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IID00666
 UniprotQ12972
ProteinNuclear inhibitor of protein phosphatase 1
GenePPP1R8
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
351
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seqdisorder 144-225
 Evidence NMR Reference
       Region 144-225 disorder
Seq 158-216 Hetero dimer : IID00311Complex
 Evidence X-RAY 3v4y B Reference
       Region 3v4y B 158-159 disorder
       Region 3v4y B 160-184 order
       Region 3v4y B 185-198 disorder
       Region 3v4y B 199-214 order
       Region 3v4y B 215-216 disorder
 Evidence X-RAY 3v4y D Reference
       Region 3v4y D 158-178 order
       Region 3v4y D 179-198 disorder
       Region 3v4y D 199-214 order
       Region 3v4y D 215-216 disorder
 Evidence X-RAY 3v4y F Reference
       Region 3v4y F 158-158 disorder
       Region 3v4y F 159-182 order
       Region 3v4y F 183-199 disorder
       Region 3v4y F 200-214 order
       Region 3v4y F 215-216 disorder
 Evidence X-RAY 3v4y H Reference
       Region 3v4y H 158-183 order
       Region 3v4y H 184-197 disorder
       Region 3v4y H 198-212 order
       Region 3v4y H 213-216 disorder
SeqProS verified 199-214 Hetero dimer : IID00311Complex
       Region 3v4y B 199-214 order
       Region 3v4y D 199-214 order
       Region 3v4y F 200-214 order
       Region 3v4y H 198-212 order
       Region 144-225 disorder
Seqphosphorylation
    161-161 Phosphothreonine
    335-335 Phosphotyrosine
    178-178 Phosphoserine
    199-199 Phosphoserine
    204-204 Phosphoserine
    249-249 Phosphoserine
    264-264 Phosphotyrosine; by LYN; in vitro
 
Prediction
NeProc
Disorder 1-8,130-201,221-224,234-351
Order 9-129,202-220,225-233
ProS 1-8,151-173,183-187,196-201,221-224,234-241,249-271,290-304,328-351
AlphaFold
Disorder 1-12,130-158,176-200,212-213,215-215,219-228,231-232,234-351
Order 13-129,159-175,201-211,214-214,216-218,229-230,233-233
Pfam Hmmer
PF00498 49-118 6.3e-12
SEG 35-49 ,144-164 ,239-251
Function
Function in SwissProt
Isoform Gamma is a site-specific single-strand endoribonuclease that cleaves single strand RNA 3' to purines and pyrimidines in A+U-rich regions. It generates 5'-phosphate termini at the site of cleavage. This isoform does not inhibit PP-1. May be implicated in mRNA splicing.