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IID00654
 UniprotP25963
ProteinNF-kappa-B inhibitor alpha
GeneNFKBIA
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
317
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 57-69 Hetero dimer : IID00301Complex
 Evidence X-RAY 6y1j P Reference
       Region 6y1j P 57-61 disorder
       Region 6y1j P 62-68 order
       Region 6y1j P 69-69 disorder
Seq 67-302 Hetero trimer : P25799,Q04207
 Evidence X-RAY 1ikn D Reference
       Region 1ikn D 67-72 disorder
       Region 1ikn D 73-95 order
       Region 1ikn D 96-100 disorder
       Region 1ikn D 101-292 order
       Region 1ikn D 293-302 disorder
Seq 70-282 Hetero trimer : IID00207Complex,IID00710Complex
 Evidence X-RAY 1nfi F Reference
       Region 1nfi F 70-282 order
 Evidence X-RAY 1nfi E Reference
       Region 1nfi E 70-282 order
SeqProS possible 62-68 This protein consists of an unstructured N-terminus, six helical ankyrin repeats (pmid= 32201828). Hetero dimer : IID00301Complex
       Region 6y1j P 62-68 order
Seqphosphorylation
    36-36 Phosphoserine; by IKKA
    32-32 Phosphoserine; by IKKA and IKKE
    42-42 Phosphotyrosine; by Tyr-kinases
    283-283 Phosphoserine; by CK2
    288-288 Phosphoserine; by CK2
    291-291 Phosphothreonine; by CK2
    293-293 Phosphoserine; by CK2
    299-299 Phosphothreonine; by CK2
 
Prediction
NeProc
Disorder 1-30,281-317
Order 31-167,173-280
ProS 1-30,281-284,298-317
AlphaFold
Disorder 1-37,53-63,283-317
Order 38-52,64-282
Pfam Hmmer
PF00023 110-142 2.6e-07
PF00023 182-214 9.8e-10
PF00023 216-248 1.2e-09
SEG 282-302
Function
Function in SwissProt
Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL (RELA/p65 and NFKB1/p50) dimers in the cytoplasm by masking their nuclear localization signals (PubMed:1493333, PubMed:7479976, PubMed:36651806). On cellular stimulation by immune and pro-inflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription (PubMed:7796813, PubMed:7628694, PubMed:7878466, PubMed:7479976).