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IID00700
 UniprotP07355
ProteinAnnexin A2
GeneANXA2
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
339
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-339 Monomer :
 Evidence X-RAY 2hyw A Reference
       Region 2hyw A 32-339 order
 Evidence X-RAY 2hyw B Reference
       Region 2hyw B 32-339 order
 Evidence X-RAY 5lpx A Reference
       Region 5lpx A 2-28 disorder
       Region 5lpx A 29-339 order
 Evidence X-RAY 5lq0 A Reference
       Region 5lq0 A 2-22 disorder
       Region 5lq0 A 23-339 order
 Evidence X-RAY 5lq0 B Reference
       Region 5lq0 B 2-20 disorder
       Region 5lq0 B 21-118 order
       Region 5lq0 B 119-123 disorder
       Region 5lq0 B 124-339 order
 Evidence X-RAY 5lq2 A Reference
       Region 5lq2 A 2-20 disorder
       Region 5lq2 A 21-339 order
 Evidence X-RAY 5lq2 B Reference
       Region 5lq2 B 2-20 disorder
       Region 5lq2 B 21-339 order
 Evidence X-RAY 1w7b A Reference
       Region 1w7b A 1-20 disorder
       Region 1w7b A 21-339 order
 Evidence X-RAY 7dto A Reference
       Region 7dto A 31-31 disorder
       Region 7dto A 32-339 order
 Evidence X-RAY 7eq7 A Reference
       Region 7eq7 A 1-21 disorder
       Region 7eq7 A 22-339 order
 Evidence X-RAY 2hyu A Reference
       Region 2hyu A 32-339 order
 Evidence X-RAY 2hyv A Reference
       Region 2hyv A 32-339 order
 Evidence X-RAY 7zvn A Reference
       Region 7zvn A 34-339 order
Seq 2-16 Hetero trimer : IID00724Complex,IID00813Complex
 Evidence X-RAY 4hrh B Reference
       Region 4hrh B 2-14 order
       Region 4hrh B 15-16 disorder
Seq 2-16 Hetero pentamer : IID00813Complex,IID00824Complex
 Evidence X-RAY 4drw D Reference
       Region 4drw D 2-14 order
       Region 4drw D 15-16 disorder
 Evidence X-RAY 4drw C Reference
       Region 4drw C 2-13 order
       Region 4drw C 14-16 disorder
Seq 2-16 Hetero pentamer : IID00813Complex,IID00824Complex
 Evidence X-RAY 4ftg D Reference
       Region 4ftg D 2-14 order
       Region 4ftg D 15-16 disorder
 Evidence X-RAY 4ftg C Reference
       Region 4ftg C 2-13 order
       Region 4ftg C 14-16 disorder
Seq 2-16 Hetero trimer : IID00724Complex,IID00813Complex
 Evidence X-RAY 4hrh A Reference
       Region 4hrh A 2-14 order
       Region 4hrh A 15-16 disorder
Seq 2-16 Hetero hexamer : IID00724Complex,IID00813Complex
 Evidence X-RAY 4hrh B Reference
       Region 4hrh B 2-14 order
       Region 4hrh B 15-16 disorder
 Evidence X-RAY 4hrh A Reference
       Region 4hrh A 2-14 order
       Region 4hrh A 15-16 disorder
Seq 2-16 Hetero pentamer : IID00813Complex,IID00824Complex
 Evidence X-RAY 4drw B Reference
       Region 4drw B 2-14 order
       Region 4drw B 15-16 disorder
 Evidence X-RAY 4drw A Reference
       Region 4drw A 2-13 order
       Region 4drw A 14-16 disorder
Seq 2-339 Hetero tetramer : IID00791Complex
 Evidence X-RAY 5lpu B Reference
       Region 5lpu B 2-339 order
 Evidence X-RAY 5lpu A Reference
       Region 5lpu A 2-339 order
Seq 21-339 Homo dimer :
 Evidence X-RAY 1xjl B Reference
       Region 1xjl B 21-339 order
 Evidence X-RAY 1xjl A Reference
       Region 1xjl A 21-339 order
Seq 22-339 Hetero trimer : P57105
 Evidence X-RAY 8ael A Reference
       Region 8ael A 22-339 order
Seq 22-339 Hetero hexamer : P60484,Q9NSN8
 Evidence X-RAY 7pc7 B Reference
       Region 7pc7 B 22-339 order
 Evidence X-RAY 7pc7 A Reference
       Region 7pc7 A 22-28 disorder
       Region 7pc7 A 29-339 order
Seq 22-339 Hetero pentamer : IID00420Complex,IID90005Complex
 Evidence X-RAY 6twu B Reference
       Region 6twu B 22-339 order
 Evidence X-RAY 6twu A Reference
       Region 6twu A 22-339 order
Seq 22-339 Hetero pentamer : IID00420Complex,IID00726Complex
 Evidence X-RAY 5n7f B Reference
       Region 5n7f B 22-339 order
 Evidence X-RAY 5n7f A Reference
       Region 5n7f A 22-339 order
Seq 22-339 Hetero trimer : P03409,Q13884
 Evidence X-RAY 7pc4 A Reference
       Region 7pc4 A 22-339 order
Seq 22-339 Hetero hexamer : Q8NET8,Q9NSN8
 Evidence X-RAY 7qqn C Reference
       Region 7qqn C 22-339 order
 Evidence X-RAY 7qqn A Reference
       Region 7qqn A 22-339 order
Seq 22-339 Hetero pentamer : IID00420Complex,IID00726Complex
 Evidence X-RAY 5n7g B Reference
       Region 5n7g B 22-339 order
 Evidence X-RAY 5n7g A Reference
       Region 5n7g A 22-339 order
Seq 22-339 Hetero hexamer : IID00420Complex,IID90005Complex
 Evidence X-RAY 6twx B Reference
       Region 6twx B 22-339 order
 Evidence X-RAY 6twx A Reference
       Region 6twx A 22-339 order
Seq 22-339 Hetero hexamer : H7C535,IID90005Complex
 Evidence X-RAY 6twq B Reference
       Region 6twq B 22-339 order
 Evidence X-RAY 6twq A Reference
       Region 6twq A 22-339 order
Seq 22-339 Hetero trimer : IID00726Complex,P57105
 Evidence X-RAY 7p74 A Reference
       Region 7p74 A 22-339 order
Seq 22-339 Hetero trimer : K9N5R3,Q96L92
 Evidence X-RAY 7p72 A Reference
       Region 7p72 A 22-339 order
Seq 22-339 Hetero trimer : P27228,Q13884
 Evidence X-RAY 7p70 A Reference
       Region 7p70 A 22-339 order
Seq 22-339 Hetero trimer : Q96A65,Q9H5P4
 Evidence X-RAY 7pc5 A Reference
       Region 7pc5 A 22-26 disorder
       Region 7pc5 A 27-339 order
Seq 22-339 Hetero pentamer : IID00420Complex,IID00726Complex
 Evidence X-RAY 5n7d B Reference
       Region 5n7d B 22-339 order
 Evidence X-RAY 5n7d A Reference
       Region 5n7d A 22-339 order
Seq 22-339 Hetero hexamer : IID00420Complex,P27228
 Evidence X-RAY 7p71 B Reference
       Region 7p71 B 22-339 order
 Evidence X-RAY 7p71 A Reference
       Region 7p71 A 22-339 order
Seq 22-339 Hetero hexamer : IID00726Complex,Q9NSN8
 Evidence X-RAY 7pc8 B Reference
       Region 7pc8 B 22-339 order
 Evidence X-RAY 7pc8 A Reference
       Region 7pc8 A 22-339 order
Seq 22-339 Hetero pentamer : IID00420Complex,IID00726Complex
 Evidence X-RAY 6twy B Reference
       Region 6twy B 22-339 order
 Evidence X-RAY 6twy A Reference
       Region 6twy A 22-339 order
Seq 23-339 Hetero dimer : Q96NW7
 Evidence X-RAY 7qqm A Reference
       Region 7qqm A 23-339 order
Seq 23-339 Hetero trimer : P03409,P57105
 Evidence X-RAY 7p73 A Reference
       Region 7p73 A 23-339 order
Seq 29-339 Hetero nonamer : IID00726Complex,Q9NY99
 Evidence X-RAY 7qql C Reference
       Region 7qql C 29-339 order
 Evidence X-RAY 7qql B Reference
       Region 7qql B 29-30 disorder
       Region 7qql B 31-339 order
 Evidence X-RAY 7qql A Reference
       Region 7qql A 29-339 order
Seq 29-339 Hetero trimer : IID00513Complex,P03409
 Evidence X-RAY 7pc3 A Reference
       Region 7pc3 A 29-339 order
Seq 29-339 Hetero dimer : Q96L92
 Evidence X-RAY 7pcb A Reference
       Region 7pcb A 29-339 order
Seq 29-339 Hetero trimer : IID00015Complex,P25815
 Evidence X-RAY 7nmi B Reference
       Region 7nmi B 29-31 disorder
       Region 7nmi B 32-339 order
Seq 29-339 Hetero pentamer : P03409,P57105
 Evidence X-RAY 7pc9 B Reference
       Region 7pc9 B 29-31 disorder
       Region 7pc9 B 32-339 order
 Evidence X-RAY 7pc9 A Reference
       Region 7pc9 A 29-339 order
Seq 34-339 Homo dimer :
 Evidence X-RAY 7zvx B Reference
       Region 7zvx B 34-339 order
 Evidence X-RAY 7zvx A Reference
       Region 7zvx A 34-339 order
SeqProS verified 2-14 Hetero pentamer : IID00813Complex,IID00824Complex
       Region 4drw A 2-13 order
       Region 4drw B 2-14 order
       Region 1w7b A 1-20 disorder
SeqProS verified 2-14 Hetero trimer : IID00724Complex,IID00813Complex
       Region 4hrh A 2-14 order
       Region 1w7b A 1-20 disorder
SeqProS verified 2-14 Hetero trimer : IID00724Complex,IID00813Complex
       Region 4hrh B 2-14 order
       Region 1w7b A 1-20 disorder
SeqProS verified 2-14 Hetero pentamer : IID00813Complex,IID00824Complex
       Region 4ftg C 2-13 order
       Region 4ftg D 2-14 order
       Region 1w7b A 1-20 disorder
SeqProS verified 2-14 Hetero pentamer : IID00813Complex,IID00824Complex
       Region 4drw C 2-13 order
       Region 4drw D 2-14 order
       Region 1w7b A 1-20 disorder
SeqProS verified 2-14 Hetero hexamer : IID00724Complex,IID00813Complex
       Region 4hrh A 2-14 order
       Region 4hrh B 2-14 order
       Region 1w7b A 1-20 disorder
SeqProS verified 2-20 Hetero tetramer : IID00791Complex
       Region 5lpu A 2-339 order
       Region 5lpu B 2-339 order
       Region 1w7b A 1-20 disorder
Seqphosphorylation
    24-24 Phosphotyrosine; by SRC
    26-26 Phosphoserine; by PKC
    199-199 Phosphotyrosine
    184-184 Phosphoserine
Seqacetylation
    2-2 N-acetylserine
    49-49 N6-acetyllysine; alternate
    152-152 N6-acetyllysine
    227-227 N6-acetyllysine
 
Prediction
NeProc
Disorder 1-8
Order 9-16,20-339
ProS 1-8
AlphaFold
Disorder 1-20
Order 21-339
Pfam Hmmer
PF00191 37-102 4.2e-23
PF00191 109-174 2e-35
PF00191 193-259 1.4e-18
PF00191 269-334 6.5e-29
Function
Function in SwissProt
(Microbial infection) Binds M.pneumoniae CARDS toxin, probably serves as one receptor for this pathogen. When ANXA2 is down-regulated by siRNA, less toxin binds to human cells and less vacuolization (a symptom of M.pneumoniae infection) is seen.
Biological Process
Diagram with PDB data
ANXA2/S100A4Crystal structure of Annexin A2 complexed with S100A4
ANXA2/S100A10P11 (S100A10), LIGAND OF ANNEXIN II IN COMPLEX WITH ANNEXIN II N-TERMINUS
ANXA2Crystal structure of Tyr24 phosphorylated Annexin A2 at 2.9 A resolution
See also
Diagram with PDB data
AHNAK/ANXA2/S100A10The crystal structure of an AHNAK peptide in complex with the S100A10/AnxA2 heterotetramer
HLTF/S100A10/ANXA2Crystal Structure of p11-Annexin A2(N-terminal) Fusion Protein in Complex with SMARCA3 Peptide