Search Keyword:


Search option:


IID00707
 UniprotP10415
ProteinApoptosis regulator Bcl-2
GeneBCL2
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
239
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-34,66-69,73-82,91-207 Hetero tetramer : IID00669Complex,IID00720Complex
 Evidence X-RAY 5vay D Reference
       Region 5vay D 1-9 disorder
       Region 5vay D 10-31 order
       Region 5vay D 32-34 disorder
       Region 5vay D 66-69 disorder
       Region 5vay D 73-81 disorder
       Region 5vay D 82-82 order
       Region 5vay D 91-203 order
       Region 5vay D 204-207 disorder
Seq 1-34,50-64,91-207 Homo trimer :
 Evidence X-RAY 7lhb C Reference
       Region 7lhb C 1-9 disorder
       Region 7lhb C 10-30 order
       Region 7lhb C 31-34 disorder
       Region 7lhb C 50-64 disorder
       Region 7lhb C 91-93 disorder
       Region 7lhb C 94-202 order
       Region 7lhb C 203-207 disorder
 Evidence X-RAY 7lhb B Reference
       Region 7lhb B 1-8 disorder
       Region 7lhb B 9-30 order
       Region 7lhb B 31-34 disorder
       Region 7lhb B 50-64 disorder
       Region 7lhb B 91-204 order
       Region 7lhb B 205-207 disorder
 Evidence X-RAY 7lhb A Reference
       Region 7lhb A 1-8 disorder
       Region 7lhb A 9-30 order
       Region 7lhb A 31-34 disorder
       Region 7lhb A 50-63 disorder
       Region 7lhb A 64-64 order
       Region 7lhb A 91-204 order
       Region 7lhb A 205-207 disorder
Seq 1-34,66-69,73-82,91-207 Hetero trimer : IID00720Complex
 Evidence X-RAY 6o0p A Reference
       Region 6o0p A 1-8 disorder
       Region 6o0p A 9-34 order
       Region 6o0p A 66-69 disorder
       Region 6o0p A 73-81 disorder
       Region 6o0p A 82-82 order
       Region 6o0p A 91-203 order
       Region 6o0p A 204-207 disorder
Seq 1-34,66-69,73-82,91-207 Hetero hexamer : IID00720Complex
 Evidence X-RAY 6o0o C Reference
       Region 6o0o C 1-9 disorder
       Region 6o0o C 10-32 order
       Region 6o0o C 33-34 disorder
       Region 6o0o C 66-69 disorder
       Region 6o0o C 73-82 disorder
       Region 6o0o C 91-203 order
       Region 6o0o C 204-207 disorder
 Evidence X-RAY 6o0o A Reference
       Region 6o0o A 1-8 disorder
       Region 6o0o A 9-32 order
       Region 6o0o A 33-34 disorder
       Region 6o0o A 66-69 disorder
       Region 6o0o A 73-82 disorder
       Region 6o0o A 91-203 order
       Region 6o0o A 204-207 disorder
Seq 1-34,92-207 Hetero dimer :
 Evidence X-RAY 4lxd A Reference
       Region 4lxd A 1-5 disorder
       Region 4lxd A 6-33 order
       Region 4lxd A 34-34 disorder
       Region 4lxd A 92-204 order
       Region 4lxd A 205-207 disorder
Seq 1-34,92-207 Hetero dimer :
 Evidence X-RAY 4lvt B Reference
       Region 4lvt B 1-8 disorder
       Region 4lvt B 9-32 order
       Region 4lvt B 33-34 disorder
       Region 4lvt B 92-204 order
       Region 4lvt B 205-207 disorder
Seq 1-34,92-207 Hetero dimer :
 Evidence NMR 1gjh A Reference
       Region 1gjh A 1-2 disorder
       Region 1gjh A 3-34 order
       Region 1gjh A 92-207 order
Seq 1-34,92-207 Hetero tetramer : IID00720Complex,IID00746Complex
 Evidence X-RAY 5agx B Reference
       Region 5agx B 1-7 disorder
       Region 5agx B 8-32 order
       Region 5agx B 33-34 disorder
       Region 5agx B 92-204 order
       Region 5agx B 205-207 disorder
Seq 1-34,66-69,73-82,91-207 Hetero trimer : IID00720Complex
 Evidence X-RAY 6o0k A Reference
       Region 6o0k A 1-8 disorder
       Region 6o0k A 9-34 order
       Region 6o0k A 66-69 disorder
       Region 6o0k A 73-81 disorder
       Region 6o0k A 82-82 order
       Region 6o0k A 91-203 order
       Region 6o0k A 204-207 disorder
Seq 1-34,92-207 Hetero trimer : IID00720Complex
 Evidence X-RAY 4ieh A Reference
       Region 4ieh A 1-8 disorder
       Region 4ieh A 9-31 order
       Region 4ieh A 32-34 disorder
       Region 4ieh A 92-204 order
       Region 4ieh A 205-207 disorder
Seq 1-34,66-69,73-82,91-207 Hetero tetramer : IID00669Complex,IID00720Complex
 Evidence X-RAY 5vay B Reference
       Region 5vay B 1-3 disorder
       Region 5vay B 4-31 order
       Region 5vay B 32-34 disorder
       Region 5vay B 66-69 disorder
       Region 5vay B 73-80 disorder
       Region 5vay B 81-82 order
       Region 5vay B 91-205 order
       Region 5vay B 206-207 disorder
Seq 1-34,50-64,91-207 Hetero dimer : IID00669Complex
 Evidence X-RAY 5vau A Reference
       Region 5vau A 1-32 order
       Region 5vau A 33-34 disorder
       Region 5vau A 50-63 disorder
       Region 5vau A 64-64 order
       Region 5vau A 91-206 order
       Region 5vau A 207-207 disorder
 Evidence X-RAY 5vau B Reference
       Region 5vau B 1-9 disorder
       Region 5vau B 10-31 order
       Region 5vau B 32-34 disorder
       Region 5vau B 50-62 disorder
       Region 5vau B 63-64 order
       Region 5vau B 91-203 order
       Region 5vau B 204-207 disorder
 Evidence X-RAY 5vau C Reference
       Region 5vau C 1-8 disorder
       Region 5vau C 9-32 order
       Region 5vau C 33-34 disorder
       Region 5vau C 50-63 disorder
       Region 5vau C 64-64 order
       Region 5vau C 91-204 order
       Region 5vau C 205-207 disorder
 Evidence X-RAY 5vau D Reference
       Region 5vau D 1-9 disorder
       Region 5vau D 10-32 order
       Region 5vau D 33-34 disorder
       Region 5vau D 50-63 disorder
       Region 5vau D 64-64 order
       Region 5vau D 91-203 order
       Region 5vau D 204-207 disorder
 Evidence X-RAY 5vax A Reference
       Region 5vax A 1-8 disorder
       Region 5vax A 9-31 order
       Region 5vax A 32-34 disorder
       Region 5vax A 50-61 disorder
       Region 5vax A 62-64 order
       Region 5vax A 91-207 order
 Evidence X-RAY 5vax B Reference
       Region 5vax B 1-6 disorder
       Region 5vax B 7-31 order
       Region 5vax B 32-34 disorder
       Region 5vax B 50-59 disorder
       Region 5vax B 60-64 order
       Region 5vax B 91-207 order
 Evidence X-RAY 5vax C Reference
       Region 5vax C 1-9 disorder
       Region 5vax C 10-31 order
       Region 5vax C 32-34 disorder
       Region 5vax C 50-63 disorder
       Region 5vax C 64-64 order
       Region 5vax C 91-203 order
       Region 5vax C 204-207 disorder
 Evidence X-RAY 5vax D Reference
       Region 5vax D 1-8 disorder
       Region 5vax D 9-32 order
       Region 5vax D 33-34 disorder
       Region 5vax D 50-64 disorder
       Region 5vax D 91-203 order
       Region 5vax D 204-207 disorder
Seq 1-34,92-207 Hetero dimer :
 Evidence X-RAY 4lvt A Reference
       Region 4lvt A 1-8 disorder
       Region 4lvt A 9-32 order
       Region 4lvt A 33-34 disorder
       Region 4lvt A 92-204 order
       Region 4lvt A 205-207 disorder
Seq 1-207 Hetero dimer : Q07813
 Evidence X-RAY 2xa0 B Reference
       Region 2xa0 B 1-9 disorder
       Region 2xa0 B 10-31 order
       Region 2xa0 B 32-91 disorder
       Region 2xa0 B 92-206 order
       Region 2xa0 B 207-207 disorder
 Evidence X-RAY 2xa0 A Reference
       Region 2xa0 A 1-9 disorder
       Region 2xa0 A 10-31 order
       Region 2xa0 A 32-91 disorder
       Region 2xa0 A 92-206 order
       Region 2xa0 A 207-207 disorder
Seq 1-34,92-207 Hetero tetramer : IID00720Complex,IID00746Complex
 Evidence X-RAY 5agw B Reference
       Region 5agw B 1-9 disorder
       Region 5agw B 10-31 order
       Region 5agw B 32-34 disorder
       Region 5agw B 92-204 order
       Region 5agw B 205-207 disorder
Seq 1-34,66-69,73-82,91-207 Hetero hexamer : IID00720Complex
 Evidence X-RAY 6o0l C Reference
       Region 6o0l C 1-7 disorder
       Region 6o0l C 8-33 order
       Region 6o0l C 34-34 disorder
       Region 6o0l C 66-69 disorder
       Region 6o0l C 73-81 disorder
       Region 6o0l C 82-82 order
       Region 6o0l C 91-203 order
       Region 6o0l C 204-207 disorder
 Evidence X-RAY 6o0l A Reference
       Region 6o0l A 1-8 disorder
       Region 6o0l A 9-33 order
       Region 6o0l A 34-34 disorder
       Region 6o0l A 66-69 disorder
       Region 6o0l A 73-81 disorder
       Region 6o0l A 82-82 order
       Region 6o0l A 91-203 order
       Region 6o0l A 204-207 disorder
Seq 1-34,92-207 Hetero hexamer : P02649
 Evidence X-RAY 6iwb D Reference
       Region 6iwb D 1-8 disorder
       Region 6iwb D 9-31 order
       Region 6iwb D 32-34 disorder
       Region 6iwb D 92-205 order
       Region 6iwb D 206-207 disorder
 Evidence X-RAY 6iwb B Reference
       Region 6iwb B 1-8 disorder
       Region 6iwb B 9-31 order
       Region 6iwb B 32-34 disorder
       Region 6iwb B 92-205 order
       Region 6iwb B 206-207 disorder
Seq 1-34,66-69,73-82,91-207 Hetero tetramer : IID00669Complex,IID00720Complex
 Evidence X-RAY 5vay A Reference
       Region 5vay A 1-32 order
       Region 5vay A 33-34 disorder
       Region 5vay A 66-69 disorder
       Region 5vay A 73-81 disorder
       Region 5vay A 82-82 order
       Region 5vay A 91-206 order
       Region 5vay A 207-207 disorder
Seq 1-33,92-207 Hetero tetradecamer : IID00720Complex
 Evidence X-RAY 4aq3 E Reference
       Region 4aq3 E 1-9 disorder
       Region 4aq3 E 10-32 order
       Region 4aq3 E 33-33 disorder
       Region 4aq3 E 92-203 order
       Region 4aq3 E 204-207 disorder
 Evidence X-RAY 4aq3 C Reference
       Region 4aq3 C 1-8 disorder
       Region 4aq3 C 9-31 order
       Region 4aq3 C 32-33 disorder
       Region 4aq3 C 92-203 order
       Region 4aq3 C 204-207 disorder
 Evidence X-RAY 4aq3 B Reference
       Region 4aq3 B 1-8 disorder
       Region 4aq3 B 9-31 order
       Region 4aq3 B 32-33 disorder
       Region 4aq3 B 92-203 order
       Region 4aq3 B 204-207 disorder
 Evidence X-RAY 4aq3 A Reference
       Region 4aq3 A 1-8 disorder
       Region 4aq3 A 9-31 order
       Region 4aq3 A 32-33 disorder
       Region 4aq3 A 92-203 order
       Region 4aq3 A 204-207 disorder
 Evidence X-RAY 4aq3 F Reference
       Region 4aq3 F 1-8 disorder
       Region 4aq3 F 9-32 order
       Region 4aq3 F 33-33 disorder
       Region 4aq3 F 92-203 order
       Region 4aq3 F 204-207 disorder
 Evidence X-RAY 4aq3 D Reference
       Region 4aq3 D 1-8 disorder
       Region 4aq3 D 9-31 order
       Region 4aq3 D 32-33 disorder
       Region 4aq3 D 92-203 order
       Region 4aq3 D 204-207 disorder
Seq 1-207 Hetero dimer :
 Evidence X-RAY 5jsn A Reference
       Region 5jsn A 1-6 disorder
       Region 5jsn A 7-32 order
       Region 5jsn A 33-86 disorder
       Region 5jsn A 87-207 order
Seq 1-34,92-207 Hetero dimer :
 Evidence NMR 1g5m A Reference
       Region 1g5m A 1-2 disorder
       Region 1g5m A 3-34 order
       Region 1g5m A 92-207 order
Seq 1-34,92-207 Hetero tetramer : IID00720Complex,IID00746Complex
 Evidence X-RAY 5agx A Reference
       Region 5agx A 1-7 disorder
       Region 5agx A 8-32 order
       Region 5agx A 33-34 disorder
       Region 5agx A 92-204 order
       Region 5agx A 205-207 disorder
Seq 1-34,92-207 Hetero dimer : Q99HR6
 Evidence X-RAY 5fcg A Reference
       Region 5fcg A 1-5 disorder
       Region 5fcg A 6-34 order
       Region 5fcg A 92-203 order
       Region 5fcg A 204-207 disorder
Seq 1-34,92-207 Hetero trimer :
 Evidence X-RAY 7y90 A Reference
       Region 7y90 A 1-6 disorder
       Region 7y90 A 7-28 order
       Region 7y90 A 29-34 disorder
       Region 7y90 A 92-203 order
       Region 7y90 A 204-207 disorder
Seq 1-34,66-69,73-82,91-207 Hetero trimer : IID00720Complex
 Evidence X-RAY 6o0m A Reference
       Region 6o0m A 1-7 disorder
       Region 6o0m A 8-34 order
       Region 6o0m A 66-69 disorder
       Region 6o0m A 73-81 disorder
       Region 6o0m A 82-82 order
       Region 6o0m A 91-203 order
       Region 6o0m A 204-207 disorder
Seq 1-207 Hetero dimer :
 Evidence X-RAY 5jsn C Reference
       Region 5jsn C 1-6 disorder
       Region 5jsn C 7-32 order
       Region 5jsn C 33-86 disorder
       Region 5jsn C 87-207 order
Seq 1-34,92-207 Hetero dimer :
 Evidence X-RAY 4man B Reference
       Region 4man B 1-7 disorder
       Region 4man B 8-29 order
       Region 4man B 30-34 disorder
       Region 4man B 92-204 order
       Region 4man B 205-207 disorder
Seq 1-34,66-69,73-82,91-207 Hetero tetramer : IID00669Complex,IID00720Complex
 Evidence X-RAY 5vay C Reference
       Region 5vay C 1-8 disorder
       Region 5vay C 9-32 order
       Region 5vay C 33-34 disorder
       Region 5vay C 66-69 disorder
       Region 5vay C 73-81 disorder
       Region 5vay C 82-82 order
       Region 5vay C 91-204 order
       Region 5vay C 205-207 disorder
Seq 1-34,92-207 Hetero tetramer : IID00720Complex,IID00746Complex
 Evidence X-RAY 5agw A Reference
       Region 5agw A 1-7 disorder
       Region 5agw A 8-31 order
       Region 5agw A 32-34 disorder
       Region 5agw A 92-204 order
       Region 5agw A 205-207 disorder
Seq 1-34,92-207 Hetero dimer :
 Evidence X-RAY 4man A Reference
       Region 4man A 1-7 disorder
       Region 4man A 8-29 order
       Region 4man A 30-34 disorder
       Region 4man A 92-204 order
       Region 4man A 205-207 disorder
Seq 1-34,92-207 Hetero trimer :
 Evidence X-RAY 7ya5 A Reference
       Region 7ya5 A 1-7 disorder
       Region 7ya5 A 8-31 order
       Region 7ya5 A 32-34 disorder
       Region 7ya5 A 92-203 order
       Region 7ya5 A 204-207 disorder
Seq 1-34,66-82,91-218 Hetero trimer : IID00720Complex
 Evidence NMR 8u27 A Reference
       Region 8u27 A 1-34 order
       Region 8u27 A 1-7 high_rmsd
       Region 8u27 A 66-69 order
       Region 8u27 A 66-74 high_rmsd
       Region 8u27 A 73-82 order
       Region 8u27 A 91-218 order
Seq 3-33,92-206 Hetero dimer :
 Evidence NMR 1ysw A Reference
       Region 1ysw A 3-33 order
       Region 1ysw A 92-206 order
Seq 3-34,92-207 Hetero dimer :
 Evidence NMR 2o22 A Reference
       Region 2o22 A 3-34 order
       Region 2o22 A 92-207 order
Seq 3-34,92-207 Hetero dimer :
 Evidence NMR 2o21 A Reference
       Region 2o21 A 3-34 order
       Region 2o21 A 92-207 order
Seq 8-31,92-204 Hetero dimer :
 Evidence NMR 2o2f A Reference
       Region 2o2f A 8-31 order
       Region 2o2f A 92-204 order
Seq 9-33,67-82,91-206 Monomer :
 Evidence X-RAY 2w3l A Reference
       Region 2w3l A 92-206 order
 Evidence X-RAY 2w3l B Reference
       Region 2w3l B 92-204 order
       Region 2w3l B 205-206 disorder
 Evidence X-RAY 6gl8 A Reference
       Region 6gl8 A 9-33 order
       Region 6gl8 A 67-68 order
       Region 6gl8 A 69-80 disorder
       Region 6gl8 A 81-82 order
       Region 6gl8 A 91-203 order
       Region 6gl8 A 204-206 disorder
Seq 10-35,92-203 Hetero trimer : IID00015Complex
 Evidence X-RAY 8hlm B Reference
       Region 8hlm B 10-32 order
       Region 8hlm B 33-35 disorder
       Region 8hlm B 92-202 order
       Region 8hlm B 203-203 disorder
Seq 10-35,92-203 Hetero trimer : IID00015Complex
 Evidence X-RAY 8hll B Reference
       Region 8hll B 10-32 order
       Region 8hll B 33-35 disorder
       Region 8hll B 92-202 order
       Region 8hll B 203-203 disorder
Seq 10-35,92-203 Hetero trimer : IID00015Complex
 Evidence X-RAY 8hln B Reference
       Region 8hln B 10-31 order
       Region 8hln B 32-35 disorder
       Region 8hln B 92-203 order
Seqphosphorylation
    70-70 Phosphoserine; by MAPK8 and PKC
    87-87 Phosphoserine; by MAPK8
    69-69 Phosphothreonine; by MAPK8
 
Prediction
NeProc
Disorder 1-9,36-90,237-239
Order 10-35,91-236
ProS 1-9,53-58,64-70,237-239
AlphaFold
Disorder 1-7,33-85,204-239
Order 8-32,86-203
Pfam Hmmer
PF02180 7-33 4.6e-14
PF00452 97-195 4.2e-56
SEG 31-47 ,75-93 ,213-225
Function
Function in SwissProt
Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells (PubMed:1508712, PubMed:8183370). Regulates cell death by controlling the mitochondrial membrane permeability (PubMed:11368354). Appears to function in a feedback loop system with caspases (PubMed:11368354). Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1) (PubMed:11368354). Also acts as an inhibitor of autophagy: interacts with BECN1 and AMBRA1 during non-starvation conditions and inhibits their autophagy function (PubMed:18570871, PubMed:21358617, PubMed:20889974). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (PubMed:17418785).