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IID00689
 UniprotO00291
ProteinHuntingtin-interacting protein 1
GeneHIP1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS xml
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1037
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 361-481 Homo dimer :
 Evidence X-RAY 2qa7 D Reference
       Region 2qa7 D 370-370 disorder
       Region 2qa7 D 371-440 order
       Region 2qa7 D 441-481 disorder
 Evidence X-RAY 2qa7 C Reference
       Region 2qa7 C 370-370 disorder
       Region 2qa7 C 371-472 order
       Region 2qa7 C 473-481 disorder
 Evidence X-RAY 2qa7 B Reference
       Region 2qa7 B 370-370 disorder
       Region 2qa7 B 371-440 order
       Region 2qa7 B 441-481 disorder
 Evidence X-RAY 2qa7 A Reference
       Region 2qa7 A 370-370 disorder
       Region 2qa7 A 371-469 order
       Region 2qa7 A 470-481 disorder
 Evidence X-RAY 3i00 B Reference
       Region 3i00 B 361-366 disorder
       Region 3i00 B 367-446 order
       Region 3i00 B 447-480 disorder
 Evidence X-RAY 3i00 A Reference
       Region 3i00 A 361-369 disorder
       Region 3i00 A 370-445 order
       Region 3i00 A 446-480 disorder
Seq 482-586 Homo dimer :
 Evidence X-RAY 2no2 A Reference
       Region 2no2 A 482-581 order
       Region 2no2 A 582-586 disorder
Seqphosphorylation
    338-338 Phosphoserine
 
Prediction
NeProc
Disorder 1-34,303-369,647-652,855-864,876-882,954-964,1015-1037
Order 35-302,370-646,653-854,865-875,883-953,965-1014
ProS 1-34,338-352,860-864,954-958,1015-1020
AlphaFold
Disorder 1-29,208-211,313-313,315-374,535-535,538-538,541-542,544-570,573-573,645-651,741-747,769-777,962-968,970-970,1009-1009,1012-1037
Order 30-207,212-312,314-314,375-534,536-537,539-540,543-543,571-572,574-644,652-740,748-768,778-961,969-969,971-1008,1010-1011
Pfam Hmmer
PF07651 37-309 1.3e-115
PF01608 819-1012 1.3e-127
SEG 347-366 ,788-803
Function
Function in SwissProt
Plays a role in clathrin-mediated endocytosis and trafficking (PubMed:11532990, PubMed:11577110, PubMed:11889126). Involved in regulating AMPA receptor trafficking in the central nervous system in an NMDA-dependent manner (By similarity). Regulates presynaptic nerve terminal activity (By similarity). Enhances androgen receptor (AR)-mediated transcription (PubMed:16027218). May act as a proapoptotic protein that induces cell death by acting through the intrinsic apoptosis pathway (PubMed:11007801). Binds 3-phosphoinositides (via ENTH domain) (PubMed:14732715). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis (PubMed:14732715). May play a functional role in the cell filament networks (PubMed:18790740). May be required for differentiation, proliferation, and/or survival of somatic and germline progenitors (PubMed:11007801, PubMed:12163454).