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IID00629
 UniprotQ99814
ProteinEndothelial PAS domain-containing protein 1
GeneEPAS1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
870
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 239-350 Monomer :
 Evidence NMR 1p97 A Reference
       Region 1p97 A 240-350 order
 Evidence NMR 5kiz A Reference
       Region 5kiz A 239-349 order
       Region 5kiz A 239-239 high_rmsd
Seq 239-350 Hetero heptamer : IID00794Complex,Q9JJ11
 Evidence X-RAY 4pky G Reference
       Region 4pky G 239-328 order
       Region 4pky G 329-334 disorder
       Region 4pky G 335-344 order
       Region 4pky G 345-350 disorder
Seq 239-350 Hetero dimer : IID00794Complex
 Evidence NMR 2a24 A Reference
       Region 2a24 A 242-348 order
 Evidence X-RAY 3f1n A Reference
       Region 3f1n A 239-327 order
       Region 3f1n A 328-333 disorder
       Region 3f1n A 334-349 order
       Region 3f1n A 350-350 disorder
 Evidence X-RAY 3f1o A Reference
       Region 3f1o A 239-328 order
       Region 3f1o A 329-333 disorder
       Region 3f1o A 334-349 order
       Region 3f1o A 350-350 disorder
 Evidence X-RAY 3f1p A Reference
       Region 3f1p A 239-349 order
       Region 3f1p A 350-350 disorder
 Evidence X-RAY 3h7w A Reference
       Region 3h7w A 239-327 order
       Region 3h7w A 328-333 disorder
       Region 3h7w A 334-349 order
       Region 3h7w A 350-350 disorder
 Evidence X-RAY 3h82 A Reference
       Region 3h82 A 239-349 order
       Region 3h82 A 350-350 disorder
 Evidence X-RAY 4ghi A Reference
       Region 4ghi A 239-327 order
       Region 4ghi A 328-333 disorder
       Region 4ghi A 334-348 order
       Region 4ghi A 349-350 disorder
 Evidence X-RAY 4gs9 A Reference
       Region 4gs9 A 239-327 order
       Region 4gs9 A 328-333 disorder
       Region 4gs9 A 334-348 order
       Region 4gs9 A 349-350 disorder
 Evidence X-RAY 4xt2 A Reference
       Region 4xt2 A 239-349 order
       Region 4xt2 A 350-350 disorder
 Evidence X-RAY 4xt2 C Reference
       Region 4xt2 C 239-349 order
       Region 4xt2 C 350-350 disorder
 Evidence X-RAY 5tbm A Reference
       Region 5tbm A 239-329 order
       Region 5tbm A 330-333 disorder
       Region 5tbm A 334-348 order
 Evidence X-RAY 5ufp A Reference
       Region 5ufp A 239-329 order
       Region 5ufp A 330-333 disorder
       Region 5ufp A 334-346 order
       Region 5ufp A 347-348 disorder
 Evidence X-RAY 6czw A Reference
       Region 6czw A 239-329 order
       Region 6czw A 330-333 disorder
       Region 6czw A 334-348 order
       Region 6czw A 349-350 disorder
 Evidence X-RAY 6d09 A Reference
       Region 6d09 A 239-329 order
       Region 6d09 A 330-333 disorder
       Region 6d09 A 334-346 order
       Region 6d09 A 347-350 disorder
 Evidence X-RAY 6d0b A Reference
       Region 6d0b A 239-329 order
       Region 6d0b A 330-333 disorder
       Region 6d0b A 334-348 order
       Region 6d0b A 349-350 disorder
 Evidence X-RAY 6d0c A Reference
       Region 6d0c A 239-329 order
       Region 6d0c A 330-333 disorder
       Region 6d0c A 334-348 order
       Region 6d0c A 349-350 disorder
 Evidence X-RAY 6x21 A Reference
       Region 6x21 A 239-327 order
       Region 6x21 A 328-333 disorder
       Region 6x21 A 334-348 order
 Evidence X-RAY 6x28 A Reference
       Region 6x28 A 239-329 order
       Region 6x28 A 330-333 disorder
       Region 6x28 A 334-345 order
       Region 6x28 A 346-348 disorder
 Evidence X-RAY 6x2h A Reference
       Region 6x2h A 239-329 order
       Region 6x2h A 330-333 disorder
       Region 6x2h A 334-348 order
 Evidence X-RAY 6x37 A Reference
       Region 6x37 A 239-328 order
       Region 6x37 A 329-333 disorder
       Region 6x37 A 334-348 order
 Evidence X-RAY 6x3d A Reference
       Region 6x3d A 239-327 order
       Region 6x3d A 328-333 disorder
       Region 6x3d A 334-346 order
       Region 6x3d A 347-348 disorder
 Evidence X-RAY 8ck3 A Reference
       Region 8ck3 A 239-329 order
       Region 8ck3 A 330-332 disorder
       Region 8ck3 A 333-349 order
       Region 8ck3 A 350-350 disorder
 Evidence X-RAY 8ck4 A Reference
       Region 8ck4 A 239-328 order
       Region 8ck4 A 329-333 disorder
       Region 8ck4 A 334-348 order
       Region 8ck4 A 349-350 disorder
 Evidence X-RAY 8ck8 A Reference
       Region 8ck8 A 239-329 order
       Region 8ck8 A 330-333 disorder
       Region 8ck8 A 334-348 order
       Region 8ck8 A 349-350 disorder
Seq 523-541 Hetero tetramer : IID00371Complex
 Evidence X-RAY 6i7q H Reference
       Region 6i7q H 523-525 disorder
       Region 6i7q H 526-541 order
Seq 523-542 Hetero tetramer : IID00371Complex
 Evidence X-RAY 6bvb H Reference
       Region 6bvb H 523-526 disorder
       Region 6bvb H 527-540 order
 Evidence X-RAY 6i7r H Reference
       Region 6i7r H 523-525 disorder
       Region 6i7r H 526-542 order
Seq 523-542 Hetero dimer : IID00345Complex
 Evidence X-RAY 7q5v B Reference
       Region 7q5v B 523-542 order
 Evidence X-RAY 7q5x B Reference
       Region 7q5x B 523-523 disorder
       Region 7q5x B 524-542 order
 Evidence X-RAY 7ujv A Reference
       Region 7ujv A 523-542 order
SeqProS predicted 523-542 This region is predicted to be disordered by AlphaFold (pLDDT <68.5) and NeProc. Hetero dimer : IID00345Complex
       Region 7q5v B 523-542 order
       Region 7ujv A 523-542 order
       Region 7q5x B 524-542 order
SeqProS predicted 527-540 This region is predicted to be disordered by AlphaFold (pLDDT <68.5) and NeProc. Hetero tetramer : IID00371Complex
       Region 6bvb H 527-540 order
Seqphosphorylation
    840-840 Phosphothreonine
 
Prediction
NeProc
Disorder 1-25,79-85,151-162,208-215,355-830
Order 26-78,86-150,163-207,216-354,831-870
ProS 1-25,355-359,388-431,455-461,490-509,518-546,619-646,685-707,721-726,737-751,761-773,791-798,807-812,823-830
AlphaFold
Disorder 1-6,73-86,150-162,203-218,236-237,361-405,407-407,411-411,413-870
Order 7-72,87-149,163-202,219-235,238-360,406-406,408-410,412-412
Pfam Hmmer
PF08447 254-347 3.9e-26
SEG 5-20 ,462-485 ,771-786
Function
Function in SwissProt
Transcription factor involved in the induction of oxygen regulated genes. Heterodimerizes with ARNT; heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters (By similarity). Regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. May also play a role in the formation of the endothelium that gives rise to the blood brain barrier. Potent activator of the Tie-2 tyrosine kinase expression. Activation requires recruitment of transcriptional coactivators such as CREBBP and probably EP300. Interaction with redox regulatory protein APEX1 seems to activate CTAD (By similarity).
Biological Process
Diagram with PDB data
EPAS1/VHL/ELOB/ELOCCrystal structure of HIF-2alpha-pVHL-elongin B-elongin C
EPAS1/EGLN1HIF PROLYL HYDROXYLASE 2 (PHD2/EGLN1) IN COMPLEX WITH N-OXALYLGLYCINE (NOG) AND HIF-2 ALPHA CODD (523-542)