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IID00657  Insulin receptor substrate 1 (Homo sapiens) P35568
  :order  :disorder  :conflict  :PDB cluster  :ProS  :SCOP Domain  :Pfam Domain
Networkxml
Experiment
1242
fasta
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 4-267 Homo dimer :
 Evidence X-RAY 1qqg A Reference
       Region 1qqg A 4-11 disorder
       Region 1qqg A 12-114 order
       Region 1qqg A 115-158 disorder
       Region 1qqg A 159-262 order
       Region 1qqg A 263-267 disorder
 Evidence X-RAY 1qqg B Reference
       Region 1qqg B 4-10 disorder
       Region 1qqg B 11-114 order
       Region 1qqg B 115-158 disorder
       Region 1qqg B 159-264 order
       Region 1qqg B 265-267 disorder
Seq 157-267 Hetero dimer : IID00653Complex
 Evidence NMR 1irs A Reference
       Region 1irs A 157-267 order
Seq 161-265 Hetero dimer : P06213
 Evidence X-RAY 5u1m A Reference
       Region 5u1m A 161-265 order
Seq 731-736 Hetero dimer : P06213
 Evidence X-RAY 2z8c B Reference
       Region 2z8c B 731-736 order
Seq 891-902 Hetero dimer : P08069
 Evidence X-RAY 1k3a B Reference
       Region 1k3a B 891-893 disorder
       Region 1k3a B 894-901 order
       Region 1k3a B 902-902 disorder
Seqphosphorylation
    3-3 Phosphoserine
    99-99 Phosphoserine; by CK2
    270-270 Phosphoserine; by RPS6KB1
    307-307 Phosphoserine; by RPS6KB1
    312-312 Phosphoserine; by IKKB
    323-323 Phosphoserine
    330-330 Phosphoserine
    345-345 Phosphoserine
    348-348 Phosphoserine
    419-419 Phosphoserine
    446-446 Phosphothreonine
    453-453 Phosphothreonine
    465-465 Phosphotyrosine; by INSR
    527-527 Phosphoserine; by RPS6KB1
    612-612 Phosphotyrosine; by INSR
    629-629 Phosphoserine
    632-632 Phosphotyrosine; by INSR
    636-636 Phosphoserine; by RPS6KB1
    662-662 Phosphotyrosine
    794-794 Phosphoserine; by AMPK and SIK2
    892-892 Phosphoserine
    896-896 Phosphotyrosine; by INSR
    941-941 Phosphotyrosine; by INSR
    989-989 Phosphotyrosine; by INSR
    1100-1100 Phosphoserine
    1101-1101 Phosphoserine; by RPS6KB1 and PKC/PRKCQ
    1179-1179 Phosphotyrosine; by INSR
    1229-1229 Phosphotyrosine; by INSR
 
Prediction
DICHOT
Disorder 1-11,263-1242
Known Domain 12-262
SCOPe RPS-Blast
     1qqgA1 12-114 3e-40 b.55.1.2 Amyloid beta A4 precursor protein-bindi...
     5u1mA 161-265 2e-42 b.55.1.2 Amyloid beta A4 precursor protein-bind...
SCOP Hmmer
     1qqgA1 12-112 7.6e-30 b.55.1.2 Amyloid beta A4 ...
     1qqgA2 160-260 1.4e-37 b.55.1.2 Amyloid beta A4...
Pfam RPS-Blast
     PF02174 160-260 9e-17 PTB domain (IRS-1 type)
Pfam Hmmer
    PF00169 22-111 1.2e-13 PH domain
    PF02174 161-261 5.4e-35 PTB domain (IRS-1 type)