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IID00717
 UniprotP51608
ProteinMethyl-CpG-binding protein 2
GeneMECP2
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
486
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 77-166 Homo dimer :
 Evidence X-RAY 6ogj B Reference
       Region 6ogj B 77-86 disorder
       Region 6ogj B 87-166 order
 Evidence X-RAY 6ogj A Reference
       Region 6ogj A 77-92 disorder
       Region 6ogj A 93-166 order
Seq 77-181 Monomer :
 Evidence NMR 1qk9 A Reference
       Region 1qk9 A 77-166 order
       Region 1qk9 A 77-91 high_rmsd
       Region 1qk9 A 114-114 high_rmsd
       Region 1qk9 A 164-166 high_rmsd
 Evidence X-RAY 3c2i A Reference
       Region 3c2i A 77-90 disorder
       Region 3c2i A 91-162 order
       Region 3c2i A 163-167 disorder
 Evidence X-RAY 5bt2 A Reference
       Region 5bt2 A 77-91 disorder
       Region 5bt2 A 92-162 order
       Region 5bt2 A 163-167 disorder
 Evidence X-RAY 6c1y A Reference
       Region 6c1y A 80-91 disorder
       Region 6c1y A 92-162 order
       Region 6c1y A 163-164 disorder
 Evidence X-RAY 6c1y B Reference
       Region 6c1y B 80-91 disorder
       Region 6c1y B 92-162 order
       Region 6c1y B 163-164 disorder
 Evidence X-RAY 6ogk A Reference
       Region 6ogk A 77-89 disorder
       Region 6ogk A 90-165 order
       Region 6ogk A 166-167 disorder
 Evidence X-RAY 6yww A Reference
       Region 6yww A 77-91 disorder
       Region 6yww A 92-161 order
 Evidence NMR 8ajr A Reference
       Region 8ajr A 89-181 order
       Region 8ajr A 89-97 high_rmsd
       Region 8ajr A 164-181 high_rmsd
 Evidence NMR 8alq A Reference
       Region 8alq A 89-181 order
       Region 8alq A 94-95 high_rmsd
       Region 8alq A 164-181 high_rmsd
Seqdisorder 1-90,165-330,335-486
 Evidence CD Reference
       Region 1-90 disorder
       Region 165-210 disorder
       Region 207-310 disorder
       Region 261-330 disorder
       Region 335-486 disorder
Seqphosphorylation
    423-423 Phosphoserine
    426-426 Phosphoserine
    216-216 Phosphoserine
    229-229 Phosphoserine
    13-13 Phosphoserine
    80-80 Phosphoserine
    116-116 Phosphoserine
Seqacetylation
    449-449 N6-acetyllysine
    321-321 N6-acetyllysine
 
Prediction
NeProc
Disorder 1-101,164-486
Order 102-163
ProS 1-37,90-101,219-228,267-274,295-301,307-314,336-349,404-408,457-486
AlphaFold
Disorder 1-91,162-174,176-222,224-383,391-401,403-482,484-486
Order 92-161,175-175,223-223,384-390,402-402,483-483
Pfam Hmmer
PF01429 90-165 4.4e-29
SEG 20-46 ,68-81 ,171-199 ,274-292 ,340-405 ,434-447
Function
Function in SwissProt
Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC).
Biological Process
See also
Diagram with PDB data
REST/Sin3bSolution structure of the NRSF/REST-mSin3B PAH1 complex