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IID00768
 UniprotP05107
ProteinIntegrin beta-2
GeneITGB2
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
769
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 23-482 Hetero hexamer : P20701
 Evidence X-RAY 5e6s F Reference
       Region 5e6s F 23-90 order
       Region 5e6s F 91-94 disorder
       Region 5e6s F 95-481 order
       Region 5e6s F 482-482 disorder
 Evidence X-RAY 5e6s D Reference
       Region 5e6s D 23-90 order
       Region 5e6s D 91-94 disorder
       Region 5e6s D 95-481 order
       Region 5e6s D 482-482 disorder
 Evidence X-RAY 5e6s B Reference
       Region 5e6s B 23-90 order
       Region 5e6s B 91-94 disorder
       Region 5e6s B 95-481 order
       Region 5e6s B 482-482 disorder
Seq 23-125,365-482 Hetero dimer :
 Evidence X-RAY 1yuk B Reference
       Region 1yuk B 365-482 order
 Evidence X-RAY 1yuk A Reference
       Region 1yuk A 23-89 order
       Region 1yuk A 90-94 disorder
       Region 1yuk A 95-121 order
       Region 1yuk A 122-125 disorder
Seq 23-482 Hetero trimer : P11215
 Evidence X-RAY 7p2d B Reference
       Region 7p2d B 23-481 order
       Region 7p2d B 482-482 disorder
Seq 23-482 Hetero dimer : P20701
 Evidence X-RAY 5e6r B Reference
       Region 5e6r B 23-89 order
       Region 5e6r B 90-94 disorder
       Region 5e6r B 95-481 order
       Region 5e6r B 482-482 disorder
 Evidence X-RAY 5e6s B Reference
       Region 5e6s B 23-90 order
       Region 5e6s B 91-94 disorder
       Region 5e6s B 95-481 order
       Region 5e6s B 482-482 disorder
 Evidence X-RAY 5e6s D Reference
       Region 5e6s D 23-90 order
       Region 5e6s D 91-94 disorder
       Region 5e6s D 95-481 order
       Region 5e6s D 482-482 disorder
 Evidence X-RAY 5e6s F Reference
       Region 5e6s F 23-90 order
       Region 5e6s F 91-94 disorder
       Region 5e6s F 95-481 order
       Region 5e6s F 482-482 disorder
 Evidence X-RAY 5e6u B Reference
       Region 5e6u B 23-88 order
       Region 5e6u B 89-94 disorder
       Region 5e6u B 95-481 order
       Region 5e6u B 482-482 disorder
Seq 23-125,362-535 Monomer :
 Evidence X-RAY 5e6x A Reference
       Region 5e6x A 23-122 order
       Region 5e6x A 362-535 order
 Evidence X-RAY 2p26 A Reference
       Region 2p26 A 23-122 order
       Region 2p26 A 362-535 order
 Evidence X-RAY 5e6v A Reference
       Region 5e6v A 24-125 order
       Region 5e6v A 365-482 order
Seq 23-118,362-574 Hetero dimer :
 Evidence X-RAY 5e6w A Reference
       Region 5e6w A 23-90 order
       Region 5e6w A 91-94 disorder
       Region 5e6w A 95-118 order
       Region 5e6w A 362-454 order
       Region 5e6w A 455-456 disorder
       Region 5e6w A 457-488 order
       Region 5e6w A 489-489 disorder
       Region 5e6w A 490-574 order
Seq 23-122,362-574 Hetero dimer :
 Evidence X-RAY 2p28 B Reference
       Region 2p28 B 362-454 order
       Region 2p28 B 455-456 disorder
       Region 2p28 B 457-488 order
       Region 2p28 B 489-489 disorder
       Region 2p28 B 490-574 order
 Evidence X-RAY 2p28 A Reference
       Region 2p28 A 23-90 order
       Region 2p28 A 91-94 disorder
       Region 2p28 A 95-122 order
Seq 23-696 Hetero dimer : P20702
 Evidence X-RAY 4nen B Reference
       Region 4nen B 23-90 order
       Region 4nen B 91-94 disorder
       Region 4nen B 95-450 order
       Region 4nen B 451-457 disorder
       Region 4nen B 458-696 order
 Evidence X-RAY 4neh B Reference
       Region 4neh B 23-90 order
       Region 4neh B 91-94 disorder
       Region 4neh B 95-450 order
       Region 4neh B 451-454 disorder
       Region 4neh B 455-695 order
Seq 23-699 Hetero octamer : P20702
 Evidence X-RAY 5es4 B Reference
       Region 5es4 B 23-696 order
 Evidence X-RAY 5es4 D Reference
       Region 5es4 D 23-696 order
 Evidence X-RAY 5es4 F Reference
       Region 5es4 F 23-696 order
 Evidence X-RAY 5es4 H Reference
       Region 5es4 H 23-696 order
 Evidence X-RAY 3k6s B Reference
       Region 3k6s B 23-696 order
       Region 3k6s B 697-699 disorder
 Evidence X-RAY 3k6s D Reference
       Region 3k6s D 23-696 order
       Region 3k6s D 697-699 disorder
 Evidence X-RAY 3k6s F Reference
       Region 3k6s F 23-696 order
       Region 3k6s F 697-699 disorder
 Evidence X-RAY 3k6s H Reference
       Region 3k6s H 23-696 order
       Region 3k6s H 697-699 disorder
 Evidence X-RAY 3k71 B Reference
       Region 3k71 B 23-695 order
       Region 3k71 B 696-699 disorder
 Evidence X-RAY 3k71 D Reference
       Region 3k71 D 23-695 order
       Region 3k71 D 696-699 disorder
 Evidence X-RAY 3k71 F Reference
       Region 3k71 F 23-695 order
       Region 3k71 F 696-699 disorder
 Evidence X-RAY 3k71 H Reference
       Region 3k71 H 23-695 order
       Region 3k71 H 696-699 disorder
Seq 23-699 Hetero tetramer : P20702
 Evidence X-RAY 3k72 D Reference
       Region 3k72 D 23-695 order
       Region 3k72 D 696-699 disorder
 Evidence X-RAY 3k72 B Reference
       Region 3k72 B 23-695 order
       Region 3k72 B 696-699 disorder
Seq 535-574 Monomer :
 Evidence NMR 1l3y A Reference
       Region 1l3y A 535-574 order
       Region 1l3y A 535-535 high_rmsd
Seq 689-739 Monomer :
 Evidence NMR 5zaz A Reference
       Region 5zaz A 689-739 order
       Region 5zaz A 689-695 high_rmsd
       Region 5zaz A 739-739 high_rmsd
Seq 735-769 Hetero hexamer : P21333
 Evidence X-RAY 2jf1 T Reference
       Region 2jf1 T 735-752 disorder
       Region 2jf1 T 753-763 order
       Region 2jf1 T 764-769 disorder
Seq 752-763 Hetero dimer : P21333
 Evidence NMR 5xr1 A Reference
       Region 5xr1 A 752-763 order
Seq 755-764 Hetero tetramer : P63103
 Evidence X-RAY 2v7d S Reference
       Region 2v7d S 755-761 order
       Region 2v7d S 762-764 disorder
 Evidence X-RAY 2v7d R Reference
       Region 2v7d R 755-761 order
       Region 2v7d R 762-764 disorder
 Evidence X-RAY 2v7d Q Reference
       Region 2v7d Q 755-761 order
       Region 2v7d Q 762-764 disorder
 Evidence X-RAY 2v7d P Reference
       Region 2v7d P 755-761 order
       Region 2v7d P 762-764 disorder
SeqProS possible 753-763 Same region of homolog (P05106, ITGB3) is disordered in the free state (PubMed=12230976). Hetero tetramer : P63103
       Region 2v7d P 755-761 order
       Region 2v7d Q 755-761 order
       Region 2v7d R 755-761 order
       Region 2v7d S 755-761 order
SeqProS possible 753-763 Same region of homolog (P05106, ITGB3) is disordered in the free state (PubMed=12230976). Hetero hexamer : P21333
       Region 2jf1 T 753-763 order
Seqphosphorylation
    760-760 Phosphothreonine; by PKC/PRKCA; in vitro
    759-759 Phosphothreonine
    758-758 Phosphothreonine; by PKC; in vitro
    756-756 Phosphoserine
    745-745 Phosphoserine; by PKC
 
Prediction
NeProc
Disorder 1-18,486-501
Order 19-451,456-485,502-769
ProS 1-18,494-501
AlphaFold
Disorder 1-23,28-28,54-55,91-95,150-150,451-456,487-492,697-698,744-769
Order 24-27,29-53,56-90,96-149,151-450,457-486,493-696,699-743
Pfam Hmmer
PF07974 582-612 9.6e-05
PF07965 622-700 1.5e-36
SEG 2-22 ,128-143 ,701-722
Function
Function in SwissProt
Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is also a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL (PubMed:29100055). Integrins ITGAM/ITGB2 and ITGAX/ITGB2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin ITGAX/ITGB2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin ITGAM/ITGB2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin ITGAM/ITGB2 is also a receptor for factor X. Integrin ITGAD/ITGB2 is a receptor for ICAM3 and VCAM1. Contributes to natural killer cell cytotoxicity (PubMed:15356110). Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils (PubMed:11812992, PubMed:28807980). Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation (PubMed:18587400). Integrin ITGAL/ITGB2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages (PubMed:23775590). In association with alpha subunit ITGAM/CD11b, required for CD177-PRTN3-mediated activation of TNF primed neutrophils (PubMed:21193407).