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IID00727  Histone-lysine N-methyltransferase EZH2 (Homo sapiens) Q15910
  :order  :disorder  :conflict  :PDB cluster  :ProS  :SCOP Domain  :Pfam Domain
Networkxml
Experiment
746
fasta
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-182,211-385,421-746 Hetero tetramer : IID00530Complex,IID00725Complex,Q92833
 Evidence X-RAY 5ls6 A Reference
       Region 5ls6 A 1-9 disorder
       Region 5ls6 A 10-182 order
       Region 5ls6 A 211-216 order
       Region 5ls6 A 217-219 disorder
       Region 5ls6 A 220-249 order
       Region 5ls6 A 250-256 disorder
       Region 5ls6 A 257-345 order
       Region 5ls6 A 346-385 disorder
       Region 5ls6 A 421-421 disorder
       Region 5ls6 A 422-480 order
       Region 5ls6 A 481-515 disorder
       Region 5ls6 A 516-728 order
       Region 5ls6 A 729-746 disorder
Seq 1-182,211-385,421-746 Hetero tetramer : IID00530Complex,IID00725Complex,Q92833
 Evidence X-RAY 5ls6 J Reference
       Region 5ls6 J 1-9 disorder
       Region 5ls6 J 10-182 order
       Region 5ls6 J 211-216 order
       Region 5ls6 J 217-219 disorder
       Region 5ls6 J 220-249 order
       Region 5ls6 J 250-256 disorder
       Region 5ls6 J 257-345 order
       Region 5ls6 J 346-385 disorder
       Region 5ls6 J 421-421 disorder
       Region 5ls6 J 422-480 order
       Region 5ls6 J 481-515 disorder
       Region 5ls6 J 516-728 order
       Region 5ls6 J 729-746 disorder
Seq 1-182,211-385,421-746 Hetero tetramer : IID00530Complex,IID00725Complex,Q92833
 Evidence X-RAY 5ls6 G Reference
       Region 5ls6 G 1-9 disorder
       Region 5ls6 G 10-182 order
       Region 5ls6 G 211-216 order
       Region 5ls6 G 217-219 disorder
       Region 5ls6 G 220-249 order
       Region 5ls6 G 250-256 disorder
       Region 5ls6 G 257-345 order
       Region 5ls6 G 346-385 disorder
       Region 5ls6 G 421-421 disorder
       Region 5ls6 G 422-480 order
       Region 5ls6 G 481-515 disorder
       Region 5ls6 G 516-730 order
       Region 5ls6 G 731-746 disorder
Seq 1-182,211-385,421-746 Hetero tetramer : IID00530Complex,IID00725Complex,Q92833
 Evidence X-RAY 5ls6 D Reference
       Region 5ls6 D 1-9 disorder
       Region 5ls6 D 10-182 order
       Region 5ls6 D 211-216 order
       Region 5ls6 D 217-219 disorder
       Region 5ls6 D 220-249 order
       Region 5ls6 D 250-256 disorder
       Region 5ls6 D 257-345 order
       Region 5ls6 D 346-385 disorder
       Region 5ls6 D 421-421 disorder
       Region 5ls6 D 422-480 order
       Region 5ls6 D 481-515 disorder
       Region 5ls6 D 516-728 order
       Region 5ls6 D 729-746 disorder
Seq 1-746 Hetero pentamer : IID00062Complex,IID00530Complex,IID00725Complex,Q92833
 Evidence X-RAY 5hyn Q Reference
       Region 5hyn Q 1-11 disorder
       Region 5hyn Q 12-180 order
       Region 5hyn Q 181-218 disorder
       Region 5hyn Q 219-248 order
       Region 5hyn Q 249-258 disorder
       Region 5hyn Q 259-345 order
       Region 5hyn Q 346-424 disorder
       Region 5hyn Q 425-478 order
       Region 5hyn Q 479-514 disorder
       Region 5hyn Q 515-739 order
       Region 5hyn Q 740-746 disorder
 Evidence X-RAY 5hyn K Reference
       Region 5hyn K 1-9 disorder
       Region 5hyn K 10-181 order
       Region 5hyn K 182-218 disorder
       Region 5hyn K 219-247 order
       Region 5hyn K 248-259 disorder
       Region 5hyn K 260-345 order
       Region 5hyn K 346-422 disorder
       Region 5hyn K 423-479 order
       Region 5hyn K 480-514 disorder
       Region 5hyn K 515-732 order
       Region 5hyn K 733-746 disorder
 Evidence X-RAY 5hyn F Reference
       Region 5hyn F 1-9 disorder
       Region 5hyn F 10-181 order
       Region 5hyn F 182-218 disorder
       Region 5hyn F 219-248 order
       Region 5hyn F 249-258 disorder
       Region 5hyn F 259-345 order
       Region 5hyn F 346-423 disorder
       Region 5hyn F 424-478 order
       Region 5hyn F 479-515 disorder
       Region 5hyn F 516-739 order
       Region 5hyn F 740-746 disorder
 Evidence X-RAY 5hyn A Reference
       Region 5hyn A 1-9 disorder
       Region 5hyn A 10-182 order
       Region 5hyn A 183-210 disorder
       Region 5hyn A 211-216 order
       Region 5hyn A 217-219 disorder
       Region 5hyn A 220-249 order
       Region 5hyn A 250-256 disorder
       Region 5hyn A 257-345 order
       Region 5hyn A 346-421 disorder
       Region 5hyn A 422-479 order
       Region 5hyn A 480-515 disorder
       Region 5hyn A 516-740 order
       Region 5hyn A 741-746 disorder
Seq 39-68 Hetero dimer : IID00530Complex
 Evidence X-RAY 5wuk B Reference
       Region 5wuk B 41-68 order
 Evidence X-RAY 5u62 D Reference
       Region 5u62 D 39-40 disorder
       Region 5u62 D 41-68 order
 Evidence X-RAY 5u62 C Reference
       Region 5u62 C 39-42 disorder
       Region 5u62 C 43-68 order
 Evidence X-RAY 5u5t D Reference
       Region 5u5t D 39-40 disorder
       Region 5u5t D 41-68 order
 Evidence X-RAY 5u5t C Reference
       Region 5u5t C 39-42 disorder
       Region 5u5t C 43-68 order
 Evidence X-RAY 5h25 D Reference
       Region 5h25 D 40-68 order
 Evidence X-RAY 5h25 C Reference
       Region 5h25 C 40-68 order
 Evidence X-RAY 5h24 D Reference
       Region 5h24 D 40-68 order
 Evidence X-RAY 5h24 C Reference
       Region 5h24 C 40-68 order
 Evidence X-RAY 5h19 B Reference
       Region 5h19 B 40-68 order
 Evidence X-RAY 5h17 B Reference
       Region 5h17 B 40-66 order
       Region 5h17 B 67-68 disorder
 Evidence X-RAY 5h15 D Reference
       Region 5h15 D 40-68 order
 Evidence X-RAY 5h15 C Reference
       Region 5h15 C 40-68 order
 Evidence X-RAY 5h14 C Reference
       Region 5h14 C 40-68 order
 Evidence X-RAY 5h14 D Reference
       Region 5h14 D 40-68 order
 Evidence X-RAY 5gsa D Reference
       Region 5gsa D 40-68 order
 Evidence X-RAY 5gsa C Reference
       Region 5gsa C 40-68 order
Seq 429-487,511-531,533-746 Hetero trimer : G1KPH4,IID00530Complex,IID00725Complex
 Evidence X-RAY 5ij8 B This entry is Anolis carolinensis EZH2 (G1KPH4). Reference
       Region 5ij8 B 429-432 disorder
       Region 5ij8 B 433-472 order
       Region 5ij8 B 473-487 disorder
       Region 5ij8 B 511-516 disorder
       Region 5ij8 B 517-531 order
       Region 5ij8 B 533-733 order
       Region 5ij8 B 734-746 disorder
Seq 429-487,511-746 Hetero trimer : G1KPH4,IID00530Complex,IID00725Complex
 Evidence X-RAY 5ij7 B This entry is Anolis carolinensis EZH2 (G1KPH4). Reference
       Region 5ij7 B 429-429 disorder
       Region 5ij7 B 430-472 order
       Region 5ij7 B 473-487 disorder
       Region 5ij7 B 511-516 disorder
       Region 5ij7 B 517-733 order
       Region 5ij7 B 734-746 disorder
Seq 429-487,511-746 Hetero trimer : G1KPH4,IID00530Complex,IID00725Complex
 Evidence X-RAY 5ij7 A This entry is Anolis carolinensis EZH2 (G1KPH4). Reference
       Region 5ij7 A 429-431 disorder
       Region 5ij7 A 432-472 order
       Region 5ij7 A 473-487 disorder
       Region 5ij7 A 511-516 disorder
       Region 5ij7 A 517-733 order
       Region 5ij7 A 734-746 disorder
Seq 429-487,511-531,533-746 Hetero trimer : G1KPH4,IID00530Complex,IID00725Complex
 Evidence X-RAY 5ij8 A This entry is Anolis carolinensis EZH2 (G1KPH4). Reference
       Region 5ij8 A 429-431 disorder
       Region 5ij8 A 432-472 order
       Region 5ij8 A 473-487 disorder
       Region 5ij8 A 511-516 disorder
       Region 5ij8 A 517-531 order
       Region 5ij8 A 533-733 order
       Region 5ij8 A 734-746 disorder
Seq 520-746 Monomer :
 Evidence X-RAY 4mi0 A Reference
       Region 4mi0 A 520-657 order
       Region 4mi0 A 658-659 disorder
       Region 4mi0 A 660-729 order
       Region 4mi0 A 730-746 disorder
 Evidence X-RAY 4mi5 A Reference
       Region 4mi5 A 521-592 order
       Region 4mi5 A 593-598 disorder
       Region 4mi5 A 599-731 order
       Region 4mi5 A 732-746 disorder
SeqProS possible 125-163 This region corresponds to SRM, shown to be disordered in a basal state in yeast EZH2(G0SDW4) (PubMed=28008038) Hetero pentamer : IID00062Complex,IID00530Complex,IID00725Complex,Q92833
       Region 5hyn A 10-182 order
       Region 5hyn F 10-181 order
       Region 5hyn K 10-181 order
       Region 5hyn Q 12-180 order
Seqphosphorylation
    367-367 Phosphothreonine
    487-487 Phosphothreonine
    366-366 Phosphoserine
    363-363 Phosphoserine
    345-345 Phosphothreonine; by CDK1 and CDK2
    339-339 Phosphothreonine
    76-76 Phosphoserine
    21-21 Phosphoserine; by PKB/AKT1
    487-487 Phosphothreonine
    366-366 Phosphoserine
    367-367 Phosphothreonine
    345-345 Phosphothreonine; by CDK1 and CDK2
    363-363 Phosphoserine
    76-76 Phosphoserine
    339-339 Phosphothreonine
    21-21 Phosphoserine; by PKB/AKT1
 
Prediction
DICHOT
Disorder 1-124,177-430,470-519,730-746
Known Domain 431-469,520-729
Cryptic Domain 125-176
SCOPe RPS-Blast
     2f69A2 611-732 2e-39
SCOP Hmmer
     2crgA1 431-469 6.2e-07
     1ml9A_ 506-736 3e-64
Pfam RPS-Blast
     PF11616 39-68 7e-10 WD repeat binding protein EZH...
     PF18118 158-249 1e-32 Polycomb repressive complex...
     PF18264 559-588 3e-11 CXC domain
Pfam Hmmer
    PF11616 39-68 6.4e-20 WD repeat binding protein EZ...
    PF18118 158-249 3e-35 Polycomb repressive complex ...
    PF18264 559-590 1.1e-15 CXC domain
    PF00856 623-726 1.4e-21 SET domain