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IID00776
 UniprotP09874
ProteinPoly [ADP-ribose] polymerase 1
GenePARP1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1014
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-108 Monomer :
 Evidence NMR 2l30 A Reference
       Region 2l30 A 1-108 order
       Region 2l30 A 1-3 high_rmsd
       Region 2l30 A 97-99 high_rmsd
       Region 2l30 A 104-108 high_rmsd
 Evidence NMR 2dmj A Reference
       Region 2dmj A 1-93 order
       Region 2dmj A 1-3 high_rmsd
Seq 1-214 Monomer :
 Evidence NMR 2n8a A Reference
       Region 2n8a A 1-214 order
       Region 2n8a A 1-3 high_rmsd
       Region 2n8a A 94-106 high_rmsd
       Region 2n8a A 203-214 high_rmsd
Seq 1-96,216-366,527-662,677-786 Hetero dodecamer :
 Evidence X-RAY 7s81 P Reference
       Region 7s81 P 527-531 disorder
       Region 7s81 P 532-644 order
       Region 7s81 P 645-662 disorder
       Region 7s81 P 677-692 disorder
       Region 7s81 P 693-775 order
       Region 7s81 P 776-786 disorder
 Evidence X-RAY 7s81 K Reference
       Region 7s81 K 527-530 disorder
       Region 7s81 K 531-646 order
       Region 7s81 K 647-662 disorder
       Region 7s81 K 677-689 disorder
       Region 7s81 K 690-776 order
       Region 7s81 K 777-786 disorder
 Evidence X-RAY 7s81 H Reference
       Region 7s81 H 527-530 disorder
       Region 7s81 H 531-647 order
       Region 7s81 H 648-662 disorder
       Region 7s81 H 677-693 disorder
       Region 7s81 H 694-776 order
       Region 7s81 H 777-786 disorder
 Evidence X-RAY 7s81 C Reference
       Region 7s81 C 527-530 disorder
       Region 7s81 C 531-644 order
       Region 7s81 C 645-662 disorder
       Region 7s81 C 677-677 disorder
       Region 7s81 C 678-776 order
       Region 7s81 C 777-786 disorder
 Evidence X-RAY 7s81 O Reference
       Region 7s81 O 216-221 disorder
       Region 7s81 O 222-359 order
       Region 7s81 O 360-366 disorder
 Evidence X-RAY 7s81 J Reference
       Region 7s81 J 216-222 disorder
       Region 7s81 J 223-361 order
       Region 7s81 J 362-366 disorder
 Evidence X-RAY 7s81 G Reference
       Region 7s81 G 216-223 disorder
       Region 7s81 G 224-358 order
       Region 7s81 G 359-366 disorder
 Evidence X-RAY 7s81 B Reference
       Region 7s81 B 216-228 disorder
       Region 7s81 B 229-358 order
       Region 7s81 B 359-366 disorder
 Evidence X-RAY 7s81 N Reference
       Region 7s81 N 1-5 disorder
       Region 7s81 N 6-94 order
       Region 7s81 N 95-96 disorder
 Evidence X-RAY 7s81 I Reference
       Region 7s81 I 1-4 disorder
       Region 7s81 I 5-91 order
       Region 7s81 I 92-96 disorder
 Evidence X-RAY 7s81 F Reference
       Region 7s81 F 1-5 disorder
       Region 7s81 F 6-90 order
       Region 7s81 F 91-96 disorder
 Evidence X-RAY 7s81 A Reference
       Region 7s81 A 1-4 disorder
       Region 7s81 A 5-95 order
       Region 7s81 A 96-96 disorder
Seq 1-95,206-366,527-662,677-786 Hetero dimer :
 Evidence X-RAY 7s68 B Reference
       Region 7s68 B 527-531 disorder
       Region 7s68 B 532-644 order
       Region 7s68 B 645-662 disorder
       Region 7s68 B 677-678 disorder
       Region 7s68 B 679-776 order
       Region 7s68 B 777-786 disorder
 Evidence X-RAY 7s68 A Reference
       Region 7s68 A 1-4 disorder
       Region 7s68 A 5-91 order
       Region 7s68 A 92-95 disorder
       Region 7s68 A 206-223 disorder
       Region 7s68 A 224-359 order
       Region 7s68 A 360-366 disorder
Seq 1-95,206-366,518-686,689-1014 Hetero tetramer :
 Evidence X-RAY 7s6m D Reference
       Region 7s6m D 518-530 disorder
       Region 7s6m D 531-646 order
       Region 7s6m D 647-659 disorder
       Region 7s6m D 660-686 order
       Region 7s6m D 689-780 order
       Region 7s6m D 781-784 disorder
       Region 7s6m D 785-1014 order
 Evidence X-RAY 7s6m B Reference
       Region 7s6m B 518-530 disorder
       Region 7s6m B 531-646 order
       Region 7s6m B 647-661 disorder
       Region 7s6m B 662-686 order
       Region 7s6m B 689-780 order
       Region 7s6m B 781-786 disorder
       Region 7s6m B 787-1014 order
 Evidence X-RAY 7s6h D Reference
       Region 7s6h D 518-530 disorder
       Region 7s6h D 531-647 order
       Region 7s6h D 648-661 disorder
       Region 7s6h D 662-686 order
       Region 7s6h D 689-780 order
       Region 7s6h D 781-783 disorder
       Region 7s6h D 784-1014 order
 Evidence X-RAY 7s6h B Reference
       Region 7s6h B 518-530 disorder
       Region 7s6h B 531-646 order
       Region 7s6h B 647-659 disorder
       Region 7s6h B 660-686 order
       Region 7s6h B 689-781 order
       Region 7s6h B 782-787 disorder
       Region 7s6h B 788-1014 order
 Evidence X-RAY 7s6m C Reference
       Region 7s6m C 1-5 disorder
       Region 7s6m C 6-91 order
       Region 7s6m C 92-95 disorder
       Region 7s6m C 206-223 disorder
       Region 7s6m C 224-359 order
       Region 7s6m C 360-366 disorder
 Evidence X-RAY 7s6m A Reference
       Region 7s6m A 1-5 disorder
       Region 7s6m A 6-91 order
       Region 7s6m A 92-95 disorder
       Region 7s6m A 206-226 disorder
       Region 7s6m A 227-359 order
       Region 7s6m A 360-366 disorder
 Evidence X-RAY 7s6h C Reference
       Region 7s6h C 1-5 disorder
       Region 7s6h C 6-90 order
       Region 7s6h C 91-95 disorder
       Region 7s6h C 206-223 disorder
       Region 7s6h C 224-359 order
       Region 7s6h C 360-366 disorder
 Evidence X-RAY 7s6h A Reference
       Region 7s6h A 1-5 disorder
       Region 7s6h A 6-91 order
       Region 7s6h A 92-95 disorder
       Region 7s6h A 206-222 disorder
       Region 7s6h A 223-359 order
       Region 7s6h A 360-366 disorder
Seq 1-97,207-366,518-1014 Hetero trimer :
 Evidence X-RAY 4oqb F Reference
       Region 4oqb F 518-530 disorder
       Region 4oqb F 531-575 order
       Region 4oqb F 576-583 disorder
       Region 4oqb F 584-644 order
       Region 4oqb F 645-661 disorder
       Region 4oqb F 662-1011 order
       Region 4oqb F 1012-1014 disorder
 Evidence X-RAY 4oqb D Reference
       Region 4oqb D 1-5 disorder
       Region 4oqb D 6-91 order
       Region 4oqb D 92-97 disorder
       Region 4oqb D 207-223 disorder
       Region 4oqb D 224-359 order
       Region 4oqb D 360-366 disorder
Seq 1-97,207-366,518-1014 Hetero trimer :
 Evidence X-RAY 4opx C Reference
       Region 4opx C 518-530 disorder
       Region 4opx C 531-575 order
       Region 4opx C 576-583 disorder
       Region 4opx C 584-644 order
       Region 4opx C 645-661 disorder
       Region 4opx C 662-1011 order
       Region 4opx C 1012-1014 disorder
 Evidence X-RAY 4opx A Reference
       Region 4opx A 1-5 disorder
       Region 4opx A 6-91 order
       Region 4opx A 92-97 disorder
       Region 4opx A 207-223 disorder
       Region 4opx A 224-359 order
       Region 4opx A 360-366 disorder
Seq 1-97,207-366,518-1014 Hetero trimer :
 Evidence X-RAY 4oqa F Reference
       Region 4oqa F 518-530 disorder
       Region 4oqa F 531-575 order
       Region 4oqa F 576-583 disorder
       Region 4oqa F 584-644 order
       Region 4oqa F 645-661 disorder
       Region 4oqa F 662-1011 order
       Region 4oqa F 1012-1014 disorder
 Evidence X-RAY 4oqa D Reference
       Region 4oqa D 1-5 disorder
       Region 4oqa D 6-91 order
       Region 4oqa D 92-97 disorder
       Region 4oqa D 207-223 disorder
       Region 4oqa D 224-359 order
       Region 4oqa D 360-366 disorder
Seq 1-97,207-366,518-1014 Hetero trimer :
 Evidence X-RAY 4oqa C Reference
       Region 4oqa C 518-530 disorder
       Region 4oqa C 531-575 order
       Region 4oqa C 576-583 disorder
       Region 4oqa C 584-644 order
       Region 4oqa C 645-661 disorder
       Region 4oqa C 662-1011 order
       Region 4oqa C 1012-1014 disorder
 Evidence X-RAY 4oqa A Reference
       Region 4oqa A 1-5 disorder
       Region 4oqa A 6-91 order
       Region 4oqa A 92-97 disorder
       Region 4oqa A 207-223 disorder
       Region 4oqa A 224-359 order
       Region 4oqa A 360-366 disorder
Seq 1-97,207-366,518-1014 Hetero trimer :
 Evidence X-RAY 4opx F Reference
       Region 4opx F 518-530 disorder
       Region 4opx F 531-575 order
       Region 4opx F 576-583 disorder
       Region 4opx F 584-644 order
       Region 4opx F 645-661 disorder
       Region 4opx F 662-1011 order
       Region 4opx F 1012-1014 disorder
 Evidence X-RAY 4opx D Reference
       Region 4opx D 1-5 disorder
       Region 4opx D 6-91 order
       Region 4opx D 92-97 disorder
       Region 4opx D 207-223 disorder
       Region 4opx D 224-359 order
       Region 4opx D 360-366 disorder
Seq 1-97,207-366,518-1014 Hetero trimer :
 Evidence X-RAY 4oqb C Reference
       Region 4oqb C 518-530 disorder
       Region 4oqb C 531-575 order
       Region 4oqb C 576-583 disorder
       Region 4oqb C 584-644 order
       Region 4oqb C 645-661 disorder
       Region 4oqb C 662-1011 order
       Region 4oqb C 1012-1014 disorder
 Evidence X-RAY 4oqb A Reference
       Region 4oqb A 1-5 disorder
       Region 4oqb A 6-91 order
       Region 4oqb A 92-97 disorder
       Region 4oqb A 207-223 disorder
       Region 4oqb A 224-359 order
       Region 4oqb A 360-366 disorder
Seq 1-96,216-366,518-1014 Hetero trimer :
 Evidence X-RAY 4dqy A Reference
       Region 4dqy A 1-5 disorder
       Region 4dqy A 6-91 order
       Region 4dqy A 92-96 disorder
 Evidence X-RAY 4dqy D Reference
       Region 4dqy D 1-5 disorder
       Region 4dqy D 6-91 order
       Region 4dqy D 92-96 disorder
 Evidence X-RAY 4dqy B Reference
       Region 4dqy B 216-223 disorder
       Region 4dqy B 224-359 order
       Region 4dqy B 360-366 disorder
 Evidence X-RAY 4dqy E Reference
       Region 4dqy E 216-223 disorder
       Region 4dqy E 224-359 order
       Region 4dqy E 360-366 disorder
 Evidence X-RAY 4dqy C Reference
       Region 4dqy C 518-530 disorder
       Region 4dqy C 531-575 order
       Region 4dqy C 576-583 disorder
       Region 4dqy C 584-644 order
       Region 4dqy C 645-661 disorder
       Region 4dqy C 662-1011 order
       Region 4dqy C 1012-1014 disorder
 Evidence X-RAY 4dqy F Reference
       Region 4dqy F 518-530 disorder
       Region 4dqy F 531-575 order
       Region 4dqy F 576-583 disorder
       Region 4dqy F 584-644 order
       Region 4dqy F 645-661 disorder
       Region 4dqy F 662-1011 order
       Region 4dqy F 1012-1014 disorder
Seq 2-96 Homo dimer :
 Evidence X-RAY 3od8 A Reference
       Region 3od8 A 2-4 disorder
       Region 3od8 A 5-91 order
       Region 3od8 A 92-96 disorder
 Evidence X-RAY 3od8 B Reference
       Region 3od8 B 2-4 disorder
       Region 3od8 B 5-91 order
       Region 3od8 B 92-96 disorder
 Evidence X-RAY 3od8 C Reference
       Region 3od8 C 2-4 disorder
       Region 3od8 C 5-91 order
       Region 3od8 C 92-96 disorder
 Evidence X-RAY 3od8 D Reference
       Region 3od8 D 2-4 disorder
       Region 3od8 D 5-93 order
       Region 3od8 D 94-96 disorder
 Evidence X-RAY 3od8 E Reference
       Region 3od8 E 2-4 disorder
       Region 3od8 E 5-91 order
       Region 3od8 E 92-96 disorder
 Evidence X-RAY 3od8 F Reference
       Region 3od8 F 2-4 disorder
       Region 3od8 F 5-94 order
       Region 3od8 F 95-96 disorder
 Evidence X-RAY 3od8 G Reference
       Region 3od8 G 2-4 disorder
       Region 3od8 G 5-91 order
       Region 3od8 G 92-96 disorder
 Evidence X-RAY 3od8 H Reference
       Region 3od8 H 2-4 disorder
       Region 3od8 H 5-92 order
       Region 3od8 H 93-96 disorder
 Evidence X-RAY 3oda A Reference
       Region 3oda A 2-4 disorder
       Region 3oda A 5-91 order
       Region 3oda A 92-96 disorder
 Evidence X-RAY 3oda B Reference
       Region 3oda B 2-5 disorder
       Region 3oda B 6-91 order
       Region 3oda B 92-96 disorder
 Evidence X-RAY 3oda C Reference
       Region 3oda C 2-4 disorder
       Region 3oda C 5-91 order
       Region 3oda C 92-96 disorder
 Evidence X-RAY 3oda D Reference
       Region 3oda D 2-4 disorder
       Region 3oda D 5-93 order
       Region 3oda D 94-96 disorder
 Evidence X-RAY 3oda E Reference
       Region 3oda E 2-5 disorder
       Region 3oda E 6-91 order
       Region 3oda E 92-96 disorder
 Evidence X-RAY 3oda F Reference
       Region 3oda F 2-4 disorder
       Region 3oda F 5-94 order
       Region 3oda F 95-96 disorder
 Evidence X-RAY 3oda G Reference
       Region 3oda G 2-4 disorder
       Region 3oda G 5-91 order
       Region 3oda G 92-96 disorder
 Evidence X-RAY 3oda H Reference
       Region 3oda H 2-4 disorder
       Region 3oda H 5-92 order
       Region 3oda H 93-96 disorder
Seq 5-202 Homo dimer :
 Evidence X-RAY 4av1 D Reference
       Region 4av1 D 5-107 disorder
       Region 4av1 D 108-202 order
 Evidence X-RAY 4av1 B Reference
       Region 4av1 B 5-106 disorder
       Region 4av1 B 107-202 order
 Evidence X-RAY 4av1 C Reference
       Region 4av1 C 5-5 disorder
       Region 4av1 C 6-90 order
       Region 4av1 C 91-202 disorder
 Evidence X-RAY 4av1 A Reference
       Region 4av1 A 5-5 disorder
       Region 4av1 A 6-91 order
       Region 4av1 A 92-202 disorder
Seq 103-223 Monomer :
 Evidence NMR 2l31 A Reference
       Region 2l31 A 103-214 order
       Region 2l31 A 103-107 high_rmsd
       Region 2l31 A 203-214 high_rmsd
 Evidence X-RAY 3odc A Reference
       Region 3odc A 105-108 disorder
       Region 3odc A 109-201 order
       Region 3odc A 202-206 disorder
 Evidence X-RAY 3odc B Reference
       Region 3odc B 105-203 order
       Region 3odc B 204-206 disorder
 Evidence X-RAY 3ode A Reference
       Region 3ode A 105-109 disorder
       Region 3ode A 110-200 order
       Region 3ode A 201-206 disorder
 Evidence X-RAY 3ode B Reference
       Region 3ode B 105-107 disorder
       Region 3ode B 108-200 order
       Region 3ode B 201-206 disorder
 Evidence NMR 2cs2 A Reference
       Region 2cs2 A 103-223 order
       Region 2cs2 A 103-104 high_rmsd
       Region 2cs2 A 204-223 high_rmsd
Seq 216-366 Homo dimer :
 Evidence X-RAY 2riq A Reference
       Region 2riq A 216-224 disorder
       Region 2riq A 225-359 order
       Region 2riq A 360-366 disorder
Seq 233-358 Monomer :
 Evidence NMR 2jvn A Reference
       Region 2jvn A 233-358 order
Seq 387-486 Monomer :
 Evidence NMR 2cok A Reference
       Region 2cok A 387-486 order
       Region 2cok A 485-486 high_rmsd
Seq 518-643 Monomer :
 Evidence NMR 2cr9 A Reference
       Region 2cr9 A 518-643 order
       Region 2cr9 A 518-529 high_rmsd
Seq 655-1014 Homo dimer :
 Evidence X-RAY 5ha9 A Reference
       Region 5ha9 A 662-1011 order
 Evidence X-RAY 5ha9 B Reference
       Region 5ha9 B 662-1011 order
 Evidence X-RAY 4zzz A Reference
       Region 4zzz A 655-661 disorder
       Region 4zzz A 662-783 order
       Region 4zzz A 784-786 disorder
       Region 4zzz A 787-1014 order
 Evidence X-RAY 4zzz B Reference
       Region 4zzz B 655-663 disorder
       Region 4zzz B 664-781 order
       Region 4zzz B 782-787 disorder
       Region 4zzz B 788-1011 order
       Region 4zzz B 1012-1014 disorder
 Evidence X-RAY 7aaa A Reference
       Region 7aaa A 662-1011 order
 Evidence X-RAY 7aaa B Reference
       Region 7aaa B 662-1011 order
 Evidence X-RAY 7aab A Reference
       Region 7aab A 662-1011 order
 Evidence X-RAY 7aab B Reference
       Region 7aab B 662-1011 order
 Evidence X-RAY 7aac A Reference
       Region 7aac A 662-1011 order
 Evidence X-RAY 7aac B Reference
       Region 7aac B 662-1011 order
 Evidence X-RAY 7aad A Reference
       Region 7aad A 662-1011 order
 Evidence X-RAY 7aad B Reference
       Region 7aad B 662-1011 order
 Evidence X-RAY 7cmw A Reference
       Region 7cmw A 662-1011 order
 Evidence X-RAY 7cmw B Reference
       Region 7cmw B 662-1011 order
 Evidence X-RAY 6ghk A Reference
       Region 6ghk A 662-782 order
       Region 6ghk A 783-784 disorder
       Region 6ghk A 785-823 order
       Region 6ghk A 824-826 disorder
       Region 6ghk A 827-1011 order
 Evidence X-RAY 6ghk B Reference
       Region 6ghk B 662-782 order
       Region 6ghk B 783-784 disorder
       Region 6ghk B 785-1011 order
 Evidence X-RAY 8he7 A Reference
       Region 8he7 A 662-1011 order
 Evidence X-RAY 8he7 B Reference
       Region 8he7 B 662-1011 order
 Evidence X-RAY 7kk2 A Reference
       Region 7kk2 A 662-1011 order
 Evidence X-RAY 7kk2 B Reference
       Region 7kk2 B 662-1010 order
       Region 7kk2 B 1011-1011 disorder
 Evidence X-RAY 7kk4 A Reference
       Region 7kk4 A 662-744 order
       Region 7kk4 A 745-748 disorder
       Region 7kk4 A 749-780 order
       Region 7kk4 A 781-785 disorder
       Region 7kk4 A 786-1010 order
       Region 7kk4 A 1011-1011 disorder
 Evidence X-RAY 7kk4 B Reference
       Region 7kk4 B 662-744 order
       Region 7kk4 B 745-747 disorder
       Region 7kk4 B 748-780 order
       Region 7kk4 B 781-785 disorder
       Region 7kk4 B 786-1010 order
       Region 7kk4 B 1011-1011 disorder
 Evidence X-RAY 7kk6 A Reference
       Region 7kk6 A 662-1011 order
 Evidence X-RAY 7kk6 B Reference
       Region 7kk6 B 662-1010 order
       Region 7kk6 B 1011-1011 disorder
 Evidence X-RAY 7onr A Reference
       Region 7onr A 662-1011 order
 Evidence X-RAY 7onr B Reference
       Region 7onr B 662-1011 order
 Evidence X-RAY 7ons A Reference
       Region 7ons A 662-1011 order
 Evidence X-RAY 7ons B Reference
       Region 7ons B 662-780 order
       Region 7ons B 781-782 disorder
       Region 7ons B 783-1011 order
 Evidence X-RAY 7ont A Reference
       Region 7ont A 662-1011 order
 Evidence X-RAY 7ont B Reference
       Region 7ont B 662-1011 order
 Evidence X-RAY 6xvw A Reference
       Region 6xvw A 663-745 order
       Region 6xvw A 746-748 disorder
       Region 6xvw A 749-780 order
       Region 6xvw A 781-783 disorder
       Region 6xvw A 784-1011 order
       Region 6xvw A 1012-1014 disorder
 Evidence X-RAY 6xvw B Reference
       Region 6xvw B 663-744 order
       Region 6xvw B 745-749 disorder
       Region 6xvw B 750-1011 order
       Region 6xvw B 1012-1014 disorder
Seq 655-1014 Monomer :
 Evidence X-RAY 5a00 A Reference
       Region 5a00 A 655-661 disorder
       Region 5a00 A 662-743 order
       Region 5a00 A 744-748 disorder
       Region 5a00 A 749-782 order
       Region 5a00 A 783-786 disorder
       Region 5a00 A 787-1010 order
       Region 5a00 A 1011-1014 disorder
 Evidence X-RAY 6bhv A Reference
       Region 6bhv A 788-788 disorder
       Region 6bhv A 789-1010 order
       Region 6bhv A 1011-1012 disorder
 Evidence X-RAY 6bhv B Reference
       Region 6bhv B 788-788 disorder
       Region 6bhv B 789-1010 order
       Region 6bhv B 1011-1012 disorder
 Evidence X-RAY 6bhv C Reference
       Region 6bhv C 788-788 disorder
       Region 6bhv C 789-879 order
       Region 6bhv C 880-888 disorder
       Region 6bhv C 889-1010 order
       Region 6bhv C 1011-1012 disorder
 Evidence X-RAY 6bhv D Reference
       Region 6bhv D 788-788 disorder
       Region 6bhv D 789-1011 order
       Region 6bhv D 1012-1012 disorder
 Evidence X-RAY 5ds3 A Reference
       Region 5ds3 A 788-822 order
       Region 5ds3 A 823-825 disorder
       Region 5ds3 A 826-1010 order
       Region 5ds3 A 1011-1012 disorder
 Evidence X-RAY 3gjw A Reference
       Region 3gjw A 662-1011 order
 Evidence X-RAY 3gn7 A Reference
       Region 3gn7 A 662-1011 order
 Evidence X-RAY 4gv7 A Reference
       Region 4gv7 A 662-662 disorder
       Region 4gv7 A 663-1010 order
       Region 4gv7 A 1011-1011 disorder
 Evidence X-RAY 4gv7 B Reference
       Region 4gv7 B 662-662 disorder
       Region 4gv7 B 663-1010 order
       Region 4gv7 B 1011-1011 disorder
 Evidence X-RAY 4gv7 C Reference
       Region 4gv7 C 662-662 disorder
       Region 4gv7 C 663-1010 order
       Region 4gv7 C 1011-1011 disorder
 Evidence X-RAY 4gv7 D Reference
       Region 4gv7 D 662-662 disorder
       Region 4gv7 D 663-1010 order
       Region 4gv7 D 1011-1011 disorder
 Evidence X-RAY 4hhy C Reference
       Region 4hhy C 660-661 disorder
       Region 4hhy C 662-720 order
       Region 4hhy C 721-725 disorder
       Region 4hhy C 726-1011 order
 Evidence X-RAY 4hhy D Reference
       Region 4hhy D 660-664 disorder
       Region 4hhy D 665-679 order
       Region 4hhy D 680-683 disorder
       Region 4hhy D 684-688 order
       Region 4hhy D 689-691 disorder
       Region 4hhy D 692-694 order
       Region 4hhy D 695-698 disorder
       Region 4hhy D 699-743 order
       Region 4hhy D 744-752 disorder
       Region 4hhy D 753-777 order
       Region 4hhy D 778-788 disorder
       Region 4hhy D 789-1004 order
       Region 4hhy D 1005-1011 disorder
 Evidence X-RAY 4hhy A Reference
       Region 4hhy A 660-661 disorder
       Region 4hhy A 662-1010 order
       Region 4hhy A 1011-1011 disorder
 Evidence X-RAY 4hhy B Reference
       Region 4hhy B 660-662 disorder
       Region 4hhy B 663-779 order
       Region 4hhy B 780-787 disorder
       Region 4hhy B 788-1010 order
       Region 4hhy B 1011-1011 disorder
 Evidence X-RAY 4hhz C Reference
       Region 4hhz C 660-661 disorder
       Region 4hhz C 662-1011 order
 Evidence X-RAY 4hhz D Reference
       Region 4hhz D 660-662 disorder
       Region 4hhz D 663-691 order
       Region 4hhz D 692-699 disorder
       Region 4hhz D 700-709 order
       Region 4hhz D 710-732 disorder
       Region 4hhz D 733-743 order
       Region 4hhz D 744-755 disorder
       Region 4hhz D 756-780 order
       Region 4hhz D 781-789 disorder
       Region 4hhz D 790-1010 order
       Region 4hhz D 1011-1011 disorder
 Evidence X-RAY 4hhz A Reference
       Region 4hhz A 660-661 disorder
       Region 4hhz A 662-1010 order
       Region 4hhz A 1011-1011 disorder
 Evidence X-RAY 4hhz B Reference
       Region 4hhz B 660-661 disorder
       Region 4hhz B 662-1011 order
 Evidence X-RAY 5kpn A Reference
       Region 5kpn A 662-723 order
       Region 5kpn A 724-724 disorder
       Region 5kpn A 725-1011 order
 Evidence X-RAY 5kpn B Reference
       Region 5kpn B 662-723 order
       Region 5kpn B 724-724 disorder
       Region 5kpn B 725-747 order
       Region 5kpn B 748-748 disorder
       Region 5kpn B 749-1011 order
 Evidence X-RAY 5kpo A Reference
       Region 5kpo A 662-723 order
       Region 5kpo A 724-724 disorder
       Region 5kpo A 725-1011 order
 Evidence X-RAY 5kpo B Reference
       Region 5kpo B 662-723 order
       Region 5kpo B 724-724 disorder
       Region 5kpo B 725-747 order
       Region 5kpo B 748-748 disorder
       Region 5kpo B 749-1011 order
 Evidence X-RAY 5kpp A Reference
       Region 5kpp A 662-723 order
       Region 5kpp A 724-724 disorder
       Region 5kpp A 725-1011 order
 Evidence X-RAY 5kpp B Reference
       Region 5kpp B 662-723 order
       Region 5kpp B 724-724 disorder
       Region 5kpp B 725-1011 order
 Evidence X-RAY 5kpq A Reference
       Region 5kpq A 662-723 order
       Region 5kpq A 724-724 disorder
       Region 5kpq A 725-1011 order
 Evidence X-RAY 5kpq B Reference
       Region 5kpq B 662-723 order
       Region 5kpq B 724-724 disorder
       Region 5kpq B 725-1011 order
 Evidence X-RAY 3l3l A Reference
       Region 3l3l A 662-1011 order
 Evidence X-RAY 3l3m A Reference
       Region 3l3m A 662-662 disorder
       Region 3l3m A 663-1010 order
       Region 3l3m A 1011-1011 disorder
 Evidence X-RAY 4l6s A Reference
       Region 4l6s A 662-723 order
       Region 4l6s A 724-724 disorder
       Region 4l6s A 725-1011 order
 Evidence X-RAY 4l6s B Reference
       Region 4l6s B 662-1011 order
 Evidence X-RAY 4pjt A Reference
       Region 4pjt A 662-722 order
       Region 4pjt A 723-725 disorder
       Region 4pjt A 726-744 order
       Region 4pjt A 745-747 disorder
       Region 4pjt A 748-780 order
       Region 4pjt A 781-785 disorder
       Region 4pjt A 786-1010 order
       Region 4pjt A 1011-1011 disorder
 Evidence X-RAY 4pjt B Reference
       Region 4pjt B 662-721 order
       Region 4pjt B 722-725 disorder
       Region 4pjt B 726-743 order
       Region 4pjt B 744-749 disorder
       Region 4pjt B 750-780 order
       Region 4pjt B 781-785 disorder
       Region 4pjt B 786-936 order
       Region 4pjt B 937-938 disorder
       Region 4pjt B 939-1010 order
       Region 4pjt B 1011-1011 disorder
 Evidence X-RAY 4pjt C Reference
       Region 4pjt C 662-781 order
       Region 4pjt C 782-784 disorder
       Region 4pjt C 785-1010 order
       Region 4pjt C 1011-1011 disorder
 Evidence X-RAY 4pjt D Reference
       Region 4pjt D 662-662 disorder
       Region 4pjt D 663-721 order
       Region 4pjt D 722-729 disorder
       Region 4pjt D 730-743 order
       Region 4pjt D 744-748 disorder
       Region 4pjt D 749-779 order
       Region 4pjt D 780-787 disorder
       Region 4pjt D 788-1009 order
       Region 4pjt D 1010-1011 disorder
 Evidence X-RAY 4r5w A Reference
       Region 4r5w A 662-782 order
       Region 4r5w A 783-784 disorder
       Region 4r5w A 785-1011 order
 Evidence X-RAY 4r5w B Reference
       Region 4r5w B 662-782 order
       Region 4r5w B 783-784 disorder
       Region 4r5w B 785-1011 order
 Evidence X-RAY 4r6e A Reference
       Region 4r6e A 662-1010 order
       Region 4r6e A 1011-1011 disorder
 Evidence X-RAY 4r6e B Reference
       Region 4r6e B 662-1011 order
 Evidence X-RAY 4r6e C Reference
       Region 4r6e C 662-1010 order
       Region 4r6e C 1011-1011 disorder
 Evidence X-RAY 4r6e D Reference
       Region 4r6e D 662-662 disorder
       Region 4r6e D 663-1010 order
       Region 4r6e D 1011-1011 disorder
 Evidence X-RAY 2rcw A Reference
       Region 2rcw A 662-1011 order
 Evidence X-RAY 4rv6 A Reference
       Region 4rv6 A 662-783 order
       Region 4rv6 A 784-785 disorder
       Region 4rv6 A 786-1010 order
       Region 4rv6 A 1011-1011 disorder
 Evidence X-RAY 4rv6 B Reference
       Region 4rv6 B 662-1010 order
       Region 4rv6 B 1011-1011 disorder
 Evidence X-RAY 4rv6 C Reference
       Region 4rv6 C 662-782 order
       Region 4rv6 C 783-784 disorder
       Region 4rv6 C 785-1010 order
       Region 4rv6 C 1011-1011 disorder
 Evidence X-RAY 4rv6 D Reference
       Region 4rv6 D 662-1010 order
       Region 4rv6 D 1011-1011 disorder
 Evidence X-RAY 1uk0 A Reference
       Region 1uk0 A 662-1011 order
 Evidence X-RAY 1uk0 B Reference
       Region 1uk0 B 662-1011 order
 Evidence X-RAY 1uk1 A Reference
       Region 1uk1 A 662-1011 order
 Evidence X-RAY 1uk1 B Reference
       Region 1uk1 B 662-1011 order
 Evidence X-RAY 4und A Reference
       Region 4und A 662-1010 order
       Region 4und A 1011-1011 disorder
 Evidence X-RAY 4und B Reference
       Region 4und B 662-1010 order
       Region 4und B 1011-1011 disorder
 Evidence X-RAY 4uxb A Reference
       Region 4uxb A 662-722 order
       Region 4uxb A 723-725 disorder
       Region 4uxb A 726-743 order
       Region 4uxb A 744-749 disorder
       Region 4uxb A 750-779 order
       Region 4uxb A 780-787 disorder
       Region 4uxb A 788-823 order
       Region 4uxb A 824-826 disorder
       Region 4uxb A 827-934 order
       Region 4uxb A 935-938 disorder
       Region 4uxb A 939-977 order
       Region 4uxb A 978-980 disorder
       Region 4uxb A 981-1010 order
       Region 4uxb A 1011-1011 disorder
 Evidence X-RAY 4uxb B Reference
       Region 4uxb B 662-743 order
       Region 4uxb B 744-749 disorder
       Region 4uxb B 750-780 order
       Region 4uxb B 781-786 disorder
       Region 4uxb B 787-1009 order
       Region 4uxb B 1010-1011 disorder
 Evidence X-RAY 5wrq A Reference
       Region 5wrq A 662-723 order
       Region 5wrq A 724-724 disorder
       Region 5wrq A 725-1011 order
 Evidence X-RAY 5wrq B Reference
       Region 5wrq B 662-723 order
       Region 5wrq B 724-724 disorder
       Region 5wrq B 725-1011 order
 Evidence X-RAY 5wry A Reference
       Region 5wry A 662-723 order
       Region 5wry A 724-724 disorder
       Region 5wry A 725-1011 order
 Evidence X-RAY 5wry B Reference
       Region 5wry B 662-1011 order
 Evidence X-RAY 5wrz A Reference
       Region 5wrz A 662-723 order
       Region 5wrz A 724-724 disorder
       Region 5wrz A 725-1011 order
 Evidence X-RAY 5wrz B Reference
       Region 5wrz B 662-723 order
       Region 5wrz B 724-724 disorder
       Region 5wrz B 725-1011 order
 Evidence X-RAY 5ws0 A Reference
       Region 5ws0 A 662-723 order
       Region 5ws0 A 724-724 disorder
       Region 5ws0 A 725-1011 order
 Evidence X-RAY 5ws0 B Reference
       Region 5ws0 B 662-723 order
       Region 5ws0 B 724-724 disorder
       Region 5ws0 B 725-1011 order
 Evidence X-RAY 5ws1 A Reference
       Region 5ws1 A 662-723 order
       Region 5ws1 A 724-724 disorder
       Region 5ws1 A 725-1011 order
 Evidence X-RAY 5ws1 B Reference
       Region 5ws1 B 662-723 order
       Region 5ws1 B 724-724 disorder
       Region 5ws1 B 725-1011 order
 Evidence X-RAY 5wtc A Reference
       Region 5wtc A 662-723 order
       Region 5wtc A 724-724 disorder
       Region 5wtc A 725-1011 order
 Evidence X-RAY 5wtc B Reference
       Region 5wtc B 662-723 order
       Region 5wtc B 724-724 disorder
       Region 5wtc B 725-1011 order
 Evidence X-RAY 5xsr A Reference
       Region 5xsr A 662-782 order
       Region 5xsr A 783-784 disorder
       Region 5xsr A 785-823 order
       Region 5xsr A 824-827 disorder
       Region 5xsr A 828-1010 order
       Region 5xsr A 1011-1011 disorder
 Evidence X-RAY 5xst A Reference
       Region 5xst A 662-1010 order
 Evidence X-RAY 5xsu A Reference
       Region 5xsu A 662-781 order
       Region 5xsu A 782-784 disorder
       Region 5xsu A 785-1010 order
       Region 5xsu A 1011-1011 disorder
 Evidence X-RAY 5xsu B Reference
       Region 5xsu B 662-719 order
       Region 5xsu B 720-721 disorder
       Region 5xsu B 722-744 order
       Region 5xsu B 745-746 disorder
       Region 5xsu B 747-781 order
       Region 5xsu B 782-786 disorder
       Region 5xsu B 787-1010 order
       Region 5xsu B 1011-1011 disorder
 Evidence X-RAY 5xsu C Reference
       Region 5xsu C 662-720 order
       Region 5xsu C 721-731 disorder
       Region 5xsu C 732-743 order
       Region 5xsu C 744-748 disorder
       Region 5xsu C 749-780 order
       Region 5xsu C 781-784 disorder
       Region 5xsu C 785-937 order
       Region 5xsu C 938-939 disorder
       Region 5xsu C 940-1011 order
 Evidence X-RAY 5xsu D Reference
       Region 5xsu D 662-664 disorder
       Region 5xsu D 665-691 order
       Region 5xsu D 692-694 disorder
       Region 5xsu D 695-696 order
       Region 5xsu D 697-697 disorder
       Region 5xsu D 698-713 order
       Region 5xsu D 714-714 disorder
       Region 5xsu D 715-720 order
       Region 5xsu D 721-725 disorder
       Region 5xsu D 726-735 order
       Region 5xsu D 736-736 disorder
       Region 5xsu D 737-743 order
       Region 5xsu D 744-748 disorder
       Region 5xsu D 749-754 order
       Region 5xsu D 755-755 disorder
       Region 5xsu D 756-780 order
       Region 5xsu D 781-784 disorder
       Region 5xsu D 785-1009 order
       Region 5xsu D 1010-1011 disorder
 Evidence X-RAY 6nrf A Reference
       Region 6nrf A 788-1010 order
       Region 6nrf A 1011-1012 disorder
 Evidence X-RAY 6nrg A Reference
       Region 6nrg A 788-1010 order
       Region 6nrg A 1011-1012 disorder
 Evidence X-RAY 6nrh A Reference
       Region 6nrh A 788-1010 order
       Region 6nrh A 1011-1012 disorder
 Evidence X-RAY 6nri A Reference
       Region 6nri A 788-1010 order
       Region 6nri A 1011-1012 disorder
 Evidence X-RAY 6nrj A Reference
       Region 6nrj A 788-1010 order
       Region 6nrj A 1011-1012 disorder
 Evidence X-RAY 6ntu A Reference
       Region 6ntu A 788-1010 order
       Region 6ntu A 1011-1012 disorder
Seq 661-1011 Homo tetramer :
 Evidence X-RAY 6vkq D Reference
       Region 6vkq D 661-663 disorder
       Region 6vkq D 664-781 order
       Region 6vkq D 782-789 disorder
       Region 6vkq D 790-1011 order
 Evidence X-RAY 6vkq C Reference
       Region 6vkq C 661-663 disorder
       Region 6vkq C 664-781 order
       Region 6vkq C 782-789 disorder
       Region 6vkq C 790-1011 order
 Evidence X-RAY 6vkq B Reference
       Region 6vkq B 661-663 disorder
       Region 6vkq B 664-781 order
       Region 6vkq B 782-789 disorder
       Region 6vkq B 790-1011 order
 Evidence X-RAY 6vkq A Reference
       Region 6vkq A 661-663 disorder
       Region 6vkq A 664-781 order
       Region 6vkq A 782-789 disorder
       Region 6vkq A 790-1011 order
 Evidence X-RAY 6vko D Reference
       Region 6vko D 661-663 disorder
       Region 6vko D 664-781 order
       Region 6vko D 782-789 disorder
       Region 6vko D 790-1011 order
 Evidence X-RAY 6vko C Reference
       Region 6vko C 661-663 disorder
       Region 6vko C 664-781 order
       Region 6vko C 782-789 disorder
       Region 6vko C 790-1011 order
 Evidence X-RAY 6vko B Reference
       Region 6vko B 661-663 disorder
       Region 6vko B 664-781 order
       Region 6vko B 782-789 disorder
       Region 6vko B 790-1011 order
 Evidence X-RAY 6vko A Reference
       Region 6vko A 661-663 disorder
       Region 6vko A 664-781 order
       Region 6vko A 782-789 disorder
       Region 6vko A 790-1011 order
Seq 661-1011 Homo tetramer :
 Evidence X-RAY 6vkk D Reference
       Region 6vkk D 661-661 disorder
       Region 6vkk D 662-742 order
       Region 6vkk D 743-748 disorder
       Region 6vkk D 749-780 order
       Region 6vkk D 781-785 disorder
       Region 6vkk D 786-1011 order
 Evidence X-RAY 6vkk C Reference
       Region 6vkk C 661-661 disorder
       Region 6vkk C 662-743 order
       Region 6vkk C 744-748 disorder
       Region 6vkk C 749-780 order
       Region 6vkk C 781-785 disorder
       Region 6vkk C 786-1011 order
 Evidence X-RAY 6vkk B Reference
       Region 6vkk B 661-661 disorder
       Region 6vkk B 662-780 order
       Region 6vkk B 781-785 disorder
       Region 6vkk B 786-1011 order
 Evidence X-RAY 6vkk A Reference
       Region 6vkk A 661-661 disorder
       Region 6vkk A 662-780 order
       Region 6vkk A 781-785 disorder
       Region 6vkk A 786-1011 order
Seq 661-1014 Hetero dimer : Q9UNS1
 Evidence X-RAY 4xhu A Reference
       Region 4xhu A 661-721 order
       Region 4xhu A 722-727 disorder
       Region 4xhu A 728-779 order
       Region 4xhu A 780-784 disorder
       Region 4xhu A 785-1012 order
       Region 4xhu A 1013-1014 disorder
 Evidence X-RAY 4xhu C Reference
       Region 4xhu C 661-664 disorder
       Region 4xhu C 665-722 order
       Region 4xhu C 723-723 disorder
       Region 4xhu C 724-779 order
       Region 4xhu C 780-784 disorder
       Region 4xhu C 785-822 order
       Region 4xhu C 823-827 disorder
       Region 4xhu C 828-979 order
       Region 4xhu C 980-980 disorder
       Region 4xhu C 981-1009 order
       Region 4xhu C 1010-1014 disorder
Seq 662-1011 Homo tetramer :
 Evidence X-RAY 1wok D Reference
       Region 1wok D 662-1011 order
 Evidence X-RAY 1wok C Reference
       Region 1wok C 662-1011 order
 Evidence X-RAY 1wok B Reference
       Region 1wok B 662-1011 order
 Evidence X-RAY 1wok A Reference
       Region 1wok A 662-1011 order
Seq 662-1011 Homo hexamer :
 Evidence X-RAY 2rd6 A Reference
       Region 2rd6 A 662-1011 order
Seq 662-1011 Homo tetramer :
 Evidence X-RAY 7kk5 D Reference
       Region 7kk5 D 662-720 order
       Region 7kk5 D 721-726 disorder
       Region 7kk5 D 727-743 order
       Region 7kk5 D 744-748 disorder
       Region 7kk5 D 749-781 order
       Region 7kk5 D 782-787 disorder
       Region 7kk5 D 788-1010 order
       Region 7kk5 D 1011-1011 disorder
 Evidence X-RAY 7kk5 C Reference
       Region 7kk5 C 662-743 order
       Region 7kk5 C 744-749 disorder
       Region 7kk5 C 750-1010 order
       Region 7kk5 C 1011-1011 disorder
 Evidence X-RAY 7kk5 B Reference
       Region 7kk5 B 662-744 order
       Region 7kk5 B 745-746 disorder
       Region 7kk5 B 747-780 order
       Region 7kk5 B 781-784 disorder
       Region 7kk5 B 785-1010 order
       Region 7kk5 B 1011-1011 disorder
 Evidence X-RAY 7kk5 A Reference
       Region 7kk5 A 662-722 order
       Region 7kk5 A 723-725 disorder
       Region 7kk5 A 726-745 order
       Region 7kk5 A 746-747 disorder
       Region 7kk5 A 748-780 order
       Region 7kk5 A 781-785 disorder
       Region 7kk5 A 786-1010 order
       Region 7kk5 A 1011-1011 disorder
 Evidence X-RAY 7kk3 D Reference
       Region 7kk3 D 662-720 order
       Region 7kk3 D 721-726 disorder
       Region 7kk3 D 727-743 order
       Region 7kk3 D 744-748 disorder
       Region 7kk3 D 749-781 order
       Region 7kk3 D 782-787 disorder
       Region 7kk3 D 788-822 order
       Region 7kk3 D 823-826 disorder
       Region 7kk3 D 827-1010 order
       Region 7kk3 D 1011-1011 disorder
 Evidence X-RAY 7kk3 C Reference
       Region 7kk3 C 662-743 order
       Region 7kk3 C 744-749 disorder
       Region 7kk3 C 750-822 order
       Region 7kk3 C 823-826 disorder
       Region 7kk3 C 827-1010 order
       Region 7kk3 C 1011-1011 disorder
 Evidence X-RAY 7kk3 B Reference
       Region 7kk3 B 662-744 order
       Region 7kk3 B 745-746 disorder
       Region 7kk3 B 747-780 order
       Region 7kk3 B 781-784 disorder
       Region 7kk3 B 785-821 order
       Region 7kk3 B 822-827 disorder
       Region 7kk3 B 828-1010 order
       Region 7kk3 B 1011-1011 disorder
 Evidence X-RAY 7kk3 A Reference
       Region 7kk3 A 662-722 order
       Region 7kk3 A 723-725 disorder
       Region 7kk3 A 726-744 order
       Region 7kk3 A 745-747 disorder
       Region 7kk3 A 748-750 order
       Region 7kk3 A 751-752 disorder
       Region 7kk3 A 753-780 order
       Region 7kk3 A 781-785 disorder
       Region 7kk3 A 786-1010 order
       Region 7kk3 A 1011-1011 disorder
Seq 788-1014 Hetero dimer : Q9NWY4
 Evidence X-RAY 6m3i B Reference
       Region 6m3i B 788-880 order
       Region 6m3i B 881-888 disorder
       Region 6m3i B 889-1014 order
Seqphosphorylation
    786-786 Phosphoserine
    782-782 Phosphoserine
    594-594 Phosphothreonine; by PRKDC
    277-277 Phosphoserine
    364-364 Phosphoserine
    368-368 Phosphothreonine
    274-274 Phosphoserine
    185-185 Phosphoserine
    179-179 Phosphoserine
    177-177 Phosphoserine
    41-41 Phosphoserine
Seqacetylation
    621-621 N6-acetyllysine
    600-600 N6-acetyllysine
    105-105 N6-acetyllysine
    131-131 N6-acetyllysine
    97-97 N6-acetyllysine
    2-2 N-acetylalanine
 
Prediction
NeProc
Disorder 1-4,96-109,202-215,358-388,483-521,648-661,781-786
Order 5-91,110-201,216-357,389-482,522-647,662-780,787-1014
ProS 202-202,483-493
AlphaFold
Disorder 1-6,61-61,92-108,202-228,359-387,482-531,643-660,694-695,697-700,781-783,1011-1014
Order 7-60,62-91,109-201,229-358,388-481,532-642,661-693,696-696,701-780,784-1010
Pfam Hmmer
PF00645 12-90 1.8e-39
PF00645 116-200 9.8e-44
PF08063 279-332 3.1e-34
PF00533 385-463 7.2e-12
PF05406 548-633 8.9e-40
PF02877 662-795 1.4e-82
PF00644 797-1007 3.2e-123
SEG 220-239 ,358-386 ,433-448 ,483-495 ,497-509 ,998-1010
Function
Function in SwissProt
This cleavage form irreversibly binds to DNA breaks and interferes with DNA repair, promoting DNA damage-induced apoptosis.