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IID00756
 UniprotO43353
ProteinReceptor-interacting serine/threonine-protein kinase 2
GeneRIPK2
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
540
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-317 Monomer :
 Evidence X-RAY 5ng3 D Reference
       Region 5ng3 D 1-8 disorder
       Region 5ng3 D 9-179 order
       Region 5ng3 D 180-185 disorder
       Region 5ng3 D 186-200 order
       Region 5ng3 D 201-204 disorder
       Region 5ng3 D 205-297 order
       Region 5ng3 D 298-300 disorder
 Evidence X-RAY 5ng3 B Reference
       Region 5ng3 B 1-8 disorder
       Region 5ng3 B 9-178 order
       Region 5ng3 B 179-186 disorder
       Region 5ng3 B 187-200 order
       Region 5ng3 B 201-206 disorder
       Region 5ng3 B 207-297 order
       Region 5ng3 B 298-300 disorder
 Evidence X-RAY 5ng3 A Reference
       Region 5ng3 A 1-7 disorder
       Region 5ng3 A 8-179 order
       Region 5ng3 A 180-185 disorder
       Region 5ng3 A 186-297 order
       Region 5ng3 A 298-300 disorder
 Evidence X-RAY 5ng3 C Reference
       Region 5ng3 C 1-8 disorder
       Region 5ng3 C 9-178 order
       Region 5ng3 C 179-187 disorder
       Region 5ng3 C 188-198 order
       Region 5ng3 C 199-206 disorder
       Region 5ng3 C 207-297 order
       Region 5ng3 C 298-300 disorder
 Evidence X-RAY 6es0 A Reference
       Region 6es0 A 3-4 disorder
       Region 6es0 A 5-170 order
       Region 6es0 A 171-187 disorder
       Region 6es0 A 188-198 order
       Region 6es0 A 199-205 disorder
       Region 6es0 A 206-316 order
       Region 6es0 A 317-317 disorder
 Evidence X-RAY 6es0 B Reference
       Region 6es0 B 3-4 disorder
       Region 6es0 B 5-49 order
       Region 6es0 B 50-57 disorder
       Region 6es0 B 58-171 order
       Region 6es0 B 172-187 disorder
       Region 6es0 B 188-315 order
       Region 6es0 B 316-317 disorder
Seq 1-317 Homo dimer :
 Evidence X-RAY 4c8b A Reference
       Region 4c8b A 8-165 order
       Region 4c8b A 166-187 disorder
       Region 4c8b A 188-198 order
       Region 4c8b A 199-206 disorder
       Region 4c8b A 207-316 order
       Region 4c8b A 317-317 disorder
 Evidence X-RAY 4c8b B Reference
       Region 4c8b B 8-8 disorder
       Region 4c8b B 9-49 order
       Region 4c8b B 50-54 disorder
       Region 4c8b B 55-165 order
       Region 4c8b B 166-187 disorder
       Region 4c8b B 188-316 order
       Region 4c8b B 317-317 disorder
 Evidence X-RAY 5ar2 A Reference
       Region 5ar2 A 1-3 disorder
       Region 5ar2 A 4-25 order
       Region 5ar2 A 26-29 disorder
       Region 5ar2 A 30-48 order
       Region 5ar2 A 49-54 disorder
       Region 5ar2 A 55-172 order
       Region 5ar2 A 173-186 disorder
       Region 5ar2 A 187-200 order
       Region 5ar2 A 201-206 disorder
       Region 5ar2 A 207-310 order
 Evidence X-RAY 5ar2 B Reference
       Region 5ar2 B 1-3 disorder
       Region 5ar2 B 4-26 order
       Region 5ar2 B 27-29 disorder
       Region 5ar2 B 30-50 order
       Region 5ar2 B 51-56 disorder
       Region 5ar2 B 57-172 order
       Region 5ar2 B 173-183 disorder
       Region 5ar2 B 184-204 order
       Region 5ar2 B 205-206 disorder
       Region 5ar2 B 207-310 order
 Evidence X-RAY 5ar3 A Reference
       Region 5ar3 A 1-5 disorder
       Region 5ar3 A 6-50 order
       Region 5ar3 A 51-55 disorder
       Region 5ar3 A 56-172 order
       Region 5ar3 A 173-186 disorder
       Region 5ar3 A 187-198 order
       Region 5ar3 A 199-205 disorder
       Region 5ar3 A 206-310 order
 Evidence X-RAY 5ar3 B Reference
       Region 5ar3 B 1-5 disorder
       Region 5ar3 B 6-50 order
       Region 5ar3 B 51-58 disorder
       Region 5ar3 B 59-172 order
       Region 5ar3 B 173-188 disorder
       Region 5ar3 B 189-200 order
       Region 5ar3 B 201-205 disorder
       Region 5ar3 B 206-310 order
 Evidence X-RAY 5ar4 A Reference
       Region 5ar4 A 1-4 disorder
       Region 5ar4 A 5-50 order
       Region 5ar4 A 51-55 disorder
       Region 5ar4 A 56-167 order
       Region 5ar4 A 168-188 disorder
       Region 5ar4 A 189-199 order
       Region 5ar4 A 200-205 disorder
       Region 5ar4 A 206-310 order
 Evidence X-RAY 5ar4 B Reference
       Region 5ar4 B 1-5 disorder
       Region 5ar4 B 6-49 order
       Region 5ar4 B 50-55 disorder
       Region 5ar4 B 56-167 order
       Region 5ar4 B 168-187 disorder
       Region 5ar4 B 188-310 order
 Evidence X-RAY 5ar5 A Reference
       Region 5ar5 A 1-3 disorder
       Region 5ar5 A 4-50 order
       Region 5ar5 A 51-54 disorder
       Region 5ar5 A 55-172 order
       Region 5ar5 A 173-185 disorder
       Region 5ar5 A 186-200 order
       Region 5ar5 A 201-206 disorder
       Region 5ar5 A 207-310 order
 Evidence X-RAY 5ar5 B Reference
       Region 5ar5 B 1-3 disorder
       Region 5ar5 B 4-50 order
       Region 5ar5 B 51-54 disorder
       Region 5ar5 B 55-171 order
       Region 5ar5 B 172-188 disorder
       Region 5ar5 B 189-199 order
       Region 5ar5 B 200-206 disorder
       Region 5ar5 B 207-310 order
 Evidence X-RAY 5ar7 A Reference
       Region 5ar7 A 1-5 disorder
       Region 5ar7 A 6-50 order
       Region 5ar7 A 51-55 disorder
       Region 5ar7 A 56-172 order
       Region 5ar7 A 173-188 disorder
       Region 5ar7 A 189-199 order
       Region 5ar7 A 200-205 disorder
       Region 5ar7 A 206-310 order
 Evidence X-RAY 5ar7 B Reference
       Region 5ar7 B 1-5 disorder
       Region 5ar7 B 6-50 order
       Region 5ar7 B 51-55 disorder
       Region 5ar7 B 56-166 order
       Region 5ar7 B 167-187 disorder
       Region 5ar7 B 188-245 order
       Region 5ar7 B 246-246 disorder
       Region 5ar7 B 247-310 order
 Evidence X-RAY 5ar8 A Reference
       Region 5ar8 A 1-8 disorder
       Region 5ar8 A 9-49 order
       Region 5ar8 A 50-63 disorder
       Region 5ar8 A 64-86 order
       Region 5ar8 A 87-90 disorder
       Region 5ar8 A 91-165 order
       Region 5ar8 A 166-187 disorder
       Region 5ar8 A 188-198 order
       Region 5ar8 A 199-205 disorder
       Region 5ar8 A 206-310 order
 Evidence X-RAY 5ar8 B Reference
       Region 5ar8 B 1-7 disorder
       Region 5ar8 B 8-49 order
       Region 5ar8 B 50-59 disorder
       Region 5ar8 B 60-167 order
       Region 5ar8 B 168-186 disorder
       Region 5ar8 B 187-310 order
 Evidence X-RAY 5j79 A Reference
       Region 5j79 A 1-1 disorder
       Region 5j79 A 2-49 order
       Region 5j79 A 50-59 disorder
       Region 5j79 A 60-172 order
       Region 5j79 A 173-182 disorder
       Region 5j79 A 183-200 order
       Region 5j79 A 201-206 disorder
       Region 5j79 A 207-310 order
 Evidence X-RAY 5j79 B Reference
       Region 5j79 B 1-4 disorder
       Region 5j79 B 5-49 order
       Region 5j79 B 50-59 disorder
       Region 5j79 B 60-172 order
       Region 5j79 B 173-187 disorder
       Region 5j79 B 188-202 order
       Region 5j79 B 203-206 disorder
       Region 5j79 B 207-310 order
 Evidence X-RAY 5j7b A Reference
       Region 5j7b A 1-4 disorder
       Region 5j7b A 5-49 order
       Region 5j7b A 50-54 disorder
       Region 5j7b A 55-167 order
       Region 5j7b A 168-187 disorder
       Region 5j7b A 188-199 order
       Region 5j7b A 200-203 disorder
       Region 5j7b A 204-310 order
 Evidence X-RAY 5j7b B Reference
       Region 5j7b B 1-3 disorder
       Region 5j7b B 4-49 order
       Region 5j7b B 50-57 disorder
       Region 5j7b B 58-167 order
       Region 5j7b B 168-185 disorder
       Region 5j7b B 186-310 order
 Evidence X-RAY 5ng0 A Reference
       Region 5ng0 A 1-5 disorder
       Region 5ng0 A 6-172 order
       Region 5ng0 A 173-187 disorder
       Region 5ng0 A 188-200 order
       Region 5ng0 A 201-206 disorder
       Region 5ng0 A 207-300 order
 Evidence X-RAY 5ng0 B Reference
       Region 5ng0 B 1-4 disorder
       Region 5ng0 B 5-172 order
       Region 5ng0 B 173-182 disorder
       Region 5ng0 B 183-201 order
       Region 5ng0 B 202-204 disorder
       Region 5ng0 B 205-299 order
       Region 5ng0 B 300-300 disorder
 Evidence X-RAY 5ng2 A Reference
       Region 5ng2 A 1-4 disorder
       Region 5ng2 A 5-173 order
       Region 5ng2 A 174-187 disorder
       Region 5ng2 A 188-200 order
       Region 5ng2 A 201-206 disorder
       Region 5ng2 A 207-298 order
       Region 5ng2 A 299-300 disorder
 Evidence X-RAY 5ng2 B Reference
       Region 5ng2 B 1-4 disorder
       Region 5ng2 B 5-172 order
       Region 5ng2 B 173-187 disorder
       Region 5ng2 B 188-200 order
       Region 5ng2 B 201-201 disorder
       Region 5ng2 B 202-298 order
       Region 5ng2 B 299-300 disorder
 Evidence X-RAY 5w5j A Reference
       Region 5w5j A 2-8 disorder
       Region 5w5j A 9-48 order
       Region 5w5j A 49-68 disorder
       Region 5w5j A 69-88 order
       Region 5w5j A 89-89 disorder
       Region 5w5j A 90-165 order
       Region 5w5j A 166-188 disorder
       Region 5w5j A 189-200 order
       Region 5w5j A 201-207 disorder
       Region 5w5j A 208-310 order
       Region 5w5j A 311-311 disorder
 Evidence X-RAY 5w5j B Reference
       Region 5w5j B 2-9 disorder
       Region 5w5j B 10-26 order
       Region 5w5j B 27-27 disorder
       Region 5w5j B 28-50 order
       Region 5w5j B 51-61 disorder
       Region 5w5j B 62-141 order
       Region 5w5j B 142-143 disorder
       Region 5w5j B 144-165 order
       Region 5w5j B 166-188 disorder
       Region 5w5j B 189-199 order
       Region 5w5j B 200-207 disorder
       Region 5w5j B 208-311 order
 Evidence X-RAY 5w5o A Reference
       Region 5w5o A 2-4 disorder
       Region 5w5o A 5-48 order
       Region 5w5o A 49-57 disorder
       Region 5w5o A 58-172 order
       Region 5w5o A 173-187 disorder
       Region 5w5o A 188-200 order
       Region 5w5o A 201-207 disorder
       Region 5w5o A 208-310 order
       Region 5w5o A 311-311 disorder
 Evidence X-RAY 5w5o B Reference
       Region 5w5o B 2-4 disorder
       Region 5w5o B 5-48 order
       Region 5w5o B 49-57 disorder
       Region 5w5o B 58-172 order
       Region 5w5o B 173-187 disorder
       Region 5w5o B 188-200 order
       Region 5w5o B 201-207 disorder
       Region 5w5o B 208-310 order
       Region 5w5o B 311-311 disorder
 Evidence X-RAY 5w5o C Reference
       Region 5w5o C 2-4 disorder
       Region 5w5o C 5-48 order
       Region 5w5o C 49-57 disorder
       Region 5w5o C 58-172 order
       Region 5w5o C 173-187 disorder
       Region 5w5o C 188-200 order
       Region 5w5o C 201-207 disorder
       Region 5w5o C 208-310 order
       Region 5w5o C 311-311 disorder
 Evidence X-RAY 5w5o D Reference
       Region 5w5o D 2-4 disorder
       Region 5w5o D 5-48 order
       Region 5w5o D 49-57 disorder
       Region 5w5o D 58-172 order
       Region 5w5o D 173-187 disorder
       Region 5w5o D 188-200 order
       Region 5w5o D 201-207 disorder
       Region 5w5o D 208-310 order
       Region 5w5o D 311-311 disorder
 Evidence X-RAY 5w5o E Reference
       Region 5w5o E 2-4 disorder
       Region 5w5o E 5-48 order
       Region 5w5o E 49-57 disorder
       Region 5w5o E 58-172 order
       Region 5w5o E 173-187 disorder
       Region 5w5o E 188-200 order
       Region 5w5o E 201-207 disorder
       Region 5w5o E 208-310 order
       Region 5w5o E 311-311 disorder
 Evidence X-RAY 5w5o F Reference
       Region 5w5o F 2-4 disorder
       Region 5w5o F 5-48 order
       Region 5w5o F 49-57 disorder
       Region 5w5o F 58-172 order
       Region 5w5o F 173-187 disorder
       Region 5w5o F 188-200 order
       Region 5w5o F 201-207 disorder
       Region 5w5o F 208-310 order
       Region 5w5o F 311-311 disorder
 Evidence X-RAY 5w5o G Reference
       Region 5w5o G 2-4 disorder
       Region 5w5o G 5-48 order
       Region 5w5o G 49-57 disorder
       Region 5w5o G 58-172 order
       Region 5w5o G 173-187 disorder
       Region 5w5o G 188-200 order
       Region 5w5o G 201-207 disorder
       Region 5w5o G 208-310 order
       Region 5w5o G 311-311 disorder
 Evidence X-RAY 5w5o H Reference
       Region 5w5o H 2-4 disorder
       Region 5w5o H 5-48 order
       Region 5w5o H 49-57 disorder
       Region 5w5o H 58-172 order
       Region 5w5o H 173-187 disorder
       Region 5w5o H 188-200 order
       Region 5w5o H 201-207 disorder
       Region 5w5o H 208-310 order
       Region 5w5o H 311-311 disorder
 Evidence X-RAY 5w5o I Reference
       Region 5w5o I 2-4 disorder
       Region 5w5o I 5-48 order
       Region 5w5o I 49-57 disorder
       Region 5w5o I 58-172 order
       Region 5w5o I 173-187 disorder
       Region 5w5o I 188-200 order
       Region 5w5o I 201-207 disorder
       Region 5w5o I 208-310 order
       Region 5w5o I 311-311 disorder
 Evidence X-RAY 5w5o J Reference
       Region 5w5o J 2-4 disorder
       Region 5w5o J 5-48 order
       Region 5w5o J 49-57 disorder
       Region 5w5o J 58-172 order
       Region 5w5o J 173-187 disorder
       Region 5w5o J 188-200 order
       Region 5w5o J 201-207 disorder
       Region 5w5o J 208-310 order
       Region 5w5o J 311-311 disorder
 Evidence X-RAY 5w5o K Reference
       Region 5w5o K 2-4 disorder
       Region 5w5o K 5-48 order
       Region 5w5o K 49-57 disorder
       Region 5w5o K 58-172 order
       Region 5w5o K 173-187 disorder
       Region 5w5o K 188-200 order
       Region 5w5o K 201-207 disorder
       Region 5w5o K 208-310 order
       Region 5w5o K 311-311 disorder
 Evidence X-RAY 5w5o L Reference
       Region 5w5o L 2-4 disorder
       Region 5w5o L 5-48 order
       Region 5w5o L 49-57 disorder
       Region 5w5o L 58-172 order
       Region 5w5o L 173-187 disorder
       Region 5w5o L 188-200 order
       Region 5w5o L 201-207 disorder
       Region 5w5o L 208-310 order
       Region 5w5o L 311-311 disorder
 Evidence X-RAY 5w5o M Reference
       Region 5w5o M 2-4 disorder
       Region 5w5o M 5-49 order
       Region 5w5o M 50-57 disorder
       Region 5w5o M 58-172 order
       Region 5w5o M 173-187 disorder
       Region 5w5o M 188-200 order
       Region 5w5o M 201-207 disorder
       Region 5w5o M 208-310 order
       Region 5w5o M 311-311 disorder
 Evidence X-RAY 5w5o N Reference
       Region 5w5o N 2-4 disorder
       Region 5w5o N 5-48 order
       Region 5w5o N 49-60 disorder
       Region 5w5o N 61-172 order
       Region 5w5o N 173-187 disorder
       Region 5w5o N 188-200 order
       Region 5w5o N 201-207 disorder
       Region 5w5o N 208-310 order
       Region 5w5o N 311-311 disorder
 Evidence X-RAY 5w5o O Reference
       Region 5w5o O 2-4 disorder
       Region 5w5o O 5-50 order
       Region 5w5o O 51-58 disorder
       Region 5w5o O 59-172 order
       Region 5w5o O 173-187 disorder
       Region 5w5o O 188-200 order
       Region 5w5o O 201-207 disorder
       Region 5w5o O 208-310 order
       Region 5w5o O 311-311 disorder
 Evidence X-RAY 5w5o P Reference
       Region 5w5o P 2-4 disorder
       Region 5w5o P 5-48 order
       Region 5w5o P 49-57 disorder
       Region 5w5o P 58-172 order
       Region 5w5o P 173-187 disorder
       Region 5w5o P 188-200 order
       Region 5w5o P 201-207 disorder
       Region 5w5o P 208-310 order
       Region 5w5o P 311-311 disorder
 Evidence X-RAY 6fu5 A Reference
       Region 6fu5 A 3-4 disorder
       Region 6fu5 A 5-49 order
       Region 6fu5 A 50-52 disorder
       Region 6fu5 A 53-167 order
       Region 6fu5 A 168-187 disorder
       Region 6fu5 A 188-200 order
       Region 6fu5 A 201-206 disorder
       Region 6fu5 A 207-315 order
       Region 6fu5 A 316-317 disorder
 Evidence X-RAY 6fu5 B Reference
       Region 6fu5 B 3-4 disorder
       Region 6fu5 B 5-50 order
       Region 6fu5 B 51-54 disorder
       Region 6fu5 B 55-165 order
       Region 6fu5 B 166-187 disorder
       Region 6fu5 B 188-316 order
       Region 6fu5 B 317-317 disorder
 Evidence X-RAY 6hmx A Reference
       Region 6hmx A 1-4 disorder
       Region 6hmx A 5-49 order
       Region 6hmx A 50-54 disorder
       Region 6hmx A 55-171 order
       Region 6hmx A 172-186 disorder
       Region 6hmx A 187-200 order
       Region 6hmx A 201-206 disorder
       Region 6hmx A 207-310 order
 Evidence X-RAY 6hmx B Reference
       Region 6hmx B 1-4 disorder
       Region 6hmx B 5-49 order
       Region 6hmx B 50-59 disorder
       Region 6hmx B 60-172 order
       Region 6hmx B 173-186 disorder
       Region 6hmx B 187-310 order
 Evidence X-RAY 6rn8 A Reference
       Region 6rn8 A 1-4 disorder
       Region 6rn8 A 5-50 order
       Region 6rn8 A 51-53 disorder
       Region 6rn8 A 54-172 order
       Region 6rn8 A 173-187 disorder
       Region 6rn8 A 188-199 order
       Region 6rn8 A 200-206 disorder
       Region 6rn8 A 207-310 order
 Evidence X-RAY 6rn8 B Reference
       Region 6rn8 B 1-4 disorder
       Region 6rn8 B 5-28 order
       Region 6rn8 B 29-29 disorder
       Region 6rn8 B 30-51 order
       Region 6rn8 B 52-53 disorder
       Region 6rn8 B 54-172 order
       Region 6rn8 B 173-185 disorder
       Region 6rn8 B 186-200 order
       Region 6rn8 B 201-206 disorder
       Region 6rn8 B 207-310 order
 Evidence X-RAY 6rna A Reference
       Region 6rna A 1-4 disorder
       Region 6rna A 5-27 order
       Region 6rna A 28-28 disorder
       Region 6rna A 29-48 order
       Region 6rna A 49-54 disorder
       Region 6rna A 55-172 order
       Region 6rna A 173-186 disorder
       Region 6rna A 187-198 order
       Region 6rna A 199-206 disorder
       Region 6rna A 207-310 order
 Evidence X-RAY 6rna B Reference
       Region 6rna B 1-3 disorder
       Region 6rna B 4-26 order
       Region 6rna B 27-29 disorder
       Region 6rna B 30-48 order
       Region 6rna B 49-55 disorder
       Region 6rna B 56-172 order
       Region 6rna B 173-185 disorder
       Region 6rna B 186-310 order
 Evidence X-RAY 6sze A Reference
       Region 6sze A 1-4 disorder
       Region 6sze A 5-49 order
       Region 6sze A 50-54 disorder
       Region 6sze A 55-168 order
       Region 6sze A 169-188 disorder
       Region 6sze A 189-199 order
       Region 6sze A 200-206 disorder
       Region 6sze A 207-310 order
 Evidence X-RAY 6sze B Reference
       Region 6sze B 1-4 disorder
       Region 6sze B 5-26 order
       Region 6sze B 27-29 disorder
       Region 6sze B 30-49 order
       Region 6sze B 50-55 disorder
       Region 6sze B 56-170 order
       Region 6sze B 171-185 disorder
       Region 6sze B 186-200 order
       Region 6sze B 201-206 disorder
       Region 6sze B 207-310 order
 Evidence X-RAY 6szj A Reference
       Region 6szj A 1-4 disorder
       Region 6szj A 5-49 order
       Region 6szj A 50-52 disorder
       Region 6szj A 53-167 order
       Region 6szj A 168-187 disorder
       Region 6szj A 188-202 order
       Region 6szj A 203-206 disorder
       Region 6szj A 207-310 order
 Evidence X-RAY 6szj B Reference
       Region 6szj B 1-4 disorder
       Region 6szj B 5-49 order
       Region 6szj B 50-55 disorder
       Region 6szj B 56-168 order
       Region 6szj B 169-185 disorder
       Region 6szj B 186-310 order
 Evidence X-RAY 6ul8 A Reference
       Region 6ul8 A 5-51 order
       Region 6ul8 A 52-54 disorder
       Region 6ul8 A 55-170 order
       Region 6ul8 A 171-187 disorder
       Region 6ul8 A 188-199 order
       Region 6ul8 A 200-206 disorder
       Region 6ul8 A 207-310 order
 Evidence X-RAY 6ul8 B Reference
       Region 6ul8 B 5-49 order
       Region 6ul8 B 50-55 disorder
       Region 6ul8 B 56-170 order
       Region 6ul8 B 171-187 disorder
       Region 6ul8 B 188-310 order
Seq 3-317 Homo tetramer :
 Evidence X-RAY 6s1f D Reference
       Region 6s1f D 3-4 disorder
       Region 6s1f D 5-170 order
       Region 6s1f D 171-187 disorder
       Region 6s1f D 188-198 order
       Region 6s1f D 199-205 disorder
       Region 6s1f D 206-316 order
       Region 6s1f D 317-317 disorder
 Evidence X-RAY 6s1f C Reference
       Region 6s1f C 3-4 disorder
       Region 6s1f C 5-171 order
       Region 6s1f C 172-187 disorder
       Region 6s1f C 188-200 order
       Region 6s1f C 201-206 disorder
       Region 6s1f C 207-315 order
       Region 6s1f C 316-317 disorder
 Evidence X-RAY 6s1f B Reference
       Region 6s1f B 3-4 disorder
       Region 6s1f B 5-49 order
       Region 6s1f B 50-54 disorder
       Region 6s1f B 55-174 order
       Region 6s1f B 175-188 disorder
       Region 6s1f B 189-196 order
       Region 6s1f B 197-202 disorder
       Region 6s1f B 203-315 order
       Region 6s1f B 316-317 disorder
 Evidence X-RAY 6s1f A Reference
       Region 6s1f A 3-4 disorder
       Region 6s1f A 5-171 order
       Region 6s1f A 172-187 disorder
       Region 6s1f A 188-203 order
       Region 6s1f A 204-208 disorder
       Region 6s1f A 209-316 order
       Region 6s1f A 317-317 disorder
Seq 434-539 Monomer :
 Evidence NMR 2n7z A Reference
       Region 2n7z A 434-539 order
       Region 2n7z A 525-539 high_rmsd
Seq 434-539 Hetero dimer : P08138
 Evidence NMR 2n83 B Reference
       Region 2n83 B 434-434 disorder
       Region 2n83 B 435-539 order
       Region 2n83 B 535-539 high_rmsd
Seq 435-540 Homo tetramer :
 Evidence X-RAY 6gfj D Reference
       Region 6gfj D 435-522 order
       Region 6gfj D 523-540 disorder
 Evidence X-RAY 6gfj C Reference
       Region 6gfj C 435-521 order
       Region 6gfj C 522-540 disorder
 Evidence X-RAY 6gfj B Reference
       Region 6gfj B 435-522 order
       Region 6gfj B 523-540 disorder
 Evidence X-RAY 6gfj A Reference
       Region 6gfj A 435-522 order
       Region 6gfj A 523-540 disorder
Seq 530-540 Hetero dimer : IID00301Complex
 Evidence X-RAY 7obs B Reference
       Region 7obs B 530-534 disorder
       Region 7obs B 535-540 order
 Evidence X-RAY 7obt B Reference
       Region 7obt B 530-535 disorder
       Region 7obt B 536-540 order
SeqProS verified 535-540 Hetero dimer : IID00301Complex
       Region 7obt B 536-540 order
       Region 7obs B 535-540 order
       Region 6gfj A 523-540 disorder
Seqphosphorylation
    531-531 Phosphoserine
    539-539 Phosphoserine
    527-527 Phosphoserine
    529-529 Phosphoserine
    474-474 Phosphotyrosine; by autocatalysis
    393-393 Phosphoserine
    381-381 Phosphotyrosine; by CSK
    363-363 Phosphoserine
    181-181 Phosphoserine; alternate
    180-180 Phosphoserine
    178-178 Phosphoserine; alternate
    176-176 Phosphoserine; by autocatalysis and LRRK2; alternate
    174-174 Phosphoserine; alternate
    168-168 Phosphoserine
Seqacetylation
    423-423 (Microbial infection) O-acetylserine; by Yersinia YopJ
    397-397 (Microbial infection) O-acetylthreonine; by Yersinia YopJ
    363-363 (Microbial infection) O-acetylserine; by Yersinia YopJ
    189-189 (Microbial infection) O-acetylthreonine; by Yersinia YopJ
    183-183 (Microbial infection) O-acetylserine; by Yersinia YopJ
    181-181 (Microbial infection) O-acetylserine; by Yersinia YopJ
    178-178 (Microbial infection) O-acetylserine; by Yersinia YopJ
    176-176 (Microbial infection) O-acetylserine; by Yersinia YopJ; alternate
    174-174 (Microbial infection) O-acetylserine; by Yersinia YopJ
    149-149 (Microbial infection) O-acetylthreonine; by Yersinia YopJ
 
Prediction
NeProc
Disorder 1-5,178-184,308-430,529-540
Order 6-177,185-307,431-528
ProS 1-5,178-184,308-323,332-337,345-350,408-422,529-540
AlphaFold
Disorder 1-4,28-29,50-53,166-189,199-206,320-432,524-540
Order 5-27,30-49,54-165,190-198,207-319,433-523
Pfam Hmmer
PF00069 18-290 8.6e-42
PF00619 437-524 5.5e-24
SEG 174-183
Function
Function in SwissProt
Serine/threonine/tyrosine-protein kinase that plays an essential role in modulation of innate and adaptive immune responses (PubMed:9575181, PubMed:9642260, PubMed:14638696, PubMed:21123652, PubMed:17054981, PubMed:28656966). Acts as a key effector of NOD1 and NOD2 signaling pathways: upon activation by bacterial peptidoglycans, NOD1 and NOD2 oligomerize and recruit RIPK2 via CARD-CARD domains, leading to the formation of RIPK2 filaments (PubMed:17562858, PubMed:21123652, PubMed:17054981, PubMed:22607974, PubMed:28656966, PubMed:29452636, PubMed:30026309). Once recruited, RIPK2 autophosphorylates and undergoes 'Lys-63'-linked polyubiquitination by E3 ubiquitin ligases XIAP, BIRC2 and BIRC3, as well as 'Met-1'-linked (linear) polyubiquitination by the LUBAC complex, becoming a scaffolding protein for downstream effectors (PubMed:22607974, PubMed:29452636, PubMed:28545134, PubMed:30279485, PubMed:30478312, PubMed:30026309). 'Met-1'-linked polyubiquitin chains attached to RIPK2 recruit IKBKG/NEMO, which undergoes 'Lys-63'-linked polyubiquitination in a RIPK2-dependent process (PubMed:22607974, PubMed:17562858, PubMed:29452636, PubMed:30026309). 'Lys-63'-linked polyubiquitin chains attached to RIPK2 serve as docking sites for TAB2 and TAB3 and mediate the recruitment of MAP3K7/TAK1 to IKBKG/NEMO, inducing subsequent activation of IKBKB/IKKB (PubMed:18079694). In turn, NF-kappa-B is released from NF-kappa-B inhibitors and translocates into the nucleus where it activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis (PubMed:18079694). The protein kinase activity is dispensable for the NOD1 and NOD2 signaling pathways (PubMed:29452636, PubMed:30026309). Contributes to the tyrosine phosphorylation of the guanine exchange factor ARHGEF2 through Src tyrosine kinase leading to NF-kappa-B activation by NOD2 (PubMed:21887730). Also involved in adaptive immunity: plays a role during engagement of the T-cell receptor (TCR) in promoting BCL10 phosphorylation and subsequent NF-kappa-B activation (PubMed:14638696). Plays a role in the inactivation of RHOA in response to NGFR signaling (PubMed:26646181).