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IID00773
 UniprotP08100
ProteinRhodopsin
GeneRHO
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
348
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-348 Hetero hexamer : P00720,P20443
 Evidence X-RAY 5dgy C Reference
       Region 5dgy C 1-326 order
       Region 5dgy C 327-348 disorder
 Evidence X-RAY 5dgy A Reference
       Region 5dgy A 1-326 order
       Region 5dgy A 327-348 disorder
Seq 1-348 Hetero trimer : P00720,P20443
 Evidence X-RAY 4zwj A Reference
       Region 4zwj A 1-326 order
       Region 4zwj A 327-348 disorder
Seq 1-348 Hetero trimer : P00720,P20443
 Evidence X-RAY 4zwj D Reference
       Region 4zwj D 1-326 order
       Region 4zwj D 327-348 disorder
Seq 1-348 Hetero dimer : P20443
 Evidence X-RAY 4zwj B Reference
       Region 4zwj B 1-326 order
       Region 4zwj B 327-348 disorder
Seq 1-348 Hetero trimer : P00720,P20443
 Evidence X-RAY 5dgy B Reference
       Region 5dgy B 1-326 order
       Region 5dgy B 327-348 disorder
 Evidence X-RAY 5dgy D Reference
       Region 5dgy D 1-326 order
       Region 5dgy D 327-348 disorder
Seq 1-348 Hetero trimer : P00720,P20443
 Evidence X-RAY 4zwj C Reference
       Region 4zwj C 1-326 order
       Region 4zwj C 327-348 disorder
Seq 1-348 Hetero octamer : P20443
 Evidence X-RAY 5w0p D Reference
       Region 5w0p D 1-324 order
       Region 5w0p D 325-329 disorder
       Region 5w0p D 330-343 order
       Region 5w0p D 344-348 disorder
 Evidence X-RAY 5w0p C Reference
       Region 5w0p C 1-324 order
       Region 5w0p C 325-328 disorder
       Region 5w0p C 329-343 order
       Region 5w0p C 344-348 disorder
 Evidence X-RAY 5w0p B Reference
       Region 5w0p B 1-323 order
       Region 5w0p B 324-328 disorder
       Region 5w0p B 329-343 order
       Region 5w0p B 344-348 disorder
 Evidence X-RAY 5w0p A Reference
       Region 5w0p A 1-324 order
       Region 5w0p A 325-329 disorder
       Region 5w0p A 330-343 order
       Region 5w0p A 344-348 disorder
SeqProS verified 329-343 Arrestin binds to the phosphorylated C-terminus of light-activated rhodopsin and hinders the dephosphorylation (PubMed=33840915, 35332081). Hetero octamer : P20443
       Region 5w0p A 330-343 order
       Region 5w0p B 329-343 order
       Region 5w0p C 329-343 order
       Region 5w0p D 330-343 order
       Region 4zwj A 327-348 disorder
Seqphosphorylation
    343-343 Phosphoserine
    340-340 Phosphothreonine
    342-342 Phosphothreonine
    338-338 Phosphoserine
    336-336 Phosphothreonine
    334-334 Phosphoserine
Seqacetylation
    1-1 N-acetylmethionine
 
Prediction
NeProc
Disorder 1-5,327-348
Order 6-326
AlphaFold
Disorder 1-1,329-348
Order 2-328
Pfam Hmmer
PF00001 54-306 4.7e-57
SEG 231-247
Function
Function in SwissProt
Photoreceptor required for image-forming vision at low light intensity (PubMed:8107847, PubMed:7846071). Required for photoreceptor cell viability after birth (PubMed:2215617, PubMed:12566452). Light-induced isomerization of the chromophore 11-cis-retinal to all-trans-retinal triggers a conformational change that activates signaling via G-proteins (PubMed:8107847, PubMed:28524165, PubMed:26200343, PubMed:28753425). Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by the arrestin SAG and terminates signaling (PubMed:28524165, PubMed:26200343).
Biological Process
Diagram with PDB data
RHO/SAGCrystal structure of rhodopsin bound to visual arrestin determined by X-ray free electron laser