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IID00736
 UniprotQ9H0W5
ProteinCoiled-coil domain-containing protein 8
GeneCCDC8
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
538
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 494-510 Hetero dimer : Q9H9E1
 Evidence X-RAY 4lg6 B Reference
       Region 4lg6 B 494-497 disorder
       Region 4lg6 B 498-510 order
Seqphosphorylation
    142-142 Phosphoserine
    146-146 Phosphoserine
    261-261 Phosphoserine
 
Prediction
NeProc
Disorder 67-73,80-538
Order 1-62,74-79
ProS 89-99,128-159,171-179,193-197,207-212,245-255,263-274,412-419,480-500,506-525,535-538
AlphaFold
Disorder 1-16,18-21,23-23,27-35,52-52,56-56,59-153,155-189,191-191,194-194,197-538
Order 17-17,22-22,24-26,36-51,53-55,57-58,154-154,190-190,192-193,195-196
SEG 66-84 ,142-152 ,321-333 ,345-356 ,428-441 ,458-471 ,514-538
Function
Function in SwissProt
Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer (PubMed:24793695, PubMed:24793696). Required for localization of CUL7 to the centrosome (PubMed:24793695).
Biological Process
Diagram with PDB data
CCDC8/ANKRA2Crystal structure of ANKRA2-CCDC8 complex