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IID00764
 UniprotO75886
ProteinSignal transducing adapter molecule 2
GeneSTAM2
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
525
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-150 Hetero dimer : P62979
 Evidence NMR 2l0t B Reference
       Region 2l0t B 1-150 order
       Region 2l0t B 1-2 high_rmsd
Seq 1-150 Monomer :
 Evidence NMR 1x5b A Reference
       Region 1x5b A 1-150 order
       Region 1x5b A 1-3 high_rmsd
       Region 1x5b A 148-150 high_rmsd
Seq 162-265 Hetero dimer : IID00261Complex
 Evidence NMR 5ixf A Reference
       Region 5ixf A 162-195 disorder
       Region 5ixf A 196-263 order
       Region 5ixf A 264-265 disorder
Seq 195-269 Monomer :
 Evidence NMR 1x2q A Reference
       Region 1x2q A 195-269 order
       Region 1x2q A 195-200 high_rmsd
       Region 1x2q A 262-269 high_rmsd
Seq 350-370 Hetero dimer : Q9H3S7
 Evidence X-RAY 5crv C Reference
       Region 5crv C 350-350 disorder
       Region 5crv C 351-367 order
       Region 5crv C 368-370 disorder
 Evidence X-RAY 5crv D Reference
       Region 5crv D 350-367 order
       Region 5crv D 368-370 disorder
 
Prediction
NeProc
Disorder 1-4,147-204,253-293,310-316,368-525
Order 5-146,205-252,294-309,317-367
ProS 1-4,153-161,184-187,195-204,253-257,267-272,289-293,310-310,393-401,521-525
AlphaFold
Disorder 1-3,147-164,181-203,261-290,368-525
Order 4-146,165-180,204-260,291-367
Pfam Hmmer
PF00790 7-140 1.1e-55
PF02809 164-181 5.9e-05
PF00018 205-259 3.7e-25
Function
Function in SwissProt
Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as a sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes (By similarity).