IDEAL List

IDEAL

IID00757
UniprotO43447
ProteinPeptidyl-prolyl cis-trans isomerase H
GenePPIH
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf

Structure

Experiment

:order disorder conflict PDB cluster ProS Pfam Domain SEG

177

order/disorder by at least rule

disorder by at least rule

order by at least rule

order/disorder by majority rule

Seq 1-177 Hetero dimer : IID00754Complex

Evidence X-RAY 1mzw A Reference

Region 1mzw A 1-4 disorder

Region 1mzw A 5-177 order

Seq 1-177 Monomer :

Evidence X-RAY 1qoi A Reference

Region 1qoi A 1-4 disorder

Region 1qoi A 5-177 order

Seqacetylation

2-2 N-acetylalanine

Prediction

NeProc

Disorder 1-8,160-164

Order 9-159,165-177

ProS 160-164

AlphaFold

Disorder 1-4

Order 5-177

Pfam Hmmer

PF00160 12-177 4.3e-93

Function

Function in SwissProt

PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). Participates in pre-mRNA splicing. May play a role in the assembly of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome. May act as a chaperone.