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IID00769
 UniprotP05556
ProteinIntegrin beta-1
GeneITGB1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
798
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 21-465 Hetero decamer : P08648
 Evidence X-RAY 3vi4 D Reference
       Region 3vi4 D 21-24 disorder
       Region 3vi4 D 25-53 order
       Region 3vi4 D 54-61 disorder
       Region 3vi4 D 62-465 order
 Evidence X-RAY 3vi4 B Reference
       Region 3vi4 B 21-25 disorder
       Region 3vi4 B 26-50 order
       Region 3vi4 B 51-59 disorder
       Region 3vi4 B 60-465 order
Seq 21-465 Hetero octamer : P08648
 Evidence X-RAY 3vi3 D Reference
       Region 3vi3 D 21-24 disorder
       Region 3vi3 D 25-53 order
       Region 3vi3 D 54-62 disorder
       Region 3vi3 D 63-465 order
 Evidence X-RAY 3vi3 B Reference
       Region 3vi3 B 21-25 disorder
       Region 3vi3 B 26-49 order
       Region 3vi3 B 50-62 disorder
       Region 3vi3 B 63-465 order
Seq 21-465 Hetero trimer : P08648
 Evidence X-RAY 4wk4 B Reference
       Region 4wk4 B 21-23 disorder
       Region 4wk4 B 24-99 order
       Region 4wk4 B 100-104 disorder
       Region 4wk4 B 105-436 order
       Region 4wk4 B 437-438 disorder
       Region 4wk4 B 439-465 order
Seq 21-465 Hetero trimer : P08648
 Evidence X-RAY 4wk2 B Reference
       Region 4wk2 B 21-24 disorder
       Region 4wk2 B 25-54 order
       Region 4wk2 B 55-60 disorder
       Region 4wk2 B 61-97 order
       Region 4wk2 B 98-104 disorder
       Region 4wk2 B 105-464 order
       Region 4wk2 B 465-465 disorder
Seq 21-465 Hetero trimer : P08648
 Evidence X-RAY 4wk0 B Reference
       Region 4wk0 B 21-24 disorder
       Region 4wk0 B 25-54 order
       Region 4wk0 B 55-59 disorder
       Region 4wk0 B 60-97 order
       Region 4wk0 B 98-105 disorder
       Region 4wk0 B 106-464 order
       Region 4wk0 B 465-465 disorder
Seq 21-465 Hetero tetramer : P23229
 Evidence X-RAY 7ceb B Reference
       Region 7ceb B 21-80 disorder
       Region 7ceb B 81-97 order
       Region 7ceb B 98-105 disorder
       Region 7ceb B 106-462 order
       Region 7ceb B 463-465 disorder
Seq 21-465 Hetero dimer : P08648
 Evidence X-RAY 4wjk B Reference
       Region 4wjk B 21-24 disorder
       Region 4wjk B 25-50 order
       Region 4wjk B 51-57 disorder
       Region 4wjk B 58-72 order
       Region 4wjk B 73-74 disorder
       Region 4wjk B 75-97 order
       Region 4wjk B 98-105 disorder
       Region 4wjk B 106-465 order
Seq 752-785 Hetero dimer : Q71LX4
 Evidence X-RAY 3g9w D Reference
       Region 3g9w D 752-785 order
 Evidence X-RAY 3g9w C Reference
       Region 3g9w C 752-785 order
Seqdisorder 758-769
 Evidence X-RAY 3t9k B Reference
       Region 3t9k B 758-769 disorder
Seqdisorder 758-769
 Evidence X-RAY 3t9k A Reference
       Region 3t9k A 758-769 disorder
Seq 784-798 Hetero 61mer : O14713
 Evidence X-RAY 4dx9 z Reference
       Region 4dx9 z 784-788 disorder
       Region 4dx9 z 789-793 order
       Region 4dx9 z 794-798 disorder
 Evidence X-RAY 4dx9 x Reference
       Region 4dx9 x 784-784 disorder
       Region 4dx9 x 785-788 order
       Region 4dx9 x 789-798 disorder
 Evidence X-RAY 4dx9 v Reference
       Region 4dx9 v 784-785 disorder
       Region 4dx9 v 786-793 order
       Region 4dx9 v 794-798 disorder
 Evidence X-RAY 4dx9 t Reference
       Region 4dx9 t 784-787 order
       Region 4dx9 t 788-790 disorder
       Region 4dx9 t 791-794 order
       Region 4dx9 t 795-798 disorder
 Evidence X-RAY 4dx9 r Reference
       Region 4dx9 r 784-791 disorder
       Region 4dx9 r 792-793 order
       Region 4dx9 r 794-798 disorder
 Evidence X-RAY 4dx9 p Reference
       Region 4dx9 p 784-789 disorder
       Region 4dx9 p 790-794 order
       Region 4dx9 p 795-798 disorder
 Evidence X-RAY 4dx9 n Reference
       Region 4dx9 n 784-794 order
       Region 4dx9 n 795-798 disorder
 Evidence X-RAY 4dx9 l Reference
       Region 4dx9 l 784-784 disorder
       Region 4dx9 l 785-787 order
       Region 4dx9 l 788-790 disorder
       Region 4dx9 l 791-794 order
       Region 4dx9 l 795-798 disorder
 Evidence X-RAY 4dx9 j Reference
       Region 4dx9 j 784-787 order
       Region 4dx9 j 788-798 disorder
 Evidence X-RAY 4dx9 h Reference
       Region 4dx9 h 784-793 order
       Region 4dx9 h 794-798 disorder
 Evidence X-RAY 4dx9 f Reference
       Region 4dx9 f 784-794 order
       Region 4dx9 f 795-798 disorder
 Evidence X-RAY 4dx9 d Reference
       Region 4dx9 d 784-794 order
       Region 4dx9 d 795-798 disorder
 Evidence X-RAY 4dx9 b Reference
       Region 4dx9 b 784-793 order
       Region 4dx9 b 794-798 disorder
 Evidence X-RAY 4dx9 Z Reference
       Region 4dx9 Z 784-794 order
       Region 4dx9 Z 795-798 disorder
 Evidence X-RAY 4dx9 X Reference
       Region 4dx9 X 784-795 order
       Region 4dx9 X 796-798 disorder
 Evidence X-RAY 4dx9 V Reference
       Region 4dx9 V 784-793 order
       Region 4dx9 V 794-798 disorder
 Evidence X-RAY 4dx9 T Reference
       Region 4dx9 T 784-794 order
       Region 4dx9 T 795-798 disorder
 Evidence X-RAY 4dx9 R Reference
       Region 4dx9 R 784-794 order
       Region 4dx9 R 795-798 disorder
 Evidence X-RAY 4dx9 P Reference
       Region 4dx9 P 784-794 order
       Region 4dx9 P 795-798 disorder
 Evidence X-RAY 4dx9 N Reference
       Region 4dx9 N 784-794 order
       Region 4dx9 N 795-798 disorder
 Evidence X-RAY 4dx9 L Reference
       Region 4dx9 L 784-794 order
       Region 4dx9 L 795-798 disorder
 Evidence X-RAY 4dx9 J Reference
       Region 4dx9 J 784-794 order
       Region 4dx9 J 795-798 disorder
 Evidence X-RAY 4dx9 H Reference
       Region 4dx9 H 784-794 order
       Region 4dx9 H 795-798 disorder
 Evidence X-RAY 4dx9 F Reference
       Region 4dx9 F 784-794 order
       Region 4dx9 F 795-798 disorder
 Evidence X-RAY 4dx9 D Reference
       Region 4dx9 D 784-794 order
       Region 4dx9 D 795-798 disorder
 Evidence X-RAY 4dx9 B Reference
       Region 4dx9 B 784-793 order
       Region 4dx9 B 794-798 disorder
 Evidence X-RAY 4dx9 9 Reference
       Region 4dx9 9 784-784 disorder
       Region 4dx9 9 785-792 order
       Region 4dx9 9 793-798 disorder
 Evidence X-RAY 4dx9 8 Reference
       Region 4dx9 8 784-791 order
       Region 4dx9 8 792-798 disorder
 Evidence X-RAY 4dx9 7 Reference
       Region 4dx9 7 784-794 order
       Region 4dx9 7 795-798 disorder
 Evidence X-RAY 4dx9 6 Reference
       Region 4dx9 6 784-794 order
       Region 4dx9 6 795-798 disorder
SeqProS possible 784-795 Same region of homolog (P05106, ITGB3) is disordered in the free state (PubMed=12230976). Hetero : O14713
       Region 4dx9 6 784-794 order
       Region 4dx9 7 784-794 order
       Region 4dx9 8 784-791 order
       Region 4dx9 9 785-792 order
       Region 4dx9 B 784-793 order
       Region 4dx9 D 784-794 order
       Region 4dx9 F 784-794 order
       Region 4dx9 H 784-794 order
       Region 4dx9 J 784-794 order
       Region 4dx9 L 784-794 order
       Region 4dx9 N 784-794 order
       Region 4dx9 P 784-794 order
       Region 4dx9 R 784-794 order
       Region 4dx9 T 784-794 order
       Region 4dx9 V 784-793 order
       Region 4dx9 X 784-795 order
       Region 4dx9 Z 784-794 order
       Region 4dx9 b 784-793 order
       Region 4dx9 d 784-794 order
       Region 4dx9 f 784-794 order
       Region 4dx9 h 784-793 order
       Region 4dx9 j 784-787 order
       Region 4dx9 l 785-787 order
       Region 4dx9 l 791-794 order
       Region 4dx9 n 784-794 order
       Region 4dx9 p 790-794 order
       Region 4dx9 r 792-793 order
       Region 4dx9 t 784-787 order
       Region 4dx9 t 791-794 order
       Region 4dx9 v 786-793 order
       Region 4dx9 x 785-788 order
       Region 4dx9 z 789-793 order
Seqphosphorylation
    789-789 Phosphothreonine
    785-785 Phosphoserine
    783-783 Phosphotyrosine
    777-777 Phosphothreonine
Seqacetylation
    794-794 N6-acetyllysine; alternate
 
Prediction
NeProc
Disorder 1-28,101-106,505-520
Order 29-100,107-504,521-798
ProS 1-28,512-520
AlphaFold
Disorder 1-24,98-105,506-512,624-624,632-638,682-687,709-709,725-728,773-784,787-787,791-791,793-798
Order 25-97,106-505,513-623,625-631,639-681,688-708,710-724,729-772,785-786,788-790,792-792
Pfam Hmmer
PF07974 599-630 7.2e-07
PF07965 640-728 1.1e-44
SEG 729-757
Function
Function in SwissProt
(Microbial infection) May serve as a receptor for adhesin A (nadA) of N.meningitidis.
Biological Process
See also
Diagram with PDB data
ITGA4/Ap2m1Mu2 adaptin subunit of the AP2 adaptor (C-terminal domain) complexed with Integrin alpha4 internalisation peptide QYKSILQE