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IID00775
UniprotP08631
ProteinTyrosine-protein kinase HCK
GeneHCK
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
526
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 61-141 Hetero dimer :
 Evidence NMR 2oj2 A Reference
       Region 2oj2 A 61-141 order
       Region 2oj2 A 61-77 high_rmsd
       Region 2oj2 A 141-141 high_rmsd
Seq 61-141 Hetero dimer :
 Evidence NMR 2oi3 A Reference
       Region 2oi3 A 61-141 order
Seq 72-143 Monomer :
 Evidence NMR 4hck A Reference
       Region 4hck A 72-77 disorder
       Region 4hck A 78-138 order
       Region 4hck A 78-78 high_rmsd
       Region 4hck A 138-138 high_rmsd
       Region 4hck A 139-143 disorder
 Evidence NMR 5hck A Reference
       Region 5hck A 72-77 disorder
       Region 5hck A 78-138 order
       Region 5hck A 139-143 disorder
Seq 72-242 Hetero tetramer : P03407
 Evidence X-RAY 4u5w D Reference
       Region 4u5w D 72-79 disorder
       Region 4u5w D 80-172 order
       Region 4u5w D 173-177 disorder
       Region 4u5w D 178-242 order
 Evidence X-RAY 4u5w B Reference
       Region 4u5w B 72-79 disorder
       Region 4u5w B 80-242 order
Seq 72-256 Monomer :
 Evidence X-RAY 3nhn A Reference
       Region 3nhn A 72-79 disorder
       Region 3nhn A 80-242 order
       Region 3nhn A 243-256 disorder
Seq 77-138 Hetero trimer : P03407
 Evidence X-RAY 4orz A Reference
       Region 4orz A 77-80 disorder
       Region 4orz A 81-136 order
       Region 4orz A 137-138 disorder
Seq 77-140 Hetero dimer : P03407
 Evidence X-RAY 3rbb B Reference
       Region 3rbb B 79-138 order
 Evidence X-RAY 3rbb D Reference
       Region 3rbb D 79-79 disorder
       Region 3rbb D 80-137 order
       Region 3rbb D 138-138 disorder
 Evidence X-RAY 3rea B Reference
       Region 3rea B 79-138 order
 Evidence X-RAY 3rea D Reference
       Region 3rea D 79-137 order
       Region 3rea D 138-138 disorder
 Evidence X-RAY 3reb B Reference
       Region 3reb B 79-79 disorder
       Region 3reb B 80-138 order
 Evidence X-RAY 3reb D Reference
       Region 3reb D 79-138 order
 Evidence X-RAY 8f2p B Reference
       Region 8f2p B 77-79 disorder
       Region 8f2p B 80-135 order
       Region 8f2p B 136-140 disorder
Seq 79-90,96-138 Hetero dimer : Q5QGG3
 Evidence X-RAY 5nuh C Reference
       Region 5nuh C 79-80 disorder
       Region 5nuh C 81-90 order
       Region 5nuh C 96-135 order
       Region 5nuh C 136-138 disorder
 Evidence X-RAY 5nuh D Reference
       Region 5nuh D 79-79 disorder
       Region 5nuh D 80-90 order
       Region 5nuh D 96-135 order
       Region 5nuh D 136-138 disorder
Seq 79-405,416-526 Homo dimer :
 Evidence X-RAY 2hck B Reference
       Region 2hck B 79-405 order
       Region 2hck B 416-526 order
 Evidence X-RAY 2hck A Reference
       Region 2hck A 79-405 order
       Region 2hck A 416-526 order
Seq 79-526 Monomer :
 Evidence X-RAY 1ad5 A Reference
       Region 1ad5 A 79-405 order
       Region 1ad5 A 416-526 order
 Evidence X-RAY 1ad5 B Reference
       Region 1ad5 B 79-405 order
       Region 1ad5 B 416-526 order
 Evidence X-RAY 2c0i A Reference
       Region 2c0i A 81-406 order
       Region 2c0i A 407-419 disorder
       Region 2c0i A 420-526 order
 Evidence X-RAY 2c0i B Reference
       Region 2c0i B 81-406 order
       Region 2c0i B 407-419 disorder
       Region 2c0i B 420-526 order
 Evidence X-RAY 2c0o A Reference
       Region 2c0o A 81-406 order
       Region 2c0o A 407-419 disorder
       Region 2c0o A 420-526 order
 Evidence X-RAY 2c0o B Reference
       Region 2c0o B 81-406 order
       Region 2c0o B 407-419 disorder
       Region 2c0o B 420-526 order
 Evidence X-RAY 2c0t A Reference
       Region 2c0t A 81-201 order
       Region 2c0t A 202-207 disorder
       Region 2c0t A 208-406 order
       Region 2c0t A 407-419 disorder
       Region 2c0t A 420-526 order
 Evidence X-RAY 2c0t B Reference
       Region 2c0t B 81-202 order
       Region 2c0t B 203-206 disorder
       Region 2c0t B 207-406 order
       Region 2c0t B 407-419 disorder
       Region 2c0t B 420-526 order
 Evidence X-RAY 5h09 A Reference
       Region 5h09 A 81-526 order
 Evidence X-RAY 5h0b A Reference
       Region 5h0b A 81-526 order
 Evidence X-RAY 5h0e A Reference
       Region 5h0e A 81-526 order
 Evidence X-RAY 5h0g A Reference
       Region 5h0g A 81-526 order
 Evidence X-RAY 5h0h A Reference
       Region 5h0h A 81-526 order
 Evidence X-RAY 4lud A Reference
       Region 4lud A 81-135 order
       Region 4lud A 136-138 disorder
       Region 4lud A 139-204 order
       Region 4lud A 205-206 disorder
       Region 4lud A 207-294 order
       Region 4lud A 295-297 disorder
       Region 4lud A 298-406 order
       Region 4lud A 407-419 disorder
       Region 4lud A 420-465 order
       Region 4lud A 466-469 disorder
       Region 4lud A 470-526 order
 Evidence X-RAY 4lud B Reference
       Region 4lud B 81-175 order
       Region 4lud B 176-178 disorder
       Region 4lud B 179-200 order
       Region 4lud B 201-217 disorder
       Region 4lud B 218-295 order
       Region 4lud B 296-297 disorder
       Region 4lud B 298-406 order
       Region 4lud B 407-419 disorder
       Region 4lud B 420-524 order
       Region 4lud B 525-526 disorder
 Evidence X-RAY 4lue A Reference
       Region 4lue A 81-202 order
       Region 4lue A 203-206 disorder
       Region 4lue A 207-296 order
       Region 4lue A 297-302 disorder
       Region 4lue A 303-406 order
       Region 4lue A 407-419 disorder
       Region 4lue A 420-525 order
       Region 4lue A 526-526 disorder
 Evidence X-RAY 4lue B Reference
       Region 4lue B 81-202 order
       Region 4lue B 203-206 disorder
       Region 4lue B 207-294 order
       Region 4lue B 295-302 disorder
       Region 4lue B 303-406 order
       Region 4lue B 407-419 disorder
       Region 4lue B 420-430 order
       Region 4lue B 431-433 disorder
       Region 4lue B 434-525 order
       Region 4lue B 526-526 disorder
 Evidence X-RAY 1qcf A Reference
       Region 1qcf A 81-526 order
 Evidence X-RAY 3vry A Reference
       Region 3vry A 81-201 order
       Region 3vry A 202-207 disorder
       Region 3vry A 208-406 order
       Region 3vry A 407-418 disorder
       Region 3vry A 419-526 order
 Evidence X-RAY 3vry B Reference
       Region 3vry B 81-406 order
       Region 3vry B 407-418 disorder
       Region 3vry B 419-526 order
 Evidence X-RAY 3vrz A Reference
       Region 3vrz A 81-202 order
       Region 3vrz A 203-206 disorder
       Region 3vrz A 207-406 order
       Region 3vrz A 407-419 disorder
       Region 3vrz A 420-526 order
 Evidence X-RAY 3vrz B Reference
       Region 3vrz B 81-202 order
       Region 3vrz B 203-206 disorder
       Region 3vrz B 207-406 order
       Region 3vrz B 407-418 disorder
       Region 3vrz B 419-526 order
 Evidence X-RAY 3vs0 A Reference
       Region 3vs0 A 81-201 order
       Region 3vs0 A 202-206 disorder
       Region 3vs0 A 207-406 order
       Region 3vs0 A 407-419 disorder
       Region 3vs0 A 420-526 order
 Evidence X-RAY 3vs0 B Reference
       Region 3vs0 B 81-406 order
       Region 3vs0 B 407-419 disorder
       Region 3vs0 B 420-526 order
 Evidence X-RAY 3vs1 A Reference
       Region 3vs1 A 81-201 order
       Region 3vs1 A 202-210 disorder
       Region 3vs1 A 211-406 order
       Region 3vs1 A 407-419 disorder
       Region 3vs1 A 420-526 order
 Evidence X-RAY 3vs1 B Reference
       Region 3vs1 B 81-406 order
       Region 3vs1 B 407-419 disorder
       Region 3vs1 B 420-526 order
 Evidence X-RAY 3vs2 A Reference
       Region 3vs2 A 81-203 order
       Region 3vs2 A 204-206 disorder
       Region 3vs2 A 207-406 order
       Region 3vs2 A 407-419 disorder
       Region 3vs2 A 420-526 order
 Evidence X-RAY 3vs2 B Reference
       Region 3vs2 B 81-406 order
       Region 3vs2 B 407-419 disorder
       Region 3vs2 B 420-526 order
 Evidence X-RAY 3vs3 A Reference
       Region 3vs3 A 81-406 order
       Region 3vs3 A 407-418 disorder
       Region 3vs3 A 419-526 order
 Evidence X-RAY 3vs3 B Reference
       Region 3vs3 B 81-202 order
       Region 3vs3 B 203-207 disorder
       Region 3vs3 B 208-407 order
       Region 3vs3 B 408-417 disorder
       Region 3vs3 B 418-526 order
 Evidence X-RAY 3vs4 A Reference
       Region 3vs4 A 81-201 order
       Region 3vs4 A 202-207 disorder
       Region 3vs4 A 208-407 order
       Region 3vs4 A 408-418 disorder
       Region 3vs4 A 419-526 order
 Evidence X-RAY 3vs4 B Reference
       Region 3vs4 B 81-406 order
       Region 3vs4 B 407-418 disorder
       Region 3vs4 B 419-526 order
 Evidence X-RAY 3vs5 A Reference
       Region 3vs5 A 81-202 order
       Region 3vs5 A 203-206 disorder
       Region 3vs5 A 207-406 order
       Region 3vs5 A 407-419 disorder
       Region 3vs5 A 420-526 order
 Evidence X-RAY 3vs5 B Reference
       Region 3vs5 B 81-201 order
       Region 3vs5 B 202-207 disorder
       Region 3vs5 B 208-406 order
       Region 3vs5 B 407-419 disorder
       Region 3vs5 B 420-526 order
 Evidence X-RAY 3vs6 A Reference
       Region 3vs6 A 81-406 order
       Region 3vs6 A 407-418 disorder
       Region 3vs6 A 419-526 order
 Evidence X-RAY 3vs6 B Reference
       Region 3vs6 B 81-406 order
       Region 3vs6 B 407-418 disorder
       Region 3vs6 B 419-526 order
 Evidence X-RAY 3vs7 A Reference
       Region 3vs7 A 81-405 order
       Region 3vs7 A 406-419 disorder
       Region 3vs7 A 420-526 order
 Evidence X-RAY 3vs7 B Reference
       Region 3vs7 B 81-202 order
       Region 3vs7 B 203-207 disorder
       Region 3vs7 B 208-404 order
       Region 3vs7 B 405-419 disorder
       Region 3vs7 B 420-526 order
Seq 81-137 Homo hexamer :
 Evidence X-RAY 1bu1 F Reference
       Region 1bu1 F 81-136 order
       Region 1bu1 F 137-137 disorder
 Evidence X-RAY 1bu1 E Reference
       Region 1bu1 E 81-137 order
 Evidence X-RAY 1bu1 D Reference
       Region 1bu1 D 81-136 order
       Region 1bu1 D 137-137 disorder
 Evidence X-RAY 1bu1 C Reference
       Region 1bu1 C 81-136 order
       Region 1bu1 C 137-137 disorder
 Evidence X-RAY 1bu1 B Reference
       Region 1bu1 B 81-137 order
 Evidence X-RAY 1bu1 A Reference
       Region 1bu1 A 81-137 order
Seq 140-245 Monomer :
 Evidence NMR 3hck A Reference
       Region 3hck A 140-245 order
Seq 242-521 Homo dimer :
 Evidence X-RAY 5zj6 B Reference
       Region 5zj6 B 242-248 disorder
       Region 5zj6 B 249-518 order
       Region 5zj6 B 519-521 disorder
 Evidence X-RAY 5zj6 A Reference
       Region 5zj6 A 242-247 disorder
       Region 5zj6 A 248-518 order
       Region 5zj6 A 519-521 disorder
Seq 247-514 Monomer :
 Evidence X-RAY 2hk5 A Reference
       Region 2hk5 A 247-514 order
Seqphosphorylation
    36-36 Phosphothreonine
    202-202 Phosphothreonine
    51-51 Phosphotyrosine; by autocatalysis
    209-209 Phosphotyrosine
    522-522 Phosphotyrosine
    462-462 Phosphoserine
    411-411 Phosphotyrosine; by autocatalysis
 
Prediction
NeProc
Disorder 1-77,519-526
Order 78-518
ProS 4-40,49-56,519-526
AlphaFold
Disorder 1-78,406-418,517-520,526-526
Order 79-405,419-516,521-525
Pfam Hmmer
PF00018 81-136 1.1e-26
PF00017 144-226 3.1e-44
PF07714 262-511 1.1e-153
Function
Function in SwissProt
Non-receptor tyrosine-protein kinase found in hematopoietic cells that transmits signals from cell surface receptors and plays an important role in the regulation of innate immune responses, including neutrophil, monocyte, macrophage and mast cell functions, phagocytosis, cell survival and proliferation, cell adhesion and migration. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as FCGR1A and FCGR2A, but also CSF3R, PLAUR, the receptors for IFNG, IL2, IL6 and IL8, and integrins, such as ITGB1 and ITGB2. During the phagocytic process, mediates mobilization of secretory lysosomes, degranulation, and activation of NADPH oxidase to bring about the respiratory burst. Plays a role in the release of inflammatory molecules. Promotes reorganization of the actin cytoskeleton and actin polymerization, formation of podosomes and cell protrusions. Inhibits TP73-mediated transcription activation and TP73-mediated apoptosis. Phosphorylates CBL in response to activation of immunoglobulin gamma Fc region receptors. Phosphorylates ADAM15, BCR, ELMO1, FCGR2A, GAB1, GAB2, RAPGEF1, STAT5B, TP73, VAV1 and WAS.