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IID00720
 UniprotQ07817
ProteinBcl-2-like protein 1
GeneBCL2L1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
233
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-27,83-196 Hetero dimer :
 Evidence X-RAY 7y8d A Reference
       Region 7y8d A 1-1 disorder
       Region 7y8d A 2-27 order
       Region 7y8d A 83-196 order
Seq 1-26,82-196 Hetero dimer :
 Evidence X-RAY 7yaa A Reference
       Region 7yaa A 1-26 order
       Region 7yaa A 82-196 order
Seq 1-26,83-197 Hetero dimer : Q9Y5Z4
 Evidence X-RAY 3r85 A Reference
       Region 3r85 A 1-3 disorder
       Region 3r85 A 4-26 order
       Region 3r85 A 83-197 order
 Evidence X-RAY 3r85 B Reference
       Region 3r85 B 1-3 disorder
       Region 3r85 B 4-26 order
       Region 3r85 B 83-197 order
 Evidence X-RAY 3r85 C Reference
       Region 3r85 C 1-2 disorder
       Region 3r85 C 3-26 order
       Region 3r85 C 83-197 order
 Evidence X-RAY 3r85 D Reference
       Region 3r85 D 1-2 disorder
       Region 3r85 D 3-26 order
       Region 3r85 D 83-197 order
Seq 1-26,83-208 Hetero octamer : IID00651Complex
 Evidence X-RAY 4z9v B Reference
       Region 4z9v B 1-26 order
       Region 4z9v B 83-207 order
       Region 4z9v B 208-208 disorder
 Evidence X-RAY 4z9v A Reference
       Region 4z9v A 1-26 order
       Region 4z9v A 83-208 order
Seq 1-26,83-208 Hetero hexamer : IID00669Complex
 Evidence X-RAY 6dcn B Reference
       Region 6dcn B 1-26 order
       Region 6dcn B 83-197 order
       Region 6dcn B 198-208 disorder
 Evidence X-RAY 6dcn A Reference
       Region 6dcn A 1-26 order
       Region 6dcn A 83-197 order
       Region 6dcn A 198-208 disorder
Seq 1-26,83-208 Hetero hexamer : IID00669Complex
 Evidence X-RAY 6dco B Reference
       Region 6dco B 1-26 order
       Region 6dco B 83-198 order
       Region 6dco B 199-208 disorder
 Evidence X-RAY 6dco A Reference
       Region 6dco A 1-26 order
       Region 6dco A 83-198 order
       Region 6dco A 199-208 disorder
Seq 1-44,85-209 Hetero dimer : IID00753Complex
 Evidence NMR 6ijq B Reference
       Region 6ijq B 1-44 order
       Region 6ijq B 29-41 high_rmsd
       Region 6ijq B 85-209 order
       Region 6ijq B 159-169 high_rmsd
Seq 1-25,83-209 Hetero tetramer :
 Evidence X-RAY 6vwc B Reference
       Region 6vwc B 1-1 disorder
       Region 6vwc B 2-24 order
       Region 6vwc B 25-25 disorder
       Region 6vwc B 83-196 order
       Region 6vwc B 197-209 disorder
 Evidence X-RAY 6vwc A Reference
       Region 6vwc A 1-1 disorder
       Region 6vwc A 2-25 order
       Region 6vwc A 83-196 order
       Region 6vwc A 197-209 disorder
Seq 1-209 Hetero dimer : IID00015Complex
 Evidence NMR 2mej A Reference
       Region 2mej A 1-28 order
       Region 2mej A 29-82 disorder
       Region 2mej A 83-198 order
       Region 2mej A 199-209 disorder
Seq 1-26,79-209 Hetero dimer :
 Evidence X-RAY 4cin A Reference
       Region 4cin A 1-1 disorder
       Region 4cin A 2-26 order
       Region 4cin A 83-197 order
       Region 4cin A 198-209 disorder
 Evidence X-RAY 4cin B Reference
       Region 4cin B 1-26 order
       Region 4cin B 83-105 order
       Region 4cin B 106-112 disorder
       Region 4cin B 113-197 order
       Region 4cin B 198-209 disorder
 Evidence X-RAY 4cin C Reference
       Region 4cin C 79-79 disorder
       Region 4cin C 80-102 order
 Evidence X-RAY 4cin D Reference
       Region 4cin D 79-82 disorder
       Region 4cin D 83-101 order
       Region 4cin D 102-102 disorder
Seq 1-44,85-209 Hetero trimer : Q07812
 Evidence X-RAY 3pl7 B Reference
       Region 3pl7 B 1-3 disorder
       Region 3pl7 B 4-29 order
       Region 3pl7 B 30-41 disorder
       Region 3pl7 B 42-44 order
       Region 3pl7 B 85-196 order
       Region 3pl7 B 197-209 disorder
 Evidence X-RAY 3pl7 A Reference
       Region 3pl7 A 1-2 disorder
       Region 3pl7 A 3-28 order
       Region 3pl7 A 29-41 disorder
       Region 3pl7 A 42-44 order
       Region 3pl7 A 85-196 order
       Region 3pl7 A 197-209 disorder
Seq 1-26,83-209 Homo tetramer :
 Evidence X-RAY 4c5d B Reference
       Region 4c5d B 1-26 order
       Region 4c5d B 83-198 order
       Region 4c5d B 199-209 disorder
 Evidence X-RAY 4c5d A Reference
       Region 4c5d A 1-26 order
       Region 4c5d A 83-196 order
       Region 4c5d A 197-209 disorder
Seq 1-25,83-209 Hetero tetramer :
 Evidence X-RAY 7lh7 B Reference
       Region 7lh7 B 1-3 disorder
       Region 7lh7 B 4-22 order
       Region 7lh7 B 23-25 disorder
       Region 7lh7 B 83-198 order
       Region 7lh7 B 199-209 disorder
 Evidence X-RAY 7lh7 A Reference
       Region 7lh7 A 1-2 disorder
       Region 7lh7 A 3-25 order
       Region 7lh7 A 83-207 order
       Region 7lh7 A 208-209 disorder
Seq 1-44,85-209 Hetero dimer : Q9BXH1
 Evidence NMR 2m04 A Reference
       Region 2m04 A 1-44 order
       Region 2m04 A 27-40 high_rmsd
       Region 2m04 A 85-209 order
       Region 2m04 A 158-169 high_rmsd
Seq 1-44,85-209 Hetero hexamer :
 Evidence X-RAY 7xgg F Reference
       Region 7xgg F 1-28 order
       Region 7xgg F 29-40 disorder
       Region 7xgg F 41-44 order
       Region 7xgg F 85-197 order
       Region 7xgg F 198-209 disorder
 Evidence X-RAY 7xgg E Reference
       Region 7xgg E 1-2 disorder
       Region 7xgg E 3-31 order
       Region 7xgg E 32-40 disorder
       Region 7xgg E 41-44 order
       Region 7xgg E 85-197 order
       Region 7xgg E 198-209 disorder
 Evidence X-RAY 7xgg C Reference
       Region 7xgg C 1-30 order
       Region 7xgg C 31-39 disorder
       Region 7xgg C 40-44 order
       Region 7xgg C 85-196 order
       Region 7xgg C 197-209 disorder
 Evidence X-RAY 7xgg B Reference
       Region 7xgg B 1-2 disorder
       Region 7xgg B 3-28 order
       Region 7xgg B 29-38 disorder
       Region 7xgg B 39-44 order
       Region 7xgg B 85-197 order
       Region 7xgg B 198-209 disorder
Seq 1-26,83-209 Hetero tetramer : IID00746Complex
 Evidence X-RAY 4a1w A Reference
       Region 4a1w A 1-26 order
       Region 4a1w A 83-197 order
       Region 4a1w A 198-209 disorder
 Evidence X-RAY 4a1w D Reference
       Region 4a1w D 1-26 order
       Region 4a1w D 83-196 order
       Region 4a1w D 197-209 disorder
 Evidence X-RAY 4a1w B Reference
       Region 4a1w B 1-26 order
       Region 4a1w B 83-197 order
       Region 4a1w B 198-209 disorder
 Evidence X-RAY 4a1w C Reference
       Region 4a1w C 1-2 disorder
       Region 4a1w C 3-26 order
       Region 4a1w C 83-196 order
       Region 4a1w C 197-209 disorder
 Evidence X-RAY 5vx3 A Reference
       Region 5vx3 A 1-26 order
       Region 5vx3 A 83-196 order
       Region 5vx3 A 197-209 disorder
 Evidence X-RAY 5vx3 E Reference
       Region 5vx3 E 1-26 order
       Region 5vx3 E 83-197 order
       Region 5vx3 E 198-209 disorder
 Evidence X-RAY 5vx3 C Reference
       Region 5vx3 C 1-26 order
       Region 5vx3 C 83-196 order
       Region 5vx3 C 197-209 disorder
 Evidence X-RAY 5vx3 G Reference
       Region 5vx3 G 1-26 order
       Region 5vx3 G 83-197 order
       Region 5vx3 G 198-209 disorder
 Evidence X-RAY 2yq6 A Reference
       Region 2yq6 A 1-26 order
       Region 2yq6 A 83-196 order
       Region 2yq6 A 197-209 disorder
 Evidence X-RAY 2yq7 A Reference
       Region 2yq7 A 1-26 order
       Region 2yq7 A 83-196 order
       Region 2yq7 A 197-209 disorder
Seq 1-44,85-209 Hetero tetramer : A0A369S334
 Evidence X-RAY 6yli C Reference
       Region 6yli C 1-28 order
       Region 6yli C 29-38 disorder
       Region 6yli C 39-44 order
       Region 6yli C 85-201 order
       Region 6yli C 202-209 disorder
 Evidence X-RAY 6yli A Reference
       Region 6yli A 1-29 order
       Region 6yli A 30-38 disorder
       Region 6yli A 39-44 order
       Region 6yli A 85-200 order
       Region 6yli A 201-209 disorder
Seq 1-44,85-209 Hetero dimer : P55957
 Evidence X-RAY 4qve A Reference
       Region 4qve A 1-3 disorder
       Region 4qve A 4-25 order
       Region 4qve A 26-44 disorder
       Region 4qve A 85-198 order
       Region 4qve A 199-209 disorder
Seq 1-44,83-209 Hetero dimer : IID00746Complex
 Evidence X-RAY 4a1u A Reference
       Region 4a1u A 1-26 order
       Region 4a1u A 83-206 order
       Region 4a1u A 207-209 disorder
 Evidence X-RAY 3fdl A Reference
       Region 3fdl A 1-26 order
       Region 3fdl A 83-194 order
       Region 3fdl A 195-209 disorder
 Evidence X-RAY 3io8 A Reference
       Region 3io8 A 1-26 order
       Region 3io8 A 83-108 order
       Region 3io8 A 109-111 disorder
       Region 3io8 A 112-197 order
       Region 3io8 A 198-209 disorder
 Evidence X-RAY 3io8 C Reference
       Region 3io8 C 1-26 order
       Region 3io8 C 83-197 order
       Region 3io8 C 198-209 disorder
 Evidence X-RAY 4qvf A Reference
       Region 4qvf A 1-1 disorder
       Region 4qvf A 2-30 order
       Region 4qvf A 31-44 disorder
       Region 4qvf A 85-196 order
       Region 4qvf A 197-209 disorder
Seq 1-44,85-209 Hetero dimer : Q92934
 Evidence NMR 1g5j A Reference
       Region 1g5j A 1-44 order
       Region 1g5j A 85-209 order
Seq 1-26,83-209 Hetero tetramer : Q9BXH1
 Evidence X-RAY 4bpk B Reference
       Region 4bpk B 1-1 disorder
       Region 4bpk B 2-26 order
       Region 4bpk B 83-195 order
       Region 4bpk B 196-209 disorder
 Evidence X-RAY 4bpk A Reference
       Region 4bpk A 1-26 order
       Region 4bpk A 83-195 order
       Region 4bpk A 196-209 disorder
Seq 1-209 Hetero dimer : Q16611
 Evidence NMR 2lp8 A Reference
       Region 2lp8 A 1-44 order
       Region 2lp8 A 1-1 high_rmsd
       Region 2lp8 A 85-209 order
       Region 2lp8 A 163-169 high_rmsd
 Evidence NMR 1bxl A Reference
       Region 1bxl A 1-44 order
       Region 1bxl A 45-84 disorder
       Region 1bxl A 85-209 order
Seq 1-26,83-209 Homo dodecamer :
 Evidence X-RAY 6uvf L Reference
       Region 6uvf L 1-26 order
       Region 6uvf L 83-195 order
       Region 6uvf L 196-209 disorder
 Evidence X-RAY 6uvf K Reference
       Region 6uvf K 1-26 order
       Region 6uvf K 83-202 order
       Region 6uvf K 203-209 disorder
 Evidence X-RAY 6uvf J Reference
       Region 6uvf J 1-26 order
       Region 6uvf J 83-195 order
       Region 6uvf J 196-209 disorder
 Evidence X-RAY 6uvf I Reference
       Region 6uvf I 1-2 disorder
       Region 6uvf I 3-26 order
       Region 6uvf I 83-196 order
       Region 6uvf I 197-209 disorder
 Evidence X-RAY 6uvf H Reference
       Region 6uvf H 1-26 order
       Region 6uvf H 83-196 order
       Region 6uvf H 197-209 disorder
 Evidence X-RAY 6uvf G Reference
       Region 6uvf G 1-26 order
       Region 6uvf G 83-195 order
       Region 6uvf G 196-209 disorder
 Evidence X-RAY 6uvf F Reference
       Region 6uvf F 1-26 order
       Region 6uvf F 83-196 order
       Region 6uvf F 197-209 disorder
 Evidence X-RAY 6uvf E Reference
       Region 6uvf E 1-26 order
       Region 6uvf E 83-195 order
       Region 6uvf E 196-209 disorder
 Evidence X-RAY 6uvf D Reference
       Region 6uvf D 1-26 order
       Region 6uvf D 83-196 order
       Region 6uvf D 197-209 disorder
 Evidence X-RAY 6uvf C Reference
       Region 6uvf C 1-26 order
       Region 6uvf C 83-196 order
       Region 6uvf C 197-209 disorder
 Evidence X-RAY 6uvf B Reference
       Region 6uvf B 1-26 order
       Region 6uvf B 83-196 order
       Region 6uvf B 197-209 disorder
 Evidence X-RAY 6uvf A Reference
       Region 6uvf A 1-26 order
       Region 6uvf A 83-196 order
       Region 6uvf A 197-209 disorder
Seq 1-209 Hetero trimer : Q9BXH1
 Evidence X-RAY 4hnj B Reference
       Region 4hnj B 1-32 order
       Region 4hnj B 33-81 disorder
       Region 4hnj B 82-105 order
       Region 4hnj B 106-120 disorder
       Region 4hnj B 121-131 order
       Region 4hnj B 132-134 disorder
       Region 4hnj B 135-195 order
       Region 4hnj B 196-209 disorder
 Evidence X-RAY 4hnj A Reference
       Region 4hnj A 1-24 order
       Region 4hnj A 25-80 disorder
       Region 4hnj A 81-196 order
       Region 4hnj A 197-209 disorder
Seq 1-44,85-209 Homo hexamer :
 Evidence X-RAY 4ppi A Reference
       Region 4ppi A 1-2 disorder
       Region 4ppi A 3-25 order
       Region 4ppi A 26-44 disorder
       Region 4ppi A 85-196 order
       Region 4ppi A 197-209 disorder
Seq 1-26,83-209 Homo dodecamer :
 Evidence X-RAY 6uvg L Reference
       Region 6uvg L 1-26 order
       Region 6uvg L 83-107 order
       Region 6uvg L 108-111 disorder
       Region 6uvg L 112-195 order
       Region 6uvg L 196-209 disorder
 Evidence X-RAY 6uvg K Reference
       Region 6uvg K 1-26 order
       Region 6uvg K 83-197 order
       Region 6uvg K 198-209 disorder
 Evidence X-RAY 6uvg J Reference
       Region 6uvg J 1-3 disorder
       Region 6uvg J 4-26 order
       Region 6uvg J 83-110 order
       Region 6uvg J 111-113 disorder
       Region 6uvg J 114-195 order
       Region 6uvg J 196-209 disorder
 Evidence X-RAY 6uvg I Reference
       Region 6uvg I 1-1 disorder
       Region 6uvg I 2-26 order
       Region 6uvg I 83-195 order
       Region 6uvg I 196-209 disorder
 Evidence X-RAY 6uvg H Reference
       Region 6uvg H 1-26 order
       Region 6uvg H 83-197 order
       Region 6uvg H 198-209 disorder
 Evidence X-RAY 6uvg G Reference
       Region 6uvg G 1-26 order
       Region 6uvg G 83-196 order
       Region 6uvg G 197-209 disorder
 Evidence X-RAY 6uvg F Reference
       Region 6uvg F 1-26 order
       Region 6uvg F 83-197 order
       Region 6uvg F 198-209 disorder
 Evidence X-RAY 6uvg E Reference
       Region 6uvg E 1-26 order
       Region 6uvg E 83-196 order
       Region 6uvg E 197-209 disorder
 Evidence X-RAY 6uvg D Reference
       Region 6uvg D 1-26 order
       Region 6uvg D 83-195 order
       Region 6uvg D 196-209 disorder
 Evidence X-RAY 6uvg C Reference
       Region 6uvg C 1-3 disorder
       Region 6uvg C 4-26 order
       Region 6uvg C 83-197 order
       Region 6uvg C 198-209 disorder
 Evidence X-RAY 6uvg B Reference
       Region 6uvg B 1-26 order
       Region 6uvg B 83-196 order
       Region 6uvg B 197-209 disorder
 Evidence X-RAY 6uvg A Reference
       Region 6uvg A 1-26 order
       Region 6uvg A 83-197 order
       Region 6uvg A 198-209 disorder
Seq 1-26,83-209 Homo trimer :
 Evidence X-RAY 6uve C Reference
       Region 6uve C 1-2 disorder
       Region 6uve C 3-26 order
       Region 6uve C 83-206 order
       Region 6uve C 207-209 disorder
 Evidence X-RAY 6uve B Reference
       Region 6uve B 1-3 disorder
       Region 6uve B 4-26 order
       Region 6uve B 83-105 order
       Region 6uve B 106-113 disorder
       Region 6uve B 114-201 order
       Region 6uve B 202-209 disorder
 Evidence X-RAY 6uve A Reference
       Region 6uve A 1-26 order
       Region 6uve A 83-104 order
       Region 6uve A 105-112 disorder
       Region 6uve A 113-196 order
       Region 6uve A 197-209 disorder
Seq 1-44,83-209 Hetero dimer : IID00669Complex
 Evidence X-RAY 2p1l A Reference
       Region 2p1l A 1-1 disorder
       Region 2p1l A 2-26 order
       Region 2p1l A 83-198 order
       Region 2p1l A 199-209 disorder
 Evidence X-RAY 2p1l C Reference
       Region 2p1l C 1-1 disorder
       Region 2p1l C 2-26 order
       Region 2p1l C 83-198 order
       Region 2p1l C 199-209 disorder
 Evidence X-RAY 2p1l E Reference
       Region 2p1l E 1-1 disorder
       Region 2p1l E 2-26 order
       Region 2p1l E 83-198 order
       Region 2p1l E 199-209 disorder
 Evidence X-RAY 2p1l G Reference
       Region 2p1l G 1-1 disorder
       Region 2p1l G 2-26 order
       Region 2p1l G 83-198 order
       Region 2p1l G 199-209 disorder
 Evidence NMR 2pon B Reference
       Region 2pon B 1-44 order
       Region 2pon B 32-35 high_rmsd
       Region 2pon B 85-196 order
Seq 1-26,83-209 Hetero tetramer : Q16611
 Evidence X-RAY 5fmk A Reference
       Region 5fmk A 1-1 disorder
       Region 5fmk A 2-26 order
       Region 5fmk A 83-207 order
       Region 5fmk A 208-209 disorder
Seq 1-26,83-209 Hetero tetramer : I3XMW8
 Evidence X-RAY 5b1z B Reference
       Region 5b1z B 1-26 order
       Region 5b1z B 83-200 order
       Region 5b1z B 201-209 disorder
 Evidence X-RAY 5b1z A Reference
       Region 5b1z A 1-26 order
       Region 5b1z A 83-200 order
       Region 5b1z A 201-209 disorder
Seq 1-26,83-209 Hetero tetramer :
 Evidence X-RAY 6st2 B Reference
       Region 6st2 B 1-1 disorder
       Region 6st2 B 2-26 order
       Region 6st2 B 83-199 order
       Region 6st2 B 200-209 disorder
 Evidence X-RAY 6st2 A Reference
       Region 6st2 A 1-26 order
       Region 6st2 A 83-199 order
       Region 6st2 A 200-209 disorder
Seq 1-26,83-209 Homo tetramer :
 Evidence X-RAY 6uvh D Reference
       Region 6uvh D 1-26 order
       Region 6uvh D 83-196 order
       Region 6uvh D 197-209 disorder
 Evidence X-RAY 6uvh C Reference
       Region 6uvh C 1-26 order
       Region 6uvh C 83-196 order
       Region 6uvh C 197-209 disorder
 Evidence X-RAY 6uvh B Reference
       Region 6uvh B 1-26 order
       Region 6uvh B 83-196 order
       Region 6uvh B 197-209 disorder
 Evidence X-RAY 6uvh A Reference
       Region 6uvh A 1-26 order
       Region 6uvh A 83-196 order
       Region 6uvh A 197-209 disorder
Seq 1-26,83-209 Hetero tetramer : O08734
 Evidence X-RAY 5fmj A Reference
       Region 5fmj A 1-26 order
       Region 5fmj A 83-208 order
       Region 5fmj A 209-209 disorder
Seq 1-44,85-209 Hetero hexamer :
 Evidence X-RAY 7xgf F Reference
       Region 7xgf F 1-3 disorder
       Region 7xgf F 4-30 order
       Region 7xgf F 31-39 disorder
       Region 7xgf F 40-44 order
       Region 7xgf F 85-196 order
       Region 7xgf F 197-209 disorder
 Evidence X-RAY 7xgf E Reference
       Region 7xgf E 1-28 order
       Region 7xgf E 29-38 disorder
       Region 7xgf E 39-44 order
       Region 7xgf E 85-201 order
       Region 7xgf E 202-209 disorder
 Evidence X-RAY 7xgf C Reference
       Region 7xgf C 1-30 order
       Region 7xgf C 31-39 disorder
       Region 7xgf C 40-44 order
       Region 7xgf C 85-197 order
       Region 7xgf C 198-209 disorder
 Evidence X-RAY 7xgf B Reference
       Region 7xgf B 1-28 order
       Region 7xgf B 29-38 disorder
       Region 7xgf B 39-44 order
       Region 7xgf B 85-201 order
       Region 7xgf B 202-209 disorder
Seq 1-23,83-209 Hetero tetramer :
 Evidence X-RAY 4qvx B Reference
       Region 4qvx B 1-1 disorder
       Region 4qvx B 2-22 order
       Region 4qvx B 23-23 disorder
       Region 4qvx B 83-196 order
       Region 4qvx B 197-209 disorder
 Evidence X-RAY 4qvx A Reference
       Region 4qvx A 1-1 disorder
       Region 4qvx A 2-22 order
       Region 4qvx A 23-23 disorder
       Region 4qvx A 83-196 order
       Region 4qvx A 197-209 disorder
Seq 1-211 Homo dimer :
 Evidence X-RAY 2b48 A Reference
       Region 2b48 A 1-24 order
       Region 2b48 A 25-81 disorder
       Region 2b48 A 82-200 order
       Region 2b48 A 201-211 disorder
 Evidence X-RAY 4c52 A Reference
       Region 4c52 A 1-26 order
       Region 4c52 A 83-196 order
       Region 4c52 A 197-209 disorder
 Evidence X-RAY 4c52 B Reference
       Region 4c52 B 1-26 order
       Region 4c52 B 83-198 order
       Region 4c52 B 199-209 disorder
 Evidence X-RAY 3fdm A Reference
       Region 3fdm A 1-26 order
       Region 3fdm A 83-198 order
       Region 3fdm A 199-209 disorder
 Evidence X-RAY 3fdm B Reference
       Region 3fdm B 1-26 order
       Region 3fdm B 83-197 order
       Region 3fdm B 198-209 disorder
 Evidence X-RAY 3fdm C Reference
       Region 3fdm C 1-1 disorder
       Region 3fdm C 2-26 order
       Region 3fdm C 83-198 order
       Region 3fdm C 199-209 disorder
 Evidence X-RAY 3inq A Reference
       Region 3inq A 1-2 disorder
       Region 3inq A 3-26 order
       Region 3inq A 83-196 order
       Region 3inq A 197-209 disorder
 Evidence X-RAY 3inq B Reference
       Region 3inq B 1-26 order
       Region 3inq B 83-196 order
       Region 3inq B 197-209 disorder
 Evidence X-RAY 4tuh A Reference
       Region 4tuh A 1-26 order
       Region 4tuh A 83-196 order
       Region 4tuh A 197-209 disorder
 Evidence X-RAY 4tuh B Reference
       Region 4tuh B 1-26 order
       Region 4tuh B 83-196 order
       Region 4tuh B 197-209 disorder
 Evidence X-RAY 4tuh C Reference
       Region 4tuh C 1-26 order
       Region 4tuh C 83-197 order
       Region 4tuh C 198-209 disorder
 Evidence X-RAY 4tuh D Reference
       Region 4tuh D 1-26 order
       Region 4tuh D 83-197 order
       Region 4tuh D 198-209 disorder
 Evidence X-RAY 4tuh E Reference
       Region 4tuh E 1-26 order
       Region 4tuh E 83-196 order
       Region 4tuh E 197-209 disorder
 Evidence X-RAY 4tuh F Reference
       Region 4tuh F 1-26 order
       Region 4tuh F 83-198 order
       Region 4tuh F 199-209 disorder
 Evidence X-RAY 4tuh G Reference
       Region 4tuh G 1-26 order
       Region 4tuh G 83-196 order
       Region 4tuh G 197-209 disorder
 Evidence X-RAY 4tuh H Reference
       Region 4tuh H 1-26 order
       Region 4tuh H 83-197 order
       Region 4tuh H 198-209 disorder
 Evidence X-RAY 3wiz A Reference
       Region 3wiz A 1-2 disorder
       Region 3wiz A 3-27 order
       Region 3wiz A 28-40 disorder
       Region 3wiz A 41-44 order
       Region 3wiz A 85-196 order
       Region 3wiz A 197-209 disorder
 Evidence X-RAY 3wiz B Reference
       Region 3wiz B 1-2 disorder
       Region 3wiz B 3-27 order
       Region 3wiz B 28-40 disorder
       Region 3wiz B 41-44 order
       Region 3wiz B 85-196 order
       Region 3wiz B 197-209 disorder
 Evidence X-RAY 2yj1 A Reference
       Region 2yj1 A 1-26 order
       Region 2yj1 A 83-202 order
       Region 2yj1 A 203-209 disorder
 Evidence X-RAY 2yj1 C Reference
       Region 2yj1 C 1-26 order
       Region 2yj1 C 83-196 order
       Region 2yj1 C 197-209 disorder
 Evidence X-RAY 3zlr A Reference
       Region 3zlr A 1-26 order
       Region 3zlr A 83-197 order
       Region 3zlr A 198-209 disorder
 Evidence X-RAY 3zlr B Reference
       Region 3zlr B 1-3 disorder
       Region 3zlr B 4-26 order
       Region 3zlr B 83-203 order
       Region 3zlr B 204-209 disorder
 Evidence X-RAY 7jgv A Reference
       Region 7jgv A 1-26 order
       Region 7jgv A 83-196 order
       Region 7jgv A 197-209 disorder
 Evidence X-RAY 7jgv B Reference
       Region 7jgv B 1-26 order
       Region 7jgv B 83-197 order
       Region 7jgv B 198-209 disorder
 Evidence X-RAY 6rnu A Reference
       Region 6rnu A 1-1 disorder
       Region 6rnu A 2-28 order
       Region 6rnu A 29-41 disorder
       Region 6rnu A 42-44 order
       Region 6rnu A 85-196 order
       Region 6rnu A 197-209 disorder
 Evidence X-RAY 6rnu B Reference
       Region 6rnu B 1-1 disorder
       Region 6rnu B 2-28 order
       Region 6rnu B 29-41 disorder
       Region 6rnu B 42-44 order
       Region 6rnu B 85-196 order
       Region 6rnu B 197-209 disorder
 Evidence X-RAY 6uvc A Reference
       Region 6uvc A 1-1 disorder
       Region 6uvc A 2-26 order
       Region 6uvc A 83-197 order
       Region 6uvc A 198-209 disorder
 Evidence X-RAY 6uvc B Reference
       Region 6uvc B 1-26 order
       Region 6uvc B 83-197 order
       Region 6uvc B 198-209 disorder
 Evidence X-RAY 6uvd A Reference
       Region 6uvd A 1-26 order
       Region 6uvd A 83-197 order
       Region 6uvd A 198-209 disorder
 Evidence X-RAY 6uvd B Reference
       Region 6uvd B 1-2 disorder
       Region 6uvd B 3-26 order
       Region 6uvd B 83-196 order
       Region 6uvd B 197-209 disorder
Seq 1-211 Monomer :
 Evidence NMR 6bf2 A Reference
       Region 6bf2 A 1-209 order
       Region 6bf2 A 32-40 high_rmsd
       Region 6bf2 A 48-48 high_rmsd
       Region 6bf2 A 77-80 high_rmsd
       Region 6bf2 A 202-209 high_rmsd
 Evidence X-RAY 3cva X Reference
       Region 3cva X 1-1 disorder
       Region 3cva X 2-27 order
       Region 3cva X 28-81 disorder
       Region 3cva X 82-196 order
       Region 3cva X 197-211 disorder
 Evidence X-RAY 4ehr A Reference
       Region 4ehr A 1-1 disorder
       Region 4ehr A 2-26 order
       Region 4ehr A 27-42 disorder
       Region 4ehr A 43-44 order
       Region 4ehr A 85-196 order
       Region 4ehr A 197-209 disorder
 Evidence NMR 2lpc A Reference
       Region 2lpc A 1-44 order
       Region 2lpc A 85-209 order
       Region 2lpc A 158-169 high_rmsd
 Evidence NMR 2m03 A Reference
       Region 2m03 A 1-44 order
       Region 2m03 A 24-41 high_rmsd
       Region 2m03 A 85-209 order
       Region 2m03 A 156-169 high_rmsd
 Evidence X-RAY 1maz A Reference
       Region 1maz A 1-27 order
       Region 1maz A 28-80 disorder
       Region 1maz A 81-196 order
       Region 1maz A 197-209 disorder
 Evidence NMR 2me8 A Reference
       Region 2me8 A 1-209 order
       Region 2me8 A 1-1 high_rmsd
       Region 2me8 A 25-84 high_rmsd
       Region 2me8 A 197-209 high_rmsd
 Evidence NMR 2me9 A Reference
       Region 2me9 A 1-209 order
       Region 2me9 A 21-84 high_rmsd
       Region 2me9 A 103-104 high_rmsd
       Region 2me9 A 117-117 high_rmsd
       Region 2me9 A 193-209 high_rmsd
 Evidence X-RAY 3qkd A Reference
       Region 3qkd A 1-3 disorder
       Region 3qkd A 4-28 order
       Region 3qkd A 29-42 disorder
       Region 3qkd A 43-44 order
       Region 3qkd A 85-197 order
       Region 3qkd A 198-209 disorder
 Evidence X-RAY 3qkd B Reference
       Region 3qkd B 1-1 disorder
       Region 3qkd B 2-29 order
       Region 3qkd B 30-42 disorder
       Region 3qkd B 43-44 order
       Region 3qkd B 85-196 order
       Region 3qkd B 197-209 disorder
 Evidence X-RAY 1r2d A Reference
       Region 1r2d A 1-27 order
       Region 1r2d A 28-81 disorder
       Region 1r2d A 82-196 order
       Region 1r2d A 197-211 disorder
 Evidence X-RAY 1r2e A Reference
       Region 1r2e A 1-1 disorder
       Region 1r2e A 2-27 order
       Region 1r2e A 28-79 disorder
       Region 1r2e A 80-196 order
       Region 1r2e A 197-211 disorder
 Evidence X-RAY 1r2g A Reference
       Region 1r2g A 1-27 order
       Region 1r2g A 28-80 disorder
       Region 1r2g A 81-196 order
       Region 1r2g A 197-211 disorder
 Evidence X-RAY 1r2h A Reference
       Region 1r2h A 1-27 order
       Region 1r2h A 28-81 disorder
       Region 1r2h A 82-196 order
       Region 1r2h A 197-211 disorder
 Evidence X-RAY 1r2i A Reference
       Region 1r2i A 1-27 order
       Region 1r2i A 28-81 disorder
       Region 1r2i A 82-197 order
       Region 1r2i A 198-211 disorder
 Evidence X-RAY 3sp7 A Reference
       Region 3sp7 A 1-29 order
       Region 3sp7 A 30-41 disorder
       Region 3sp7 A 42-44 order
       Region 3sp7 A 85-199 order
       Region 3sp7 A 200-209 disorder
 Evidence X-RAY 3spf A Reference
       Region 3spf A 1-25 order
       Region 3spf A 26-41 disorder
       Region 3spf A 42-44 order
       Region 3spf A 85-197 order
       Region 3spf A 198-209 disorder
 Evidence X-RAY 2yxj A Reference
       Region 2yxj A 1-3 disorder
       Region 2yxj A 4-25 order
       Region 2yxj A 26-42 disorder
       Region 2yxj A 43-44 order
       Region 2yxj A 85-197 order
       Region 2yxj A 198-209 disorder
 Evidence X-RAY 2yxj B Reference
       Region 2yxj B 1-1 disorder
       Region 2yxj B 2-29 order
       Region 2yxj B 30-42 disorder
       Region 2yxj B 43-44 order
       Region 2yxj B 85-196 order
       Region 2yxj B 197-209 disorder
 Evidence X-RAY 3zk6 A Reference
       Region 3zk6 A 1-1 disorder
       Region 3zk6 A 2-28 order
       Region 3zk6 A 29-40 disorder
       Region 3zk6 A 81-197 order
       Region 3zk6 A 198-209 disorder
 Evidence X-RAY 3zk6 B Reference
       Region 3zk6 B 1-1 disorder
       Region 3zk6 B 2-28 order
       Region 3zk6 B 29-40 disorder
       Region 3zk6 B 81-197 order
       Region 3zk6 B 198-209 disorder
 Evidence X-RAY 3zln A Reference
       Region 3zln A 1-27 order
       Region 3zln A 28-40 disorder
       Region 3zln A 41-44 order
       Region 3zln A 85-196 order
       Region 3zln A 197-209 disorder
 Evidence X-RAY 3zlo A Reference
       Region 3zlo A 1-1 disorder
       Region 3zlo A 2-26 order
       Region 3zlo A 27-40 disorder
       Region 3zlo A 41-44 order
       Region 3zlo A 85-196 order
       Region 3zlo A 197-209 disorder
 Evidence X-RAY 7ca4 A Reference
       Region 7ca4 A 1-27 order
       Region 7ca4 A 28-81 disorder
       Region 7ca4 A 82-197 order
       Region 7ca4 A 198-211 disorder
 Evidence X-RAY 7jgw A Reference
       Region 7jgw A 1-26 order
       Region 7jgw A 83-196 order
       Region 7jgw A 197-209 disorder
 Evidence NMR 1lxl A Reference
       Region 1lxl A 1-209 order
 Evidence NMR 2o1y A Reference
       Region 2o1y A 1-44 order
       Region 2o1y A 85-209 order
 Evidence NMR 1ysg A Reference
       Region 1ysg A 1-44 order
       Region 1ysg A 85-209 order
 Evidence NMR 1ysi A Reference
       Region 1ysi A 1-44 order
       Region 1ysi A 85-209 order
 Evidence NMR 1ysn A Reference
       Region 1ysn A 1-44 order
       Region 1ysn A 85-209 order
Seq 2-20,83-196 Hetero dimer :
 Evidence NMR 2o2m A Reference
       Region 2o2m A 2-20 order
       Region 2o2m A 83-196 order
Seq 2-20,83-196 Hetero dimer :
 Evidence NMR 2o2n A Reference
       Region 2o2n A 2-20 order
       Region 2o2n A 83-196 order
Seq 2-44,85-201 Hetero tetramer : IID00015Complex
 Evidence X-RAY 6lhd B Reference
       Region 6lhd B 2-2 disorder
       Region 6lhd B 3-29 order
       Region 6lhd B 30-43 disorder
       Region 6lhd B 44-44 order
       Region 6lhd B 85-195 order
       Region 6lhd B 196-201 disorder
 Evidence X-RAY 6lhd A Reference
       Region 6lhd A 2-2 disorder
       Region 6lhd A 3-25 order
       Region 6lhd A 26-44 disorder
       Region 6lhd A 85-103 order
       Region 6lhd A 104-111 disorder
       Region 6lhd A 112-130 order
       Region 6lhd A 131-132 disorder
       Region 6lhd A 133-189 order
       Region 6lhd A 190-201 disorder
Seqdisorder 29-44
 Evidence X-RAY 4aq3 B Reference
       Region 4aq3 B 29-44 disorder
Seq 29-44 Hetero tetramer : IID00707Complex,IID00746Complex
 Evidence X-RAY 5agx B Reference
       Region 5agx B 29-41 disorder
       Region 5agx B 42-44 order
Seq 29-44 Hetero trimer : IID00707Complex
 Evidence X-RAY 4ieh A Reference
       Region 4ieh A 29-42 disorder
       Region 4ieh A 43-44 order
Seq 29-44 Hetero tetramer : IID00669Complex,IID00707Complex
 Evidence X-RAY 5vay C Reference
       Region 5vay C 29-42 disorder
       Region 5vay C 43-44 order
Seq 29-44 Hetero tetramer : IID00707Complex,IID00746Complex
 Evidence X-RAY 5agw A Reference
       Region 5agw A 29-42 disorder
       Region 5agw A 43-44 order
Seq 29-44 Hetero trimer : IID00707Complex
 Evidence X-RAY 6o0m A Reference
       Region 6o0m A 29-42 disorder
       Region 6o0m A 43-44 order
Seqdisorder 29-44
 Evidence X-RAY 4aq3 C Reference
       Region 4aq3 C 29-44 disorder
Seqdisorder 29-44
 Evidence X-RAY 4aq3 A Reference
       Region 4aq3 A 29-44 disorder
Seq 29-44 Hetero tetramer : IID00707Complex,IID00746Complex
 Evidence X-RAY 5agw B Reference
       Region 5agw B 29-42 disorder
       Region 5agw B 43-44 order
Seq 29-44 Hetero hexamer : IID00707Complex
 Evidence X-RAY 6o0o C Reference
       Region 6o0o C 29-43 disorder
       Region 6o0o C 44-44 order
 Evidence X-RAY 6o0o A Reference
       Region 6o0o A 29-43 disorder
       Region 6o0o A 44-44 order
Seq 29-44 Hetero trimer : IID00707Complex
 Evidence X-RAY 6o0k A Reference
       Region 6o0k A 29-29 order
       Region 6o0k A 30-42 disorder
       Region 6o0k A 43-44 order
Seq 29-44 Hetero trimer : IID00707Complex
 Evidence NMR 8u27 A Reference
       Region 8u27 A 29-44 order
       Region 8u27 A 29-38 high_rmsd
Seq 29-44 Hetero tetramer : IID00669Complex,IID00707Complex
 Evidence X-RAY 5vay A Reference
       Region 5vay A 29-42 disorder
       Region 5vay A 43-44 order
Seq 29-44 Hetero trimer : IID00707Complex
 Evidence X-RAY 6o0p A Reference
       Region 6o0p A 29-29 order
       Region 6o0p A 30-42 disorder
       Region 6o0p A 43-44 order
Seqdisorder 29-44
 Evidence X-RAY 4aq3 E Reference
       Region 4aq3 E 29-44 disorder
Seq 29-44 Hetero tetramer : IID00707Complex,IID00746Complex
 Evidence X-RAY 5agx A Reference
       Region 5agx A 29-42 disorder
       Region 5agx A 43-44 order
Seq 29-44 Hetero tetramer : IID00669Complex,IID00707Complex
 Evidence X-RAY 5vay B Reference
       Region 5vay B 29-41 disorder
       Region 5vay B 42-44 order
Seq 29-44 Hetero tetradecamer : IID00707Complex
 Evidence X-RAY 4aq3 F Reference
       Region 4aq3 F 29-43 disorder
       Region 4aq3 F 44-44 order
 Evidence X-RAY 4aq3 D Reference
       Region 4aq3 D 29-42 disorder
       Region 4aq3 D 43-44 order
Seq 29-44 Hetero hexamer : IID00707Complex
 Evidence X-RAY 6o0l C Reference
       Region 6o0l C 29-42 disorder
       Region 6o0l C 43-44 order
 Evidence X-RAY 6o0l A Reference
       Region 6o0l A 29-42 disorder
       Region 6o0l A 43-44 order
Seq 29-44 Hetero tetramer : IID00669Complex,IID00707Complex
 Evidence X-RAY 5vay D Reference
       Region 5vay D 29-42 disorder
       Region 5vay D 43-44 order
Seq 83-197 Hetero octamer :
 Evidence X-RAY 6hjl F Reference
       Region 6hjl F 83-195 order
 Evidence X-RAY 6hjl E Reference
       Region 6hjl E 83-195 order
 Evidence X-RAY 6hjl B Reference
       Region 6hjl B 83-195 order
 Evidence X-RAY 6hjl A Reference
       Region 6hjl A 83-197 order
Seq 83-209 Hetero hexamer : IID00746Complex,IID50336Complex
 Evidence X-RAY 5c3g A Reference
       Region 5c3g A 83-196 order
       Region 5c3g A 197-209 disorder
Seq 202-233 Monomer :
 Evidence NMR 6f46 A Reference
       Region 6f46 A 202-233 order
       Region 6f46 A 202-211 high_rmsd
       Region 6f46 A 232-233 high_rmsd
SeqProS verified 51-66 Allosteric regulation of Bcl-xL enabled by posttranslational modifications in the IDR. The ProS region is defined based on Fig.3 in PMID: 29507390. :
       Region 6bf2 A 1-209 order
       Region 1r2g A 28-80 disorder
Seqphosphorylation
    62-62 Phosphoserine; by CDK1
    49-49 Phosphoserine; by PLK3
 
Prediction
NeProc
Disorder 28-82,201-212,231-233
Order 1-27,83-200,213-230
ProS 31-36,53-65,207-212,231-233
AlphaFold
Disorder 1-1,29-81,105-105,108-108,197-233
Order 2-28,82-104,106-107,109-196
Pfam Hmmer
PF02180 1-27 2.5e-14
PF00452 90-188 4.3e-59
Function
Function in SwissProt
Isoform Bcl-X(S) promotes apoptosis.
Biological Process
See also
Diagram with PDB data
BECN1/BCL2L1Solution structure of the Bcl-xL/Beclin-1 complex