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IID00779
 UniprotP11388
ProteinDNA topoisomerase 2-alpha
GeneTOP2A
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1531
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 29-428 Homo dimer :
 Evidence X-RAY 1zxm A Reference
       Region 1zxm A 29-345 order
       Region 1zxm A 346-349 disorder
       Region 1zxm A 350-405 order
       Region 1zxm A 406-428 disorder
 Evidence X-RAY 1zxm B Reference
       Region 1zxm B 29-345 order
       Region 1zxm B 346-350 disorder
       Region 1zxm B 351-411 order
       Region 1zxm B 412-428 disorder
 Evidence X-RAY 1zxn A Reference
       Region 1zxn A 29-276 order
       Region 1zxn A 277-287 disorder
       Region 1zxn A 288-338 order
       Region 1zxn A 339-353 disorder
       Region 1zxn A 354-404 order
       Region 1zxn A 405-406 disorder
       Region 1zxn A 407-422 order
       Region 1zxn A 423-428 disorder
 Evidence X-RAY 1zxn B Reference
       Region 1zxn B 29-276 order
       Region 1zxn B 277-286 disorder
       Region 1zxn B 287-344 order
       Region 1zxn B 345-351 disorder
       Region 1zxn B 352-424 order
       Region 1zxn B 425-428 disorder
 Evidence X-RAY 1zxn C Reference
       Region 1zxn C 29-153 order
       Region 1zxn C 154-156 disorder
       Region 1zxn C 157-275 order
       Region 1zxn C 276-286 disorder
       Region 1zxn C 287-426 order
       Region 1zxn C 427-428 disorder
 Evidence X-RAY 1zxn D Reference
       Region 1zxn D 29-276 order
       Region 1zxn D 277-286 disorder
       Region 1zxn D 287-342 order
       Region 1zxn D 343-351 disorder
       Region 1zxn D 352-374 order
       Region 1zxn D 375-376 disorder
       Region 1zxn D 377-408 order
       Region 1zxn D 409-413 disorder
       Region 1zxn D 414-425 order
       Region 1zxn D 426-428 disorder
 Evidence X-RAY 4r1f A Reference
       Region 4r1f A 29-276 order
       Region 4r1f A 277-287 disorder
       Region 4r1f A 288-338 order
       Region 4r1f A 339-353 disorder
       Region 4r1f A 354-404 order
       Region 4r1f A 405-406 disorder
       Region 4r1f A 407-422 order
       Region 4r1f A 423-428 disorder
 Evidence X-RAY 4r1f B Reference
       Region 4r1f B 29-276 order
       Region 4r1f B 277-286 disorder
       Region 4r1f B 287-344 order
       Region 4r1f B 345-351 disorder
       Region 4r1f B 352-424 order
       Region 4r1f B 425-428 disorder
 Evidence X-RAY 4r1f C Reference
       Region 4r1f C 29-153 order
       Region 4r1f C 154-156 disorder
       Region 4r1f C 157-275 order
       Region 4r1f C 276-286 disorder
       Region 4r1f C 287-426 order
       Region 4r1f C 427-428 disorder
 Evidence X-RAY 4r1f D Reference
       Region 4r1f D 29-276 order
       Region 4r1f D 277-286 disorder
       Region 4r1f D 287-342 order
       Region 4r1f D 343-351 disorder
       Region 4r1f D 352-408 order
       Region 4r1f D 409-413 disorder
       Region 4r1f D 414-425 order
       Region 4r1f D 426-428 disorder
Seq 429-1193 Homo dimer :
 Evidence X-RAY 4fm9 A Reference
       Region 4fm9 A 431-432 disorder
       Region 4fm9 A 433-1092 order
       Region 4fm9 A 1093-1123 disorder
       Region 4fm9 A 1124-1190 order
       Region 4fm9 A 1191-1193 disorder
 Evidence X-RAY 5gwk A Reference
       Region 5gwk A 429-435 disorder
       Region 5gwk A 436-946 order
       Region 5gwk A 947-949 disorder
       Region 5gwk A 950-1095 order
       Region 5gwk A 1096-1120 disorder
       Region 5gwk A 1121-1187 order
       Region 5gwk A 1188-1188 disorder
 Evidence X-RAY 5gwk B Reference
       Region 5gwk B 429-435 disorder
       Region 5gwk B 436-946 order
       Region 5gwk B 947-949 disorder
       Region 5gwk B 950-1095 order
       Region 5gwk B 1096-1120 disorder
       Region 5gwk B 1121-1187 order
       Region 5gwk B 1188-1188 disorder
Seq 1198-1207 Hetero dimer : IID00111Complex
 Evidence X-RAY 5nne C Reference
       Region 5nne C 1198-1207 order
SeqProS predicted 1198-1207 This region is predicted to be disordered by AlphaFold (pLDDT <68.5) and NeProc. Hetero dimer : IID00111Complex
       Region 5nne C 1198-1207 order
Seqphosphorylation
    1504-1504 Phosphoserine
    1525-1525 Phosphoserine
    1476-1476 Phosphoserine
    1495-1495 Phosphoserine
    1471-1471 Phosphoserine
    1474-1474 Phosphoserine
    1469-1469 Phosphoserine; by CK2
    1470-1470 Phosphothreonine
    1449-1449 Phosphoserine
    1393-1393 Phosphoserine
    1391-1391 Phosphoserine
    1392-1392 Phosphoserine
    1387-1387 Phosphoserine
    1374-1374 Phosphoserine
    1377-1377 Phosphoserine
    1351-1351 Phosphoserine
    1354-1354 Phosphoserine
    1343-1343 Phosphothreonine; by PLK3
    1337-1337 Phosphoserine
    1327-1327 Phosphothreonine
    1332-1332 Phosphoserine
    1302-1302 Phosphoserine
    1297-1297 Phosphoserine
    1299-1299 Phosphoserine
    1295-1295 Phosphoserine
    1244-1244 Phosphothreonine
    1247-1247 Phosphoserine
    1213-1213 Phosphoserine
    1205-1205 Phosphothreonine
    282-282 Phosphothreonine
    1106-1106 Phosphoserine; by CK1
    4-4 Phosphoserine
Seqacetylation
    1422-1422 N6-acetyllysine; alternate
    1442-1442 N6-acetyllysine; alternate
    1-1 N-acetylmethionine
 
Prediction
NeProc
Disorder 1-32,1088-1121,1185-1531
Order 33-1087,1122-1184
ProS 4-10,28-32,1088-1096,1185-1191,1209-1225,1325-1328,1516-1531
AlphaFold
Disorder 1-27,281-282,346-348,428-429,1095-1123,1190-1208,1234-1531
Order 28-280,283-345,349-427,430-1094,1124-1189,1209-1233
Pfam Hmmer
PF02518 76-224 1.7e-15
PF00204 270-430 2.6e-53
PF00521 713-1183 2.6e-159
PF08070 1435-1523 5.5e-53
SEG 334-352 ,684-695 ,1099-1117 ,1192-1204 ,1228-1243 ,1295-1306 ,1329-1348 ,1406-1434
Function
Function in SwissProt
Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand (PubMed:17567603, PubMed:18790802, PubMed:22013166, PubMed:22323612). May play a role in regulating the period length of BMAL1 transcriptional oscillation (By similarity).