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IID00767
 UniprotP05106
ProteinIntegrin beta-3
GeneITGB3
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
788
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 27-487 Hetero pentamer : P02679,P08514
 Evidence X-RAY 2vdp B Reference
       Region 2vdp B 27-98 order
       Region 2vdp B 99-104 disorder
       Region 2vdp B 105-487 order
Seq 27-487 Hetero tetramer : P08514
 Evidence X-RAY 2vdm B Reference
       Region 2vdm B 27-98 order
       Region 2vdm B 99-103 disorder
       Region 2vdm B 104-487 order
Seq 27-487 Hetero tetramer : P08514
 Evidence X-RAY 2vdn B Reference
       Region 2vdn B 27-98 order
       Region 2vdn B 99-104 disorder
       Region 2vdn B 105-487 order
Seq 27-487 Hetero tetramer : P08514
 Evidence X-RAY 2vc2 B Reference
       Region 2vc2 B 27-98 order
       Region 2vc2 B 99-102 disorder
       Region 2vc2 B 103-487 order
Seq 27-487 Hetero tetramer : P08514
 Evidence X-RAY 2vdl B Reference
       Region 2vdl B 27-98 order
       Region 2vdl B 99-103 disorder
       Region 2vdl B 104-487 order
Seq 27-487 Hetero hexamer : P08514
 Evidence X-RAY 1tye F Reference
       Region 1tye F 27-466 order
 Evidence X-RAY 1tye D Reference
       Region 1tye D 27-466 order
 Evidence X-RAY 1tye B Reference
       Region 1tye B 27-466 order
 Evidence X-RAY 3fcu F Reference
       Region 3fcu F 27-98 order
       Region 3fcu F 99-104 disorder
       Region 3fcu F 105-487 order
 Evidence X-RAY 3fcu D Reference
       Region 3fcu D 27-98 order
       Region 3fcu D 99-104 disorder
       Region 3fcu D 105-487 order
 Evidence X-RAY 3fcu B Reference
       Region 3fcu B 27-98 order
       Region 3fcu B 99-104 disorder
       Region 3fcu B 105-487 order
Seq 27-487 Hetero tetramer : P08514
 Evidence X-RAY 2vdk B Reference
       Region 2vdk B 27-98 order
       Region 2vdk B 99-104 disorder
       Region 2vdk B 105-487 order
Seq 27-487 Hetero pentamer : P02679,P08514
 Evidence X-RAY 2vdo B Reference
       Region 2vdo B 27-98 order
       Region 2vdo B 99-104 disorder
       Region 2vdo B 105-487 order
Seq 27-487 Hetero pentamer : P02679,P08514
 Evidence X-RAY 2vdr B Reference
       Region 2vdr B 27-98 order
       Region 2vdr B 99-104 disorder
       Region 2vdr B 105-487 order
Seq 27-487 Hetero pentamer : P02679,P08514
 Evidence X-RAY 2vdq B Reference
       Region 2vdq B 27-98 order
       Region 2vdq B 99-104 disorder
       Region 2vdq B 105-487 order
Seq 27-497 Hetero octamer : P08514
 Evidence X-RAY 7td8 D Reference
       Region 7td8 D 27-497 order
 Evidence X-RAY 7td8 B Reference
       Region 7td8 B 27-492 order
       Region 7td8 B 493-497 disorder
Seq 27-497 Hetero octamer : P08514
 Evidence X-RAY 7u9f D Reference
       Region 7u9f D 27-497 order
 Evidence X-RAY 7u9f B Reference
       Region 7u9f B 27-492 order
       Region 7u9f B 493-497 disorder
Seq 27-497 Hetero octamer : P08514
 Evidence X-RAY 7tmz D Reference
       Region 7tmz D 27-497 order
 Evidence X-RAY 7tmz B Reference
       Region 7tmz B 27-492 order
       Region 7tmz B 493-497 disorder
Seq 27-497 Hetero octamer : P08514
 Evidence X-RAY 5hdb D Reference
       Region 5hdb D 27-497 order
 Evidence X-RAY 5hdb B Reference
       Region 5hdb B 27-492 order
       Region 5hdb B 493-497 disorder
Seq 27-497 Hetero octamer : P08514
 Evidence X-RAY 3nif D Reference
       Region 3nif D 27-493 order
       Region 3nif D 494-497 disorder
 Evidence X-RAY 3nif B Reference
       Region 3nif B 27-492 order
       Region 3nif B 493-497 disorder
Seq 27-497 Hetero octamer : P08514
 Evidence X-RAY 7uje D Reference
       Region 7uje D 27-497 order
 Evidence X-RAY 7uje B Reference
       Region 7uje B 27-492 order
       Region 7uje B 493-497 disorder
Seq 27-497 Hetero octamer : P08514
 Evidence X-RAY 3nid D Reference
       Region 3nid D 27-497 order
 Evidence X-RAY 3nid B Reference
       Region 3nid B 27-492 order
       Region 3nid B 493-497 disorder
Seq 27-497 Hetero octamer : P08514
 Evidence X-RAY 7tpd D Reference
       Region 7tpd D 27-497 order
 Evidence X-RAY 7tpd B Reference
       Region 7tpd B 27-492 order
       Region 7tpd B 493-497 disorder
Seq 27-497 Hetero decamer : P08514
 Evidence X-RAY 4z7q D Reference
       Region 4z7q D 27-497 order
 Evidence X-RAY 4z7q B Reference
       Region 4z7q B 27-492 order
       Region 4z7q B 493-497 disorder
Seq 27-497 Hetero octamer : P08514
 Evidence X-RAY 7u9v D Reference
       Region 7u9v D 27-497 order
 Evidence X-RAY 7u9v B Reference
       Region 7u9v B 27-492 order
       Region 7u9v B 493-497 disorder
Seq 27-497 Hetero octamer : P08514
 Evidence X-RAY 7tho D Reference
       Region 7tho D 27-497 order
 Evidence X-RAY 7tho B Reference
       Region 7tho B 27-492 order
       Region 7tho B 493-497 disorder
Seq 27-497 Hetero decamer : P08514
 Evidence X-RAY 7u60 D Reference
       Region 7u60 D 27-28 disorder
       Region 7u60 D 29-497 order
 Evidence X-RAY 7u60 B Reference
       Region 7u60 B 27-28 disorder
       Region 7u60 B 29-492 order
       Region 7u60 B 493-497 disorder
Seq 27-497 Hetero octamer : P08514
 Evidence X-RAY 3nig D Reference
       Region 3nig D 27-497 order
 Evidence X-RAY 3nig B Reference
       Region 3nig B 27-492 order
       Region 3nig B 493-497 disorder
Seq 27-498 Hetero octamer : P08514
 Evidence X-RAY 7ucy D Reference
       Region 7ucy D 27-497 order
       Region 7ucy D 498-498 disorder
 Evidence X-RAY 7ucy B Reference
       Region 7ucy B 27-492 order
       Region 7ucy B 493-498 disorder
Seq 27-498 Hetero octamer : P08514
 Evidence X-RAY 7uh8 D Reference
       Region 7uh8 D 27-497 order
       Region 7uh8 D 498-498 disorder
 Evidence X-RAY 7uh8 B Reference
       Region 7uh8 B 27-492 order
       Region 7uh8 B 493-498 disorder
Seq 27-498 Hetero octamer : P08514
 Evidence X-RAY 7udh D Reference
       Region 7udh D 27-497 order
       Region 7udh D 498-498 disorder
 Evidence X-RAY 7udh B Reference
       Region 7udh B 27-492 order
       Region 7udh B 493-498 disorder
Seq 27-498 Hetero octamer : P08514
 Evidence X-RAY 7ukt D Reference
       Region 7ukt D 27-497 order
       Region 7ukt D 498-498 disorder
 Evidence X-RAY 7ukt B Reference
       Region 7ukt B 27-492 order
       Region 7ukt B 493-498 disorder
Seq 27-498 Hetero octamer : P08514
 Evidence X-RAY 3t3p D Reference
       Region 3t3p D 27-497 order
       Region 3t3p D 498-498 disorder
 Evidence X-RAY 3t3p B Reference
       Region 3t3p B 27-492 order
       Region 3t3p B 493-498 disorder
Seq 27-498 Hetero octamer : P08514
 Evidence X-RAY 7ufh D Reference
       Region 7ufh D 27-497 order
       Region 7ufh D 498-498 disorder
 Evidence X-RAY 7ufh B Reference
       Region 7ufh B 27-492 order
       Region 7ufh B 493-498 disorder
Seq 27-498 Hetero octamer : P08514
 Evidence X-RAY 3zdx D Reference
       Region 3zdx D 27-28 disorder
       Region 3zdx D 29-497 order
       Region 3zdx D 498-498 disorder
 Evidence X-RAY 3zdx B Reference
       Region 3zdx B 27-28 disorder
       Region 3zdx B 29-492 order
       Region 3zdx B 493-498 disorder
Seq 27-498 Hetero decamer : P08514
 Evidence X-RAY 3zdz D Reference
       Region 3zdz D 27-28 disorder
       Region 3zdz D 29-497 order
       Region 3zdz D 498-498 disorder
 Evidence X-RAY 3zdz B Reference
       Region 3zdz B 27-28 disorder
       Region 3zdz B 29-492 order
       Region 3zdz B 493-498 disorder
Seq 27-498 Hetero octamer : P08514
 Evidence X-RAY 7udg D Reference
       Region 7udg D 27-497 order
       Region 7udg D 498-498 disorder
 Evidence X-RAY 7udg B Reference
       Region 7udg B 27-492 order
       Region 7udg B 493-498 disorder
Seq 27-498 Hetero octamer : P08514
 Evidence X-RAY 7uk9 D Reference
       Region 7uk9 D 27-497 order
       Region 7uk9 D 498-498 disorder
 Evidence X-RAY 7uk9 B Reference
       Region 7uk9 B 27-492 order
       Region 7uk9 B 493-498 disorder
Seq 27-498 Hetero octamer : P08514
 Evidence X-RAY 3t3m D Reference
       Region 3t3m D 27-497 order
       Region 3t3m D 498-498 disorder
 Evidence X-RAY 3t3m B Reference
       Region 3t3m B 27-492 order
       Region 3t3m B 493-498 disorder
Seq 27-498 Hetero octamer : P08514
 Evidence X-RAY 7l8p D Reference
       Region 7l8p D 27-497 order
       Region 7l8p D 498-498 disorder
 Evidence X-RAY 7l8p B Reference
       Region 7l8p B 27-492 order
       Region 7l8p B 493-498 disorder
Seq 27-498 Hetero octamer : P08514
 Evidence X-RAY 7ubr D Reference
       Region 7ubr D 27-497 order
       Region 7ubr D 498-498 disorder
 Evidence X-RAY 7ubr B Reference
       Region 7ubr B 27-492 order
       Region 7ubr B 493-498 disorder
Seq 27-498 Hetero octamer : P08514
 Evidence X-RAY 7ue0 D Reference
       Region 7ue0 D 27-497 order
       Region 7ue0 D 498-498 disorder
 Evidence X-RAY 7ue0 B Reference
       Region 7ue0 B 27-492 order
       Region 7ue0 B 493-498 disorder
Seq 27-498 Hetero decamer : P08514
 Evidence X-RAY 3zdy D Reference
       Region 3zdy D 27-28 disorder
       Region 3zdy D 29-497 order
       Region 3zdy D 498-498 disorder
 Evidence X-RAY 3zdy B Reference
       Region 3zdy B 27-28 disorder
       Region 3zdy B 29-492 order
       Region 3zdy B 493-498 disorder
Seq 27-498 Hetero decamer : P08514
 Evidence X-RAY 3ze0 D Reference
       Region 3ze0 D 27-28 disorder
       Region 3ze0 D 29-497 order
       Region 3ze0 D 498-498 disorder
 Evidence X-RAY 3ze0 B Reference
       Region 3ze0 B 27-27 disorder
       Region 3ze0 B 28-492 order
       Region 3ze0 B 493-498 disorder
Seq 27-498 Hetero octamer : P08514
 Evidence X-RAY 7tct D Reference
       Region 7tct D 27-497 order
       Region 7tct D 498-498 disorder
 Evidence X-RAY 7tct B Reference
       Region 7tct B 27-492 order
       Region 7tct B 493-498 disorder
Seq 27-498 Hetero decamer : P08514
 Evidence X-RAY 3ze1 D Reference
       Region 3ze1 D 27-28 disorder
       Region 3ze1 D 29-497 order
       Region 3ze1 D 498-498 disorder
 Evidence X-RAY 3ze1 B Reference
       Region 3ze1 B 27-28 disorder
       Region 3ze1 B 29-492 order
       Region 3ze1 B 493-498 disorder
Seq 27-498 Hetero octamer : P08514
 Evidence X-RAY 7uko D Reference
       Region 7uko D 27-497 order
       Region 7uko D 498-498 disorder
 Evidence X-RAY 7uko B Reference
       Region 7uko B 27-492 order
       Region 7uko B 493-498 disorder
Seq 27-498 Hetero octamer : P08514
 Evidence X-RAY 7ukp D Reference
       Region 7ukp D 27-497 order
       Region 7ukp D 498-498 disorder
 Evidence X-RAY 7ukp B Reference
       Region 7ukp B 27-492 order
       Region 7ukp B 493-498 disorder
Seq 27-498 Hetero decamer : P08514
 Evidence X-RAY 3ze2 D Reference
       Region 3ze2 D 27-84 disorder
       Region 3ze2 D 85-97 order
       Region 3ze2 D 98-105 disorder
       Region 3ze2 D 106-459 order
       Region 3ze2 D 460-498 disorder
 Evidence X-RAY 3ze2 B Reference
       Region 3ze2 B 27-28 disorder
       Region 3ze2 B 29-497 order
       Region 3ze2 B 498-498 disorder
Seq 27-498 Hetero octamer : P08514
 Evidence X-RAY 7ujk D Reference
       Region 7ujk D 27-497 order
       Region 7ujk D 498-498 disorder
 Evidence X-RAY 7ujk B Reference
       Region 7ujk B 27-492 order
       Region 7ujk B 493-498 disorder
Seq 27-135,378-548 Hetero hexamer : P20701
 Evidence X-RAY 6ckb B Reference
       Region 6ckb B 27-135 order
       Region 6ckb B 378-548 order
 Evidence X-RAY 6ckb A Reference
       Region 6ckb A 27-135 order
       Region 6ckb A 378-548 order
Seq 27-135,378-548 Hetero hexamer : P20701
 Evidence X-RAY 6bxb B Reference
       Region 6bxb B 27-135 order
       Region 6bxb B 378-548 order
 Evidence X-RAY 6bxb A Reference
       Region 6bxb A 27-135 order
       Region 6bxb A 378-548 order
Seq 27-135,378-548 Hetero hexamer : P20701
 Evidence X-RAY 6bxf B Reference
       Region 6bxf B 27-135 order
       Region 6bxf B 378-548 order
 Evidence X-RAY 6bxf A Reference
       Region 6bxf A 27-135 order
       Region 6bxf A 378-548 order
Seq 27-135,378-714 Hetero trimer : P20701
 Evidence X-RAY 6bxj A Reference
       Region 6bxj A 27-135 order
       Region 6bxj A 378-502 order
       Region 6bxj A 503-508 disorder
       Region 6bxj A 509-714 order
Seq 27-716 Hetero tetramer : P08514
 Evidence X-RAY 3fcs D Reference
       Region 3fcs D 27-101 order
       Region 3fcs D 102-104 disorder
       Region 3fcs D 105-502 order
       Region 3fcs D 503-508 disorder
       Region 3fcs D 509-638 order
       Region 3fcs D 639-716 disorder
 Evidence X-RAY 3fcs B Reference
       Region 3fcs B 27-100 order
       Region 3fcs B 101-104 disorder
       Region 3fcs B 105-502 order
       Region 3fcs B 503-508 disorder
       Region 3fcs B 509-716 order
Seq 27-718 Hetero trimer : P02751,P06756
 Evidence X-RAY 4mmx B Reference
       Region 4mmx B 27-716 order
       Region 4mmx B 717-718 disorder
 Evidence X-RAY 4mmz B Reference
       Region 4mmz B 27-716 order
       Region 4mmz B 717-718 disorder
 Evidence X-RAY 6naj B Reference
       Region 6naj B 27-716 order
Seq 27-718 Hetero trimer : P06756
 Evidence X-RAY 1l5g B Reference
       Region 1l5g B 27-80 disorder
       Region 1l5g B 81-460 order
       Region 1l5g B 461-557 disorder
       Region 1l5g B 558-716 order
       Region 1l5g B 717-718 disorder
Seq 27-718 Hetero trimer : P02751,P06756
 Evidence X-RAY 4mmy B Reference
       Region 4mmy B 27-716 order
       Region 4mmy B 717-718 disorder
Seq 27-718 Hetero tetramer : P06756
 Evidence X-RAY 4o02 B Reference
       Region 4o02 B 27-713 order
       Region 4o02 B 714-718 disorder
Seq 27-721 Hetero dimer : P06756
 Evidence X-RAY 4g1e B Reference
       Region 4g1e B 27-59 order
       Region 4g1e B 60-61 disorder
       Region 4g1e B 62-504 order
       Region 4g1e B 505-508 disorder
       Region 4g1e B 509-717 order
 Evidence X-RAY 4g1m B Reference
       Region 4g1m B 27-718 order
 Evidence X-RAY 3ije B Reference
       Region 3ije B 27-721 order
 Evidence X-RAY 1jv2 B Reference
       Region 1jv2 B 27-80 disorder
       Region 1jv2 B 81-460 order
       Region 1jv2 B 461-557 disorder
       Region 1jv2 B 558-716 order
       Region 1jv2 B 717-718 disorder
 Evidence X-RAY 1m1x B Reference
       Region 1m1x B 27-80 disorder
       Region 1m1x B 81-460 order
       Region 1m1x B 461-557 disorder
       Region 1m1x B 558-716 order
       Region 1m1x B 717-718 disorder
 Evidence X-RAY 6mk0 B Reference
       Region 6mk0 B 30-716 order
 Evidence X-RAY 1u8c B Reference
       Region 1u8c B 27-76 order
       Region 1u8c B 77-79 disorder
       Region 1u8c B 80-460 order
       Region 1u8c B 461-548 disorder
       Region 1u8c B 549-716 order
       Region 1u8c B 717-718 disorder
Seq 27-721 Hetero trimer : P06756,P12071
 Evidence X-RAY 6msu B Reference
       Region 6msu B 27-716 order
       Region 6msu B 717-721 disorder
 Evidence X-RAY 6msl B Reference
       Region 6msl B 27-716 order
       Region 6msl B 717-721 disorder
Seq 29-497 Hetero decamer : P08514
 Evidence X-RAY 4z7o D Reference
       Region 4z7o D 29-497 order
 Evidence X-RAY 4z7o B Reference
       Region 4z7o B 29-492 order
       Region 4z7o B 493-497 disorder
Seq 29-497 Hetero decamer : P08514
 Evidence X-RAY 4z7n D Reference
       Region 4z7n D 29-497 order
 Evidence X-RAY 4z7n B Reference
       Region 4z7n B 29-492 order
       Region 4z7n B 493-497 disorder
Seq 50-61 Hetero trimer : P01903,P79483
 Evidence X-RAY 2q6w F Reference
       Region 2q6w F 50-61 order
 Evidence X-RAY 2q6w C Reference
       Region 2q6w C 50-60 order
       Region 2q6w C 61-61 disorder
Seq 711-753 Hetero dimer : P08514
 Evidence NMR 2k9j B Reference
       Region 2k9j B 711-753 order
       Region 2k9j B 711-717 high_rmsd
       Region 2k9j B 751-753 high_rmsd
 Evidence NMR 2n9y B Reference
       Region 2n9y B 712-753 order
       Region 2n9y B 712-714 high_rmsd
       Region 2n9y B 752-753 high_rmsd
 Evidence NMR 7kn0 B Reference
       Region 7kn0 B 712-753 order
       Region 7kn0 B 712-714 high_rmsd
       Region 7kn0 B 753-753 high_rmsd
Seq 711-753 Monomer :
 Evidence NMR 2l91 A Reference
       Region 2l91 A 711-753 order
       Region 2l91 A 711-716 high_rmsd
       Region 2l91 A 751-753 high_rmsd
 Evidence NMR 2rmz A Reference
       Region 2rmz A 711-753 order
       Region 2rmz A 711-716 high_rmsd
       Region 2rmz A 751-753 high_rmsd
 Evidence NMR 2rn0 A Reference
       Region 2rn0 A 711-753 order
       Region 2rn0 A 711-717 high_rmsd
       Region 2rn0 A 749-753 high_rmsd
Seq 715-788 Hetero dimer : P08514
 Evidence NMR 2knc B Reference
       Region 2knc B 715-788 order
       Region 2knc B 774-788 high_rmsd
Seq 739-788 Monomer :
 Evidence NMR 2kv9 B Reference
       Region 2kv9 B 739-788 order
 Evidence NMR 2ljd A Reference
       Region 2ljd A 742-788 order
 Evidence NMR 2lje A Reference
       Region 2lje A 742-788 order
       Region 2lje A 742-745 high_rmsd
       Region 2lje A 772-772 high_rmsd
       Region 2lje A 778-788 high_rmsd
 Evidence NMR 2ljf A Reference
       Region 2ljf A 742-788 order
       Region 2ljf A 781-788 high_rmsd
 Evidence NMR 1s4x A Reference
       Region 1s4x A 742-788 order
       Region 1s4x A 781-788 high_rmsd
Seq 742-766 Hetero dimer : P08514
 Evidence NMR 1kuz B Reference
       Region 1kuz B 742-766 order
       Region 1kuz B 761-766 high_rmsd
 Evidence NMR 1kup B Reference
       Region 1kup B 742-766 order
Seq 742-788 Hetero trimer : P08514,P21333
 Evidence NMR 2mtp C Reference
       Region 2mtp C 742-788 order
       Region 2mtp C 761-767 high_rmsd
       Region 2mtp C 784-788 high_rmsd
Seq 742-788 Hetero dimer : P08514
 Evidence NMR 1m8o B Reference
       Region 1m8o B 742-788 order
       Region 1m8o B 758-788 high_rmsd
Seq 762-788 Hetero dimer : IID00511Complex
 Evidence NMR 2l1c B Reference
       Region 2l1c B 762-788 order
       Region 2l1c B 762-763 high_rmsd
Seqdisorder 763-788
 Evidence NMR Reference
       Region 763-788 disorder
Seq 765-776 Hetero dimer : IID50213Complex
 Evidence X-RAY 1miz A Reference
       Region 1miz A 765-769 order
 Evidence X-RAY 1mk7 A Reference
       Region 1mk7 A 765-775 order
 Evidence X-RAY 1mk7 C Reference
       Region 1mk7 C 765-775 order
 Evidence X-RAY 1mk9 A Reference
       Region 1mk9 A 765-776 order
 Evidence X-RAY 1mk9 C Reference
       Region 1mk9 C 765-776 order
 Evidence X-RAY 1mk9 E Reference
       Region 1mk9 E 765-776 order
 Evidence X-RAY 1mk9 G Reference
       Region 1mk9 G 765-776 order
SeqProS verified 765-776 Hetero dimer : IID50213Complex
       Region 1mk9 A 765-776 order
       Region 1mk9 C 765-776 order
       Region 1mk9 E 765-776 order
       Region 1mk9 G 765-776 order
       Region 1mk7 A 765-775 order
       Region 1mk7 C 765-775 order
       Region 1miz A 765-769 order
       Region 763-788 disorder
Seqphosphorylation
    785-785 Phosphotyrosine
    779-779 Phosphothreonine; by PDPK1 and PKB/AKT1; in vitro
    773-773 Phosphotyrosine
    767-767 Phosphothreonine
 
Prediction
NeProc
Disorder 1-25,502-515
Order 26-501,516-788
ProS 1-25,511-515
AlphaFold
Disorder 1-27,35-35,101-104,502-510,674-676,698-702,717-717,762-788
Order 28-34,36-100,105-501,511-673,677-697,703-716,718-761
Pfam Hmmer
PF07974 512-547 3.1e-06
PF07974 554-584 0.0008
PF07974 593-624 6.7e-06
PF07965 634-718 2.4e-35
SEG 14-27 ,729-747 ,750-764
Function
Function in SwissProt
(Microbial infection) In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.