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IID00716
UniprotP50613
ProteinCyclin-dependent kinase 7
GeneCDK7
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
xml
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
346
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-346 Monomer :
 Evidence X-RAY 1ua2 D Reference
       Region 1ua2 D 1-12 disorder
       Region 1ua2 D 13-43 order
       Region 1ua2 D 44-55 disorder
       Region 1ua2 D 56-311 order
       Region 1ua2 D 312-346 disorder
 Evidence X-RAY 1ua2 C Reference
       Region 1ua2 C 1-12 disorder
       Region 1ua2 C 13-43 order
       Region 1ua2 C 44-55 disorder
       Region 1ua2 C 56-311 order
       Region 1ua2 C 312-346 disorder
 Evidence X-RAY 1ua2 B Reference
       Region 1ua2 B 1-12 disorder
       Region 1ua2 B 13-43 order
       Region 1ua2 B 44-55 disorder
       Region 1ua2 B 56-311 order
       Region 1ua2 B 312-346 disorder
 Evidence X-RAY 1ua2 A Reference
       Region 1ua2 A 1-12 disorder
       Region 1ua2 A 13-43 order
       Region 1ua2 A 44-55 disorder
       Region 1ua2 A 56-311 order
       Region 1ua2 A 312-346 disorder
Seqphosphorylation
    321-321 Phosphoserine
    164-164 Phosphoserine; by CDK1 and CDK2
    7-7 Phosphoserine
    170-170 Phosphothreonine; by CDK2
Seqacetylation
    2-2 N-acetylalanine
 
Prediction
NeProc
Disorder 1-7,309-346
Order 8-308
ProS 332-336,341-346
AlphaFold
Disorder 1-7,21-23,45-59,83-85,157-174,311-346
Order 8-20,24-44,60-82,86-156,175-310
Pfam Hmmer
PF00069 12-295 2.5e-105
Function
Function in SwissProt
Serine/threonine kinase involved in cell cycle control and in RNA polymerase II-mediated RNA transcription. Cyclin-dependent kinases (CDKs) are activated by the binding to a cyclin and mediate the progression through the cell cycle. Each different complex controls a specific transition between 2 subsequent phases in the cell cycle. Required for both activation and complex formation of CDK1/cyclin-B during G2-M transition, and for activation of CDK2/cyclins during G1-S transition (but not complex formation). CDK7 is the catalytic subunit of the CDK-activating kinase (CAK) complex. Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation, thus regulating cell cycle progression. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Phosphorylation of POLR2A in complex with DNA promotes transcription initiation by triggering dissociation from DNA. Its expression and activity are constant throughout the cell cycle. Upon DNA damage, triggers p53/TP53 activation by phosphorylation, but is inactivated in turn by p53/TP53; this feedback loop may lead to an arrest of the cell cycle and of the transcription, helping in cell recovery, or to apoptosis. Required for DNA-bound peptides-mediated transcription and cellular growth inhibition.