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IID00619
 UniprotQ07666
ProteinKH domain-containing, RNA-binding, signal transduction-associated protein 1
GeneKHDRBS1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
443
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 97-135 Homo dimer :
 Evidence NMR 2xa6 B Reference
       Region 2xa6 B 97-98 disorder
       Region 2xa6 B 99-135 order
 Evidence NMR 2xa6 A Reference
       Region 2xa6 A 97-98 disorder
       Region 2xa6 A 99-135 order
Seq 365-419 Hetero dimer : IID00035Complex
 Evidence X-RAY 3qhe D Reference
       Region 3qhe D 365-378 disorder
       Region 3qhe D 379-389 order
       Region 3qhe D 390-419 disorder
 Evidence X-RAY 3qhe B Reference
       Region 3qhe B 365-378 disorder
       Region 3qhe B 379-388 order
       Region 3qhe B 389-419 disorder
SeqProS possible 379-388 This region is described to be disordered in the free state (PubMed=22000517). Hetero dimer : IID00035Complex
       Region 3qhe B 379-388 order
       Region 3qhe D 379-389 order
Seqphosphorylation
    390-390 Phosphoserine
    435-435 Phosphotyrosine; by PTK6
    440-440 Phosphotyrosine; by PTK6
    443-443 Phosphotyrosine; by PTK6
    20-20 Phosphoserine
    18-18 Phosphoserine
    387-387 Phosphotyrosine
    33-33 Phosphothreonine
    58-58 Phosphoserine
    84-84 Phosphothreonine; by MAPK1
    113-113 Phosphoserine
    150-150 Phosphoserine
    183-183 Phosphothreonine
    29-29 Phosphoserine
Seqacetylation
    175-175 N6-acetyllysine; alternate
 
Prediction
NeProc
Disorder 1-99,265-443
Order 100-264
ProS 1-10,29-33,39-43,51-56,265-277,362-386,394-421,432-443
AlphaFold
Disorder 1-67,69-101,136-143,277-296,299-299,301-357,361-436,442-443
Order 68-68,102-135,144-276,297-298,300-300,358-360,437-441
Pfam Hmmer
PF00013 157-211 1.8e-06
SEG 10-21 ,43-74 ,81-94 ,276-316 ,326-351 ,356-392
Function
Function in SwissProt
Isoform 3, which is expressed in growth-arrested cells only, inhibits S phase.