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IID00758
 UniprotO60343
ProteinTBC1 domain family member 4
GeneTBC1D4
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1298
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 637-647 Hetero dimer : IID00301Complex
 Evidence X-RAY 7nix B Reference
       Region 7nix B 637-647 order
Seq 874-1170 Monomer :
 Evidence X-RAY 3qyb A Reference
       Region 3qyb A 874-1168 order
       Region 3qyb A 1169-1170 disorder
SeqProS predicted 637-647 This region is predicted to be disordered by NeProc and AlphaFold (pLDDT < 68.5). Hetero dimer : IID00301Complex
       Region 7nix B 637-647 order
Seqphosphorylation
    591-591 Phosphoserine
    588-588 Phosphoserine; by PKB/AKT1
    570-570 Phosphoserine
    568-568 Phosphothreonine
    609-609 Phosphoserine
    566-566 Phosphoserine
    341-341 Phosphoserine
    344-344 Phosphoserine
    314-314 Phosphoserine
    318-318 Phosphoserine; by PKB/AKT1
    262-262 Phosphoserine
    672-672 Phosphoserine
    666-666 Phosphoserine
    613-613 Phosphothreonine
    678-678 Phosphoserine
    763-763 Phosphothreonine
    757-757 Phosphoserine
    754-754 Phosphoserine
    751-751 Phosphoserine; by PKB/AKT1
    666-666 Phosphoserine
    642-642 Phosphothreonine; by PKB/AKT1
    617-617 Phosphoserine
Seqacetylation
    477-477 N6-acetyllysine
    1-1 N-acetylmethionine
 
Prediction
NeProc
Disorder 1-31,99-105,175-195,235-345,535-845,881-881,1188-1197,1278-1298
Order 32-68,78-98,106-174,196-234,346-405,410-442,448-534,846-880,882-1187,1198-1277
ProS 4-18,175-187,235-238,312-315,335-345,535-545,554-586,637-646,666-671,712-717,774-781,793-801,838-845,881-881,1193-1197,1278-1298
AlphaFold
Disorder 1-32,68-78,97-115,147-151,182-198,217-217,239-355,405-411,444-454,532-834,900-902,1188-1197,1269-1269,1271-1298
Order 33-67,79-96,116-146,152-181,199-216,218-238,356-404,412-443,455-531,835-899,903-1187,1198-1268,1270-1270
Pfam Hmmer
PF00566 915-1134 2.1e-30
SEG 95-110 ,605-622 ,672-682 ,690-713 ,1274-1290
Function
Function in SwissProt
May act as a GTPase-activating protein for RAB2A, RAB8A, RAB10 and RAB14. Isoform 2 promotes insulin-induced glucose transporter SLC2A4/GLUT4 translocation at the plasma membrane, thus increasing glucose uptake.