IDEAL List

IDEAL

IID00644
UniprotO95163
ProteinElongator complex protein 1
GeneELP1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
xml rdf

Structure

Experiment

:order disorder conflict PDB cluster ProS Pfam Domain SEG

1332

order/disorder by at least rule

disorder by at least rule

order by at least rule

order/disorder by majority rule

Seq 715-1332 Homo dimer :

Evidence X-RAY 5cqr A Reference

Region 5cqr A 715-719 disorder

Region 5cqr A 720-800 order

Region 5cqr A 801-810 disorder

Region 5cqr A 811-911 order

Region 5cqr A 912-914 disorder

Region 5cqr A 915-1131 order

Region 5cqr A 1132-1224 disorder

Region 5cqr A 1225-1269 order

Region 5cqr A 1270-1320 disorder

Region 5cqr A 1321-1331 order

Region 5cqr A 1332-1332 disorder

Seqphosphorylation

471-471 Phosphoserine

804-804 Phosphoserine

867-867 Phosphoserine

1171-1171 Phosphoserine

1174-1174 Phosphoserine

Prediction

NeProc

Disorder 1157-1207,1284-1319

Order 1-803,811-1156,1208-1276,1320-1332

ProS 1157-1162,1172-1182,1187-1191,1202-1207,1284-1300,1308-1319

AlphaFold

Disorder 158-186,309-315,341-341,455-458,469-476,491-497,522-522,535-540,667-667,678-685,799-813,863-869,1148-1201,1276-1291,1293-1293,1295-1314,1322-1324

Order 1-157,187-308,316-340,342-454,459-468,477-490,498-521,523-534,541-666,668-677,686-798,814-862,870-1147,1202-1275,1292-1292,1294-1294,1315-1321,1325-1332

SEG 1077-1095 ,1185-1204 ,1213-1222

Function

Function in SwissProt

Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. Involved in cell migration. Involved in neurogenesis (By similarity). Regulates the migration and branching of projection neurons in the developing cerebral cortex, through a process depending on alpha-tubulin acetylation.