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IID00653
 UniprotP24394
ProteinInterleukin-4 receptor subunit alpha
GeneIL4R
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
825
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 26-228 Hetero trimer : P35225,P78552
 Evidence X-RAY 3bpo B Reference
       Region 3bpo B 27-221 order
       Region 3bpo B 222-227 disorder
 Evidence X-RAY 5e4e B Reference
       Region 5e4e B 26-48 order
       Region 5e4e B 49-49 disorder
       Region 5e4e B 50-132 order
       Region 5e4e B 133-135 disorder
       Region 5e4e B 136-165 order
       Region 5e4e B 166-168 disorder
       Region 5e4e B 169-189 order
       Region 5e4e B 190-195 disorder
       Region 5e4e B 196-221 order
       Region 5e4e B 222-228 disorder
Seq 26-232 Hetero dimer : P05112
 Evidence X-RAY 1iar B Reference
       Region 1iar B 26-132 order
       Region 1iar B 133-136 disorder
       Region 1iar B 137-188 order
       Region 1iar B 189-193 disorder
       Region 1iar B 194-222 order
       Region 1iar B 223-232 disorder
Seq 27-227 Hetero trimer : P05112,P31785
 Evidence X-RAY 3bpl B Reference
       Region 3bpl B 27-224 order
       Region 3bpl B 225-227 disorder
Seq 27-227 Hetero trimer : P05112,P78552
 Evidence X-RAY 3bpn B Reference
       Region 3bpn B 27-223 order
       Region 3bpn B 224-227 disorder
Seq 489-499 Hetero dimer : IID00657Complex
 Evidence NMR 1irs B Reference
       Region 1irs B 489-499 order
Seqphosphorylation
    631-631 Phosphotyrosine
    603-603 Phosphotyrosine
    575-575 Phosphotyrosine
    497-497 Phosphotyrosine
 
Prediction
NeProc
Disorder 1-27,226-259,264-272,283-712,732-825
Order 28-225,260-263,273-282,713-731
ProS 1-27,226-259,264-272,283-288,297-311,326-368,393-418,428-434,481-485,494-502,512-520,548-559,574-580,601-607,628-639,651-660,676-686,700-712,732-751,781-787,812-825
AlphaFold
Disorder 1-11,16-24,226-232,265-400,405-405,408-548,550-551,554-555,557-720,722-825
Order 12-15,25-225,233-264,401-404,406-407,549-549,552-553,556-556,721-721
SEG 362-380 ,538-551 ,607-616 ,661-682 ,786-794
Function
Function in SwissProt
Soluble IL4R (sIL4R) inhibits IL4-mediated cell proliferation and IL5 up-regulation by T-cells.