh E 2113-2114 disorder
 Evidence X-RAY 4dri B Reference
       Region 4dri B 2025-2112 order
       Region 4dri B 2113-2114 disorder
Seqphosphorylation
    567-567 Phosphoserine
    1162-1162 Phosphothreonine
    1261-1261 Phosphoserine
    2159-2159 Phosphoserine
    2164-2164 Phosphothreonine
    2173-2173 Phosphothreonine; by PKB/AKT1
    2446-2446 Phosphothreonine; by RPS6KB1
    2448-2448 Phosphoserine; by RPS6KB1
    2478-2478 Phosphoserine
    2481-2481 Phosphoserine; by autocatalysis
Seqacetylation
    1-1 N-acetylmethionine
    1218-1218 N6-acetyllysine
 
Prediction
DICHOT
Disorder 1-51,245-362,551-572
Known Domain 52-176,573-2549
Cryptic Domain 177-244,363-550
SCOPe RPS-Blast
     3ea5B 52-509 1e-06 a.118.1.1 beta-Catenin
     4xriA 644-1344 3e-21 a.118.1.0 automated matches
     4jspA3 1385-2001 0.0 a.24.7.1 mTOR FKBP12??apamycin-binding (FRB) d...
     4driB1 2025-2112 7e-41 a.24.7.1 mTOR FKBP12??apamycin-binding (FRB)...
     4jspA1 2093-2549 0.0 d.144.1.4 mTOR kinase domain
SCOP Hmmer
     1b3uA_ 20-630 5.4e-38 a.118.1.2 Constant regula...
     1u6gC_ 366-1513 1.8e-146 a.118.1.2 Constant reg...
     1wa5C_ 1132-2003 1.9e-08 a.118.1.1 beta-Catenin
     3fapB_ 2019-2112 1.1e-44 a.24.7.1 mTOR FKBP12??...
     1e8yA4 2095-2451 3.9e-101 d.144.1.4 mTOR kinase...
Pfam RPS-Blast
     PF11865 858-1023 2e-33 Domain of unknown function...
     PF02259 1513-1908 2e-50 FAT domain
     PF08771 2015-2104 4e-29 FKBP12-rapamycin binding ...
     PF00454 2184-2429 1e-08 Phosphatidylinositol 3- a...
     PF02260 2519-2549 7e-12 FATC domain
Pfam Hmmer
    PF11865 854-1024 1.2e-61 Domain of unknown functio...
    PF02259 1513-1908 7.1e-134 FAT domain
    PF08771 2015-2113 1.8e-49 FKBP12-rapamycin binding...
    PF00454 2183-2430 1.3e-79 Phosphatidylinositol 3- ...
    PF02260 2519-2549 3.6e-20 FATC domain