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IID00646  Low-density lipoprotein receptor (Homo sapiens) P01130
  :order  :disorder  :conflict  :PDB cluster  :ProS  :SCOP Domain  :Pfam Domain
Networkxml
Experiment
860
fasta
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 4-788 Hetero trimer : Q8NBP7
 Evidence X-RAY 3m0c C Reference
       Region 3m0c C 4-275 disorder
       Region 3m0c C 276-456 order
       Region 3m0c C 457-464 disorder
       Region 3m0c C 465-713 order
       Region 3m0c C 714-788 disorder
Seq 20-67 Monomer :
 Evidence NMR 1ldl A Reference
       Region 1ldl A 20-21 disorder
       Region 1ldl A 22-67 order
       Region 1ldl A 22-26 high_rmsd
       Region 1ldl A 66-67 high_rmsd
Seq 22-104 Monomer :
 Evidence NMR 1f5y A Reference
       Region 1f5y A 22-104 order
Seq 22-720 Monomer :
 Evidence X-RAY 1n7d A Reference
       Region 1n7d A 22-64 disorder
       Region 1n7d A 65-77 order
       Region 1n7d A 78-79 disorder
       Region 1n7d A 80-95 order
       Region 1n7d A 96-96 disorder
       Region 1n7d A 97-119 order
       Region 1n7d A 120-123 disorder
       Region 1n7d A 124-408 order
       Region 1n7d A 409-409 disorder
       Region 1n7d A 410-461 order
       Region 1n7d A 462-462 disorder
       Region 1n7d A 463-473 order
       Region 1n7d A 474-475 disorder
       Region 1n7d A 476-714 order
       Region 1n7d A 715-720 disorder
Seq 64-104 Monomer :
 Evidence NMR 1ldr A Reference
       Region 1ldr A 64-104 order
       Region 1ldr A 64-67 high_rmsd
Seq 82-104 Hetero dimer : IID00681Complex
 Evidence NMR 2m7p A Reference
       Region 2m7p A 82-104 order
Seq 107-186 Hetero dimer : P30533
 Evidence X-RAY 2fcw B Reference
       Region 2fcw B 107-184 order
       Region 2fcw B 185-186 disorder
Seq 144-235 Monomer :
 Evidence NMR 2lgp A Reference
       Region 2lgp A 144-235 order
Seq 147-186 Hetero dimer : IID00647Complex
 Evidence NMR 2kri B Reference
       Region 2kri B 147-184 order
       Region 2kri B 185-186 disorder
Seq 196-232 Monomer :
 Evidence X-RAY 1ajj A Reference
       Region 1ajj A 196-232 order
Seq 233-272 Monomer :
 Evidence NMR 1d2j A Reference
       Region 1d2j A 233-272 order
 Evidence NMR 1f8z A Reference
       Region 1f8z A 234-272 order
Seq 272-353 Monomer :
 Evidence NMR 1xfe A Reference
       Region 1xfe A 272-353 order
       Region 1xfe A 272-275 high_rmsd
Seq 276-715 Hetero trimer : Q8NBP7
 Evidence X-RAY 3p5b L Reference
       Region 3p5b L 316-456 order
       Region 3p5b L 457-462 disorder
       Region 3p5b L 463-715 order
 Evidence X-RAY 3p5c L Reference
       Region 3p5c L 276-715 order
Seq 314-339 Hetero trimer : Q8NBP7
 Evidence X-RAY 4ne9 D Reference
       Region 4ne9 D 314-339 order
Seq 314-339 Monomer :
 Evidence NMR 2mg9 A Reference
       Region 2mg9 A 314-339 order
Seq 314-393 Hetero trimer : Q8NBP7
 Evidence X-RAY 2w2m E Reference
       Region 2w2m E 314-354 order
       Region 2w2m E 355-393 disorder
 Evidence X-RAY 2w2n E Reference
       Region 2w2n E 314-354 order
       Region 2w2n E 355-393 disorder
 Evidence X-RAY 2w2o E Reference
       Region 2w2o E 314-353 order
       Region 2w2o E 354-393 disorder
 Evidence X-RAY 2w2p E Reference
       Region 2w2p E 314-353 order
       Region 2w2p E 354-393 disorder
 Evidence X-RAY 2w2q E Reference
       Region 2w2q E 314-353 order
       Region 2w2q E 354-393 disorder
Seq 314-393 Hetero trimer : Q8NBP7
 Evidence X-RAY 3bps E Reference
       Region 3bps E 314-353 order
       Region 3bps E 354-393 disorder
 Evidence X-RAY 3gcw E Reference
       Region 3gcw E 314-353 order
       Region 3gcw E 354-393 disorder
 Evidence X-RAY 3gcx E Reference
       Region 3gcx E 314-353 order
       Region 3gcx E 354-393 disorder
Seq 314-395 Monomer :
 Evidence NMR 1hj7 A Reference
       Region 1hj7 A 314-393 order
       Region 1hj7 A 314-314 high_rmsd
 Evidence NMR 1hz8 A Reference
       Region 1hz8 A 314-395 order
       Region 1hz8 A 314-316 high_rmsd
       Region 1hz8 A 381-395 high_rmsd
 Evidence NMR 1i0u A Reference
       Region 1i0u A 314-395 order
Seq 398-713 Monomer :
 Evidence X-RAY 1ijq A Reference
       Region 1ijq A 398-456 order
       Region 1ijq A 457-464 disorder
       Region 1ijq A 465-713 order
 Evidence X-RAY 1ijq B Reference
       Region 1ijq B 398-414 order
       Region 1ijq B 415-416 disorder
       Region 1ijq B 417-455 order
       Region 1ijq B 456-464 disorder
       Region 1ijq B 465-713 order
Seq 819-832 Hetero dimer : IID50263Complex
 Evidence X-RAY 3so6 Q Reference
       Region 3so6 Q 819-819 disorder
       Region 3so6 Q 820-832 order
Seqphosphorylation
    724-724 Phosphothreonine
 
Prediction
DICHOT
Disorder 1-26,713-860
Known Domain 27-712
SCOPe RPS-Blast
     2gtlM2 26-63 3e-08 g.12.1.1 Extracellular hemoglobin linker l2 subu...
     1v9u5 68-104 6e-10 g.12.1.1 Extracellular hemoglobin linker l2 subu...
     2fcwB1 107-145 9e-13 g.12.1.1 Extracellular hemoglobin linker l2 su...
     1j8eA 147-185 6e-08 g.12.1.1 Extracellular hemoglobin linker l2 subu...
     2fcwB1 197-233 9e-10 g.12.1.1 Extracellular hemoglobin linker l2 su...
     2fcwB1 235-270 2e-09 g.12.1.1 Extracellular hemoglobin linker l2 su...
     1xfeA2 272-314 6e-13 g.12.1.1 Extracellular hemoglobin linker l2 su...
     2w2nE1 314-354 5e-15 g.3.11.0 automated matches
     1uzkA1 354-392 2e-08 g.3.11.1 Activated protein c (autoprothrombin ...
     1ijqA1 398-663 e-113 b.68.5.1 Low density lipoprotein (LDL) receptor
     1ijqA2 664-713 5e-14 g.3.11.1 Activated protein c (autoprothrombin I...
SCOP Hmmer
     1n7dA7 26-70 3.3e-12 g.12.1.1 Extracellular hem...
     1f5yA2 66-104 1.1e-11 g.12.1.1 Extracellular he...
     1jrfA_ 103-144 4.7e-13 LDL receptor-like modul...
     1jrfA_ 142-183 9.1e-13 LDL receptor-like modul...
     1ldlA_ 196-232 5.7e-12 g.12.1.1 Extracellular h...
     1n7dAa 234-272 2.1e-11 g.12.1.1 Extracellular h...
     2dtgE6 282-394 1.4e-12 g.3.9.1 EGF receptor Cys...
     1ijqA1 398-661 7.7e-51 b.68.5.1 Low density lip...
     1ijqA2 664-712 1.4e-08 g.3.11.1 Activated prote...
Pfam RPS-Blast
     PF00057 27-58 4e-06 Low-density lipoprotein recep...
     PF00057 68-104 9e-05 Low-density lipoprotein rece...
     PF00057 109-143 2e-07 Low-density lipoprotein rec...
     PF00057 148-179 2e-05 Low-density lipoprotein rec...
     PF00057 197-231 2e-07 Low-density lipoprotein rec...
     PF00057 236-270 1e-06 Low-density lipoprotein rec...
     PF00057 279-308 5e-04 Low-density lipoprotein rec...
     PF14670 364-392 9e-04 Coagulation Factor Xa inhib...
     PF00058 439-483 2e-06 Low-density lipoprotein rec...
     PF00058 487-526 4e-07 Low-density lipoprotein rec...
     PF00058 529-569 2e-11 Low-density lipoprotein rec...
     PF00058 573-614 2e-07 Low-density lipoprotein rec...
Pfam Hmmer
    PF00057 26-63 1.5e-16 Low-density lipoprotein rece...
    PF00057 67-104 1.9e-15 Low-density lipoprotein rec...
    PF00057 107-143 3.2e-16 Low-density lipoprotein re...
    PF00057 147-184 1.7e-17 Low-density lipoprotein re...
    PF00057 196-231 6.6e-18 Low-density lipoprotein re...
    PF00057 235-270 1e-15 Low-density lipoprotein rece...
    PF00057 276-313 3.8e-15 Low-density lipoprotein re...
    PF14670 318-348 8.3e-12 Coagulation Factor Xa inhi...
    PF07645 354-392 2.1e-11 Calcium-binding EGF domain
    PF00058 439-483 1.3e-16 Low-density lipoprotein re...
    PF00058 487-526 1.4e-16 Low-density lipoprotein re...
    PF00058 529-569 1.6e-17 Low-density lipoprotein re...
    PF00058 573-614 4.6e-16 Low-density lipoprotein re...
    PF00058 616-656 8.2e-10 Low-density lipoprotein re...
    PF14670 673-711 3.7e-13 Coagulation Factor Xa inhi...