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IID00719
 UniprotQ06787
ProteinFragile X messenger ribonucleoprotein 1
GeneFMR1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
632
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-134 Monomer :
 Evidence NMR 2bkd N Reference
       Region 2bkd N 1-134 order
Seq 1-209 Homo tetramer :
 Evidence X-RAY 4ova D Reference
       Region 4ova D 1-200 order
       Region 4ova D 201-209 disorder
 Evidence X-RAY 4ova C Reference
       Region 4ova C 1-199 order
       Region 4ova C 200-209 disorder
 Evidence X-RAY 4ova B Reference
       Region 4ova B 1-200 order
       Region 4ova B 201-209 disorder
 Evidence X-RAY 4ova A Reference
       Region 4ova A 1-200 order
       Region 4ova A 201-209 disorder
Seq 1-213 Monomer :
 Evidence X-RAY 4qvz A Reference
       Region 4qvz A 1-1 disorder
       Region 4qvz A 2-97 order
       Region 4qvz A 98-103 disorder
       Region 4qvz A 104-201 order
       Region 4qvz A 202-213 disorder
 Evidence X-RAY 4qvz B Reference
       Region 4qvz B 1-98 order
       Region 4qvz B 99-101 disorder
       Region 4qvz B 102-207 order
       Region 4qvz B 208-213 disorder
 Evidence X-RAY 4qw2 A Reference
       Region 4qw2 A 1-1 disorder
       Region 4qw2 A 2-99 order
       Region 4qw2 A 100-101 disorder
       Region 4qw2 A 102-201 order
       Region 4qw2 A 202-213 disorder
 Evidence X-RAY 4qw2 B Reference
       Region 4qw2 B 1-2 disorder
       Region 4qw2 B 3-202 order
       Region 4qw2 B 203-213 disorder
Seq 216-280 Monomer :
 Evidence NMR 2fmr A Reference
       Region 2fmr A 216-280 order
       Region 2fmr A 232-237 high_rmsd
Seq 216-330,397-425 Monomer :
 Evidence X-RAY 2qnd B Reference
       Region 2qnd B 216-216 disorder
       Region 2qnd B 217-330 order
       Region 2qnd B 397-425 order
 Evidence X-RAY 2qnd A Reference
       Region 2qnd A 216-218 disorder
       Region 2qnd A 219-330 order
       Region 2qnd A 397-425 order
Seq 422-438 Hetero tetramer : IID50169Complex
 Evidence X-RAY 5uwo D Reference
       Region 5uwo D 422-429 disorder
       Region 5uwo D 430-438 order
 Evidence X-RAY 5uwj D Reference
       Region 5uwj D 423-426 disorder
       Region 5uwj D 427-437 order
Seq 527-544 Monomer :
 Evidence X-RAY 5de5 B Reference
       Region 5de5 B 528-528 disorder
       Region 5de5 B 529-542 order
       Region 5de5 B 543-544 disorder
 Evidence X-RAY 5de5 D Reference
       Region 5de5 D 528-529 disorder
       Region 5de5 D 530-542 order
       Region 5de5 D 543-544 disorder
 Evidence X-RAY 5de8 B Reference
       Region 5de8 B 528-528 disorder
       Region 5de8 B 529-542 order
       Region 5de8 B 543-544 disorder
 Evidence X-RAY 5de8 D Reference
       Region 5de8 D 528-529 disorder
       Region 5de8 D 530-543 order
       Region 5de8 D 544-544 disorder
 Evidence X-RAY 5dea B Reference
       Region 5dea B 528-528 disorder
       Region 5dea B 529-542 order
       Region 5dea B 543-544 disorder
 Evidence X-RAY 5dea D Reference
       Region 5dea D 528-528 disorder
       Region 5dea D 529-542 order
       Region 5dea D 543-544 disorder
 Evidence NMR 2la5 B Reference
       Region 2la5 B 527-541 order
SeqProS verified 527-541 :
       Region 2la5 B 527-541 order
       Region 5de8 B 529-542 order
       Region 5de8 D 530-543 order
       Region 5dea B 529-542 order
       Region 5dea D 529-542 order
       Region 5de5 B 529-542 order
       Region 5de5 D 530-542 order
Seqphosphorylation
    337-337 Phosphoserine
    370-370 Phosphoserine
    460-460 Phosphoserine
    463-463 Phosphothreonine
    500-500 Phosphoserine; by CK2
    502-502 Phosphothreonine
    504-504 Phosphoserine
    511-511 Phosphoserine
    514-514 Phosphoserine
    518-518 Phosphothreonine
    573-573 Phosphothreonine
    574-574 Phosphothreonine
    592-592 Phosphothreonine
    594-594 Phosphothreonine
    598-598 Phosphothreonine
    620-620 Phosphoserine
Seqacetylation
    1-1 N-acetylmethionine
 
Prediction
NeProc
Disorder 202-216,342-632
Order 1-201,217-341
ProS 342-379,390-480,485-515,521-524,535-558,564-571,576-584,625-632
AlphaFold
Disorder 1-1,99-102,212-217,320-396,445-632
Order 2-98,103-211,218-319,397-444
Pfam Hmmer
PF05641 59-120 1.5e-09
PF00013 220-279 8.4e-07
PF00013 283-333 2.4e-06
SEG 492-504 ,527-549
Function
Function in SwissProt
(Microbial infection) Acts as a positive regulator of influenza A virus (IAV) replication. Required for the assembly and nuclear export of the viral ribonucleoprotein (vRNP) components.