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IID00715  DNA replication licensing factor MCM2 (Homo sapiens) P49736
  :order  :disorder  :conflict  :PDB cluster  :ProS  :SCOP Domain  :Pfam Domain
Networkxml
Experiment
904
fasta
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 61-130 Hetero tetramer : IID00058Complex,IID00088Complex
 Evidence X-RAY 5bo0 C Reference
       Region 5bo0 C 61-67 disorder
       Region 5bo0 C 68-124 order
       Region 5bo0 C 125-130 disorder
Seq 61-130 Hetero tetramer : IID00058Complex,IID00239Complex
 Evidence X-RAY 5bnx C Reference
       Region 5bnx C 61-67 disorder
       Region 5bnx C 68-124 order
       Region 5bnx C 125-130 disorder
Seq 61-130 Hetero hexamer : IID00058Complex,IID00239Complex
 Evidence X-RAY 5bnv F Reference
       Region 5bnv F 61-67 disorder
       Region 5bnv F 68-125 order
       Region 5bnv F 126-130 disorder
 Evidence X-RAY 5bnv C Reference
       Region 5bnv C 61-67 disorder
       Region 5bnv C 68-124 order
       Region 5bnv C 125-130 disorder
Seq 61-130 Hetero octamer : IID00058Complex,IID00239Complex
 Evidence X-RAY 5ja4 C Reference
       Region 5ja4 C 61-67 disorder
       Region 5ja4 C 68-124 order
       Region 5ja4 C 125-130 disorder
Seq 63-124 Hetero tetramer : IID00058Complex,IID00062Complex,IID00182Complex
 Evidence X-RAY 5c3i D Reference
       Region 5c3i D 63-67 disorder
       Region 5c3i D 68-123 order
       Region 5c3i D 124-124 disorder
Seq 63-124 Hetero tetramer : IID00058Complex,IID00062Complex
 Evidence X-RAY 5c3i X Reference
       Region 5c3i X 63-67 disorder
       Region 5c3i X 68-123 order
       Region 5c3i X 124-124 disorder
 Evidence X-RAY 5c3i T Reference
       Region 5c3i T 63-68 disorder
       Region 5c3i T 69-124 order
 Evidence X-RAY 5c3i P Reference
       Region 5c3i P 63-68 disorder
       Region 5c3i P 69-116 order
       Region 5c3i P 117-124 disorder
 Evidence X-RAY 5c3i H Reference
       Region 5c3i H 63-67 disorder
       Region 5c3i H 68-123 order
       Region 5c3i H 124-124 disorder
 Evidence X-RAY 5c3i L Reference
       Region 5c3i L 63-67 disorder
       Region 5c3i L 68-123 order
       Region 5c3i L 124-124 disorder
Seqdisorder 63-153
 Evidence NMR This region is largely unfolded in solution, with a residual helix (107-122) (PubMed=25618846) Reference
       Region 63-153 disorder
Seq 69-138 Hetero trimer : P02299,P84040
 Evidence X-RAY 4uuz C Reference
       Region 4uuz C 69-121 order
       Region 4uuz C 122-138 disorder
SeqProS verified 68-123 The residues 107-122 form a helical conformation in the free state (PubMed=25618846) Hetero tetramer : IID00058Complex,IID00062Complex,IID00182Complex
       Region 5c3i D 68-123 order
       Region 63-153 disorder
SeqProS verified 68-124 The residues 107-122 form a helical conformation in the free state (PubMed=25618846) Hetero octamer : IID00058Complex,IID00239Complex
       Region 5ja4 C 68-124 order
       Region 63-153 disorder
SeqProS verified 68-124 The residues 107-122 form a helical conformation in the free state (PubMed=25618846) Hetero tetramer : IID00058Complex,IID00088Complex
       Region 5bo0 C 68-124 order
       Region 63-153 disorder
SeqProS verified 68-124 The residues 107-122 form a helical conformation in the free state (PubMed=25618846) Hetero tetramer : IID00058Complex,IID00062Complex
       Region 5c3i H 68-123 order
       Region 5c3i L 68-123 order
       Region 5c3i P 69-116 order
       Region 5c3i T 69-124 order
       Region 5c3i X 68-123 order
       Region 63-153 disorder
SeqProS verified 68-124 The residues 107-122 form a helical conformation in the free state (PubMed=25618846) Hetero tetramer : IID00058Complex,IID00239Complex
       Region 5bnx C 68-124 order
       Region 63-153 disorder
SeqProS verified 68-125 The residues 107-122 form a helical conformation in the free state (PubMed=25618846) Hetero hexamer : IID00058Complex,IID00239Complex
       Region 5bnv C 68-124 order
       Region 5bnv F 68-125 order
       Region 63-153 disorder
SeqProS verified 69-121 The residues 107-122 form a helical conformation in the free state (PubMed=25618846) Hetero trimer : P02299,P84040
       Region 4uuz C 69-121 order
       Region 63-153 disorder
Seqphosphorylation
    484-484 Phosphoserine
    381-381 Phosphoserine
    139-139 Phosphoserine
    108-108 Phosphoserine; by ATR
    137-137 Phosphotyrosine
    59-59 Phosphothreonine
    53-53 Phosphoserine; by CDC7
    41-41 Phosphoserine
    40-40 Phosphoserine; by CDC7
    39-39 Phosphothreonine
    32-32 Phosphoserine
    27-27 Phosphoserine
    26-26 Phosphoserine
    25-25 Phosphothreonine
    13-13 Phosphoserine
    12-12 Phosphoserine
    484-484 Phosphoserine
    381-381 Phosphoserine
    139-139 Phosphoserine
    137-137 Phosphotyrosine
    108-108 Phosphoserine; by ATR
    59-59 Phosphothreonine
    53-53 Phosphoserine; by CDC7
    41-41 Phosphoserine
    40-40 Phosphoserine; by CDC7
    39-39 Phosphothreonine
    32-32 Phosphoserine
    27-27 Phosphoserine
    26-26 Phosphoserine
    25-25 Phosphothreonine
    13-13 Phosphoserine
    12-12 Phosphoserine
Seqacetylation
    216-216 N6-acetyllysine
    2-2 N-acetylalanine
    216-216 N6-acetyllysine
    2-2 N-acetylalanine
 
Prediction
DICHOT
Disorder 1-198,799-904
Known Domain 199-798
SCOPe RPS-Blast
     2vl6A 192-444 7e-84
     1g8pA 485-799 7e-15
SCOP Hmmer
     1ltlA_ 198-442 1.6e-67
     1g8pA_ 483-807 2.6e-44
Pfam RPS-Blast
     PF12619 50-181 2e-23 Mini-chromosome maintenance ...
     PF14551 197-285 5e-11 MCM N-terminal domain
     PF17207 294-422 3e-18 MCM OB domain
     PF00493 462-683 6e-21 MCM P-loop domain
     PF17855 720-801 9e-18 MCM AAA-lid domain
Pfam Hmmer
    PF12619 62-180 1.1e-19 Mini-chromosome maintenance...
    PF14551 197-285 1.2e-18 MCM N-terminal domain
    PF17207 294-420 6.5e-40 MCM OB domain
    PF00493 461-683 6.2e-103 MCM P-loop domain
    PF17855 718-802 2.5e-31 MCM AAA-lid domain