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IID00641  Transcription elongation factor SPT5 (Homo sapiens) O00267
  :order  :disorder  :conflict  :PDB cluster  :ProS  :SCOP Domain  :Pfam Domain
Networkxml
Experiment
1087
fasta
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 176-273 Hetero dimer : P63272
 Evidence X-RAY 3h7h B Reference
       Region 3h7h B 176-269 order
       Region 3h7h B 270-273 disorder
Seq 420-471 Monomer :
 Evidence NMR 2e6z A Reference
       Region 2e6z A 420-471 order
Seq 462-523 Monomer :
 Evidence NMR 2do3 A Reference
       Region 2do3 A 462-523 order
       Region 2do3 A 462-468 high_rmsd
Seq 536-646 Homo dimer :
 Evidence X-RAY 5oho A Reference
       Region 5oho A 536-646 order
 Evidence X-RAY 5oho B Reference
       Region 5oho B 536-646 order
Seq 694-757 Monomer :
 Evidence NMR 2e70 A Reference
       Region 2e70 A 694-757 order
       Region 2e70 A 694-699 high_rmsd
       Region 2e70 A 756-757 high_rmsd
Seq 778-790 Hetero decamer : Q92541
 Evidence X-RAY 4l1u G Reference
       Region 4l1u G 778-780 disorder
       Region 4l1u G 781-788 order
       Region 4l1u G 789-790 disorder
 Evidence X-RAY 4l1u H Reference
       Region 4l1u H 778-779 disorder
       Region 4l1u H 780-790 order
 Evidence X-RAY 4l1u I Reference
       Region 4l1u I 778-782 disorder
       Region 4l1u I 783-787 order
       Region 4l1u I 788-790 disorder
 Evidence X-RAY 4l1u J Reference
       Region 4l1u J 778-781 disorder
       Region 4l1u J 782-786 order
       Region 4l1u J 787-790 disorder
Seq 979-1087 Monomer :
 Evidence X-RAY 5ohq A Reference
       Region 5ohq A 979-1086 order
       Region 5ohq A 1087-1087 disorder
Seq 980-988 Hetero hexamer : P18465
 Evidence X-RAY 5u98 C Reference
       Region 5u98 C 980-988 order
 Evidence X-RAY 5u98 F Reference
       Region 5u98 F 980-988 order
SeqProS predicted 780-788 The unbound state of this region is predicted to be disordered by DICHOT and MobiDB. Hetero decamer : Q92541
       Region 4l1u G 781-788 order
       Region 4l1u H 780-790 order
       Region 4l1u I 783-787 order
       Region 4l1u J 782-786 order
Seqphosphorylation
    32-32 Phosphoserine
    36-36 Phosphoserine
    666-666 Phosphoserine
    686-686 Phosphoserine
    775-775 Phosphothreonine; by CDK9
    784-784 Phosphothreonine; by CDK9
    789-789 Phosphoserine
    791-791 Phosphothreonine
    804-804 Phosphoserine
    806-806 Phosphothreonine
    1034-1034 Phosphothreonine
Seqacetylation
    718-718 N6-acetyllysine
 
Prediction
DICHOT
Disorder 1-175,320-337,409-412,640-701,758-843,969-1040
Known Domain 176-269,413-523,702-757,844-968
Cryptic Domain 270-319,338-408,524-639,1041-1087
SCOPe RPS-Blast
     2do3A1 462-523 9e-24 b.34.5.5 Transcription elongation factor SPT5
SCOP Hmmer
     1ffkQ_ 414-451 7.2e-07 b.34.5.1 Ribosomal prote...
     2do3A1 462-522 5.1e-23 b.34.5.5 Transcription e...
     1ffkQ_ 582-620 1.2e-06 b.34.5.1 Ribosomal prote...
     1m1gA2 706-735 1.6e-05 b.34.5.4 N-utilization s...
Pfam RPS-Blast
     PF06213 2-64 6e-06 Cobalamin biosynthesis protein...
     PF11942 75-172 4e-19 Spt5 transcription elongatio...
     PF03439 178-264 2e-23 Early transcription elongat...
     PF13051 705-754 7e-06 Protein of unknown function...
     PF12851 758-968 8e-11 Oxygenase domain of the 2OG...
Pfam Hmmer
    PF11942 75-172 1.1e-17 Spt5 transcription elongati...
    PF03439 178-264 1.6e-31 Early transcription elonga...
    PF00467 475-501 3.2e-11 KOW motif