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IID00700
 UniprotP07355
ProteinAnnexin A2
GeneANXA2
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
339
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-339 Monomer :
 Evidence X-RAY 1w7b A Reference
       Region 1w7b A 1-20 disorder
       Region 1w7b A 21-339 order
 Evidence X-RAY 2hyw B Reference
       Region 2hyw B 32-339 order
 Evidence X-RAY 2hyw A Reference
       Region 2hyw A 32-339 order
 Evidence X-RAY 2hyv A Reference
       Region 2hyv A 32-339 order
 Evidence X-RAY 2hyu A Reference
       Region 2hyu A 32-339 order
Seq 2-16 Hetero trimer : P60903,Q09666
 Evidence X-RAY 4drw A Reference
       Region 4drw A 2-13 order
       Region 4drw A 14-16 disorder
 Evidence X-RAY 4drw B Reference
       Region 4drw B 2-14 order
       Region 4drw B 15-16 disorder
Seq 2-16 Hetero pentamer : P60903,Q09666
 Evidence X-RAY 4ftg D Reference
       Region 4ftg D 2-14 order
       Region 4ftg D 15-16 disorder
 Evidence X-RAY 4ftg C Reference
       Region 4ftg C 2-13 order
       Region 4ftg C 14-16 disorder
Seq 2-16 Hetero tetramer : IID00724Complex,P60903
 Evidence X-RAY 4hrh B Reference
       Region 4hrh B 2-14 order
       Region 4hrh B 15-16 disorder
 Evidence X-RAY 4hrh A Reference
       Region 4hrh A 2-14 order
       Region 4hrh A 15-16 disorder
Seq 2-16 Hetero dimer : IID00724Complex,P60903
 Evidence X-RAY 4hrh A Reference
       Region 4hrh A 2-14 order
       Region 4hrh A 15-16 disorder
Seq 2-16 Hetero trimer : P60903,Q09666
 Evidence X-RAY 4drw C Reference
       Region 4drw C 2-13 order
       Region 4drw C 14-16 disorder
 Evidence X-RAY 4drw D Reference
       Region 4drw D 2-14 order
       Region 4drw D 15-16 disorder
Seq 2-16 Hetero dimer : IID00724Complex,P60903
 Evidence X-RAY 4hrh B Reference
       Region 4hrh B 2-14 order
       Region 4hrh B 15-16 disorder
Seq 21-339 Homo dimer :
 Evidence X-RAY 1xjl A Reference
       Region 1xjl A 21-339 order
 Evidence X-RAY 1xjl B Reference
       Region 1xjl B 21-339 order
SeqProS verified 2-16 Hetero dimer : IID00724Complex,P60903
       Region 4hrh A 2-14 order
       Region 1w7b A 1-20 disorder
SeqProS verified 2-16 Hetero trimer : P60903,Q09666
       Region 4drw C 2-13 order
       Region 4drw D 2-14 order
       Region 1w7b A 1-20 disorder
SeqProS verified 2-16 Hetero tetramer : IID00724Complex,P60903
       Region 4hrh A 2-14 order
       Region 4hrh B 2-14 order
       Region 1w7b A 1-20 disorder
SeqProS verified 2-16 Hetero pentamer : P60903,Q09666
       Region 4ftg C 2-13 order
       Region 4ftg D 2-14 order
       Region 1w7b A 1-20 disorder
SeqProS verified 2-16 Hetero trimer : P60903,Q09666
       Region 4drw A 2-13 order
       Region 4drw B 2-14 order
       Region 1w7b A 1-20 disorder
SeqProS verified 2-16 Hetero dimer : IID00724Complex,P60903
       Region 4hrh B 2-14 order
       Region 1w7b A 1-20 disorder
Seqphosphorylation
    24-24 Phosphotyrosine; by SRC
    26-26 Phosphoserine; by PKC
    199-199 Phosphotyrosine
    184-184 Phosphoserine
Seqacetylation
    2-2 N-acetylserine
    49-49 N6-acetyllysine; alternate
    152-152 N6-acetyllysine
    227-227 N6-acetyllysine
 
Prediction
NeProc
Disorder 1-8
Order 9-16,20-339
ProS 1-8
AlphaFold
Disorder 1-20
Order 21-339
Pfam Hmmer
PF00191 37-102 4.2e-23
PF00191 109-174 2e-35
PF00191 193-259 1.4e-18
PF00191 269-334 6.5e-29
Function
Function in SwissProt
Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 (PubMed:18799458, PubMed:24808179, PubMed:22848640).
Biological Process
Diagram with PDB data
ANXA2/S100A4Crystal structure of Annexin A2 complexed with S100A4
ANXA2/S100A10P11 (S100A10), LIGAND OF ANNEXIN II IN COMPLEX WITH ANNEXIN II N-TERMINUS
ANXA2Crystal structure of Tyr24 phosphorylated Annexin A2 at 2.9 A resolution
See also
Diagram with PDB data
AHNAK/ANXA2/S100A10The crystal structure of an AHNAK peptide in complex with the S100A10/AnxA2 heterotetramer
HLTF/S100A10/ANXA2Crystal Structure of p11-Annexin A2(N-terminal) Fusion Protein in Complex with SMARCA3 Peptide