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IID00750
 UniprotO14558
ProteinHeat shock protein beta-6
GeneHSPB6
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
160
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seqdisorder 1-74
 Evidence Reference
       Region 1-74 disorder
Seq 1-149 Hetero tetramer : IID00301Complex
 Evidence X-RAY 5ltw C Reference
       Region 5ltw C 1-20 order
       Region 5ltw C 21-25 disorder
       Region 5ltw C 26-38 order
       Region 5ltw C 39-69 disorder
       Region 5ltw C 70-149 order
 Evidence X-RAY 5ltw D Reference
       Region 5ltw D 1-20 order
       Region 5ltw D 21-71 disorder
       Region 5ltw D 72-149 order
 Evidence X-RAY 5ltw G Reference
       Region 5ltw G 1-38 order
       Region 5ltw G 39-69 disorder
       Region 5ltw G 70-149 order
 Evidence X-RAY 5ltw H Reference
       Region 5ltw H 1-20 order
       Region 5ltw H 21-71 disorder
       Region 5ltw H 72-149 order
 Evidence X-RAY 5ltw K Reference
       Region 5ltw K 1-20 order
       Region 5ltw K 21-25 disorder
       Region 5ltw K 26-38 order
       Region 5ltw K 39-68 disorder
       Region 5ltw K 69-149 order
 Evidence X-RAY 5ltw L Reference
       Region 5ltw L 1-20 order
       Region 5ltw L 21-69 disorder
       Region 5ltw L 70-149 order
Seq 2-10,72-149 Hetero tetramer :
 Evidence X-RAY 5lum A Reference
       Region 5lum A 72-149 order
 Evidence X-RAY 5lum B Reference
       Region 5lum B 72-149 order
 Evidence X-RAY 5lum C Reference
       Region 5lum C 72-149 order
 Evidence X-RAY 5lum D Reference
       Region 5lum D 72-149 order
 Evidence X-RAY 5lum E Reference
       Region 5lum E 72-149 order
 Evidence X-RAY 5lum F Reference
       Region 5lum F 2-10 order
 Evidence X-RAY 5lum G Reference
       Region 5lum G 2-10 order
 Evidence X-RAY 5lum H Reference
       Region 5lum H 2-10 order
 Evidence X-RAY 5lum I Reference
       Region 5lum I 2-10 order
 Evidence X-RAY 5lum J Reference
       Region 5lum J 2-10 order
Seq 11-23 Hetero tetramer : IID00301Complex
 Evidence X-RAY 5lu1 C Reference
       Region 5lu1 C 13-20 order
 Evidence X-RAY 5lu1 D Reference
       Region 5lu1 D 13-20 order
 Evidence X-RAY 5lu1 G Reference
       Region 5lu1 G 13-20 order
 Evidence X-RAY 5lu1 H Reference
       Region 5lu1 H 13-20 order
 Evidence X-RAY 5lu2 C Reference
       Region 5lu2 C 11-12 disorder
       Region 5lu2 C 13-20 order
       Region 5lu2 C 21-23 disorder
 Evidence X-RAY 5lu2 D Reference
       Region 5lu2 D 11-12 disorder
       Region 5lu2 D 13-20 order
       Region 5lu2 D 21-23 disorder
Seq 12-19 Hetero tetramer : IID00301Complex
 Evidence X-RAY 5okf B Reference
       Region 5okf B 12-12 disorder
       Region 5okf B 13-18 order
       Region 5okf B 19-19 disorder
 Evidence X-RAY 5okf A Reference
       Region 5okf A 12-18 order
       Region 5okf A 19-19 disorder
Seq 12-19 Hetero tetramer : IID00301Complex
 Evidence X-RAY 5ok9 B Reference
       Region 5ok9 B 12-19 order
 Evidence X-RAY 5ok9 A Reference
       Region 5ok9 A 12-19 order
Seq 12-19 Hetero tetramer : IID00301Complex
 Evidence X-RAY 5okf D Reference
       Region 5okf D 12-19 order
 Evidence X-RAY 5okf C Reference
       Region 5okf C 12-18 order
       Region 5okf C 19-19 disorder
Seq 12-19 Hetero tetramer : IID00301Complex
 Evidence X-RAY 5ok9 F Reference
       Region 5ok9 F 12-18 order
       Region 5ok9 F 19-19 disorder
 Evidence X-RAY 5ok9 E Reference
       Region 5ok9 E 12-19 order
Seq 12-19 Hetero tetramer : IID00301Complex
 Evidence X-RAY 5ok9 F Reference
       Region 5ok9 F 12-18 order
       Region 5ok9 F 19-19 disorder
 Evidence X-RAY 5ok9 E Reference
       Region 5ok9 E 12-19 order
Seq 57-160 Homo tetramer :
 Evidence X-RAY 4jus A Reference
       Region 4jus A 57-58 disorder
       Region 4jus A 59-67 order
       Region 4jus A 68-73 disorder
       Region 4jus A 74-148 order
       Region 4jus A 149-160 disorder
 Evidence X-RAY 4jus B Reference
       Region 4jus B 57-65 disorder
       Region 4jus B 66-154 order
       Region 4jus B 155-160 disorder
 Evidence X-RAY 4jus C Reference
       Region 4jus C 57-58 disorder
       Region 4jus C 59-68 order
       Region 4jus C 69-72 disorder
       Region 4jus C 73-146 order
       Region 4jus C 147-160 disorder
 Evidence X-RAY 4jus D Reference
       Region 4jus D 57-57 disorder
       Region 4jus D 58-70 order
       Region 4jus D 71-72 disorder
       Region 4jus D 73-146 order
       Region 4jus D 147-160 disorder
 Evidence X-RAY 4jus E Reference
       Region 4jus E 57-59 disorder
       Region 4jus E 60-68 order
       Region 4jus E 69-73 disorder
       Region 4jus E 74-146 order
       Region 4jus E 147-160 disorder
 Evidence X-RAY 4jus F Reference
       Region 4jus F 57-63 disorder
       Region 4jus F 64-71 order
       Region 4jus F 72-72 disorder
       Region 4jus F 73-147 order
       Region 4jus F 148-160 disorder
 Evidence X-RAY 4jus G Reference
       Region 4jus G 57-57 disorder
       Region 4jus G 58-67 order
       Region 4jus G 68-73 disorder
       Region 4jus G 74-147 order
       Region 4jus G 148-160 disorder
 Evidence X-RAY 4jus H Reference
       Region 4jus H 57-63 disorder
       Region 4jus H 64-147 order
       Region 4jus H 148-160 disorder
 Evidence X-RAY 4jut A Reference
       Region 4jut A 57-60 disorder
       Region 4jut A 61-66 order
       Region 4jut A 67-70 disorder
       Region 4jut A 71-148 order
       Region 4jut A 149-160 disorder
 Evidence X-RAY 4jut B Reference
       Region 4jut B 57-62 disorder
       Region 4jut B 63-146 order
       Region 4jut B 147-160 disorder
 Evidence X-RAY 4jut C Reference
       Region 4jut C 57-59 disorder
       Region 4jut C 60-149 order
       Region 4jut C 150-160 disorder
 Evidence X-RAY 4jut D Reference
       Region 4jut D 57-63 disorder
       Region 4jut D 64-147 order
       Region 4jut D 148-160 disorder
 Evidence X-RAY 4jut E Reference
       Region 4jut E 57-60 disorder
       Region 4jut E 61-148 order
       Region 4jut E 149-160 disorder
 Evidence X-RAY 4jut F Reference
       Region 4jut F 57-61 disorder
       Region 4jut F 62-147 order
       Region 4jut F 148-160 disorder
 Evidence X-RAY 4jut G Reference
       Region 4jut G 57-60 disorder
       Region 4jut G 61-67 order
       Region 4jut G 68-72 disorder
       Region 4jut G 73-148 order
       Region 4jut G 149-160 disorder
 Evidence X-RAY 4jut H Reference
       Region 4jut H 57-60 disorder
       Region 4jut H 61-147 order
       Region 4jut H 148-160 disorder
SeqProS verified 1-38 Hetero tetramer : IID00301Complex
       Region 5ltw C 1-20 order
       Region 5ltw C 26-38 order
       Region 5ltw D 1-20 order
       Region 5ltw G 1-38 order
       Region 5ltw H 1-20 order
       Region 5ltw K 1-20 order
       Region 5ltw K 26-38 order
       Region 5ltw L 1-20 order
       Region 1-74 disorder
SeqProS verified 2-10 Hetero tetramer :
       Region 5lum F 2-10 order
       Region 5lum G 2-10 order
       Region 5lum H 2-10 order
       Region 5lum I 2-10 order
       Region 5lum J 2-10 order
       Region 1-74 disorder
SeqProS verified 12-20 Hetero tetramer : IID00301Complex
       Region 5lu2 C 13-20 order
       Region 5lu2 D 13-20 order
       Region 5lu1 C 13-20 order
       Region 5lu1 D 13-20 order
       Region 5lu1 G 13-20 order
       Region 5lu1 H 13-20 order
       Region 1-74 disorder
SeqProS verified 12-20 Hetero tetramer : IID00301Complex
       Region 5okf A 12-18 order
       Region 5okf B 13-18 order
       Region 1-74 disorder
SeqProS verified 12-20 Hetero tetramer : IID00301Complex
       Region 5ok9 E 12-19 order
       Region 5ok9 F 12-18 order
       Region 1-74 disorder
SeqProS verified 12-20 Hetero tetramer : IID00301Complex
       Region 5ok9 E 12-19 order
       Region 5ok9 F 12-18 order
       Region 1-74 disorder
SeqProS verified 12-20 Hetero tetramer : IID00301Complex
       Region 5ok9 A 12-19 order
       Region 5ok9 B 12-19 order
       Region 1-74 disorder
SeqProS verified 12-20 Hetero tetramer : IID00301Complex
       Region 5okf C 12-18 order
       Region 5okf D 12-19 order
       Region 1-74 disorder
Seqphosphorylation
    16-16 Phosphoserine; by PKA
 
Prediction
NeProc
Disorder 59-67,149-160
Order 1-58,68-148
ProS 59-67
AlphaFold
Disorder 11-34,36-71,149-160
Order 1-10,35-35,72-148
Pfam Hmmer
PF00525 3-64 2.1e-08
PF00011 66-160 4.4e-26
SEG 34-45 ,92-105 ,145-159
Function
Function in SwissProt
Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state. Seems to have versatile functions in various biological processes. Plays a role in regulating muscle function such as smooth muscle vasorelaxation and cardiac myocyte contractility. May regulate myocardial angiogenesis implicating KDR. Overexpression mediates cardioprotection and angiogenesis after induced damage. Stabilizes monomeric YWHAZ thereby supporting YWHAZ chaperone-like activity.