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IID00616
 UniprotP26010
ProteinIntegrin beta-7
GeneITGB7
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
798
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 20-512 Hetero octamer : IID00615Complex
 Evidence X-RAY 3v4p D Reference
       Region 3v4p D 20-99 disorder
       Region 3v4p D 100-474 order
       Region 3v4p D 475-512 disorder
 Evidence X-RAY 3v4p B Reference
       Region 3v4p B 20-99 disorder
       Region 3v4p B 100-474 order
       Region 3v4p B 475-512 disorder
Seq 20-512 Hetero octamer : IID00615Complex
 Evidence X-RAY 3v4v D Reference
       Region 3v4v D 20-99 disorder
       Region 3v4v D 100-474 order
       Region 3v4v D 475-512 disorder
 Evidence X-RAY 3v4v B Reference
       Region 3v4v B 20-99 disorder
       Region 3v4v B 100-474 order
       Region 3v4v B 475-512 disorder
Seq 768-798 Hetero tetramer : P21333
 Evidence X-RAY 2brq D Reference
       Region 2brq D 768-775 disorder
       Region 2brq D 776-788 order
       Region 2brq D 789-798 disorder
 Evidence X-RAY 2brq C Reference
       Region 2brq C 768-775 disorder
       Region 2brq C 776-788 order
       Region 2brq C 789-798 disorder
SeqProS possible 776-788 Same region of the homolog (P05106, IID00767) is disordered in the free state. Hetero tetramer : P21333
       Region 2brq C 776-788 order
       Region 2brq D 776-788 order
Seqphosphorylation
    778-778 Phosphotyrosine; by Tyr-kinases
 
Prediction
NeProc
Disorder 1-29,516-531,794-798
Order 30-480,486-515,532-793
ProS 1-25,524-531
AlphaFold
Disorder 1-43,72-73,114-119,414-422,517-523,609-610,679-683,685-685,705-708,717-724,767-798
Order 44-71,74-113,120-413,423-516,524-608,611-678,684-684,686-704,709-716,725-766
Pfam Hmmer
PF07974 605-635 1.6e-06
PF07965 645-723 2.3e-24
SEG 7-14 ,74-89 ,541-557 ,726-745
Function
Function in SwissProt
(Microbial infection) Binds to HIV-1 gp120, thereby allowing the virus to enter GALT, which is thought to be the major trigger of AIDS disease. Interaction would involve a tripeptide L-D-I in HIV-1 gp120.
Biological Process
Diagram with PDB data
ITGB7/ FLNACrystal structure of the filamin A repeat 21 complexed with the integrin beta7 cytoplasmic tail peptide
See also
Diagram with PDB data
ITGA4/YWHAZ14-3-3-zeta in complex with S1011 phosphorylated integrin alpha-4 peptide
ITGA4/Ap2m1Mu2 adaptin subunit of the AP2 adaptor (C-terminal domain) complexed with Integrin alpha4 internalisation peptide QYKSILQE