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IID00713
 UniprotP27986
ProteinPhosphatidylinositol 3-kinase regulatory subunit alpha
GenePIK3R1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
724
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-83 Hetero dimer :
 Evidence X-RAY 3i5r A Reference
       Region 3i5r A 1-1 disorder
       Region 3i5r A 2-82 order
       Region 3i5r A 83-83 disorder
Seq 1-85 Monomer :
 Evidence NMR 1pkt A Reference
       Region 1pkt A 1-3 disorder
       Region 1pkt A 4-79 order
 Evidence NMR 1pks A Reference
       Region 1pks A 1-3 disorder
       Region 1pks A 4-79 order
 Evidence X-RAY 1pht A Reference
       Region 1pht A 1-2 disorder
       Region 1pht A 3-85 order
 Evidence X-RAY 3i5s D Reference
       Region 3i5s D 1-3 disorder
       Region 3i5s D 4-80 order
       Region 3i5s D 81-83 disorder
 Evidence X-RAY 3i5s C Reference
       Region 3i5s C 1-3 disorder
       Region 3i5s C 4-80 order
       Region 3i5s C 81-83 disorder
 Evidence X-RAY 3i5s B Reference
       Region 3i5s B 1-3 disorder
       Region 3i5s B 4-80 order
       Region 3i5s B 81-83 disorder
 Evidence X-RAY 3i5s A Reference
       Region 3i5s A 1-3 disorder
       Region 3i5s A 4-80 order
       Region 3i5s A 81-83 disorder
Seq 1-724 Hetero dimer : O00329
 Evidence X-RAY 5vlr B Reference
       Region 5vlr B 431-600 order
 Evidence X-RAY 5m6u B Reference
       Region 5m6u B 1-435 disorder
       Region 5m6u B 436-599 order
       Region 5m6u B 600-724 disorder
 Evidence X-RAY 5ubt B Reference
       Region 5ubt B 432-436 disorder
       Region 5ubt B 437-599 order
Seq 91-104 Hetero dimer : IID00698Complex
 Evidence NMR 1azg A Reference
       Region 1azg A 91-104 order
 Evidence NMR 1a0n A Reference
       Region 1a0n A 91-104 order
Seq 105-319 Monomer :
 Evidence X-RAY 1pbw B Reference
       Region 1pbw B 105-114 disorder
       Region 1pbw B 115-309 order
       Region 1pbw B 310-319 disorder
 Evidence X-RAY 1pbw A Reference
       Region 1pbw A 105-114 disorder
       Region 1pbw A 115-298 order
       Region 1pbw A 299-319 disorder
Seq 306-694 Hetero dimer : P42336
 Evidence X-RAY 4zop B Reference
       Region 4zop B 307-325 disorder
       Region 4zop B 326-361 order
       Region 4zop B 362-366 disorder
       Region 4zop B 367-384 order
       Region 4zop B 385-390 disorder
       Region 4zop B 391-409 order
       Region 4zop B 410-423 disorder
       Region 4zop B 424-590 order
 Evidence X-RAY 4waf B Reference
       Region 4waf B 306-324 disorder
       Region 4waf B 325-362 order
       Region 4waf B 363-366 disorder
       Region 4waf B 367-384 order
       Region 4waf B 385-391 disorder
       Region 4waf B 392-411 order
       Region 4waf B 412-412 disorder
       Region 4waf B 413-415 order
       Region 4waf B 416-419 disorder
       Region 4waf B 420-430 order
       Region 4waf B 431-431 disorder
       Region 4waf B 432-591 order
       Region 4waf B 592-617 disorder
 Evidence X-RAY 5ul1 B Reference
       Region 5ul1 B 306-326 disorder
       Region 5ul1 B 327-363 order
       Region 5ul1 B 364-366 disorder
       Region 5ul1 B 367-418 order
       Region 5ul1 B 419-420 disorder
       Region 5ul1 B 421-434 order
       Region 5ul1 B 435-437 disorder
       Region 5ul1 B 438-591 order
       Region 5ul1 B 592-593 disorder
 Evidence X-RAY 5ukj B Reference
       Region 5ukj B 306-326 disorder
       Region 5ukj B 327-363 order
       Region 5ukj B 364-366 disorder
       Region 5ukj B 367-417 order
       Region 5ukj B 418-420 disorder
       Region 5ukj B 421-434 order
       Region 5ukj B 435-436 disorder
       Region 5ukj B 437-591 order
       Region 5ukj B 592-593 disorder
 Evidence X-RAY 5uk8 B Reference
       Region 5uk8 B 306-325 disorder
       Region 5uk8 B 326-362 order
       Region 5uk8 B 363-365 disorder
       Region 5uk8 B 366-387 order
       Region 5uk8 B 388-391 disorder
       Region 5uk8 B 392-409 order
       Region 5uk8 B 410-421 disorder
       Region 5uk8 B 422-433 order
       Region 5uk8 B 434-437 disorder
       Region 5uk8 B 438-592 order
       Region 5uk8 B 593-593 disorder
 Evidence X-RAY 5sxk B Reference
       Region 5sxk B 322-327 disorder
       Region 5sxk B 328-336 order
       Region 5sxk B 337-338 disorder
       Region 5sxk B 339-359 order
       Region 5sxk B 360-361 disorder
       Region 5sxk B 362-383 order
       Region 5sxk B 384-386 disorder
       Region 5sxk B 387-423 order
       Region 5sxk B 424-425 disorder
       Region 5sxk B 426-429 order
       Region 5sxk B 430-434 disorder
       Region 5sxk B 435-598 order
       Region 5sxk B 599-600 disorder
 Evidence X-RAY 5sxj B Reference
       Region 5sxj B 322-327 disorder
       Region 5sxj B 328-330 order
       Region 5sxj B 331-333 disorder
       Region 5sxj B 334-335 order
       Region 5sxj B 336-339 disorder
       Region 5sxj B 340-351 order
       Region 5sxj B 352-353 disorder
       Region 5sxj B 354-371 order
       Region 5sxj B 372-374 disorder
       Region 5sxj B 375-385 order
       Region 5sxj B 386-390 disorder
       Region 5sxj B 391-394 order
       Region 5sxj B 395-398 disorder
       Region 5sxj B 399-408 order
       Region 5sxj B 409-412 disorder
       Region 5sxj B 413-420 order
       Region 5sxj B 421-428 disorder
       Region 5sxj B 429-435 order
       Region 5sxj B 436-445 disorder
       Region 5sxj B 446-583 order
       Region 5sxj B 584-595 disorder
       Region 5sxj B 596-598 order
       Region 5sxj B 599-600 disorder
 Evidence X-RAY 5sxi B Reference
       Region 5sxi B 322-328 disorder
       Region 5sxi B 329-336 order
       Region 5sxi B 337-339 disorder
       Region 5sxi B 340-350 order
       Region 5sxi B 351-351 disorder
       Region 5sxi B 352-357 order
       Region 5sxi B 358-362 disorder
       Region 5sxi B 363-373 order
       Region 5sxi B 374-377 disorder
       Region 5sxi B 378-382 order
       Region 5sxi B 383-400 disorder
       Region 5sxi B 401-419 order
       Region 5sxi B 420-425 disorder
       Region 5sxi B 426-428 order
       Region 5sxi B 429-444 disorder
       Region 5sxi B 445-586 order
       Region 5sxi B 587-594 disorder
       Region 5sxi B 595-598 order
       Region 5sxi B 599-600 disorder
 Evidence X-RAY 5sxf B Reference
       Region 5sxf B 322-339 disorder
       Region 5sxf B 340-352 order
       Region 5sxf B 353-368 disorder
       Region 5sxf B 369-374 order
       Region 5sxf B 375-376 disorder
       Region 5sxf B 377-381 order
       Region 5sxf B 382-411 disorder
       Region 5sxf B 412-416 order
       Region 5sxf B 417-439 disorder
       Region 5sxf B 440-588 order
       Region 5sxf B 589-592 disorder
       Region 5sxf B 593-597 order
       Region 5sxf B 598-600 disorder
 Evidence X-RAY 5sxe B Reference
       Region 5sxe B 322-327 disorder
       Region 5sxe B 328-334 order
       Region 5sxe B 335-338 disorder
       Region 5sxe B 339-349 order
       Region 5sxe B 350-351 disorder
       Region 5sxe B 352-356 order
       Region 5sxe B 357-361 disorder
       Region 5sxe B 362-374 order
       Region 5sxe B 375-378 disorder
       Region 5sxe B 379-382 order
       Region 5sxe B 383-388 disorder
       Region 5sxe B 389-390 order
       Region 5sxe B 391-392 disorder
       Region 5sxe B 393-397 order
       Region 5sxe B 398-398 disorder
       Region 5sxe B 399-410 order
       Region 5sxe B 411-411 disorder
       Region 5sxe B 412-418 order
       Region 5sxe B 419-421 disorder
       Region 5sxe B 422-422 order
       Region 5sxe B 423-425 disorder
       Region 5sxe B 426-429 order
       Region 5sxe B 430-439 disorder
       Region 5sxe B 440-586 order
       Region 5sxe B 587-591 disorder
       Region 5sxe B 592-598 order
       Region 5sxe B 599-600 disorder
 Evidence X-RAY 5sxd B Reference
       Region 5sxd B 322-326 disorder
       Region 5sxd B 327-334 order
       Region 5sxd B 335-339 disorder
       Region 5sxd B 340-359 order
       Region 5sxd B 360-361 disorder
       Region 5sxd B 362-385 order
       Region 5sxd B 386-387 disorder
       Region 5sxd B 388-390 order
       Region 5sxd B 391-395 disorder
       Region 5sxd B 396-418 order
       Region 5sxd B 419-421 disorder
       Region 5sxd B 422-428 order
       Region 5sxd B 429-434 disorder
       Region 5sxd B 435-586 order
       Region 5sxd B 587-591 disorder
       Region 5sxd B 592-598 order
       Region 5sxd B 599-600 disorder
 Evidence X-RAY 5sxc B Reference
       Region 5sxc B 322-327 disorder
       Region 5sxc B 328-329 order
       Region 5sxc B 330-331 disorder
       Region 5sxc B 332-334 order
       Region 5sxc B 335-339 disorder
       Region 5sxc B 340-350 order
       Region 5sxc B 351-352 disorder
       Region 5sxc B 353-356 order
       Region 5sxc B 357-361 disorder
       Region 5sxc B 362-363 order
       Region 5sxc B 364-366 disorder
       Region 5sxc B 367-371 order
       Region 5sxc B 372-372 disorder
       Region 5sxc B 373-374 order
       Region 5sxc B 375-379 disorder
       Region 5sxc B 380-382 order
       Region 5sxc B 383-398 disorder
       Region 5sxc B 399-409 order
       Region 5sxc B 410-411 disorder
       Region 5sxc B 412-419 order
       Region 5sxc B 420-423 disorder
       Region 5sxc B 424-427 order
       Region 5sxc B 428-439 disorder
       Region 5sxc B 440-513 order
       Region 5sxc B 514-515 disorder
       Region 5sxc B 516-585 order
       Region 5sxc B 586-588 disorder
       Region 5sxc B 589-597 order
       Region 5sxc B 598-600 disorder
 Evidence X-RAY 5sxb B Reference
       Region 5sxb B 322-328 disorder
       Region 5sxb B 329-330 order
       Region 5sxb B 331-332 disorder
       Region 5sxb B 333-334 order
       Region 5sxb B 335-339 disorder
       Region 5sxb B 340-349 order
       Region 5sxb B 350-352 disorder
       Region 5sxb B 353-359 order
       Region 5sxb B 360-361 disorder
       Region 5sxb B 362-371 order
       Region 5sxb B 372-377 disorder
       Region 5sxb B 378-383 order
       Region 5sxb B 384-388 disorder
       Region 5sxb B 389-390 order
       Region 5sxb B 391-398 disorder
       Region 5sxb B 399-418 order
       Region 5sxb B 419-422 disorder
       Region 5sxb B 423-428 order
       Region 5sxb B 429-440 disorder
       Region 5sxb B 441-514 order
       Region 5sxb B 515-515 disorder
       Region 5sxb B 516-585 order
       Region 5sxb B 586-594 disorder
       Region 5sxb B 595-597 order
       Region 5sxb B 598-600 disorder
 Evidence X-RAY 5sxa B Reference
       Region 5sxa B 322-326 disorder
       Region 5sxa B 327-330 order
       Region 5sxa B 331-339 disorder
       Region 5sxa B 340-351 order
       Region 5sxa B 352-354 disorder
       Region 5sxa B 355-360 order
       Region 5sxa B 361-365 disorder
       Region 5sxa B 366-371 order
       Region 5sxa B 372-377 disorder
       Region 5sxa B 378-385 order
       Region 5sxa B 386-394 disorder
       Region 5sxa B 395-408 order
       Region 5sxa B 409-412 disorder
       Region 5sxa B 413-420 order
       Region 5sxa B 421-424 disorder
       Region 5sxa B 425-435 order
       Region 5sxa B 436-439 disorder
       Region 5sxa B 440-585 order
       Region 5sxa B 586-595 disorder
       Region 5sxa B 596-598 order
       Region 5sxa B 599-600 disorder
 Evidence X-RAY 5sx9 B Reference
       Region 5sx9 B 322-326 disorder
       Region 5sx9 B 327-334 order
       Region 5sx9 B 335-339 disorder
       Region 5sx9 B 340-358 order
       Region 5sx9 B 359-361 disorder
       Region 5sx9 B 362-366 order
       Region 5sx9 B 367-367 disorder
       Region 5sx9 B 368-374 order
       Region 5sx9 B 375-378 disorder
       Region 5sx9 B 379-381 order
       Region 5sx9 B 382-392 disorder
       Region 5sx9 B 393-398 order
       Region 5sx9 B 399-400 disorder
       Region 5sx9 B 401-423 order
       Region 5sx9 B 424-424 disorder
       Region 5sx9 B 425-428 order
       Region 5sx9 B 429-433 disorder
       Region 5sx9 B 434-597 order
       Region 5sx9 B 598-600 disorder
 Evidence X-RAY 5sx8 B Reference
       Region 5sx8 B 322-327 disorder
       Region 5sx8 B 328-333 order
       Region 5sx8 B 334-338 disorder
       Region 5sx8 B 339-357 order
       Region 5sx8 B 358-361 disorder
       Region 5sx8 B 362-374 order
       Region 5sx8 B 375-377 disorder
       Region 5sx8 B 378-383 order
       Region 5sx8 B 384-388 disorder
       Region 5sx8 B 389-390 order
       Region 5sx8 B 391-392 disorder
       Region 5sx8 B 393-428 order
       Region 5sx8 B 429-438 disorder
       Region 5sx8 B 439-586 order
       Region 5sx8 B 587-588 disorder
       Region 5sx8 B 589-598 order
       Region 5sx8 B 599-600 disorder
 Evidence X-RAY 5swt B Reference
       Region 5swt B 322-326 disorder
       Region 5swt B 327-336 order
       Region 5swt B 337-339 disorder
       Region 5swt B 340-359 order
       Region 5swt B 360-361 disorder
       Region 5swt B 362-374 order
       Region 5swt B 375-377 disorder
       Region 5swt B 378-386 order
       Region 5swt B 387-388 disorder
       Region 5swt B 389-390 order
       Region 5swt B 391-398 disorder
       Region 5swt B 399-428 order
       Region 5swt B 429-432 disorder
       Region 5swt B 433-586 order
       Region 5swt B 587-587 disorder
       Region 5swt B 588-598 order
       Region 5swt B 599-600 disorder
 Evidence X-RAY 5swr B Reference
       Region 5swr B 322-326 disorder
       Region 5swr B 327-336 order
       Region 5swr B 337-339 disorder
       Region 5swr B 340-358 order
       Region 5swr B 359-362 disorder
       Region 5swr B 363-383 order
       Region 5swr B 384-386 disorder
       Region 5swr B 387-390 order
       Region 5swr B 391-392 disorder
       Region 5swr B 393-395 order
       Region 5swr B 396-396 disorder
       Region 5swr B 397-419 order
       Region 5swr B 420-421 disorder
       Region 5swr B 422-429 order
       Region 5swr B 430-431 disorder
       Region 5swr B 432-586 order
       Region 5swr B 587-589 disorder
       Region 5swr B 590-598 order
       Region 5swr B 599-600 disorder
 Evidence X-RAY 5swp B Reference
       Region 5swp B 322-326 disorder
       Region 5swp B 327-334 order
       Region 5swp B 335-338 disorder
       Region 5swp B 339-358 order
       Region 5swp B 359-361 disorder
       Region 5swp B 362-386 order
       Region 5swp B 387-388 disorder
       Region 5swp B 389-397 order
       Region 5swp B 398-400 disorder
       Region 5swp B 401-422 order
       Region 5swp B 423-423 disorder
       Region 5swp B 424-430 order
       Region 5swp B 431-431 disorder
       Region 5swp B 432-598 order
       Region 5swp B 599-600 disorder
 Evidence X-RAY 5swo B Reference
       Region 5swo B 322-326 disorder
       Region 5swo B 327-336 order
       Region 5swo B 337-339 disorder
       Region 5swo B 340-359 order
       Region 5swo B 360-361 disorder
       Region 5swo B 362-598 order
       Region 5swo B 599-600 disorder
 Evidence X-RAY 5swg B Reference
       Region 5swg B 322-326 disorder
       Region 5swg B 327-336 order
       Region 5swg B 337-337 disorder
       Region 5swg B 338-358 order
       Region 5swg B 359-362 disorder
       Region 5swg B 363-429 order
       Region 5swg B 430-435 disorder
       Region 5swg B 436-585 order
       Region 5swg B 586-591 disorder
       Region 5swg B 592-598 order
       Region 5swg B 599-600 disorder
 Evidence X-RAY 5sw8 B Reference
       Region 5sw8 B 322-327 disorder
       Region 5sw8 B 328-330 order
       Region 5sw8 B 331-340 disorder
       Region 5sw8 B 341-350 order
       Region 5sw8 B 351-353 disorder
       Region 5sw8 B 354-359 order
       Region 5sw8 B 360-365 disorder
       Region 5sw8 B 366-372 order
       Region 5sw8 B 373-374 disorder
       Region 5sw8 B 375-387 order
       Region 5sw8 B 388-399 disorder
       Region 5sw8 B 400-420 order
       Region 5sw8 B 421-428 disorder
       Region 5sw8 B 429-435 order
       Region 5sw8 B 436-447 disorder
       Region 5sw8 B 448-509 order
       Region 5sw8 B 510-516 disorder
       Region 5sw8 B 517-583 order
       Region 5sw8 B 584-592 disorder
       Region 5sw8 B 593-597 order
       Region 5sw8 B 598-600 disorder
 Evidence X-RAY 2rd0 B Reference
       Region 2rd0 B 322-441 disorder
       Region 2rd0 B 442-509 order
       Region 2rd0 B 510-520 disorder
       Region 2rd0 B 521-583 order
       Region 2rd0 B 584-592 disorder
       Region 2rd0 B 593-600 order
 Evidence X-RAY 4ovv B Reference
       Region 4ovv B 322-326 disorder
       Region 4ovv B 327-358 order
       Region 4ovv B 359-361 disorder
       Region 4ovv B 362-373 order
       Region 4ovv B 374-376 disorder
       Region 4ovv B 377-382 order
       Region 4ovv B 383-390 disorder
       Region 4ovv B 391-410 order
       Region 4ovv B 411-411 disorder
       Region 4ovv B 412-418 order
       Region 4ovv B 419-425 disorder
       Region 4ovv B 426-511 order
       Region 4ovv B 512-516 disorder
       Region 4ovv B 517-588 order
       Region 4ovv B 589-592 disorder
       Region 4ovv B 593-598 order
       Region 4ovv B 599-600 disorder
 Evidence X-RAY 4ovu B Reference
       Region 4ovu B 322-326 disorder
       Region 4ovu B 327-512 order
       Region 4ovu B 513-516 disorder
       Region 4ovu B 517-598 order
       Region 4ovu B 599-600 disorder
 Evidence X-RAY 4l2y B Reference
       Region 4l2y B 318-321 disorder
       Region 4l2y B 322-598 order
       Region 4l2y B 599-615 disorder
 Evidence X-RAY 4l23 B Reference
       Region 4l23 B 318-321 disorder
       Region 4l23 B 322-598 order
       Region 4l23 B 599-615 disorder
 Evidence X-RAY 4l1b B Reference
       Region 4l1b B 318-321 disorder
       Region 4l1b B 322-598 order
       Region 4l1b B 599-615 disorder
 Evidence X-RAY 4jps B Reference
       Region 4jps B 307-331 disorder
       Region 4jps B 332-363 order
       Region 4jps B 364-366 disorder
       Region 4jps B 367-386 order
       Region 4jps B 387-390 disorder
       Region 4jps B 391-398 order
       Region 4jps B 399-422 disorder
       Region 4jps B 423-430 order
       Region 4jps B 431-433 disorder
       Region 4jps B 434-592 order
       Region 4jps B 593-593 disorder
 Evidence X-RAY 5itd B Reference
       Region 5itd B 307-326 disorder
       Region 5itd B 327-362 order
       Region 5itd B 363-366 disorder
       Region 5itd B 367-383 order
       Region 5itd B 384-391 disorder
       Region 5itd B 392-409 order
       Region 5itd B 410-423 disorder
       Region 5itd B 424-430 order
       Region 5itd B 431-433 disorder
       Region 5itd B 434-592 order
       Region 5itd B 593-617 disorder
 Evidence X-RAY 3hiz B Reference
       Region 3hiz B 322-326 disorder
       Region 3hiz B 327-408 order
       Region 3hiz B 409-412 disorder
       Region 3hiz B 413-431 order
       Region 3hiz B 432-446 disorder
       Region 3hiz B 447-579 order
       Region 3hiz B 580-694 disorder
 Evidence X-RAY 3hhm B Reference
       Region 3hhm B 322-325 disorder
       Region 3hhm B 326-363 order
       Region 3hhm B 364-365 disorder
       Region 3hhm B 366-433 order
       Region 3hhm B 434-434 disorder
       Region 3hhm B 435-440 order
       Region 3hhm B 441-442 disorder
       Region 3hhm B 443-447 order
       Region 3hhm B 448-449 disorder
       Region 3hhm B 450-579 order
       Region 3hhm B 580-694 disorder
 Evidence X-RAY 5fi4 B Reference
       Region 5fi4 B 306-328 disorder
       Region 5fi4 B 329-362 order
       Region 5fi4 B 363-365 disorder
       Region 5fi4 B 366-384 order
       Region 5fi4 B 385-386 disorder
       Region 5fi4 B 387-393 order
       Region 5fi4 B 394-394 disorder
       Region 5fi4 B 395-418 order
       Region 5fi4 B 419-420 disorder
       Region 5fi4 B 421-432 order
       Region 5fi4 B 433-438 disorder
       Region 5fi4 B 439-591 order
       Region 5fi4 B 592-617 disorder
Seq 318-615 Monomer : P42336
 Evidence X-RAY 4ykn A Reference
       Region 4ykn A 318-330 disorder
       Region 4ykn A 331-359 order
       Region 4ykn A 360-367 disorder
       Region 4ykn A 368-385 order
       Region 4ykn A 386-389 disorder
       Region 4ykn A 390-397 order
       Region 4ykn A 398-400 disorder
       Region 4ykn A 401-410 order
       Region 4ykn A 411-418 disorder
       Region 4ykn A 419-428 order
       Region 4ykn A 429-451 disorder
       Region 4ykn A 452-580 order
       Region 4ykn A 581-615 disorder
Seq 321-440 Hetero dimer : P09619
 Evidence X-RAY 2iui B Reference
       Region 2iui B 321-322 disorder
       Region 2iui B 323-432 order
       Region 2iui B 433-440 disorder
 Evidence X-RAY 2iui A Reference
       Region 2iui A 321-325 disorder
       Region 2iui A 326-432 order
       Region 2iui A 433-440 disorder
Seq 321-440 Hetero dimer : P10721
 Evidence X-RAY 2iuh A Reference
       Region 2iuh A 321-324 disorder
       Region 2iuh A 325-439 order
       Region 2iuh A 440-440 disorder
Seq 321-440 Monomer :
 Evidence X-RAY 2iug A Reference
       Region 2iug A 321-323 disorder
       Region 2iug A 324-433 order
       Region 2iug A 434-440 disorder
Seq 322-600 Hetero dimer : P42337
 Evidence X-RAY 4a55 B Reference
       Region 4a55 B 322-447 disorder
       Region 4a55 B 448-582 order
       Region 4a55 B 583-592 disorder
       Region 4a55 B 593-598 order
       Region 4a55 B 599-600 disorder
Seq 325-430 Hetero dimer : IID00509Complex
 Evidence X-RAY 5gji A Reference
       Region 5gji A 325-430 order
Seq 431-600 Hetero dimer : P32871
 Evidence X-RAY 2v1y B Reference
       Region 2v1y B 431-600 order
Seq 614-720 Hetero dimer : IID00509Complex
 Evidence X-RAY 5aul A Reference
       Region 5aul A 614-720 order
Seq 617-724 Hetero dimer : P09619
 Evidence 1h9o A Reference
       Region 1h9o A 617-720 order
       Region 1h9o A 721-724 disorder
Seq 617-724 Monomer :
 Evidence NMR 1pic A Reference
       Region 1pic A 617-724 order
Seqphosphorylation
    154-154 Phosphoserine
    279-279 Phosphoserine
    467-467 Phosphotyrosine
    580-580 Phosphotyrosine
    608-608 Phosphoserine
Seqacetylation
    2-2 N-acetylserine
 
Prediction
NeProc
Disorder 86-113,273-286,312-342,513-516,601-616,724-724
Order 1-85,114-152,158-272,287-311,343-512,517-600,617-723
ProS 86-99,108-113,273-286,312-317,329-342,513-516
AlphaFold
Disorder 1-3,83-114,167-172,276-281,297-325,363-366,600-615,721-724
Order 4-82,115-166,173-275,282-296,326-362,367-599,616-720
Pfam Hmmer
PF00018 6-77 1.7e-05
PF00620 129-281 6.2e-36
PF00017 333-408 3.9e-23
PF00017 624-698 1.3e-29
SEG 79-102 ,303-314 ,533-548
Function
Function in SwissProt
Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling (PubMed:17626883, PubMed:19805105, PubMed:7518429). Modulates the cellular response to ER stress by promoting nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (PubMed:20348923).