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IID00743
 UniprotQ9Y4B6
ProteinDDB1- and CUL4-associated factor 1
GeneDCAF1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1507
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1039-1401 Homo dimer :
 Evidence X-RAY 4pxw A Reference
       Region 4pxw A 1039-1079 disorder
       Region 4pxw A 1080-1314 order
       Region 4pxw A 1315-1326 disorder
       Region 4pxw A 1327-1373 order
       Region 4pxw A 1374-1379 disorder
       Region 4pxw A 1380-1389 order
       Region 4pxw A 1390-1401 disorder
 Evidence X-RAY 4pxw B Reference
       Region 4pxw B 1039-1079 disorder
       Region 4pxw B 1080-1314 order
       Region 4pxw B 1315-1326 disorder
       Region 4pxw B 1327-1373 order
       Region 4pxw B 1374-1378 disorder
       Region 4pxw B 1379-1389 order
       Region 4pxw B 1390-1401 disorder
 Evidence X-RAY 7sse A Reference
       Region 7sse A 1077-1078 disorder
       Region 7sse A 1079-1314 order
       Region 7sse A 1315-1326 disorder
       Region 7sse A 1327-1372 order
       Region 7sse A 1373-1373 disorder
       Region 7sse A 1374-1389 order
       Region 7sse A 1390-1390 disorder
 Evidence X-RAY 7sse B Reference
       Region 7sse B 1077-1078 disorder
       Region 7sse B 1079-1167 order
       Region 7sse B 1168-1168 disorder
       Region 7sse B 1169-1314 order
       Region 7sse B 1315-1326 disorder
       Region 7sse B 1327-1374 order
       Region 7sse B 1375-1379 disorder
       Region 7sse B 1380-1390 order
 Evidence X-RAY 7ufv A Reference
       Region 7ufv A 1077-1078 disorder
       Region 7ufv A 1079-1314 order
       Region 7ufv A 1315-1325 disorder
       Region 7ufv A 1326-1373 order
       Region 7ufv A 1374-1378 disorder
       Region 7ufv A 1379-1389 order
       Region 7ufv A 1390-1390 disorder
 Evidence X-RAY 7ufv B Reference
       Region 7ufv B 1077-1078 disorder
       Region 7ufv B 1079-1315 order
       Region 7ufv B 1316-1326 disorder
       Region 7ufv B 1327-1372 order
       Region 7ufv B 1373-1379 disorder
       Region 7ufv B 1380-1389 order
       Region 7ufv B 1390-1390 disorder
 Evidence X-RAY 8f8e A Reference
       Region 8f8e A 1077-1079 disorder
       Region 8f8e A 1080-1314 order
       Region 8f8e A 1315-1326 disorder
       Region 8f8e A 1327-1373 order
       Region 8f8e A 1374-1379 disorder
       Region 8f8e A 1380-1390 order
 Evidence X-RAY 8f8e B Reference
       Region 8f8e B 1077-1078 disorder
       Region 8f8e B 1079-1314 order
       Region 8f8e B 1315-1326 disorder
       Region 8f8e B 1327-1390 order
Seq 1039-1401 Monomer :
 Evidence X-RAY 8og5 A Reference
       Region 8og5 A 1039-1079 disorder
       Region 8og5 A 1080-1317 order
       Region 8og5 A 1318-1331 disorder
       Region 8og5 A 1332-1390 order
       Region 8og5 A 1391-1401 disorder
 Evidence X-RAY 8og6 A Reference
       Region 8og6 A 1039-1079 disorder
       Region 8og6 A 1080-1315 order
       Region 8og6 A 1316-1325 disorder
       Region 8og6 A 1326-1390 order
       Region 8og6 A 1391-1401 disorder
 Evidence X-RAY 8og7 A Reference
       Region 8og7 A 1039-1079 disorder
       Region 8og7 A 1080-1315 order
       Region 8og7 A 1316-1325 disorder
       Region 8og7 A 1326-1389 order
       Region 8og7 A 1390-1401 disorder
 Evidence X-RAY 8og8 A Reference
       Region 8og8 A 1039-1079 disorder
       Region 8og8 A 1080-1315 order
       Region 8og8 A 1316-1325 disorder
       Region 8og8 A 1326-1390 order
       Region 8og8 A 1391-1401 disorder
 Evidence X-RAY 8og9 A Reference
       Region 8og9 A 1039-1079 disorder
       Region 8og9 A 1080-1315 order
       Region 8og9 A 1316-1325 disorder
       Region 8og9 A 1326-1390 order
       Region 8og9 A 1391-1401 disorder
 Evidence X-RAY 8oga P Reference
       Region 8oga P 1079-1079 disorder
       Region 8oga P 1080-1315 order
       Region 8oga P 1316-1326 disorder
       Region 8oga P 1327-1390 order
       Region 8oga P 1391-1393 disorder
 Evidence X-RAY 8ogb A Reference
       Region 8ogb A 1039-1079 disorder
       Region 8ogb A 1080-1315 order
       Region 8ogb A 1316-1325 disorder
       Region 8ogb A 1326-1389 order
       Region 8ogb A 1390-1401 disorder
 Evidence X-RAY 8ogc A Reference
       Region 8ogc A 1039-1079 disorder
       Region 8ogc A 1080-1315 order
       Region 8ogc A 1316-1325 disorder
       Region 8ogc A 1326-1389 order
       Region 8ogc A 1390-1401 disorder
 Evidence X-RAY 8oo5 P Reference
       Region 8oo5 P 1079-1079 disorder
       Region 8oo5 P 1080-1315 order
       Region 8oo5 P 1316-1326 disorder
       Region 8oo5 P 1327-1390 order
       Region 8oo5 P 1391-1393 disorder
 Evidence X-RAY 8ood A Reference
       Region 8ood A 1039-1079 disorder
       Region 8ood A 1080-1315 order
       Region 8ood A 1316-1325 disorder
       Region 8ood A 1326-1389 order
       Region 8ood A 1390-1401 disorder
Seq 1045-1396 Hetero tetramer : IID00840Complex,P12520
 Evidence X-RAY 5jk7 C Reference
       Region 5jk7 C 1045-1045 disorder
       Region 5jk7 C 1046-1314 order
       Region 5jk7 C 1315-1327 disorder
       Region 5jk7 C 1328-1389 order
       Region 5jk7 C 1390-1396 disorder
 Evidence X-RAY 5jk7 E Reference
       Region 5jk7 E 1045-1045 disorder
       Region 5jk7 E 1046-1314 order
       Region 5jk7 E 1315-1327 disorder
       Region 5jk7 E 1328-1389 order
       Region 5jk7 E 1390-1396 disorder
Seq 1045-1396 Hetero tetramer : A4UDG5,IID00840Complex,P00720
 Evidence X-RAY 6zx9 B Reference
       Region 6zx9 B 1045-1045 disorder
       Region 6zx9 B 1046-1061 order
       Region 6zx9 B 1062-1066 disorder
       Region 6zx9 B 1067-1312 order
       Region 6zx9 B 1313-1326 disorder
       Region 6zx9 B 1327-1396 order
Seq 1045-1396 Hetero dimer : IID00840Complex
 Evidence X-RAY 6zue B Reference
       Region 6zue B 1045-1045 disorder
       Region 6zue B 1046-1060 order
       Region 6zue B 1061-1067 disorder
       Region 6zue B 1068-1091 order
       Region 6zue B 1092-1095 disorder
       Region 6zue B 1096-1314 order
       Region 6zue B 1315-1328 disorder
       Region 6zue B 1329-1372 order
       Region 6zue B 1373-1380 disorder
       Region 6zue B 1381-1396 order
Seq 1057-1396 Hetero trimer : H6WEA4,Q7ZB17
 Evidence X-RAY 4z8l A Reference
       Region 4z8l A 1057-1072 disorder
       Region 4z8l A 1073-1314 order
       Region 4z8l A 1315-1327 disorder
       Region 4z8l A 1328-1390 order
       Region 4z8l A 1391-1396 disorder
 Evidence X-RAY 4z8l D Reference
       Region 4z8l D 1057-1072 disorder
       Region 4z8l D 1073-1314 order
       Region 4z8l D 1315-1327 disorder
       Region 4z8l D 1328-1390 order
       Region 4z8l D 1391-1396 disorder
 Evidence X-RAY 5aja A Reference
       Region 5aja A 1058-1074 disorder
       Region 5aja A 1075-1315 order
       Region 5aja A 1316-1326 disorder
       Region 5aja A 1327-1392 order
       Region 5aja A 1393-1396 disorder
Seq 1058-1396 Hetero trimer : IID90030Complex,Q9Y3Z3
 Evidence X-RAY 4cc9 A Reference
       Region 4cc9 A 1058-1072 disorder
       Region 4cc9 A 1073-1314 order
       Region 4cc9 A 1315-1327 disorder
       Region 4cc9 A 1328-1392 order
       Region 4cc9 A 1393-1396 disorder
Seqdisorder 1418-1507
 Evidence CD Reference
       Region 1418-1507 disorder
Seq 1418-1507 Hetero heptamer : IID50318Complex
 Evidence X-RAY 3wa0 H Reference
       Region 3wa0 H 1418-1496 disorder
       Region 3wa0 H 1497-1507 order
 Evidence X-RAY 3wa0 G Reference
       Region 3wa0 G 1418-1478 disorder
       Region 3wa0 G 1479-1489 order
       Region 3wa0 G 1490-1507 disorder
Seq 1447-1507 Hetero dimer : IID50318Complex
 Evidence X-RAY 4p7i D Reference
       Region 4p7i D 1447-1499 disorder
       Region 4p7i D 1500-1506 order
       Region 4p7i D 1507-1507 disorder
Seq 1447-1507 Hetero dimer : IID50318Complex
 Evidence X-RAY 4p7i C Reference
       Region 4p7i C 1447-1479 disorder
       Region 4p7i C 1480-1487 order
       Region 4p7i C 1488-1499 disorder
       Region 4p7i C 1500-1506 order
       Region 4p7i C 1507-1507 disorder
Seqdisorder 1475-1507
 Evidence X-RAY 6n45 A Reference
       Region 6n45 A 1475-1507 disorder
Seqdisorder 1475-1507
 Evidence X-RAY 6n45 B Reference
       Region 6n45 B 1475-1507 disorder
SeqProS verified 1479-1489,1497-1507 Hetero dimer : IID50318Complex
       Region 4p7i C 1480-1487 order
       Region 4p7i C 1500-1506 order
       Region 1418-1507 disorder
SeqProS verified 1479-1489,1497-1507 Hetero heptamer : IID50318Complex
       Region 3wa0 G 1479-1489 order
       Region 3wa0 H 1497-1507 order
       Region 1418-1507 disorder
SeqProS verified 1497-1507 Hetero dimer : IID50318Complex
       Region 4p7i D 1500-1506 order
       Region 1418-1507 disorder
Seqphosphorylation
    255-255 Phosphoserine
    202-202 Phosphoserine
    828-828 Phosphoserine
    888-888 Phosphothreonine
    895-895 Phosphoserine
    898-898 Phosphoserine
    979-979 Phosphoserine
    1000-1000 Phosphoserine
    1328-1328 Phosphoserine
Seqacetylation
    701-701 N6-acetyllysine
 
Prediction
NeProc
Disorder 1-8,189-306,545-552,651-667,678-686,695-717,876-1001,1316-1321,1419-1507
Order 9-188,307-498,504-544,553-650,668-677,687-689,718-875,1002-1315,1322-1418
ProS 202-219,296-306,545-552,653-667,678-686,698-712,897-906,955-960,1419-1423,1429-1436,1456-1466,1482-1488,1495-1507
AlphaFold
Disorder 1-8,191-309,314-315,499-504,545-554,581-581,650-650,693-719,783-784,819-833,878-1000,1038-1043,1315-1327,1373-1379,1394-1507
Order 9-190,310-313,316-498,505-544,555-580,582-649,651-692,720-782,785-818,834-877,1001-1037,1044-1314,1328-1372,1380-1393
SEG 175-192 ,201-212 ,592-606 ,1394-1453 ,1458-1484
Function
Function in SwissProt
(Microbial infection) In case of infection by HIV-2 virus, it is recruited by HIV-2 Vpx in order to hijack the CUL4A-RBX1-DDB1-DCAF1/VPRBP function leading to enhanced efficiency of macrophage infection and promotion of the replication of cognate primate lentiviruses in cells of monocyte/macrophage lineage.