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IID00753
 UniprotO15350
ProteinTumor protein p73
GeneTP73
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
636
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 10-25 Hetero dimer : IID00720Complex
 Evidence NMR 6ijq A Reference
       Region 6ijq A 10-25 order
       Region 6ijq A 10-13 high_rmsd
Seq 10-25 Hetero dimer : IID00163Complex
 Evidence NMR 2mps B Reference
       Region 2mps B 10-25 order
       Region 2mps B 10-12 high_rmsd
Seq 10-31 Hetero dimer : IID00070Complex
 Evidence NMR 6fgs A Reference
       Region 6fgs A 10-31 order
       Region 6fgs A 10-10 high_rmsd
Seq 112-311 Hetero dodecamer : IID00124Complex
 Evidence X-RAY 4a63 K Reference
       Region 4a63 K 112-113 disorder
       Region 4a63 K 114-311 order
 Evidence X-RAY 4a63 I Reference
       Region 4a63 I 112-113 disorder
       Region 4a63 I 114-311 order
 Evidence X-RAY 4a63 G Reference
       Region 4a63 G 112-113 disorder
       Region 4a63 G 114-311 order
 Evidence X-RAY 4a63 E Reference
       Region 4a63 E 112-113 disorder
       Region 4a63 E 114-311 order
 Evidence X-RAY 4a63 C Reference
       Region 4a63 C 112-113 disorder
       Region 4a63 C 114-311 order
 Evidence X-RAY 4a63 A Reference
       Region 4a63 A 112-113 disorder
       Region 4a63 A 114-311 order
Seq 112-312 Homo dimer :
 Evidence X-RAY 4guq A Reference
       Region 4guq A 115-312 order
 Evidence X-RAY 4guq B Reference
       Region 4guq B 115-165 order
       Region 4guq B 166-166 disorder
       Region 4guq B 167-311 order
       Region 4guq B 312-312 disorder
 Evidence X-RAY 5kbd A Reference
       Region 5kbd A 115-312 order
 Evidence X-RAY 5kbd B Reference
       Region 5kbd B 115-312 order
 Evidence X-RAY 3vd2 I Reference
       Region 3vd2 I 115-312 order
 Evidence X-RAY 3vd2 J Reference
       Region 3vd2 J 115-312 order
 Evidence X-RAY 2xwc A Reference
       Region 2xwc A 112-264 order
       Region 2xwc A 265-267 disorder
       Region 2xwc A 268-311 order
Seq 115-312 Homo tetramer :
 Evidence X-RAY 3vd2 D Reference
       Region 3vd2 D 115-310 order
       Region 3vd2 D 311-312 disorder
 Evidence X-RAY 3vd2 C Reference
       Region 3vd2 C 115-312 order
 Evidence X-RAY 3vd2 B Reference
       Region 3vd2 B 115-311 order
       Region 3vd2 B 312-312 disorder
 Evidence X-RAY 3vd2 A Reference
       Region 3vd2 A 115-312 order
Seq 115-312 Homo hexadecamer :
 Evidence X-RAY 7ezj l Reference
       Region 7ezj l 115-311 order
       Region 7ezj l 312-312 disorder
 Evidence X-RAY 7ezj k Reference
       Region 7ezj k 115-312 order
 Evidence X-RAY 7ezj j Reference
       Region 7ezj j 115-115 disorder
       Region 7ezj j 116-311 order
       Region 7ezj j 312-312 disorder
 Evidence X-RAY 7ezj i Reference
       Region 7ezj i 115-312 order
 Evidence X-RAY 7ezj d Reference
       Region 7ezj d 115-310 order
       Region 7ezj d 311-312 disorder
 Evidence X-RAY 7ezj c Reference
       Region 7ezj c 115-310 order
       Region 7ezj c 311-312 disorder
 Evidence X-RAY 7ezj b Reference
       Region 7ezj b 115-310 order
       Region 7ezj b 311-312 disorder
 Evidence X-RAY 7ezj a Reference
       Region 7ezj a 115-311 order
       Region 7ezj a 312-312 disorder
 Evidence X-RAY 7ezj L Reference
       Region 7ezj L 115-311 order
       Region 7ezj L 312-312 disorder
 Evidence X-RAY 7ezj K Reference
       Region 7ezj K 115-312 order
 Evidence X-RAY 7ezj J Reference
       Region 7ezj J 115-310 order
       Region 7ezj J 311-312 disorder
 Evidence X-RAY 7ezj I Reference
       Region 7ezj I 115-311 order
       Region 7ezj I 312-312 disorder
 Evidence X-RAY 7ezj D Reference
       Region 7ezj D 115-311 order
       Region 7ezj D 312-312 disorder
 Evidence X-RAY 7ezj C Reference
       Region 7ezj C 115-312 order
 Evidence X-RAY 7ezj B Reference
       Region 7ezj B 115-312 order
 Evidence X-RAY 7ezj A Reference
       Region 7ezj A 115-312 order
Seq 115-312 Homo tetramer :
 Evidence X-RAY 4g82 A Reference
       Region 4g82 A 115-312 order
 Evidence X-RAY 4g82 B Reference
       Region 4g82 B 115-312 order
 Evidence X-RAY 4g83 A Reference
       Region 4g83 A 115-310 order
       Region 4g83 A 311-312 disorder
 Evidence X-RAY 4g83 B Reference
       Region 4g83 B 115-310 order
       Region 4g83 B 311-312 disorder
 Evidence X-RAY 4guo A Reference
       Region 4guo A 115-312 order
 Evidence X-RAY 4guo B Reference
       Region 4guo B 115-311 order
       Region 4guo B 312-312 disorder
 Evidence X-RAY 4guo C Reference
       Region 4guo C 115-312 order
 Evidence X-RAY 4guo D Reference
       Region 4guo D 115-311 order
       Region 4guo D 312-312 disorder
 Evidence X-RAY 4guo I Reference
       Region 4guo I 115-312 order
 Evidence X-RAY 4guo J Reference
       Region 4guo J 115-312 order
 Evidence X-RAY 4guo K Reference
       Region 4guo K 115-311 order
       Region 4guo K 312-312 disorder
 Evidence X-RAY 4guo L Reference
       Region 4guo L 115-311 order
       Region 4guo L 312-312 disorder
 Evidence X-RAY 3vd0 A Reference
       Region 3vd0 A 115-312 order
 Evidence X-RAY 3vd0 B Reference
       Region 3vd0 B 115-312 order
 Evidence X-RAY 3vd0 C Reference
       Region 3vd0 C 115-312 order
 Evidence X-RAY 3vd0 D Reference
       Region 3vd0 D 115-312 order
 Evidence X-RAY 3vd0 I Reference
       Region 3vd0 I 115-312 order
 Evidence X-RAY 3vd0 J Reference
       Region 3vd0 J 115-312 order
 Evidence X-RAY 3vd0 K Reference
       Region 3vd0 K 115-312 order
 Evidence X-RAY 3vd0 L Reference
       Region 3vd0 L 115-312 order
 Evidence X-RAY 3vd1 A Reference
       Region 3vd1 A 115-312 order
 Evidence X-RAY 3vd1 B Reference
       Region 3vd1 B 115-312 order
 Evidence X-RAY 3vd1 C Reference
       Region 3vd1 C 115-312 order
 Evidence X-RAY 3vd1 D Reference
       Region 3vd1 D 115-312 order
 Evidence X-RAY 3vd1 I Reference
       Region 3vd1 I 115-312 order
 Evidence X-RAY 3vd1 J Reference
       Region 3vd1 J 115-312 order
 Evidence X-RAY 3vd1 K Reference
       Region 3vd1 K 115-312 order
 Evidence X-RAY 3vd1 L Reference
       Region 3vd1 L 115-312 order
Seq 351-383 Homo hexamer :
 Evidence X-RAY 2wqj X Reference
       Region 2wqj X 351-352 disorder
       Region 2wqj X 353-380 order
       Region 2wqj X 381-383 disorder
 Evidence X-RAY 2wqj W Reference
       Region 2wqj W 351-352 disorder
       Region 2wqj W 353-379 order
       Region 2wqj W 380-383 disorder
 Evidence X-RAY 2wqj V Reference
       Region 2wqj V 351-352 disorder
       Region 2wqj V 353-380 order
       Region 2wqj V 381-383 disorder
 Evidence X-RAY 2wqj U Reference
       Region 2wqj U 351-352 disorder
       Region 2wqj U 353-380 order
       Region 2wqj U 381-383 disorder
 Evidence X-RAY 2wqj T Reference
       Region 2wqj T 351-352 disorder
       Region 2wqj T 353-379 order
       Region 2wqj T 380-383 disorder
 Evidence X-RAY 2wqj S Reference
       Region 2wqj S 351-352 disorder
       Region 2wqj S 353-380 order
       Region 2wqj S 381-383 disorder
 Evidence X-RAY 2wqj L Reference
       Region 2wqj L 351-353 disorder
       Region 2wqj L 354-379 order
       Region 2wqj L 380-383 disorder
 Evidence X-RAY 2wqj K Reference
       Region 2wqj K 351-380 order
       Region 2wqj K 381-383 disorder
 Evidence X-RAY 2wqj J Reference
       Region 2wqj J 351-352 disorder
       Region 2wqj J 353-379 order
       Region 2wqj J 380-383 disorder
 Evidence X-RAY 2wqj I Reference
       Region 2wqj I 351-352 disorder
       Region 2wqj I 353-381 order
       Region 2wqj I 382-383 disorder
 Evidence X-RAY 2wqj H Reference
       Region 2wqj H 351-352 disorder
       Region 2wqj H 353-380 order
       Region 2wqj H 381-383 disorder
 Evidence X-RAY 2wqj G Reference
       Region 2wqj G 351-352 disorder
       Region 2wqj G 353-380 order
       Region 2wqj G 381-383 disorder
Seq 351-383 Homo tetramer :
 Evidence X-RAY 2wqj Z Reference
       Region 2wqj Z 351-352 disorder
       Region 2wqj Z 353-383 order
 Evidence X-RAY 2wqj Y Reference
       Region 2wqj Y 351-351 disorder
       Region 2wqj Y 352-377 order
       Region 2wqj Y 378-383 disorder
 Evidence X-RAY 2wqj 2 Reference
       Region 2wqj 2 351-352 disorder
       Region 2wqj 2 353-379 order
       Region 2wqj 2 380-383 disorder
 Evidence X-RAY 2wqj 1 Reference
       Region 2wqj 1 351-353 disorder
       Region 2wqj 1 354-379 order
       Region 2wqj 1 380-383 disorder
Seq 351-383 Homo hexamer :
 Evidence X-RAY 2wqj R Reference
       Region 2wqj R 351-351 disorder
       Region 2wqj R 352-380 order
       Region 2wqj R 381-383 disorder
 Evidence X-RAY 2wqj Q Reference
       Region 2wqj Q 351-351 disorder
       Region 2wqj Q 352-379 order
       Region 2wqj Q 380-383 disorder
 Evidence X-RAY 2wqj P Reference
       Region 2wqj P 351-352 disorder
       Region 2wqj P 353-380 order
       Region 2wqj P 381-383 disorder
 Evidence X-RAY 2wqj O Reference
       Region 2wqj O 351-352 disorder
       Region 2wqj O 353-379 order
       Region 2wqj O 380-383 disorder
 Evidence X-RAY 2wqj N Reference
       Region 2wqj N 351-351 disorder
       Region 2wqj N 352-380 order
       Region 2wqj N 381-383 disorder
 Evidence X-RAY 2wqj M Reference
       Region 2wqj M 351-352 disorder
       Region 2wqj M 353-380 order
       Region 2wqj M 381-383 disorder
Seq 351-383 Homo hexamer :
 Evidence X-RAY 2wqj F Reference
       Region 2wqj F 351-351 disorder
       Region 2wqj F 352-379 order
       Region 2wqj F 380-383 disorder
 Evidence X-RAY 2wqj E Reference
       Region 2wqj E 351-352 disorder
       Region 2wqj E 353-380 order
       Region 2wqj E 381-383 disorder
 Evidence X-RAY 2wqj D Reference
       Region 2wqj D 351-352 disorder
       Region 2wqj D 353-380 order
       Region 2wqj D 381-383 disorder
 Evidence X-RAY 2wqj C Reference
       Region 2wqj C 351-380 order
       Region 2wqj C 381-383 disorder
 Evidence X-RAY 2wqj B Reference
       Region 2wqj B 351-353 disorder
       Region 2wqj B 354-379 order
       Region 2wqj B 380-383 disorder
 Evidence X-RAY 2wqj A Reference
       Region 2wqj A 351-351 order
       Region 2wqj A 352-353 disorder
       Region 2wqj A 354-379 order
       Region 2wqj A 380-383 disorder
Seq 351-398 Hetero hexamer : IID00875Complex
 Evidence X-RAY 8p9d D Reference
       Region 8p9d D 351-351 disorder
       Region 8p9d D 352-397 order
       Region 8p9d D 398-398 disorder
 Evidence X-RAY 8p9d B Reference
       Region 8p9d B 351-397 order
       Region 8p9d B 398-398 disorder
Seq 351-398 Hetero trimer : IID00875Complex
 Evidence X-RAY 8p9c B Reference
       Region 8p9c B 351-396 order
       Region 8p9c B 397-398 disorder
Seq 351-398 Hetero tetramer : IID00875Complex
 Evidence NMR 2nb1 D Reference
       Region 2nb1 D 351-398 order
       Region 2nb1 D 351-352 high_rmsd
 Evidence NMR 2nb1 B Reference
       Region 2nb1 B 351-398 order
       Region 2nb1 B 351-352 high_rmsd
Seq 351-398 Hetero trimer : IID00875Complex
 Evidence X-RAY 8p9e B Reference
       Region 8p9e B 351-351 disorder
       Region 8p9e B 352-397 order
       Region 8p9e B 398-398 disorder
Seq 351-399 Homo hexadecamer :
 Evidence X-RAY 2wtt P Reference
       Region 2wtt P 351-355 disorder
       Region 2wtt P 356-398 order
       Region 2wtt P 399-399 disorder
 Evidence X-RAY 2wtt O Reference
       Region 2wtt O 351-352 disorder
       Region 2wtt O 353-393 order
       Region 2wtt O 394-399 disorder
 Evidence X-RAY 2wtt N Reference
       Region 2wtt N 351-353 disorder
       Region 2wtt N 354-395 order
       Region 2wtt N 396-399 disorder
 Evidence X-RAY 2wtt M Reference
       Region 2wtt M 351-352 disorder
       Region 2wtt M 353-381 order
       Region 2wtt M 382-399 disorder
 Evidence X-RAY 2wtt L Reference
       Region 2wtt L 351-352 disorder
       Region 2wtt L 353-398 order
       Region 2wtt L 399-399 disorder
 Evidence X-RAY 2wtt K Reference
       Region 2wtt K 351-352 disorder
       Region 2wtt K 353-394 order
       Region 2wtt K 395-399 disorder
 Evidence X-RAY 2wtt J Reference
       Region 2wtt J 351-353 disorder
       Region 2wtt J 354-398 order
       Region 2wtt J 399-399 disorder
 Evidence X-RAY 2wtt I Reference
       Region 2wtt I 351-351 disorder
       Region 2wtt I 352-395 order
       Region 2wtt I 396-399 disorder
 Evidence X-RAY 2wtt H Reference
       Region 2wtt H 351-353 disorder
       Region 2wtt H 354-398 order
       Region 2wtt H 399-399 disorder
 Evidence X-RAY 2wtt G Reference
       Region 2wtt G 351-352 disorder
       Region 2wtt G 353-395 order
       Region 2wtt G 396-399 disorder
 Evidence X-RAY 2wtt F Reference
       Region 2wtt F 351-353 disorder
       Region 2wtt F 354-395 order
       Region 2wtt F 396-399 disorder
 Evidence X-RAY 2wtt E Reference
       Region 2wtt E 351-351 disorder
       Region 2wtt E 352-393 order
       Region 2wtt E 394-399 disorder
 Evidence X-RAY 2wtt D Reference
       Region 2wtt D 351-352 disorder
       Region 2wtt D 353-399 order
 Evidence X-RAY 2wtt C Reference
       Region 2wtt C 351-352 disorder
       Region 2wtt C 353-394 order
       Region 2wtt C 395-399 disorder
 Evidence X-RAY 2wtt B Reference
       Region 2wtt B 351-351 disorder
       Region 2wtt B 352-394 order
       Region 2wtt B 395-399 disorder
 Evidence X-RAY 2wtt A Reference
       Region 2wtt A 351-351 disorder
       Region 2wtt A 352-393 order
       Region 2wtt A 394-399 disorder
Seq 351-399 Homo tetramer :
 Evidence X-RAY 5hob A Reference
       Region 5hob A 351-395 order
       Region 5hob A 396-398 disorder
 Evidence X-RAY 5hob B Reference
       Region 5hob B 351-352 disorder
       Region 5hob B 353-397 order
       Region 5hob B 398-398 disorder
 Evidence X-RAY 5hob C Reference
       Region 5hob C 351-351 disorder
       Region 5hob C 352-397 order
       Region 5hob C 398-398 disorder
 Evidence X-RAY 5hob D Reference
       Region 5hob D 351-352 disorder
       Region 5hob D 353-395 order
       Region 5hob D 396-398 disorder
 Evidence X-RAY 5hob E Reference
       Region 5hob E 351-396 order
       Region 5hob E 397-398 disorder
 Evidence X-RAY 5hob F Reference
       Region 5hob F 351-352 disorder
       Region 5hob F 353-396 order
       Region 5hob F 397-398 disorder
 Evidence X-RAY 5hob G Reference
       Region 5hob G 351-397 order
       Region 5hob G 398-398 disorder
 Evidence X-RAY 5hob H Reference
       Region 5hob H 351-394 order
       Region 5hob H 395-398 disorder
 Evidence X-RAY 5hoc A Reference
       Region 5hoc A 351-353 disorder
       Region 5hoc A 354-397 order
       Region 5hoc A 398-398 disorder
 Evidence X-RAY 5hoc B Reference
       Region 5hoc B 351-394 order
       Region 5hoc B 395-398 disorder
 Evidence X-RAY 2wqi A Reference
       Region 2wqi A 351-351 disorder
       Region 2wqi A 352-396 order
       Region 2wqi A 397-399 disorder
 Evidence X-RAY 2wqi B Reference
       Region 2wqi B 351-353 disorder
       Region 2wqi B 354-396 order
       Region 2wqi B 397-399 disorder
 Evidence X-RAY 2wqi C Reference
       Region 2wqi C 351-352 disorder
       Region 2wqi C 353-397 order
       Region 2wqi C 398-399 disorder
 Evidence X-RAY 2wqi D Reference
       Region 2wqi D 351-354 disorder
       Region 2wqi D 355-398 order
       Region 2wqi D 399-399 disorder
 Evidence NMR 2kby A Reference
       Region 2kby A 351-398 order
 Evidence NMR 2kby B Reference
       Region 2kby B 351-398 order
 Evidence NMR 2kby C Reference
       Region 2kby C 351-398 order
 Evidence NMR 2kby D Reference
       Region 2kby D 351-398 order
Seq 487-564 Monomer :
 Evidence X-RAY 1dxs A Reference
       Region 1dxs A 487-491 disorder
       Region 1dxs A 492-548 order
       Region 1dxs A 549-564 disorder
 Evidence NMR 1cok A Reference
       Region 1cok A 487-554 order
       Region 1cok A 487-489 high_rmsd
       Region 1cok A 551-554 high_rmsd
SeqProS possible 10-25 The TAD of the p53 family, which includes p73, is largely disordered in the free state (pmid=25591003). Hetero dimer : IID00720Complex
       Region 6ijq A 10-25 order
SeqProS possible 10-25 The TAD of the p53 family, which includes p73, is largely disordered in the free state (pmid=25591003). Hetero dimer : IID00163Complex
       Region 2mps B 10-25 order
SeqProS possible 10-31 The TAD of the p53 family, which includes p73, is largely disordered in the free state (pmid=25591003). Hetero dimer : IID00070Complex
       Region 6fgs A 10-31 order
Seqphosphorylation
    27-27 Phosphothreonine; by PLK1
    28-28 Phosphotyrosine; by SRC and HCK
    99-99 Phosphotyrosine; by ABL1
 
Prediction
NeProc
Disorder 1-15,28-114,306-350,388-488,554-578,620-636
Order 16-27,115-133,139-305,351-387,489-553,579-619
ProS 8-15,28-33,48-56,306-311,417-425,620-636
AlphaFold
Disorder 1-112,206-206,318-352,397-488,551-636
Order 113-205,207-317,353-396,489-550
Pfam Hmmer
PF00870 113-309 1e-153
PF07710 345-386 5.3e-23
PF07647 485-551 4.3e-14
SEG 366-380 ,467-479
Function
Function in SwissProt
Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. Is an activator of FOXJ1 expression (By similarity). It is an essential factor for the positive regulation of lung ciliated cell differentiation (PubMed:34077761).
Biological Process
See also
Diagram with PDB data
MDM2NMR structure of unliganded MDM2