Search Keyword:


Search option:


IID00760
 UniprotO75351
ProteinVacuolar protein sorting-associated protein 4B
GeneVPS4B
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
444
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-86 Hetero dimer : IID00895Complex
 Evidence NMR 2jqk A Reference
       Region 2jqk A 1-6 disorder
       Region 2jqk A 7-78 order
       Region 2jqk A 79-86 disorder
Seq 1-89 Hetero dimer : IID00809Complex
 Evidence X-RAY 4u7y A Reference
       Region 4u7y A 1-83 order
       Region 4u7y A 84-89 disorder
Seq 1-104 Monomer :
 Evidence NMR 2cpt A Reference
       Region 2cpt A 1-104 order
       Region 2cpt A 1-2 high_rmsd
       Region 2cpt A 83-104 high_rmsd
 Evidence NMR 2jqh A Reference
       Region 2jqh A 1-6 disorder
       Region 2jqh A 7-78 order
       Region 2jqh A 79-86 disorder
 Evidence NMR 1wr0 A Reference
       Region 1wr0 A 1-77 order
       Region 1wr0 A 1-2 high_rmsd
Seq 1-444 Monomer :
 Evidence X-RAY 7l9x A Reference
       Region 7l9x A 1-125 disorder
       Region 7l9x A 126-202 order
       Region 7l9x A 203-211 disorder
       Region 7l9x A 212-240 order
       Region 7l9x A 241-247 disorder
       Region 7l9x A 248-263 order
       Region 7l9x A 264-266 disorder
       Region 7l9x A 267-444 order
 Evidence X-RAY 1xwi A Reference
       Region 1xwi A 123-444 order
Seqphosphorylation
    93-93 Phosphoserine
    102-102 Phosphoserine
    108-108 Phosphoserine
    410-410 Phosphoserine
 
Prediction
NeProc
Disorder 1-4,83-111,441-444
Order 5-82,112-440
ProS 108-111,441-444
AlphaFold
Disorder 1-4,81-117,119-121,205-210,241-246,265-266,441-444
Order 5-80,118-118,122-204,211-240,247-264,267-440
Pfam Hmmer
PF04212 45-74 4.4e-11
PF00004 169-354 1.1e-80
SEG 69-85 ,96-115
Function
Function in SwissProt
(Microbial infection) In conjunction with the ESCRT machinery also appears to function in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding (HIV-1 and other lentiviruses).
Biological Process
Diagram with PDB data
VPS4B/CHMP2BVPS4B MIT-CHMP2B Complex