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IID00725
 UniprotQ15022
ProteinPolycomb protein SUZ12
GeneSUZ12
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
739
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 76-545 Hetero tetramer : IID00317Complex,Q6ZN18
 Evidence X-RAY 5wai B Reference
       Region 5wai B 76-78 disorder
       Region 5wai B 79-149 order
       Region 5wai B 150-153 disorder
       Region 5wai B 154-167 order
       Region 5wai B 168-181 disorder
       Region 5wai B 182-209 order
       Region 5wai B 210-210 disorder
       Region 5wai B 211-223 order
       Region 5wai B 224-227 disorder
       Region 5wai B 228-253 order
       Region 5wai B 254-294 disorder
       Region 5wai B 295-322 order
       Region 5wai B 323-350 disorder
       Region 5wai B 351-363 order
       Region 5wai B 364-422 disorder
       Region 5wai B 423-496 order
       Region 5wai B 497-513 disorder
       Region 5wai B 514-545 order
Seq 76-545 Hetero dimer : IID00317Complex
 Evidence X-RAY 5wak B Reference
       Region 5wak B 76-82 disorder
       Region 5wak B 83-149 order
       Region 5wak B 150-188 disorder
       Region 5wak B 189-200 order
       Region 5wak B 201-241 disorder
       Region 5wak B 242-250 order
       Region 5wak B 251-367 disorder
       Region 5wak B 368-379 order
       Region 5wak B 380-423 disorder
       Region 5wak B 424-496 order
       Region 5wak B 497-510 disorder
       Region 5wak B 511-533 order
       Region 5wak B 534-545 disorder
Seq 76-545 Hetero tetramer : IID00317Complex,Q6ZN18
 Evidence X-RAY 5wai F Reference
       Region 5wai F 76-77 disorder
       Region 5wai F 78-167 order
       Region 5wai F 168-181 disorder
       Region 5wai F 182-218 order
       Region 5wai F 219-227 disorder
       Region 5wai F 228-255 order
       Region 5wai F 256-293 disorder
       Region 5wai F 294-322 order
       Region 5wai F 323-351 disorder
       Region 5wai F 352-363 order
       Region 5wai F 364-422 disorder
       Region 5wai F 423-496 order
       Region 5wai F 497-513 disorder
       Region 5wai F 514-532 order
       Region 5wai F 533-545 disorder
Seq 545-725 Hetero trimer : G1KPH4,IID00530Complex,IID00727Complex
 Evidence X-RAY 5ij7 T Reference
       Region 5ij7 T 545-560 disorder
       Region 5ij7 T 561-688 order
       Region 5ij7 T 689-725 disorder
Seq 545-725 Hetero trimer : G1KPH4,IID00530Complex
 Evidence X-RAY 4w2r S Reference
       Region 4w2r S 545-560 disorder
       Region 4w2r S 561-688 order
       Region 4w2r S 689-725 disorder
Seq 545-725 Hetero trimer : G1KPH4,IID00530Complex,IID00727Complex
 Evidence X-RAY 5ij8 S Reference
       Region 5ij8 S 545-560 disorder
       Region 5ij8 S 561-688 order
       Region 5ij8 S 689-725 disorder
Seq 545-725 Hetero trimer : G1KPH4,IID00530Complex,IID00727Complex
 Evidence X-RAY 5ij7 S Reference
       Region 5ij7 S 545-561 disorder
       Region 5ij7 S 562-688 order
       Region 5ij7 S 689-725 disorder
Seq 545-725 Hetero trimer : G1KPH4,IID00530Complex
 Evidence X-RAY 6b3w S Reference
       Region 6b3w S 545-560 disorder
       Region 6b3w S 561-688 order
       Region 6b3w S 689-725 disorder
Seq 545-725 Hetero trimer : G1KPH4,IID00530Complex,IID00727Complex
 Evidence X-RAY 5ij8 T Reference
       Region 5ij8 T 545-560 disorder
       Region 5ij8 T 561-688 order
       Region 5ij8 T 689-725 disorder
Seq 545-725 Hetero trimer : G1KPH4,IID00530Complex
 Evidence X-RAY 6b3w T Reference
       Region 6b3w T 545-560 disorder
       Region 6b3w T 561-688 order
       Region 6b3w T 689-725 disorder
Seq 545-725 Hetero trimer : G1KPH4,IID00530Complex
 Evidence X-RAY 4w2r T Reference
       Region 4w2r T 545-560 disorder
       Region 4w2r T 561-688 order
       Region 4w2r T 689-725 disorder
Seq 558-685 Hetero pentamer : IID00530Complex,IID00727Complex
 Evidence X-RAY 5hyn S Reference
       Region 5hyn S 558-560 disorder
       Region 5hyn S 561-685 order
 Evidence X-RAY 5hyn M Reference
       Region 5hyn M 558-560 disorder
       Region 5hyn M 561-685 order
 Evidence X-RAY 5hyn H Reference
       Region 5hyn H 558-561 disorder
       Region 5hyn H 562-685 order
 Evidence X-RAY 5hyn C Reference
       Region 5hyn C 558-560 disorder
       Region 5hyn C 561-685 order
Seq 558-685 Hetero tetramer : IID00530Complex,IID00727Complex
 Evidence X-RAY 5ls6 F Reference
       Region 5ls6 F 558-560 disorder
       Region 5ls6 F 561-685 order
Seq 558-685 Hetero tetramer : IID00530Complex,IID00727Complex
 Evidence X-RAY 5ls6 C Reference
       Region 5ls6 C 558-560 disorder
       Region 5ls6 C 561-685 order
Seq 558-685 Hetero tetramer : IID00530Complex,IID00727Complex
 Evidence X-RAY 5ls6 I Reference
       Region 5ls6 I 558-560 disorder
       Region 5ls6 I 561-685 order
Seq 558-685 Hetero tetramer : IID00530Complex,IID00727Complex
 Evidence X-RAY 5ls6 L Reference
       Region 5ls6 L 558-560 disorder
       Region 5ls6 L 561-685 order
SeqProS verified 150-167,182-188,201-218,228-241,251-255,294-322,352-363 Hetero tetramer : IID00317Complex,Q6ZN18
       Region 5wai F 78-167 order
       Region 5wai F 182-218 order
       Region 5wai F 228-255 order
       Region 5wai F 294-322 order
       Region 5wai F 352-363 order
       Region 5wak B 150-188 disorder
       Region 5wak B 201-241 disorder
       Region 5wak B 251-367 disorder
SeqProS verified 154-167,182-188,211-223,228-241,251-253,295-322,351-363,534-545 Hetero tetramer : IID00317Complex,Q6ZN18
       Region 5wai B 154-167 order
       Region 5wai B 182-209 order
       Region 5wai B 211-223 order
       Region 5wai B 228-253 order
       Region 5wai B 295-322 order
       Region 5wai B 351-363 order
       Region 5wai B 514-545 order
       Region 5wak B 150-188 disorder
       Region 5wak B 201-241 disorder
       Region 5wak B 251-367 disorder
       Region 5wak B 534-545 disorder
SeqProS verified 368-379 Hetero dimer : IID00317Complex
       Region 5wak B 368-379 order
       Region 5wai B 364-422 disorder
Seqphosphorylation
    20-20 Phosphoserine
    541-541 Phosphoserine
    546-546 Phosphoserine
    583-583 Phosphoserine
    726-726 Phosphoserine
 
Prediction
NeProc
Disorder 1-78,220-227,263-291,326-330,373-423,520-558,689-739
Order 79-144,154-219,228-262,292-325,331-372,424-519,559-688
ProS 10-27,263-272,288-291,373-384,389-409,520-535,542-558,736-739
AlphaFold
Disorder 1-75,149-154,168-179,219-225,257-291,323-351,364-424,546-556,691-739
Order 76-148,155-167,180-218,226-256,292-322,352-363,425-545,557-690
SEG 7-67 ,726-738
Function
Function in SwissProt
Polycomb group (PcG) protein. Component of the PRC2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene (PubMed:15225548, PubMed:15231737, PubMed:15385962, PubMed:16618801, PubMed:17344414, PubMed:18285464, PubMed:28229514, PubMed:29499137, PubMed:31959557). The PRC2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems (PubMed:12435631, PubMed:12351676, PubMed:15385962, PubMed:15099518, PubMed:15225548, PubMed:15684044, PubMed:16431907, PubMed:18086877, PubMed:18285464). Genes repressed by the PRC2 complex include HOXC8, HOXA9, MYT1 and CDKN2A (PubMed:15231737, PubMed:16618801, PubMed:17200670, PubMed:31959557).
Biological Process
Diagram with PDB data
SUZ12/RBBP4/PHF19/JARID2Crystal Structure of a SUZ12-RBBP4-PHF19-JARID2 Heterotetrameric Complex
See also
Diagram with PDB data
EZH2/EED/SUZ12/H3C1/JARID2Structure of Human Polycomb Repressive Complex 2 (PRC2) with oncogenic histone H3K27M peptide