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IID00777
 UniprotP10636
ProteinMicrotubule-associated protein tau
GeneMAPT
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
758
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 5-10 Homo dimer :
 Evidence X-RAY 6n4p C Reference
       Region 6n4p C 5-10 order
 Evidence X-RAY 6n4p A Reference
       Region 6n4p A 5-10 order
Seq 15-22 Hetero trimer :
 Evidence X-RAY 6pxr A Reference
       Region 6pxr A 15-22 order
Seq 52-71 Hetero trimer :
 Evidence X-RAY 5zv3 A Reference
       Region 5zv3 A 52-56 disorder
       Region 5zv3 A 57-68 order
       Region 5zv3 A 69-71 disorder
Seq 52-71 Hetero trimer :
 Evidence X-RAY 6gk8 I Reference
       Region 6gk8 I 52-56 disorder
       Region 6gk8 I 57-69 order
       Region 6gk8 I 70-71 disorder
Seqdisorder 1-124,376-394,461-758
 Evidence NMR Reference
       Region 1-124 disorder
       Region 376-394 disorder
       Region 461-758 disorder
Seq 511-528 Hetero trimer :
 Evidence X-RAY 5e2w P Reference
       Region 5e2w P 511-518 disorder
       Region 5e2w P 519-526 order
       Region 5e2w P 527-528 disorder
Seq 511-528 Hetero trimer :
 Evidence X-RAY 5e2v P Reference
       Region 5e2v P 511-517 disorder
       Region 5e2v P 518-526 order
       Region 5e2v P 527-528 disorder
Seq 515-716 Homo decamer :
 Evidence NMR 8g55 J Reference
       Region 8g55 J 515-580 disorder
       Region 8g55 J 581-643 order
       Region 8g55 J 581-591 high_rmsd
       Region 8g55 J 619-623 high_rmsd
       Region 8g55 J 633-643 high_rmsd
       Region 8g55 J 644-716 disorder
 Evidence NMR 8g55 I Reference
       Region 8g55 I 515-580 disorder
       Region 8g55 I 581-643 order
       Region 8g55 I 581-591 high_rmsd
       Region 8g55 I 619-643 high_rmsd
       Region 8g55 I 644-716 disorder
 Evidence NMR 8g55 H Reference
       Region 8g55 H 515-580 disorder
       Region 8g55 H 581-643 order
       Region 8g55 H 581-591 high_rmsd
       Region 8g55 H 619-623 high_rmsd
       Region 8g55 H 629-643 high_rmsd
       Region 8g55 H 644-716 disorder
 Evidence NMR 8g55 G Reference
       Region 8g55 G 515-580 disorder
       Region 8g55 G 581-643 order
       Region 8g55 G 581-591 high_rmsd
       Region 8g55 G 619-623 high_rmsd
       Region 8g55 G 629-643 high_rmsd
       Region 8g55 G 644-716 disorder
 Evidence NMR 8g55 F Reference
       Region 8g55 F 515-580 disorder
       Region 8g55 F 581-643 order
       Region 8g55 F 581-591 high_rmsd
       Region 8g55 F 619-623 high_rmsd
       Region 8g55 F 629-643 high_rmsd
       Region 8g55 F 644-716 disorder
 Evidence NMR 8g55 E Reference
       Region 8g55 E 515-580 disorder
       Region 8g55 E 581-643 order
       Region 8g55 E 581-591 high_rmsd
       Region 8g55 E 619-623 high_rmsd
       Region 8g55 E 629-643 high_rmsd
       Region 8g55 E 644-716 disorder
 Evidence NMR 8g55 D Reference
       Region 8g55 D 515-580 disorder
       Region 8g55 D 581-643 order
       Region 8g55 D 581-591 high_rmsd
       Region 8g55 D 619-623 high_rmsd
       Region 8g55 D 629-643 high_rmsd
       Region 8g55 D 644-716 disorder
 Evidence NMR 8g55 C Reference
       Region 8g55 C 515-580 disorder
       Region 8g55 C 581-643 order
       Region 8g55 C 581-591 high_rmsd
       Region 8g55 C 619-623 high_rmsd
       Region 8g55 C 629-643 high_rmsd
       Region 8g55 C 644-716 disorder
 Evidence NMR 8g55 B Reference
       Region 8g55 B 515-580 disorder
       Region 8g55 B 581-643 order
       Region 8g55 B 581-591 high_rmsd
       Region 8g55 B 619-623 high_rmsd
       Region 8g55 B 629-643 high_rmsd
       Region 8g55 B 644-716 disorder
 Evidence NMR 8g55 A Reference
       Region 8g55 A 515-580 disorder
       Region 8g55 A 581-643 order
       Region 8g55 A 581-591 high_rmsd
       Region 8g55 A 619-623 high_rmsd
       Region 8g55 A 629-643 high_rmsd
       Region 8g55 A 644-716 disorder
Seq 515-716 Homo pentamer :
 Evidence NMR 8g54 E Reference
       Region 8g54 E 515-590 disorder
       Region 8g54 E 591-642 order
       Region 8g54 E 615-616 high_rmsd
       Region 8g54 E 635-642 high_rmsd
       Region 8g54 E 643-716 disorder
 Evidence NMR 8g54 D Reference
       Region 8g54 D 515-590 disorder
       Region 8g54 D 591-642 order
       Region 8g54 D 615-616 high_rmsd
       Region 8g54 D 637-642 high_rmsd
       Region 8g54 D 643-716 disorder
 Evidence NMR 8g54 C Reference
       Region 8g54 C 515-590 disorder
       Region 8g54 C 591-642 order
       Region 8g54 C 615-616 high_rmsd
       Region 8g54 C 623-623 high_rmsd
       Region 8g54 C 637-642 high_rmsd
       Region 8g54 C 643-716 disorder
 Evidence NMR 8g54 B Reference
       Region 8g54 B 515-590 disorder
       Region 8g54 B 591-642 order
       Region 8g54 B 615-616 high_rmsd
       Region 8g54 B 623-623 high_rmsd
       Region 8g54 B 637-642 high_rmsd
       Region 8g54 B 643-716 disorder
 Evidence NMR 8g54 A Reference
       Region 8g54 A 515-590 disorder
       Region 8g54 A 591-642 order
       Region 8g54 A 615-616 high_rmsd
       Region 8g54 A 623-623 high_rmsd
       Region 8g54 A 637-642 high_rmsd
       Region 8g54 A 643-716 disorder
Seq 527-536 Hetero tetramer : IID00301Complex
 Evidence X-RAY 4fl5 P Reference
       Region 4fl5 P 527-527 disorder
       Region 4fl5 P 528-535 order
       Region 4fl5 P 536-536 disorder
 Evidence X-RAY 4fl5 Q Reference
       Region 4fl5 Q 527-528 disorder
       Region 4fl5 Q 529-533 order
       Region 4fl5 Q 534-536 disorder
 Evidence X-RAY 5hf3 B Reference
       Region 5hf3 B 528-534 order
Seq 527-539 Hetero nonamer :
 Evidence X-RAY 6xli P Reference
       Region 6xli P 527-539 order
 Evidence X-RAY 6xli F Reference
       Region 6xli F 527-539 order
 Evidence X-RAY 6xli E Reference
       Region 6xli E 527-539 order
Seq 528-534 Hetero tetramer : IID00301Complex
 Evidence X-RAY 4y32 C Reference
       Region 4y32 C 528-534 order
 Evidence X-RAY 4y32 D Reference
       Region 4y32 D 528-528 disorder
       Region 4y32 D 529-534 order
 Evidence X-RAY 4y3b C Reference
       Region 4y3b C 528-534 order
 Evidence X-RAY 4y3b D Reference
       Region 4y3b D 528-528 disorder
       Region 4y3b D 529-534 order
 Evidence X-RAY 4y5i F Reference
       Region 4y5i F 528-534 order
 Evidence X-RAY 4y5i G Reference
       Region 4y5i G 528-528 disorder
       Region 4y5i G 529-534 order
 Evidence X-RAY 6fbw B Reference
       Region 6fbw B 528-533 order
 Evidence X-RAY 6fbw D Reference
       Region 6fbw D 528-528 disorder
       Region 6fbw D 529-533 order
Seq 529-533 Hetero dimer : IID00301Complex
 Evidence X-RAY 6fi5 B Reference
       Region 6fi5 B 529-533 order
Seq 532-547 Hetero trimer : A2NHM3
 Evidence X-RAY 4tqe A Reference
       Region 4tqe A 532-547 order
Seq 541-550 Hetero hexamer :
 Evidence X-RAY 7kqk P Reference
       Region 7kqk P 541-550 order
 Evidence X-RAY 7kqk C Reference
       Region 7kqk C 541-550 order
Seq 541-557 Hetero trimer :
 Evidence X-RAY 4glr B Reference
       Region 4glr B 541-541 disorder
       Region 4glr B 542-551 order
       Region 4glr B 552-557 disorder
Seq 541-557 Hetero trimer :
 Evidence X-RAY 4glr A Reference
       Region 4glr A 541-541 disorder
       Region 4glr A 542-551 order
       Region 4glr A 552-557 disorder
Seq 542-554 Hetero dimer : IID00829Complex
 Evidence NMR 1i8h A Reference
       Region 1i8h A 542-554 order
Seq 552-560 Hetero octadecamer :
 Evidence X-RAY 5zia R Reference
       Region 5zia R 552-560 order
 Evidence X-RAY 5zia Q Reference
       Region 5zia Q 552-560 order
 Evidence X-RAY 5zia N Reference
       Region 5zia N 552-560 order
 Evidence X-RAY 5zia J Reference
       Region 5zia J 552-560 order
 Evidence X-RAY 5zia F Reference
       Region 5zia F 552-560 order
 Evidence X-RAY 5zia C Reference
       Region 5zia C 552-560 order
Seq 571-585 Monomer :
 Evidence NMR 5nvb A Reference
       Region 5nvb A 571-585 order
Seq 571-607 Monomer :
 Evidence NMR 5n5a A Reference
       Region 5n5a A 571-607 order
       Region 5n5a A 588-588 high_rmsd
       Region 5n5a A 596-607 high_rmsd
Seq 584-629 Monomer :
 Evidence NMR 2mz7 A Reference
       Region 2mz7 A 584-629 order
       Region 2mz7 A 584-615 high_rmsd
Seq 592-597 Hetero trimer :
 Evidence X-RAY 6lra C Reference
       Region 6lra C 592-597 order
Seq 594-601 Hetero hexamer :
 Evidence X-RAY 7eyc Q Reference
       Region 7eyc Q 594-601 order
 Evidence X-RAY 7eyc P Reference
       Region 7eyc P 594-600 order
       Region 7eyc P 601-601 disorder
Seq 609-636 Monomer :
 Evidence NMR 5n5b A Reference
       Region 5n5b A 609-636 order
       Region 5n5b A 609-614 high_rmsd
Seq 609-638 Hetero trimer : Q52L64,Q99LC4
 Evidence X-RAY 5mp3 D Reference
       Region 5mp3 D 609-614 disorder
       Region 5mp3 D 615-623 order
       Region 5mp3 D 624-638 disorder
 Evidence X-RAY 5mp3 C Reference
       Region 5mp3 C 609-614 disorder
       Region 5mp3 C 615-623 order
       Region 5mp3 C 624-638 disorder
Seq 614-708 Homo decamer :
 Evidence NMR 8g58 A Reference
       Region 8g58 A 614-616 disorder
       Region 8g58 A 617-679 order
       Region 8g58 A 617-621 high_rmsd
       Region 8g58 A 676-679 high_rmsd
       Region 8g58 A 680-708 disorder
 Evidence NMR 8g58 B Reference
       Region 8g58 B 614-616 disorder
       Region 8g58 B 617-679 order
       Region 8g58 B 617-621 high_rmsd
       Region 8g58 B 676-679 high_rmsd
       Region 8g58 B 680-708 disorder
 Evidence NMR 8g58 C Reference
       Region 8g58 C 614-616 disorder
       Region 8g58 C 617-679 order
       Region 8g58 C 617-621 high_rmsd
       Region 8g58 C 676-679 high_rmsd
       Region 8g58 C 680-708 disorder
 Evidence NMR 8g58 D Reference
       Region 8g58 D 614-616 disorder
       Region 8g58 D 617-679 order
       Region 8g58 D 617-621 high_rmsd
       Region 8g58 D 676-679 high_rmsd
       Region 8g58 D 680-708 disorder
 Evidence NMR 8g58 E Reference
       Region 8g58 E 614-616 disorder
       Region 8g58 E 617-679 order
       Region 8g58 E 617-621 high_rmsd
       Region 8g58 E 676-679 high_rmsd
       Region 8g58 E 680-708 disorder
 Evidence NMR 8g58 F Reference
       Region 8g58 F 614-616 disorder
       Region 8g58 F 617-679 order
       Region 8g58 F 617-621 high_rmsd
       Region 8g58 F 676-679 high_rmsd
       Region 8g58 F 680-708 disorder
 Evidence NMR 8g58 G Reference
       Region 8g58 G 614-616 disorder
       Region 8g58 G 617-679 order
       Region 8g58 G 617-621 high_rmsd
       Region 8g58 G 676-679 high_rmsd
       Region 8g58 G 680-708 disorder
 Evidence NMR 8g58 H Reference
       Region 8g58 H 614-616 disorder
       Region 8g58 H 617-679 order
       Region 8g58 H 617-621 high_rmsd
       Region 8g58 H 676-679 high_rmsd
       Region 8g58 H 680-708 disorder
 Evidence NMR 8g58 I Reference
       Region 8g58 I 614-616 disorder
       Region 8g58 I 617-679 order
       Region 8g58 I 617-621 high_rmsd
       Region 8g58 I 676-679 high_rmsd
       Region 8g58 I 680-708 disorder
 Evidence NMR 8g58 J Reference
       Region 8g58 J 614-616 disorder
       Region 8g58 J 617-679 order
       Region 8g58 J 617-621 high_rmsd
       Region 8g58 J 676-679 high_rmsd
       Region 8g58 J 680-708 disorder
Seq 615-628 Hetero dodecamer :
 Evidence X-RAY 5mp1 I Reference
       Region 5mp1 I 615-615 disorder
       Region 5mp1 I 616-622 order
       Region 5mp1 I 623-628 disorder
 Evidence X-RAY 5mp1 E Reference
       Region 5mp1 E 615-615 disorder
       Region 5mp1 E 616-622 order
       Region 5mp1 E 623-628 disorder
 Evidence X-RAY 5mp1 B Reference
       Region 5mp1 B 615-615 disorder
       Region 5mp1 B 616-622 order
       Region 5mp1 B 623-628 disorder
 Evidence X-RAY 5mp1 A Reference
       Region 5mp1 A 615-615 disorder
       Region 5mp1 A 616-622 order
       Region 5mp1 A 623-628 disorder
Seq 615-628 Hetero trimer :
 Evidence X-RAY 5mp5 K Reference
       Region 5mp5 K 615-615 disorder
       Region 5mp5 K 616-622 order
       Region 5mp5 K 623-628 disorder
Seq 615-628 Hetero trimer :
 Evidence X-RAY 5mp5 J Reference
       Region 5mp5 J 615-615 disorder
       Region 5mp5 J 616-621 order
       Region 5mp5 J 622-628 disorder
Seq 615-628 Hetero trimer :
 Evidence X-RAY 5mo3 A Reference
       Region 5mo3 A 615-622 order
       Region 5mo3 A 623-628 disorder
Seq 615-628 Hetero trimer :
 Evidence X-RAY 5mp5 I Reference
       Region 5mp5 I 615-615 disorder
       Region 5mp5 I 616-622 order
       Region 5mp5 I 623-628 disorder
Seq 618-629 Hetero dimer :
 Evidence X-RAY 8opi B Reference
       Region 8opi B 618-620 disorder
       Region 8opi B 621-629 order
Seq 618-629 Hetero dimer :
 Evidence X-RAY 8op0 B Reference
       Region 8op0 B 618-620 disorder
       Region 8op0 B 621-629 order
Seq 618-631 Hetero dimer :
 Evidence X-RAY 8pii B Reference
       Region 8pii B 618-620 disorder
       Region 8pii B 621-630 order
       Region 8pii B 631-631 disorder
Seq 622-627 Homo dimer :
 Evidence X-RAY 6odg B Reference
       Region 6odg B 622-627 order
 Evidence X-RAY 6odg A Reference
       Region 6odg A 622-627 order
Seq 622-634 Homo tetramer :
 Evidence X-RAY 2on9 A Reference
       Region 2on9 A 623-628 order
 Evidence X-RAY 2on9 B Reference
       Region 2on9 B 623-628 order
 Evidence X-RAY 4e0m A Reference
       Region 4e0m A 622-631 order
       Region 4e0m A 632-632 disorder
       Region 4e0m A 633-634 order
 Evidence X-RAY 4e0m B Reference
       Region 4e0m B 622-631 order
       Region 4e0m B 632-632 disorder
       Region 4e0m B 633-634 order
 Evidence X-RAY 4e0m C Reference
       Region 4e0m C 622-631 order
       Region 4e0m C 632-632 disorder
       Region 4e0m C 633-634 order
 Evidence X-RAY 4e0m D Reference
       Region 4e0m D 622-631 order
       Region 4e0m D 632-632 disorder
       Region 4e0m D 633-634 order
 Evidence X-RAY 4e0n A Reference
       Region 4e0n A 622-631 order
       Region 4e0n A 632-632 disorder
       Region 4e0n A 633-634 order
 Evidence X-RAY 4e0n B Reference
       Region 4e0n B 622-631 order
       Region 4e0n B 632-632 disorder
       Region 4e0n B 633-634 order
 Evidence X-RAY 4e0n C Reference
       Region 4e0n C 622-631 order
       Region 4e0n C 632-632 disorder
       Region 4e0n C 633-634 order
 Evidence X-RAY 4e0n D Reference
       Region 4e0n D 622-631 order
       Region 4e0n D 632-632 disorder
       Region 4e0n D 633-634 order
 Evidence X-RAY 4e0o A Reference
       Region 4e0o A 622-631 order
       Region 4e0o A 632-632 disorder
       Region 4e0o A 633-634 order
 Evidence X-RAY 4e0o B Reference
       Region 4e0o B 622-631 order
       Region 4e0o B 632-632 disorder
       Region 4e0o B 633-634 order
 Evidence X-RAY 4e0o C Reference
       Region 4e0o C 622-631 order
       Region 4e0o C 632-632 disorder
       Region 4e0o C 633-634 order
 Evidence X-RAY 4e0o D Reference
       Region 4e0o D 622-631 order
       Region 4e0o D 632-632 disorder
       Region 4e0o D 633-634 order
Seq 623-628 Homo hexamer :
 Evidence X-RAY 3ovl A Reference
       Region 3ovl A 623-628 order
Seq 623-628 Homo octamer :
 Evidence X-RAY 4np8 A Reference
       Region 4np8 A 623-628 order
Seq 625-635 Hetero trimer :
 Evidence X-RAY 6gk7 A Reference
       Region 6gk7 A 625-635 order
Seq 696-725 Hetero hexamer :
 Evidence X-RAY 6dc9 Q Reference
       Region 6dc9 Q 696-719 disorder
       Region 6dc9 Q 720-725 order
 Evidence X-RAY 6dc9 P Reference
       Region 6dc9 P 696-719 disorder
       Region 6dc9 P 720-725 order
Seq 696-725 Hetero dodecamer :
 Evidence X-RAY 6dca S Reference
       Region 6dca S 696-719 disorder
       Region 6dca S 720-725 order
 Evidence X-RAY 6dca R Reference
       Region 6dca R 696-719 disorder
       Region 6dca R 720-725 order
 Evidence X-RAY 6dca Q Reference
       Region 6dca Q 696-719 disorder
       Region 6dca Q 720-725 order
 Evidence X-RAY 6dca P Reference
       Region 6dca P 696-719 disorder
       Region 6dca P 720-725 order
Seq 696-725 Hetero trimer :
 Evidence X-RAY 6dc8 P Reference
       Region 6dc8 P 696-720 disorder
       Region 6dc8 P 721-725 order
Seq 703-725 Hetero trimer :
 Evidence X-RAY 6bb4 P Reference
       Region 6bb4 P 703-708 disorder
       Region 6bb4 P 709-715 order
       Region 6bb4 P 716-725 disorder
Seq 703-725 Hetero trimer :
 Evidence X-RAY 6bb4 Q Reference
       Region 6bb4 Q 703-708 disorder
       Region 6bb4 Q 709-715 order
       Region 6bb4 Q 716-725 disorder
Seq 703-725 Hetero trimer :
 Evidence X-RAY 6bb4 R Reference
       Region 6bb4 R 703-708 disorder
       Region 6bb4 R 709-715 order
       Region 6bb4 R 716-725 disorder
Seq 721-746 Hetero dodecamer :
 Evidence X-RAY 6h06 K Reference
       Region 6h06 K 721-736 disorder
       Region 6h06 K 737-743 order
       Region 6h06 K 744-746 disorder
 Evidence X-RAY 6h06 J Reference
       Region 6h06 J 721-736 disorder
       Region 6h06 J 737-743 order
       Region 6h06 J 744-746 disorder
 Evidence X-RAY 6h06 I Reference
       Region 6h06 I 721-734 disorder
       Region 6h06 I 735-744 order
       Region 6h06 I 745-746 disorder
 Evidence X-RAY 6h06 G Reference
       Region 6h06 G 721-736 disorder
       Region 6h06 G 737-744 order
       Region 6h06 G 745-746 disorder
Seq 733-747 Hetero trimer :
 Evidence X-RAY 5dmg X Reference
       Region 5dmg X 733-735 disorder
       Region 5dmg X 736-742 order
       Region 5dmg X 743-747 disorder
Seq 733-747 Hetero trimer :
 Evidence X-RAY 5dmg P Reference
       Region 5dmg P 733-735 disorder
       Region 5dmg P 736-747 order
Seq 733-747 Hetero trimer :
 Evidence X-RAY 5dmg Z Reference
       Region 5dmg Z 733-736 disorder
       Region 5dmg Z 737-745 order
       Region 5dmg Z 746-747 disorder
SeqProS verified 528-535 Only representative PDB datasets are shown as ProS evidence. Hetero tetramer : IID00301Complex
       Region 4fl5 P 528-535 order
       Region 4fl5 Q 529-533 order
       Region 461-758 disorder
SeqProS verified 542-554 Hetero dimer : IID00829Complex
       Region 1i8h A 542-554 order
       Region 461-758 disorder
SeqProS verified 571-595 complexed with F-actin; Residues with high RMSD values are excluded from the ProS. :
       Region 5n5a A 571-607 order
       Region 461-758 disorder
SeqProS verified 571-595 complexed with F-actin; Residues with high RMSD values are excluded from the ProS. :
       Region 5nvb A 571-585 order
       Region 461-758 disorder
SeqProS verified 615-636 complexed with F-actin; Residues with high RMSD values are excluded from the ProS. :
       Region 5n5b A 609-636 order
       Region 461-758 disorder
SeqProS verified 616-629 complexed with microtubules (tubulin); Residues with high RMSD values are excluded from the ProS. :
       Region 2mz7 A 584-629 order
       Region 461-758 disorder
Seqphosphorylation
    739-739 Phosphoserine; by PDPK1 and TTBK1
    744-744 Phosphothreonine; by TTBK1
    733-733 Phosphoserine; by CaMK2 and TTBK1
    726-726 Phosphoserine
    721-721 Phosphoserine; by CK1 and PDPK1
    720-720 Phosphothreonine
    717-717 Phosphoserine; alternate
    711-711 Phosphotyrosine
    713-713 Phosphoserine; by CK1 and PDPK1
    673-673 Phosphoserine
    669-669 Phosphoserine; by PHK
    641-641 Phosphoserine
    622-622 Phosphoserine; by PHK
    610-610 Phosphoserine
    579-579 Phosphoserine; by MARK1
    602-602 Phosphoserine; by PHK
    552-552 Phosphoserine; by PDPK1
    554-554 Phosphoserine; by PHK
    531-531 Phosphoserine; by PKA
    534-534 Phosphothreonine; by PDPK1
    548-548 Phosphothreonine; by GSK3-beta and PDPK1
    529-529 Phosphothreonine; by BRSK1
    522-522 Phosphothreonine; by CK1 and PDPK1
    515-515 Phosphoserine; by PDPK1 and TTBK1
    519-519 Phosphoserine; by CK1
    516-516 Phosphoserine; by PDPK1 and TTBK1
    514-514 Phosphotyrosine; by TTBK1
    512-512 Phosphoserine
    508-508 Phosphoserine
    502-502 Phosphoserine
    492-492 Phosphothreonine
    498-498 Phosphothreonine; by PDPK1
    486-486 Phosphothreonine
    396-396 Phosphoserine; in PHF-tau
    470-470 Phosphothreonine; by PDPK1
    214-214 Phosphoserine; by SGK1
    111-111 Phosphothreonine
    71-71 Phosphothreonine
    61-61 Phosphoserine
    69-69 Phosphothreonine
    46-46 Phosphoserine
    29-29 Phosphotyrosine
    18-18 Phosphotyrosine; by FYN
Seqacetylation
    702-702 N6-acetyllysine; alternate
    686-686 N6-acetyllysine; alternate
    664-664 N6-acetyllysine; alternate
    660-660 N6-acetyllysine; alternate
    638-638 N6-acetyllysine; alternate
    648-648 N6-acetyllysine; alternate
    634-634 N6-acetyllysine; alternate
    628-628 N6-acetyllysine; alternate
    615-615 N6-acetyllysine; alternate
    607-607 N6-acetyllysine
    598-598 N6-acetyllysine; alternate
    576-576 N6-acetyllysine; alternate
    542-542 N6-acetyllysine
    480-480 N6-acetyllysine; alternate
    2-2 N-acetylalanine
 
Prediction
NeProc
Disorder 1-629,634-652,659-758
Order 630-633,653-658
ProS 4-11,17-41,265-273,305-309,381-386,568-629,634-652,659-717,722-758
AlphaFold
Disorder 1-567,569-569,578-580,582-583,587-587,589-594,596-596,598-625,627-627,631-631,633-645,668-669,671-682,684-685,695-743,758-758
Order 568-568,570-577,581-581,584-586,588-588,595-595,597-597,626-626,628-630,632-632,646-667,670-670,683-683,686-694,744-757
Pfam Hmmer
PF00418 560-591 1.6e-15
PF00418 592-622 6.5e-18
PF00418 623-653 1.3e-16
PF00418 654-685 1.6e-15
SEG 216-226 ,323-340 ,380-403 ,442-453 ,489-540
Function
Function in SwissProt
Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity (PubMed:21985311). The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both (PubMed:21985311, PubMed:32961270). Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.