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IID00752
 UniprotO14965
ProteinAurora kinase A
GeneAURKA
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
403
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 100-403 Monomer :
 Evidence X-RAY 5aae A Reference
       Region 5aae A 122-125 disorder
       Region 5aae A 126-279 order
       Region 5aae A 280-290 disorder
       Region 5aae A 291-388 order
       Region 5aae A 389-403 disorder
 Evidence X-RAY 5aaf A Reference
       Region 5aaf A 122-125 disorder
       Region 5aaf A 126-281 order
       Region 5aaf A 282-290 disorder
       Region 5aaf A 291-388 order
       Region 5aaf A 389-403 disorder
 Evidence X-RAY 5aag A Reference
       Region 5aag A 122-126 disorder
       Region 5aag A 127-281 order
       Region 5aag A 282-290 disorder
       Region 5aag A 291-388 order
       Region 5aag A 389-403 disorder
 Evidence X-RAY 4b0g A Reference
       Region 4b0g A 122-125 disorder
       Region 4b0g A 126-169 order
       Region 4b0g A 170-173 disorder
       Region 4b0g A 174-279 order
       Region 4b0g A 280-291 disorder
       Region 4b0g A 292-302 order
       Region 4b0g A 303-305 disorder
       Region 4b0g A 306-391 order
       Region 4b0g A 392-403 disorder
 Evidence X-RAY 4bn1 A Reference
       Region 4bn1 A 122-125 disorder
       Region 4bn1 A 126-388 order
       Region 4bn1 A 389-403 disorder
 Evidence X-RAY 4byi A Reference
       Region 4byi A 122-125 disorder
       Region 4byi A 126-281 order
       Region 4byi A 282-290 disorder
       Region 4byi A 291-388 order
       Region 4byi A 389-403 disorder
 Evidence X-RAY 4byj A Reference
       Region 4byj A 122-125 disorder
       Region 4byj A 126-274 order
       Region 4byj A 275-291 disorder
       Region 4byj A 292-388 order
       Region 4byj A 389-403 disorder
 Evidence X-RAY 4c3r A Reference
       Region 4c3r A 122-126 disorder
       Region 4c3r A 127-280 order
       Region 4c3r A 281-290 disorder
       Region 4c3r A 291-388 order
       Region 4c3r A 389-403 disorder
 Evidence X-RAY 2c6d A Reference
       Region 2c6d A 124-125 disorder
       Region 2c6d A 126-280 order
       Region 2c6d A 281-290 disorder
       Region 2c6d A 291-389 order
       Region 2c6d A 390-398 disorder
 Evidence X-RAY 2c6e A Reference
       Region 2c6e A 123-126 disorder
       Region 2c6e A 127-278 order
       Region 2c6e A 279-290 disorder
       Region 2c6e A 291-389 order
       Region 2c6e A 390-401 disorder
 Evidence X-RAY 2c6e B Reference
       Region 2c6e B 123-126 disorder
       Region 2c6e B 127-274 order
       Region 2c6e B 275-290 disorder
       Region 2c6e B 291-388 order
       Region 2c6e B 389-401 disorder
 Evidence X-RAY 4ceg A Reference
       Region 4ceg A 122-126 disorder
       Region 4ceg A 127-391 order
       Region 4ceg A 392-403 disorder
 Evidence X-RAY 3coh A Reference
       Region 3coh A 124-127 disorder
       Region 3coh A 128-274 order
       Region 3coh A 275-288 disorder
       Region 3coh A 289-388 order
       Region 3coh A 389-391 disorder
 Evidence X-RAY 3coh B Reference
       Region 3coh B 124-127 disorder
       Region 3coh B 128-274 order
       Region 3coh B 275-288 disorder
       Region 3coh B 289-388 order
       Region 3coh B 389-391 disorder
 Evidence X-RAY 4dea A Reference
       Region 4dea A 123-123 disorder
       Region 4dea A 124-389 order
       Region 4dea A 390-401 disorder
 Evidence X-RAY 4deb A Reference
       Region 4deb A 123-124 disorder
       Region 4deb A 125-388 order
       Region 4deb A 389-401 disorder
 Evidence X-RAY 4ded A Reference
       Region 4ded A 123-123 disorder
       Region 4ded A 124-388 order
       Region 4ded A 389-401 disorder
 Evidence X-RAY 4dee A Reference
       Region 4dee A 123-123 disorder
       Region 4dee A 124-394 order
       Region 4dee A 395-401 disorder
 Evidence X-RAY 4dhf A Reference
       Region 4dhf A 126-127 disorder
       Region 4dhf A 128-285 order
       Region 4dhf A 286-289 disorder
       Region 4dhf A 290-389 order
       Region 4dhf A 390-391 disorder
 Evidence X-RAY 4dhf B Reference
       Region 4dhf B 126-127 disorder
       Region 4dhf B 128-285 order
       Region 4dhf B 286-289 disorder
       Region 4dhf B 290-389 order
       Region 4dhf B 390-391 disorder
 Evidence X-RAY 5dn3 A Reference
       Region 5dn3 A 125-389 order
       Region 5dn3 A 390-391 disorder
 Evidence X-RAY 5dnr A Reference
       Region 5dnr A 125-125 disorder
       Region 5dnr A 126-390 order
       Region 5dnr A 391-391 disorder
 Evidence X-RAY 5dos A Reference
       Region 5dos A 126-126 disorder
       Region 5dos A 127-284 order
       Region 5dos A 285-289 disorder
       Region 5dos A 290-390 order
 Evidence X-RAY 5dpv A Reference
       Region 5dpv A 126-126 disorder
       Region 5dpv A 127-283 order
       Region 5dpv A 284-289 disorder
       Region 5dpv A 290-389 order
       Region 5dpv A 390-390 disorder
 Evidence X-RAY 5dr2 A Reference
       Region 5dr2 A 128-390 order
 Evidence X-RAY 5dr6 A Reference
       Region 5dr6 A 126-126 disorder
       Region 5dr6 A 127-282 order
       Region 5dr6 A 283-289 disorder
       Region 5dr6 A 290-390 order
 Evidence X-RAY 5drd A Reference
       Region 5drd A 126-126 disorder
       Region 5drd A 127-284 order
       Region 5drd A 285-289 disorder
       Region 5drd A 290-390 order
 Evidence X-RAY 5dt0 A Reference
       Region 5dt0 A 126-126 disorder
       Region 5dt0 A 127-284 order
       Region 5dt0 A 285-289 disorder
       Region 5dt0 A 290-390 order
 Evidence X-RAY 5dt3 A Reference
       Region 5dt3 A 126-126 disorder
       Region 5dt3 A 127-390 order
 Evidence X-RAY 5dt4 A Reference
       Region 5dt4 A 126-126 disorder
       Region 5dt4 A 127-284 order
       Region 5dt4 A 285-289 disorder
       Region 5dt4 A 290-390 order
 Evidence X-RAY 2dwb A Reference
       Region 2dwb A 122-125 disorder
       Region 2dwb A 126-285 order
       Region 2dwb A 286-287 disorder
       Region 2dwb A 288-389 order
       Region 2dwb A 390-403 disorder
 Evidence X-RAY 3efw A Reference
       Region 3efw A 125-125 disorder
       Region 3efw A 126-275 order
       Region 3efw A 276-292 disorder
       Region 3efw A 293-302 order
       Region 3efw A 303-308 disorder
       Region 3efw A 309-388 order
       Region 3efw A 389-391 disorder
 Evidence X-RAY 3efw B Reference
       Region 3efw B 125-125 disorder
       Region 3efw B 126-275 order
       Region 3efw B 276-292 disorder
       Region 3efw B 293-302 order
       Region 3efw B 303-307 disorder
       Region 3efw B 308-389 order
       Region 3efw B 390-391 disorder
 Evidence X-RAY 5ew9 A Reference
       Region 5ew9 A 123-126 disorder
       Region 5ew9 A 127-280 order
       Region 5ew9 A 281-285 disorder
       Region 5ew9 A 286-390 order
 Evidence X-RAY 3fdn A Reference
       Region 3fdn A 123-125 disorder
       Region 3fdn A 126-281 order
       Region 3fdn A 282-289 disorder
       Region 3fdn A 290-394 order
       Region 3fdn A 395-401 disorder
 Evidence X-RAY 3h0y A Reference
       Region 3h0y A 124-125 disorder
       Region 3h0y A 126-278 order
       Region 3h0y A 279-291 disorder
       Region 3h0y A 292-388 order
       Region 3h0y A 389-391 disorder
 Evidence X-RAY 3h0z A Reference
       Region 3h0z A 124-127 disorder
       Region 3h0z A 128-278 order
       Region 3h0z A 279-291 disorder
       Region 3h0z A 292-388 order
       Region 3h0z A 389-391 disorder
 Evidence X-RAY 3h0z B Reference
       Region 3h0z B 124-125 disorder
       Region 3h0z B 126-140 order
       Region 3h0z B 141-146 disorder
       Region 3h0z B 147-274 order
       Region 3h0z B 275-291 disorder
       Region 3h0z B 292-388 order
       Region 3h0z B 389-391 disorder
 Evidence X-RAY 3h0z C Reference
       Region 3h0z C 124-125 disorder
       Region 3h0z C 126-274 order
       Region 3h0z C 275-291 disorder
       Region 3h0z C 292-388 order
       Region 3h0z C 389-391 disorder
 Evidence X-RAY 3h10 A Reference
       Region 3h10 A 124-391 order
 Evidence X-RAY 3h10 B Reference
       Region 3h10 B 124-124 disorder
       Region 3h10 B 125-391 order
 Evidence X-RAY 3h10 D Reference
       Region 3h10 D 124-125 disorder
       Region 3h10 D 126-283 order
       Region 3h10 D 284-291 disorder
       Region 3h10 D 292-388 order
       Region 3h10 D 389-391 disorder
 Evidence X-RAY 2j4z A Reference
       Region 2j4z A 100-125 disorder
       Region 2j4z A 126-388 order
       Region 2j4z A 389-403 disorder
 Evidence X-RAY 2j4z B Reference
       Region 2j4z B 100-125 disorder
       Region 2j4z B 126-394 order
       Region 2j4z B 395-403 disorder
 Evidence X-RAY 2j50 A Reference
       Region 2j50 A 126-127 disorder
       Region 2j50 A 128-279 order
       Region 2j50 A 280-287 disorder
       Region 2j50 A 288-302 order
       Region 2j50 A 303-306 disorder
       Region 2j50 A 307-388 order
       Region 2j50 A 389-403 disorder
 Evidence X-RAY 2j50 B Reference
       Region 2j50 B 126-127 disorder
       Region 2j50 B 128-279 order
       Region 2j50 B 280-287 disorder
       Region 2j50 B 288-302 order
       Region 2j50 B 303-306 disorder
       Region 2j50 B 307-388 order
       Region 2j50 B 389-403 disorder
 Evidence X-RAY 4j8m A Reference
       Region 4j8m A 123-124 disorder
       Region 4j8m A 125-390 order
       Region 4j8m A 391-401 disorder
 Evidence X-RAY 4jai A Reference
       Region 4jai A 122-125 disorder
       Region 4jai A 126-275 order
       Region 4jai A 276-291 disorder
       Region 4jai A 292-390 order
       Region 4jai A 391-396 disorder
 Evidence X-RAY 4jaj A Reference
       Region 4jaj A 122-124 disorder
       Region 4jaj A 125-389 order
       Region 4jaj A 390-396 disorder
 Evidence X-RAY 4jbo A Reference
       Region 4jbo A 123-125 disorder
       Region 4jbo A 126-391 order
       Region 4jbo A 392-401 disorder
 Evidence X-RAY 4jbp A Reference
       Region 4jbp A 123-125 disorder
       Region 4jbp A 126-280 order
       Region 4jbp A 281-290 disorder
       Region 4jbp A 291-390 order
       Region 4jbp A 391-401 disorder
 Evidence X-RAY 4jbq A Reference
       Region 4jbq A 123-125 disorder
       Region 4jbq A 126-280 order
       Region 4jbq A 281-289 disorder
       Region 4jbq A 290-391 order
       Region 4jbq A 392-401 disorder
 Evidence X-RAY 3k5u A Reference
       Region 3k5u A 123-125 disorder
       Region 3k5u A 126-280 order
       Region 3k5u A 281-289 disorder
       Region 3k5u A 290-394 order
       Region 3k5u A 395-401 disorder
 Evidence X-RAY 3lau A Reference
       Region 3lau A 125-275 order
       Region 3lau A 276-292 disorder
       Region 3lau A 293-391 order
       Region 3lau A 392-399 disorder
 Evidence X-RAY 3m11 A Reference
       Region 3m11 A 123-125 disorder
       Region 3m11 A 126-280 order
       Region 3m11 A 281-290 disorder
       Region 3m11 A 291-391 order
       Region 3m11 A 392-401 disorder
 Evidence X-RAY 1mq4 A Reference
       Region 1mq4 A 125-125 disorder
       Region 1mq4 A 126-285 order
       Region 1mq4 A 286-287 disorder
       Region 1mq4 A 288-388 order
       Region 1mq4 A 389-391 disorder
 Evidence X-RAY 1muo A Reference
       Region 1muo A 107-127 disorder
       Region 1muo A 128-278 order
       Region 1muo A 279-288 disorder
       Region 1muo A 289-388 order
       Region 1muo A 389-403 disorder
 Evidence X-RAY 3myg A Reference
       Region 3myg A 125-125 disorder
       Region 3myg A 126-280 order
       Region 3myg A 281-291 disorder
       Region 3myg A 292-388 order
       Region 3myg A 389-391 disorder
 Evidence X-RAY 2np8 A Reference
       Region 2np8 A 125-126 disorder
       Region 2np8 A 127-285 order
       Region 2np8 A 286-291 disorder
       Region 2np8 A 292-388 order
       Region 2np8 A 389-391 disorder
 Evidence X-RAY 3nrm A Reference
       Region 3nrm A 126-388 order
       Region 3nrm A 389-403 disorder
 Evidence X-RAY 4o0s A Reference
       Region 4o0s A 122-125 disorder
       Region 4o0s A 126-286 order
       Region 4o0s A 287-287 disorder
       Region 4o0s A 288-391 order
       Region 4o0s A 392-403 disorder
 Evidence X-RAY 4o0u A Reference
       Region 4o0u A 122-125 disorder
       Region 4o0u A 126-280 order
       Region 4o0u A 281-287 disorder
       Region 4o0u A 288-391 order
       Region 4o0u A 392-403 disorder
 Evidence X-RAY 4o0w A Reference
       Region 4o0w A 122-124 disorder
       Region 4o0w A 125-280 order
       Region 4o0w A 281-288 disorder
       Region 4o0w A 289-391 order
       Region 4o0w A 392-403 disorder
 Evidence X-RAY 3o50 A Reference
       Region 3o50 A 125-125 disorder
       Region 3o50 A 126-277 order
       Region 3o50 A 278-291 disorder
       Region 3o50 A 292-302 order
       Region 3o50 A 303-305 disorder
       Region 3o50 A 306-388 order
       Region 3o50 A 389-391 disorder
 Evidence X-RAY 3o50 B Reference
       Region 3o50 B 125-125 disorder
       Region 3o50 B 126-275 order
       Region 3o50 B 276-286 disorder
       Region 3o50 B 287-302 order
       Region 3o50 B 303-306 disorder
       Region 3o50 B 307-389 order
       Region 3o50 B 390-391 disorder
 Evidence X-RAY 3o51 A Reference
       Region 3o51 A 125-125 disorder
       Region 3o51 A 126-275 order
       Region 3o51 A 276-292 disorder
       Region 3o51 A 293-388 order
       Region 3o51 A 389-391 disorder
 Evidence X-RAY 5obj A Reference
       Region 5obj A 125-126 disorder
       Region 5obj A 127-285 order
       Region 5obj A 286-289 disorder
       Region 5obj A 290-390 order
       Region 5obj A 391-391 disorder
 Evidence X-RAY 1ol6 A Reference
       Region 1ol6 A 122-127 disorder
       Region 1ol6 A 128-141 order
       Region 1ol6 A 142-142 disorder
       Region 1ol6 A 143-172 order
       Region 1ol6 A 173-174 disorder
       Region 1ol6 A 175-280 order
       Region 1ol6 A 281-291 disorder
       Region 1ol6 A 292-303 order
       Region 1ol6 A 304-304 disorder
       Region 1ol6 A 305-387 order
       Region 1ol6 A 388-403 disorder
 Evidence X-RAY 1ol7 A Reference
       Region 1ol7 A 122-126 disorder
       Region 1ol7 A 127-389 order
       Region 1ol7 A 390-403 disorder
 Evidence X-RAY 5one A Reference
       Region 5one A 122-126 disorder
       Region 5one A 127-280 order
       Region 5one A 281-288 disorder
       Region 5one A 289-391 order
       Region 5one A 392-403 disorder
 Evidence X-RAY 5orl A Reference
       Region 5orl A 127-391 order
 Evidence X-RAY 5orn A Reference
       Region 5orn A 127-391 order
 Evidence X-RAY 5oro A Reference
       Region 5oro A 127-391 order
 Evidence X-RAY 5orp A Reference
       Region 5orp A 127-391 order
 Evidence X-RAY 5orr A Reference
       Region 5orr A 127-391 order
 Evidence X-RAY 5ors A Reference
       Region 5ors A 127-391 order
 Evidence X-RAY 5ort A Reference
       Region 5ort A 127-391 order
 Evidence X-RAY 5orv A Reference
       Region 5orv A 127-391 order
 Evidence X-RAY 5orw A Reference
       Region 5orw A 127-391 order
 Evidence X-RAY 5orx A Reference
       Region 5orx A 127-391 order
 Evidence X-RAY 5ory A Reference
       Region 5ory A 127-391 order
 Evidence X-RAY 5orz A Reference
       Region 5orz A 127-391 order
 Evidence X-RAY 5os0 A Reference
       Region 5os0 A 127-391 order
 Evidence X-RAY 5os1 A Reference
       Region 5os1 A 127-391 order
 Evidence X-RAY 5os2 A Reference
       Region 5os2 A 127-285 order
       Region 5os2 A 286-289 disorder
       Region 5os2 A 290-391 order
 Evidence X-RAY 5os3 A Reference
       Region 5os3 A 127-391 order
 Evidence X-RAY 5os4 A Reference
       Region 5os4 A 127-391 order
 Evidence X-RAY 5os5 A Reference
       Region 5os5 A 125-392 order
 Evidence X-RAY 5os6 A Reference
       Region 5os6 A 127-391 order
 Evidence X-RAY 5osd A Reference
       Region 5osd A 125-391 order
 Evidence X-RAY 5ose A Reference
       Region 5ose A 127-391 order
 Evidence X-RAY 5osf A Reference
       Region 5osf A 127-391 order
 Evidence X-RAY 3p9j A Reference
       Region 3p9j A 125-125 disorder
       Region 3p9j A 126-279 order
       Region 3p9j A 280-290 disorder
       Region 3p9j A 291-303 order
       Region 3p9j A 304-306 disorder
       Region 3p9j A 307-388 order
       Region 3p9j A 389-391 disorder
 Evidence X-RAY 4prj A Reference
       Region 4prj A 124-124 disorder
       Region 4prj A 125-142 order
       Region 4prj A 143-145 disorder
       Region 4prj A 146-279 order
       Region 4prj A 280-289 disorder
       Region 4prj A 290-388 order
       Region 4prj A 389-391 disorder
 Evidence X-RAY 3qbn A Reference
       Region 3qbn A 124-125 disorder
       Region 3qbn A 126-274 order
       Region 3qbn A 275-287 disorder
       Region 3qbn A 288-388 order
       Region 3qbn A 389-403 disorder
 Evidence X-RAY 3r21 A Reference
       Region 3r21 A 126-126 disorder
       Region 3r21 A 127-279 order
       Region 3r21 A 280-288 disorder
       Region 3r21 A 289-389 order
       Region 3r21 A 390-391 disorder
 Evidence X-RAY 3r22 A Reference
       Region 3r22 A 126-281 order
       Region 3r22 A 282-290 disorder
       Region 3r22 A 291-389 order
       Region 3r22 A 390-391 disorder
 Evidence X-RAY 3unz A Reference
       Region 3unz A 123-126 disorder
       Region 3unz A 127-389 order
       Region 3unz A 390-401 disorder
 Evidence X-RAY 3unz B Reference
       Region 3unz B 123-126 disorder
       Region 3unz B 127-389 order
       Region 3unz B 390-401 disorder
 Evidence X-RAY 3uo4 A Reference
       Region 3uo4 A 123-123 disorder
       Region 3uo4 A 124-389 order
       Region 3uo4 A 390-401 disorder
 Evidence X-RAY 3uo5 A Reference
       Region 3uo5 A 123-123 disorder
       Region 3uo5 A 124-390 order
       Region 3uo5 A 391-401 disorder
 Evidence X-RAY 3uo6 A Reference
       Region 3uo6 A 123-125 disorder
       Region 3uo6 A 126-389 order
       Region 3uo6 A 390-401 disorder
 Evidence X-RAY 3uo6 B Reference
       Region 3uo6 B 123-125 disorder
       Region 3uo6 B 126-389 order
       Region 3uo6 B 390-401 disorder
 Evidence X-RAY 3uod A Reference
       Region 3uod A 123-123 disorder
       Region 3uod A 124-389 order
       Region 3uod A 390-401 disorder
 Evidence X-RAY 3uoh A Reference
       Region 3uoh A 123-125 disorder
       Region 3uoh A 126-389 order
       Region 3uoh A 390-401 disorder
 Evidence X-RAY 3uoh B Reference
       Region 3uoh B 123-125 disorder
       Region 3uoh B 126-389 order
       Region 3uoh B 390-401 disorder
 Evidence X-RAY 3uoj A Reference
       Region 3uoj A 123-126 disorder
       Region 3uoj A 127-389 order
       Region 3uoj A 390-401 disorder
 Evidence X-RAY 3uoj B Reference
       Region 3uoj B 123-126 disorder
       Region 3uoj B 127-389 order
       Region 3uoj B 390-401 disorder
 Evidence X-RAY 3uok A Reference
       Region 3uok A 123-124 disorder
       Region 3uok A 125-389 order
       Region 3uok A 390-401 disorder
 Evidence X-RAY 3uok B Reference
       Region 3uok B 123-124 disorder
       Region 3uok B 125-389 order
       Region 3uok B 390-401 disorder
 Evidence X-RAY 3uol A Reference
       Region 3uol A 123-126 disorder
       Region 3uol A 127-389 order
       Region 3uol A 390-401 disorder
 Evidence X-RAY 3uol B Reference
       Region 3uol B 123-126 disorder
       Region 3uol B 127-389 order
       Region 3uol B 390-401 disorder
 Evidence X-RAY 3up2 A Reference
       Region 3up2 A 123-123 disorder
       Region 3up2 A 124-389 order
       Region 3up2 A 390-401 disorder
 Evidence X-RAY 3up7 A Reference
       Region 3up7 A 123-123 disorder
       Region 3up7 A 124-387 order
       Region 3up7 A 388-401 disorder
 Evidence X-RAY 3vap A Reference
       Region 3vap A 125-126 disorder
       Region 3vap A 127-277 order
       Region 3vap A 278-290 disorder
       Region 3vap A 291-388 order
       Region 3vap A 389-391 disorder
 Evidence X-RAY 2w1c A Reference
       Region 2w1c A 122-126 disorder
       Region 2w1c A 127-389 order
 Evidence X-RAY 2w1d A Reference
       Region 2w1d A 122-126 disorder
       Region 2w1d A 127-279 order
       Region 2w1d A 280-290 disorder
       Region 2w1d A 291-307 order
       Region 2w1d A 308-308 disorder
       Region 2w1d A 309-389 order
 Evidence X-RAY 2w1e A Reference
       Region 2w1e A 122-126 disorder
       Region 2w1e A 127-279 order
       Region 2w1e A 280-290 disorder
       Region 2w1e A 291-389 order
 Evidence X-RAY 2w1f A Reference
       Region 2w1f A 122-126 disorder
       Region 2w1f A 127-280 order
       Region 2w1f A 281-290 disorder
       Region 2w1f A 291-389 order
 Evidence X-RAY 2w1g A Reference
       Region 2w1g A 122-126 disorder
       Region 2w1g A 127-281 order
       Region 2w1g A 282-290 disorder
       Region 2w1g A 291-389 order
 Evidence X-RAY 3w10 A Reference
       Region 3w10 A 126-388 order
       Region 3w10 A 389-403 disorder
 Evidence X-RAY 3w16 A Reference
       Region 3w16 A 126-279 order
       Region 3w16 A 280-290 disorder
       Region 3w16 A 291-303 order
       Region 3w16 A 304-306 disorder
       Region 3w16 A 307-388 order
       Region 3w16 A 389-403 disorder
 Evidence X-RAY 3w18 A Reference
       Region 3w18 A 126-143 order
       Region 3w18 A 144-145 disorder
       Region 3w18 A 146-172 order
       Region 3w18 A 173-179 disorder
       Region 3w18 A 180-273 order
       Region 3w18 A 274-290 disorder
       Region 3w18 A 291-303 order
       Region 3w18 A 304-306 disorder
       Region 3w18 A 307-388 order
       Region 3w18 A 389-403 disorder
 Evidence X-RAY 3w18 B Reference
       Region 3w18 B 126-170 order
       Region 3w18 B 171-181 disorder
       Region 3w18 B 182-277 order
       Region 3w18 B 278-290 disorder
       Region 3w18 B 291-303 order
       Region 3w18 B 304-306 disorder
       Region 3w18 B 307-388 order
       Region 3w18 B 389-403 disorder
 Evidence X-RAY 3w2c A Reference
       Region 3w2c A 128-168 order
       Region 3w2c A 169-180 disorder
       Region 3w2c A 181-247 order
       Region 3w2c A 248-256 disorder
       Region 3w2c A 257-274 order
       Region 3w2c A 275-291 disorder
       Region 3w2c A 292-302 order
       Region 3w2c A 303-309 disorder
       Region 3w2c A 310-335 order
       Region 3w2c A 336-337 disorder
       Region 3w2c A 338-368 order
       Region 3w2c A 369-379 disorder
       Region 3w2c A 380-388 order
 Evidence X-RAY 3w2c C Reference
       Region 3w2c C 128-168 order
       Region 3w2c C 169-180 disorder
       Region 3w2c C 181-247 order
       Region 3w2c C 248-257 disorder
       Region 3w2c C 258-274 order
       Region 3w2c C 275-291 disorder
       Region 3w2c C 292-302 order
       Region 3w2c C 303-309 disorder
       Region 3w2c C 310-335 order
       Region 3w2c C 336-337 disorder
       Region 3w2c C 338-368 order
       Region 3w2c C 369-379 disorder
       Region 3w2c C 380-388 order
 Evidence X-RAY 3w2c E Reference
       Region 3w2c E 128-168 order
       Region 3w2c E 169-180 disorder
       Region 3w2c E 181-247 order
       Region 3w2c E 248-257 disorder
       Region 3w2c E 258-274 order
       Region 3w2c E 275-291 disorder
       Region 3w2c E 292-302 order
       Region 3w2c E 303-309 disorder
       Region 3w2c E 310-335 order
       Region 3w2c E 336-337 disorder
       Region 3w2c E 338-368 order
       Region 3w2c E 369-379 disorder
       Region 3w2c E 380-388 order
 Evidence X-RAY 3w2c G Reference
       Region 3w2c G 128-168 order
       Region 3w2c G 169-180 disorder
       Region 3w2c G 181-247 order
       Region 3w2c G 248-257 disorder
       Region 3w2c G 258-274 order
       Region 3w2c G 275-291 disorder
       Region 3w2c G 292-302 order
       Region 3w2c G 303-309 disorder
       Region 3w2c G 310-335 order
       Region 3w2c G 336-337 disorder
       Region 3w2c G 338-368 order
       Region 3w2c G 369-379 disorder
       Region 3w2c G 380-388 order
 Evidence X-RAY 2wqe A Reference
       Region 2wqe A 127-274 order
       Region 2wqe A 275-290 disorder
       Region 2wqe A 291-301 order
       Region 2wqe A 302-306 disorder
       Region 2wqe A 307-388 order
 Evidence X-RAY 2wtv A Reference
       Region 2wtv A 122-124 disorder
       Region 2wtv A 125-389 order
       Region 2wtv A 390-403 disorder
 Evidence X-RAY 2wtv B Reference
       Region 2wtv B 122-125 disorder
       Region 2wtv B 126-389 order
       Region 2wtv B 390-403 disorder
 Evidence X-RAY 2wtv C Reference
       Region 2wtv C 122-125 disorder
       Region 2wtv C 126-389 order
       Region 2wtv C 390-403 disorder
 Evidence X-RAY 2wtv D Reference
       Region 2wtv D 122-124 disorder
       Region 2wtv D 125-389 order
       Region 2wtv D 390-403 disorder
 Evidence X-RAY 2wtw A Reference
       Region 2wtw A 122-127 disorder
       Region 2wtw A 128-283 order
       Region 2wtw A 284-289 disorder
       Region 2wtw A 290-389 order
       Region 2wtw A 390-403 disorder
 Evidence X-RAY 2x6d A Reference
       Region 2x6d A 122-125 disorder
       Region 2x6d A 126-170 order
       Region 2x6d A 171-174 disorder
       Region 2x6d A 175-285 order
       Region 2x6d A 286-289 disorder
       Region 2x6d A 290-388 order
       Region 2x6d A 389-403 disorder
 Evidence X-RAY 2x6e A Reference
       Region 2x6e A 122-125 disorder
       Region 2x6e A 126-280 order
       Region 2x6e A 281-291 disorder
       Region 2x6e A 292-302 order
       Region 2x6e A 303-305 disorder
       Region 2x6e A 306-388 order
       Region 2x6e A 389-403 disorder
 Evidence X-RAY 2x81 A Reference
       Region 2x81 A 126-126 disorder
       Region 2x81 A 127-140 order
       Region 2x81 A 141-143 disorder
       Region 2x81 A 144-273 order
       Region 2x81 A 274-290 disorder
       Region 2x81 A 291-388 order
       Region 2x81 A 389-391 disorder
 Evidence X-RAY 2xne A Reference
       Region 2xne A 122-126 disorder
       Region 2xne A 127-165 order
       Region 2xne A 166-172 disorder
       Region 2xne A 173-282 order
       Region 2xne A 283-291 disorder
       Region 2xne A 292-388 order
       Region 2xne A 389-392 disorder
 Evidence X-RAY 2xng A Reference
       Region 2xng A 122-126 disorder
       Region 2xng A 127-281 order
       Region 2xng A 282-291 disorder
       Region 2xng A 292-389 order
       Region 2xng A 390-403 disorder
 Evidence X-RAY 2xru A Reference
       Region 2xru A 126-279 order
       Region 2xru A 280-289 disorder
       Region 2xru A 290-388 order
       Region 2xru A 389-403 disorder
 Evidence X-RAY 4zs0 A Reference
       Region 4zs0 A 122-126 disorder
       Region 4zs0 A 127-286 order
       Region 4zs0 A 287-291 disorder
       Region 4zs0 A 292-388 order
       Region 4zs0 A 389-403 disorder
 Evidence X-RAY 5aad A Reference
       Region 5aad A 122-126 disorder
       Region 5aad A 127-281 order
       Region 5aad A 282-291 disorder
       Region 5aad A 292-388 order
       Region 5aad A 389-403 disorder
 Evidence X-RAY 7ayh A Reference
       Region 7ayh A 122-124 disorder
       Region 7ayh A 125-275 order
       Region 7ayh A 276-291 disorder
       Region 7ayh A 292-390 order
       Region 7ayh A 391-403 disorder
 Evidence X-RAY 7ayi A Reference
       Region 7ayi A 122-124 disorder
       Region 7ayi A 125-275 order
       Region 7ayi A 276-291 disorder
       Region 7ayi A 292-392 order
       Region 7ayi A 393-403 disorder
 Evidence X-RAY 6c2r A Reference
       Region 6c2r A 125-127 disorder
       Region 6c2r A 128-279 order
       Region 6c2r A 280-291 disorder
       Region 6c2r A 292-389 order
       Region 6c2r A 390-391 disorder
 Evidence X-RAY 6c2t A Reference
       Region 6c2t A 125-127 disorder
       Region 6c2t A 128-279 order
       Region 6c2t A 280-287 disorder
       Region 6c2t A 288-388 order
       Region 6c2t A 389-391 disorder
 Evidence X-RAY 6cpe A Reference
       Region 6cpe A 122-126 disorder
       Region 6cpe A 127-284 order
       Region 6cpe A 285-291 disorder
       Region 6cpe A 292-389 order
       Region 6cpe A 390-403 disorder
 Evidence X-RAY 6cpf A Reference
       Region 6cpf A 122-127 disorder
       Region 6cpf A 128-284 order
       Region 6cpf A 285-290 disorder
       Region 6cpf A 291-392 order
       Region 6cpf A 393-403 disorder
 Evidence X-RAY 5dr9 A Reference
       Region 5dr9 A 126-126 disorder
       Region 5dr9 A 127-282 order
       Region 5dr9 A 283-289 disorder
       Region 5dr9 A 290-390 order
 Evidence X-RAY 7fic A Reference
       Region 7fic A 127-278 order
       Region 7fic A 279-289 disorder
       Region 7fic A 290-391 order
 Evidence X-RAY 6gra A Reference
       Region 6gra A 122-125 disorder
       Region 6gra A 126-277 order
       Region 6gra A 278-291 disorder
       Region 6gra A 292-389 order
       Region 6gra A 390-403 disorder
 Evidence X-RAY 6hjj A Reference
       Region 6hjj A 122-126 disorder
       Region 6hjj A 127-279 order
       Region 6hjj A 280-290 disorder
       Region 6hjj A 291-393 order
       Region 6hjj A 394-403 disorder
 Evidence X-RAY 6hjk A Reference
       Region 6hjk A 122-126 disorder
       Region 6hjk A 127-279 order
       Region 6hjk A 280-289 disorder
       Region 6hjk A 290-391 order
       Region 6hjk A 392-403 disorder
 Evidence X-RAY 6i2u A Reference
       Region 6i2u A 122-126 disorder
       Region 6i2u A 127-391 order
       Region 6i2u A 392-403 disorder
 Evidence X-RAY 8jmx A Reference
       Region 8jmx A 127-276 order
       Region 8jmx A 277-289 disorder
       Region 8jmx A 290-389 order
 Evidence X-RAY 7o2v A Reference
       Region 7o2v A 116-116 disorder
       Region 7o2v A 117-279 order
       Region 7o2v A 280-289 disorder
       Region 7o2v A 290-390 order
       Region 7o2v A 391-403 disorder
 Evidence X-RAY 5obr A Reference
       Region 5obr A 125-125 disorder
       Region 5obr A 126-280 order
       Region 5obr A 281-290 disorder
       Region 5obr A 291-390 order
       Region 5obr A 391-391 disorder
 Evidence X-RAY 6r49 A Reference
       Region 6r49 A 122-126 disorder
       Region 6r49 A 127-285 order
       Region 6r49 A 286-290 disorder
       Region 6r49 A 291-391 order
       Region 6r49 A 392-403 disorder
 Evidence X-RAY 6r4a A Reference
       Region 6r4a A 122-126 disorder
       Region 6r4a A 127-391 order
       Region 6r4a A 392-403 disorder
 Evidence X-RAY 6r4b A Reference
       Region 6r4b A 122-126 disorder
       Region 6r4b A 127-391 order
       Region 6r4b A 392-403 disorder
 Evidence X-RAY 6r4c A Reference
       Region 6r4c A 122-126 disorder
       Region 6r4c A 127-391 order
       Region 6r4c A 392-403 disorder
 Evidence X-RAY 6r4d A Reference
       Region 6r4d A 122-126 disorder
       Region 6r4d A 127-391 order
       Region 6r4d A 392-403 disorder
 Evidence X-RAY 4uyn A Reference
       Region 4uyn A 125-171 order
       Region 4uyn A 172-173 disorder
       Region 4uyn A 174-276 order
       Region 4uyn A 277-292 disorder
       Region 4uyn A 293-391 order
       Region 4uyn A 392-399 disorder
 Evidence X-RAY 4uzh A Reference
       Region 4uzh A 125-275 order
       Region 4uzh A 276-292 disorder
       Region 4uzh A 293-391 order
       Region 4uzh A 392-399 disorder
 Evidence X-RAY 6xka A Reference
       Region 6xka A 117-126 disorder
       Region 6xka A 127-280 order
       Region 6xka A 281-290 disorder
       Region 6xka A 291-388 order
       Region 6xka A 389-389 disorder
 Evidence X-RAY 6z4y A Reference
       Region 6z4y A 122-123 disorder
       Region 6z4y A 124-282 order
       Region 6z4y A 283-289 disorder
       Region 6z4y A 290-389 order
       Region 6z4y A 390-403 disorder
 Evidence X-RAY 5zan A Reference
       Region 5zan A 123-126 disorder
       Region 5zan A 127-285 order
       Region 5zan A 286-290 disorder
       Region 5zan A 291-389 order
       Region 5zan A 390-403 disorder
 Evidence X-RAY 4ztq A Reference
       Region 4ztq A 122-126 disorder
       Region 4ztq A 127-279 order
       Region 4ztq A 280-290 disorder
       Region 4ztq A 291-303 order
       Region 4ztq A 304-307 disorder
       Region 4ztq A 308-388 order
       Region 4ztq A 389-403 disorder
 Evidence X-RAY 4ztr A Reference
       Region 4ztr A 122-126 disorder
       Region 4ztr A 127-277 order
       Region 4ztr A 278-290 disorder
       Region 4ztr A 291-388 order
       Region 4ztr A 389-403 disorder
 Evidence X-RAY 4zts A Reference
       Region 4zts A 122-126 disorder
       Region 4zts A 127-278 order
       Region 4zts A 279-291 disorder
       Region 4zts A 292-388 order
       Region 4zts A 389-403 disorder
Seq 100-403 Homo dimer :
 Evidence X-RAY 2bmc A Reference
       Region 2bmc A 100-126 disorder
       Region 2bmc A 127-279 order
       Region 2bmc A 280-291 disorder
       Region 2bmc A 292-394 order
       Region 2bmc A 395-403 disorder
 Evidence X-RAY 2bmc B Reference
       Region 2bmc B 100-124 disorder
       Region 2bmc B 125-279 order
       Region 2bmc B 280-291 disorder
       Region 2bmc B 292-394 order
       Region 2bmc B 395-403 disorder
 Evidence X-RAY 2bmc C Reference
       Region 2bmc C 100-124 disorder
       Region 2bmc C 125-279 order
       Region 2bmc C 280-291 disorder
       Region 2bmc C 292-393 order
       Region 2bmc C 394-403 disorder
 Evidence X-RAY 2bmc D Reference
       Region 2bmc D 100-126 disorder
       Region 2bmc D 127-279 order
       Region 2bmc D 280-291 disorder
       Region 2bmc D 292-394 order
       Region 2bmc D 395-403 disorder
 Evidence X-RAY 2bmc E Reference
       Region 2bmc E 100-126 disorder
       Region 2bmc E 127-279 order
       Region 2bmc E 280-291 disorder
       Region 2bmc E 292-394 order
       Region 2bmc E 395-403 disorder
 Evidence X-RAY 2bmc F Reference
       Region 2bmc F 100-125 disorder
       Region 2bmc F 126-279 order
       Region 2bmc F 280-291 disorder
       Region 2bmc F 292-394 order
       Region 2bmc F 395-403 disorder
Seq 117-389 Hetero tetramer : IID00891Complex
 Evidence X-RAY 6vpl B Reference
       Region 6vpl B 117-124 disorder
       Region 6vpl B 125-282 order
       Region 6vpl B 283-286 disorder
       Region 6vpl B 287-389 order
 Evidence X-RAY 6vpl A Reference
       Region 6vpl A 117-124 disorder
       Region 6vpl A 125-282 order
       Region 6vpl A 283-286 disorder
       Region 6vpl A 287-389 order
Seq 117-389 Hetero dimer : IID00891Complex
 Evidence X-RAY 6vpi A Reference
       Region 6vpi A 117-125 disorder
       Region 6vpi A 126-389 order
Seq 117-389 Hetero dimer : IID00891Complex
 Evidence X-RAY 6vpg A Reference
       Region 6vpg A 117-117 order
       Region 6vpg A 118-123 disorder
       Region 6vpg A 124-389 order
Seq 117-389 Hetero dimer : IID00891Complex
 Evidence X-RAY 6vpj A Reference
       Region 6vpj A 117-123 disorder
       Region 6vpj A 124-283 order
       Region 6vpj A 284-286 disorder
       Region 6vpj A 287-389 order
Seq 117-389 Hetero dimer : IID00891Complex
 Evidence X-RAY 6vph A Reference
       Region 6vph A 117-122 disorder
       Region 6vph A 123-389 order
Seq 117-389 Hetero tetramer : IID00891Complex
 Evidence X-RAY 6vpm B Reference
       Region 6vpm B 117-124 disorder
       Region 6vpm B 125-282 order
       Region 6vpm B 283-286 disorder
       Region 6vpm B 287-389 order
 Evidence X-RAY 6vpm A Reference
       Region 6vpm A 117-124 disorder
       Region 6vpm A 125-282 order
       Region 6vpm A 283-286 disorder
       Region 6vpm A 287-389 order
Seq 122-403 Hetero dimer :
 Evidence X-RAY 5g15 A Reference
       Region 5g15 A 122-125 disorder
       Region 5g15 A 126-390 order
       Region 5g15 A 391-403 disorder
Seq 122-403 Hetero dimer : IID00766Complex
 Evidence X-RAY 7ztl A Reference
       Region 7ztl A 122-125 disorder
       Region 7ztl A 126-389 order
       Region 7ztl A 390-403 disorder
Seq 122-403 Hetero tetramer :
 Evidence X-RAY 8sso D Reference
       Region 8sso D 122-126 disorder
       Region 8sso D 127-280 order
       Region 8sso D 281-291 disorder
       Region 8sso D 292-389 order
       Region 8sso D 390-403 disorder
 Evidence X-RAY 8sso A Reference
       Region 8sso A 122-126 disorder
       Region 8sso A 127-281 order
       Region 8sso A 282-288 disorder
       Region 8sso A 289-389 order
       Region 8sso A 390-403 disorder
Seq 122-403 Hetero dimer : IID00766Complex
 Evidence X-RAY 5g1x A Reference
       Region 5g1x A 122-126 disorder
       Region 5g1x A 127-389 order
       Region 5g1x A 390-403 disorder
Seq 122-403 Hetero dimer : IID00891Complex
 Evidence X-RAY 3e5a A Reference
       Region 3e5a A 125-389 order
       Region 3e5a A 390-391 disorder
 Evidence X-RAY 5lxm A Reference
       Region 5lxm A 122-125 disorder
       Region 5lxm A 126-392 order
       Region 5lxm A 393-403 disorder
 Evidence X-RAY 1ol5 A Reference
       Region 1ol5 A 122-122 disorder
       Region 1ol5 A 123-387 order
       Region 1ol5 A 388-403 disorder
 Evidence X-RAY 3ha6 A Reference
       Region 3ha6 A 125-388 order
       Region 3ha6 A 389-391 disorder
Seq 122-403 Hetero tetramer : IID00891Complex
 Evidence X-RAY 4c3p D Reference
       Region 4c3p D 122-124 disorder
       Region 4c3p D 125-282 order
       Region 4c3p D 283-288 disorder
       Region 4c3p D 289-390 order
       Region 4c3p D 391-403 disorder
 Evidence X-RAY 4c3p A Reference
       Region 4c3p A 122-124 disorder
       Region 4c3p A 125-388 order
       Region 4c3p A 389-403 disorder
Seq 122-403 Hetero dimer : Q8JJ25
 Evidence X-RAY 5l8j A Reference
       Region 5l8j A 122-125 disorder
       Region 5l8j A 126-278 order
       Region 5l8j A 279-291 disorder
       Region 5l8j A 292-391 order
       Region 5l8j A 392-403 disorder
 Evidence X-RAY 5l8k A Reference
       Region 5l8k A 122-125 disorder
       Region 5l8k A 126-392 order
       Region 5l8k A 393-403 disorder
 Evidence X-RAY 5l8l A Reference
       Region 5l8l A 122-125 disorder
       Region 5l8l A 126-389 order
       Region 5l8l A 390-403 disorder
Seq 122-403 Hetero tetramer :
 Evidence X-RAY 6cpg D Reference
       Region 6cpg D 122-126 disorder
       Region 6cpg D 127-278 order
       Region 6cpg D 279-288 disorder
       Region 6cpg D 289-388 order
       Region 6cpg D 389-403 disorder
 Evidence X-RAY 6cpg A Reference
       Region 6cpg A 122-126 disorder
       Region 6cpg A 127-277 order
       Region 6cpg A 278-289 disorder
       Region 6cpg A 290-387 order
       Region 6cpg A 388-403 disorder
Seq 122-403 Hetero dimer :
 Evidence X-RAY 8ssp A Reference
       Region 8ssp A 122-125 disorder
       Region 8ssp A 126-389 order
       Region 8ssp A 390-403 disorder
Seq 122-403 Hetero dimer : IID00898Complex
 Evidence X-RAY 5odt A Reference
       Region 5odt A 122-125 disorder
       Region 5odt A 126-280 order
       Region 5odt A 281-289 disorder
       Region 5odt A 290-392 order
       Region 5odt A 393-403 disorder
Seq 122-403 Hetero tetramer :
 Evidence X-RAY 6c83 B Reference
       Region 6c83 B 122-126 disorder
       Region 6c83 B 127-275 order
       Region 6c83 B 276-290 disorder
       Region 6c83 B 291-388 order
       Region 6c83 B 389-403 disorder
 Evidence X-RAY 6c83 A Reference
       Region 6c83 A 122-126 disorder
       Region 6c83 A 127-275 order
       Region 6c83 A 276-290 disorder
       Region 6c83 A 291-389 order
       Region 6c83 A 390-403 disorder
Seq 123-401 Homo tetramer :
 Evidence X-RAY 4j8n D Reference
       Region 4j8n D 123-125 disorder
       Region 4j8n D 126-390 order
       Region 4j8n D 391-401 disorder
 Evidence X-RAY 4j8n C Reference
       Region 4j8n C 123-124 disorder
       Region 4j8n C 125-390 order
       Region 4j8n C 391-401 disorder
 Evidence X-RAY 4j8n B Reference
       Region 4j8n B 123-124 disorder
       Region 4j8n B 125-390 order
       Region 4j8n B 391-401 disorder
 Evidence X-RAY 4j8n A Reference
       Region 4j8n A 123-124 disorder
       Region 4j8n A 125-390 order
       Region 4j8n A 391-401 disorder
Seq 123-403 Hetero hexamer : Q8TEP8
 Evidence X-RAY 8guw C Reference
       Region 8guw C 123-277 order
       Region 8guw C 278-291 disorder
       Region 8guw C 292-302 order
       Region 8guw C 303-306 disorder
       Region 8guw C 307-388 order
       Region 8guw C 389-403 disorder
 Evidence X-RAY 8guw B Reference
       Region 8guw B 123-127 disorder
       Region 8guw B 128-278 order
       Region 8guw B 279-291 disorder
       Region 8guw B 292-390 order
       Region 8guw B 391-403 disorder
 Evidence X-RAY 8guw A Reference
       Region 8guw A 123-283 order
       Region 8guw A 284-290 disorder
       Region 8guw A 291-388 order
       Region 8guw A 389-403 disorder
Seq 125-399 Homo tetramer :
 Evidence X-RAY 4uzd B Reference
       Region 4uzd B 125-277 order
       Region 4uzd B 278-284 disorder
       Region 4uzd B 285-389 order
       Region 4uzd B 390-399 disorder
 Evidence X-RAY 4uzd A Reference
       Region 4uzd A 125-126 disorder
       Region 4uzd A 127-276 order
       Region 4uzd A 277-284 disorder
       Region 4uzd A 285-388 order
       Region 4uzd A 389-399 disorder
Seqphosphorylation
    41-41 Phosphoserine
    51-51 Phosphoserine
    287-287 Phosphothreonine
    288-288 Phosphothreonine
    342-342 Phosphoserine; by PKA and PAK
 
Prediction
NeProc
Disorder 1-125,390-403
Order 126-389
ProS 1-12,19-27
AlphaFold
Disorder 1-125,278-278,280-292,393-403
Order 126-277,279-279,293-392
Pfam Hmmer
PF00069 133-383 6.4e-87
Function
Function in SwissProt
Mitotic serine/threonine kinase that contributes to the regulation of cell cycle progression (PubMed:26246606, PubMed:12390251, PubMed:18615013, PubMed:11039908, PubMed:17125279, PubMed:17360485). Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis (PubMed:26246606, PubMed:14523000). Required for normal spindle positioning during mitosis and for the localization of NUMA1 and DCTN1 to the cell cortex during metaphase (PubMed:27335426). Required for initial activation of CDK1 at centrosomes (PubMed:13678582, PubMed:15128871). Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2 (PubMed:18056443, PubMed:15128871, PubMed:14702041, PubMed:11551964, PubMed:15147269, PubMed:15987997, PubMed:17604723, PubMed:18615013). Regulates KIF2A tubulin depolymerase activity (PubMed:19351716). Important for microtubule formation and/or stabilization (PubMed:18056443). Required for normal axon formation (PubMed:19812038). Plays a role in microtubule remodeling during neurite extension (PubMed:19668197). Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and destabilizing p53/TP53 (PubMed:14702041). Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity (PubMed:11551964). Inhibits cilia outgrowth (By similarity). Required for cilia disassembly via phosphorylation of HDAC6 and subsequent deacetylation of alpha-tubulin (PubMed:17604723, PubMed:20643351). Regulates protein levels of the anti-apoptosis protein BIRC5 by suppressing the expression of the SCF(FBXL7) E3 ubiquitin-protein ligase substrate adapter FBXL7 through the phosphorylation of the transcription factor FOXP1 (PubMed:28218735).
Biological Process
Diagram with PDB data
AURKA/TPX2Crystal structure of Aurora-A bound to a hydrocarbon-stapled proteomimetic of TPX2
See also
Diagram with PDB data
MYCN/AURKACrystal structure of Aurora-A kinase in complex with N-Myc
TACC3/AURKAAurora-A in complex with TACC3