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IID00745
 UniprotQ9Y6K9
ProteinNF-kappa-B essential modulator
GeneIKBKG
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
419
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seqdisorder 1-111
 Evidence NMR Reference
       Region 1-111 disorder
Seq 38-129 Homo dimer :
 Evidence X-RAY 6mi3 A Reference
       Region 6mi3 A 38-129 order
 Evidence X-RAY 6mi3 B Reference
       Region 6mi3 B 38-129 order
 Evidence X-RAY 6mi4 A Reference
       Region 6mi4 A 38-129 order
 Evidence X-RAY 6mi4 B Reference
       Region 6mi4 B 38-129 order
Seq 44-111 Hetero tetramer : IID00525Complex
 Evidence X-RAY 3brv B Reference
       Region 3brv B 44-48 disorder
       Region 3brv B 49-109 order
       Region 3brv B 110-111 disorder
 Evidence X-RAY 3brv D Reference
       Region 3brv D 44-48 disorder
       Region 3brv D 49-110 order
       Region 3brv D 111-111 disorder
Seq 44-111 Hetero trimer : IID00525Complex,IID00526Complex
 Evidence X-RAY 3brt D Reference
       Region 3brt D 44-48 disorder
       Region 3brt D 49-110 order
       Region 3brt D 111-111 disorder
Seq 44-111 Hetero trimer : IID00525Complex,IID00526Complex
 Evidence X-RAY 3brt B Reference
       Region 3brt B 44-48 disorder
       Region 3brt B 49-109 order
       Region 3brt B 110-111 disorder
Seq 44-111 Hetero trimer : IID00525Complex,IID00526Complex
 Evidence X-RAY 3brt D Reference
       Region 3brt D 44-48 disorder
       Region 3brt D 49-110 order
       Region 3brt D 111-111 disorder
Seq 44-111 Hetero trimer : IID00525Complex,IID00526Complex
 Evidence X-RAY 3brt B Reference
       Region 3brt B 44-48 disorder
       Region 3brt B 49-109 order
       Region 3brt B 110-111 disorder
Seq 150-272 Hetero tetramer : Q76RF1
 Evidence X-RAY 3cl3 D Reference
       Region 3cl3 D 150-192 disorder
       Region 3cl3 D 193-251 order
       Region 3cl3 D 252-272 disorder
 Evidence X-RAY 3cl3 E Reference
       Region 3cl3 E 150-195 disorder
       Region 3cl3 E 196-253 order
       Region 3cl3 E 254-272 disorder
Seq 226-235 Hetero hexamer : P0DTD1
 Evidence X-RAY 7t2u E Reference
       Region 7t2u E 226-234 order
       Region 7t2u E 235-235 disorder
 Evidence X-RAY 7t2u F Reference
       Region 7t2u F 226-235 order
Seq 230-249 Hetero hexamer : F5HEZ4,P19909
 Evidence X-RAY 5lde R Reference
       Region 5lde R 230-235 order
       Region 5lde R 236-236 disorder
       Region 5lde R 237-239 order
       Region 5lde R 240-240 disorder
       Region 5lde R 241-249 order
 Evidence X-RAY 5lde S Reference
       Region 5lde S 230-235 order
       Region 5lde S 236-236 disorder
       Region 5lde S 237-239 order
       Region 5lde S 240-240 disorder
       Region 5lde S 241-249 order
Seq 246-344 Homo dimer :
 Evidence X-RAY 3fx0 A Reference
       Region 3fx0 A 246-266 disorder
       Region 3fx0 A 267-329 order
       Region 3fx0 A 330-337 disorder
 Evidence X-RAY 3fx0 B Reference
       Region 3fx0 B 246-262 disorder
       Region 3fx0 B 263-333 order
       Region 3fx0 B 334-337 disorder
 Evidence X-RAY 4bwn A Reference
       Region 4bwn A 258-258 disorder
       Region 4bwn A 259-344 order
 Evidence X-RAY 4bwn B Reference
       Region 4bwn B 258-258 disorder
       Region 4bwn B 259-344 order
 Evidence X-RAY 6yek A Reference
       Region 6yek A 258-258 disorder
       Region 6yek A 259-343 order
       Region 6yek A 344-344 disorder
 Evidence X-RAY 6yek B Reference
       Region 6yek B 258-260 disorder
       Region 6yek B 261-344 order
Seq 257-346 Hetero pentamer : IID00576Complex,P0CG48
 Evidence X-RAY 7tv4 B Reference
       Region 7tv4 B 257-259 disorder
       Region 7tv4 B 260-340 order
       Region 7tv4 B 341-346 disorder
 Evidence X-RAY 7tv4 D Reference
       Region 7tv4 D 257-259 disorder
       Region 7tv4 D 260-338 order
       Region 7tv4 D 339-346 disorder
Seq 258-344 Hetero tetramer :
 Evidence X-RAY 6xx0 A Reference
       Region 6xx0 A 258-265 disorder
       Region 6xx0 A 266-340 order
       Region 6xx0 A 341-344 disorder
 Evidence X-RAY 6xx0 B Reference
       Region 6xx0 B 258-264 disorder
       Region 6xx0 B 265-339 order
       Region 6xx0 B 340-344 disorder
Seq 392-419 Monomer :
 Evidence NMR 2jvx A Reference
       Region 2jvx A 394-419 order
       Region 2jvx A 419-419 high_rmsd
 Evidence NMR 2jvy A Reference
       Region 2jvy A 394-419 order
       Region 2jvy A 419-419 high_rmsd
 Evidence NMR 5aay A Reference
       Region 5aay A 392-419 order
       Region 5aay A 392-392 high_rmsd
SeqProS verified 49-109 Hetero tetramer : IID00525Complex
       Region 3brv B 49-109 order
       Region 3brv D 49-110 order
       Region 1-111 disorder
Seqphosphorylation
    31-31 Phosphoserine; by IKKB
    43-43 Phosphoserine; by IKKB
    68-68 Phosphoserine
    85-85 Phosphoserine; by ATM
    376-376 Phosphoserine; by IKKB
    387-387 Phosphoserine
 
Prediction
NeProc
Disorder 1-50,202-212,248-252,295-304,354-391
Order 51-201,213-247,253-294,305-353,392-419
ProS 1-16,48-50,202-212,248-252,295-304,354-354
AlphaFold
Disorder 1-49,248-260,359-393,419-419
Order 50-247,261-358,394-418
SEG 259-280 ,313-339 ,364-393
Function
Function in SwissProt
(Microbial infection) Also considered to be a mediator for HTLV-1 Tax oncoprotein activation of NF-kappa-B.