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IID00696
 UniprotO95243
ProteinMethyl-CpG-binding domain protein 4
GeneMBD4
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 xml
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
580
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 80-149 Monomer :
 Evidence X-RAY 4lg7 A Reference
       Region 4lg7 A 83-145 order
       Region 4lg7 A 146-149 disorder
 Evidence NMR 2moe A Reference
       Region 2moe A 80-148 order
       Region 2moe A 80-83 high_rmsd
       Region 2moe A 148-148 high_rmsd
Seq 426-580 Monomer :
 Evidence X-RAY 3iho A Reference
       Region 3iho A 437-574 order
 Evidence X-RAY 4ofh A Reference
       Region 4ofh A 426-437 disorder
       Region 4ofh A 438-578 order
       Region 4ofh A 579-580 disorder
 Evidence X-RAY 4ofe A Reference
       Region 4ofe A 426-437 disorder
       Region 4ofe A 438-579 order
       Region 4ofe A 580-580 disorder
 Evidence X-RAY 4ofa A Reference
       Region 4ofa A 426-437 disorder
       Region 4ofa A 438-579 order
       Region 4ofa A 580-580 disorder
 Evidence X-RAY 4ea5 A Reference
       Region 4ea5 A 427-438 disorder
       Region 4ea5 A 439-574 order
       Region 4ea5 A 575-580 disorder
 Evidence X-RAY 4ea4 A Reference
       Region 4ea4 A 427-437 disorder
       Region 4ea4 A 438-574 order
 Evidence X-RAY 4e9h A Reference
       Region 4e9h A 427-437 disorder
       Region 4e9h A 438-574 order
       Region 4e9h A 575-580 disorder
 Evidence X-RAY 4e9g A Reference
       Region 4e9g A 427-437 disorder
       Region 4e9g A 438-575 order
       Region 4e9g A 576-580 disorder
 Evidence X-RAY 4e9f A Reference
       Region 4e9f A 427-436 disorder
       Region 4e9f A 437-574 order
       Region 4e9f A 575-580 disorder
 Evidence X-RAY 4e9e A Reference
       Region 4e9e A 427-436 disorder
       Region 4e9e A 437-576 order
       Region 4e9e A 577-580 disorder
 Evidence X-RAY 4dk9 A Reference
       Region 4dk9 A 426-437 disorder
       Region 4dk9 A 438-577 order
       Region 4dk9 A 578-580 disorder
 Evidence X-RAY 5chz A Reference
       Region 5chz A 426-437 disorder
       Region 5chz A 438-577 order
       Region 5chz A 578-580 disorder
Seqphosphorylation
    428-428 Phosphoserine
    318-318 Phosphoserine
 
Prediction
NeProc
Disorder 1-88,156-430
Order 89-155,431-580
ProS 10-39,80-88,156-191,228-301,321-335,349-430
AlphaFold
Disorder 1-85,147-413,416-435
Order 86-146,414-415,436-580
Pfam Hmmer
PF01429 76-151 5e-30
SEG 167-178
Function
Function in SwissProt
Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein.