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IID00771
 UniprotP07101
ProteinTyrosine 3-monooxygenase
GeneTH
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
528
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-30,62-74 Hetero dimer : IID00816Complex
 Evidence X-RAY 4j6s E Reference
       Region 4j6s E 1-15 disorder
       Region 4j6s E 16-22 order
       Region 4j6s E 23-30 disorder
       Region 4j6s E 62-74 disorder
 Evidence X-RAY 4j6s F Reference
       Region 4j6s F 1-14 disorder
       Region 4j6s F 15-23 order
       Region 4j6s F 24-30 disorder
       Region 4j6s F 62-74 disorder
 Evidence X-RAY 4j6s G Reference
       Region 4j6s G 1-14 disorder
       Region 4j6s G 15-23 order
       Region 4j6s G 24-30 disorder
       Region 4j6s G 62-74 disorder
 Evidence X-RAY 4j6s H Reference
       Region 4j6s H 1-14 disorder
       Region 4j6s H 15-23 order
       Region 4j6s H 24-30 disorder
       Region 4j6s H 62-74 disorder
Seq 193-528 Homo tetramer :
 Evidence X-RAY 2xsn A Reference
       Region 2xsn A 193-527 order
       Region 2xsn A 528-528 disorder
 Evidence X-RAY 2xsn B Reference
       Region 2xsn B 193-528 order
 Evidence X-RAY 2xsn C Reference
       Region 2xsn C 193-212 order
       Region 2xsn C 213-227 disorder
       Region 2xsn C 228-528 order
 Evidence X-RAY 2xsn D Reference
       Region 2xsn D 193-193 disorder
       Region 2xsn D 194-528 order
SeqProS predicted 15-23 This region is predicted to be disordered by NeProc and AlphaFold (pLDDT < 68.5). Hetero dimer : IID00816Complex
       Region 4j6s E 16-22 order
       Region 4j6s F 15-23 order
       Region 4j6s G 15-23 order
       Region 4j6s H 15-23 order
Seqphosphorylation
    502-502 Phosphoserine
    71-71 Phosphoserine; by CaMK2 and PKA
    62-62 Phosphoserine
    19-19 Phosphoserine; by CaMK2
 
Prediction
NeProc
Disorder 1-15,25-106
Order 16-24,107-528
ProS 12-15,25-49,63-82,94-106
AlphaFold
Disorder 1-102,122-125,150-157,189-193,213-214
Order 103-121,126-149,158-188,194-212,215-528
Pfam Hmmer
PF00351 195-526 8.7e-290
SEG 47-60 ,82-91
Function
Function in SwissProt
Lacks catalytic activity.