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IID00780
 UniprotP12830
ProteinCadherin-1
GeneCDH1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
882
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 155-253 Hetero tetramer : Q96E93
 Evidence X-RAY 3ff7 B Reference
       Region 3ff7 B 155-166 order
       Region 3ff7 B 167-168 disorder
       Region 3ff7 B 169-253 order
 Evidence X-RAY 3ff7 A Reference
       Region 3ff7 A 155-164 order
       Region 3ff7 A 165-167 disorder
       Region 3ff7 A 168-253 order
Seq 155-254 Hetero tetramer : O88713
 Evidence X-RAY 3ff8 B Reference
       Region 3ff8 B 155-253 order
       Region 3ff8 B 254-254 disorder
 Evidence X-RAY 3ff8 A Reference
       Region 3ff8 A 155-254 order
Seq 155-367 Hetero dimer : P0DJM0
 Evidence X-RAY 8h62 B Reference
       Region 8h62 B 155-367 order
Seq 155-367 Homo dimer :
 Evidence X-RAY 2o72 A Reference
       Region 2o72 A 155-367 order
 Evidence X-RAY 4zt1 A Reference
       Region 4zt1 A 157-158 disorder
       Region 4zt1 A 159-367 order
 Evidence X-RAY 4zt1 B Reference
       Region 4zt1 B 157-158 disorder
       Region 4zt1 B 159-367 order
 Evidence X-RAY 4zte A Reference
       Region 4zte A 157-157 disorder
       Region 4zte A 158-367 order
 Evidence X-RAY 4zte B Reference
       Region 4zte B 157-157 disorder
       Region 4zte B 158-367 order
Seq 155-371 Hetero trimer :
 Evidence X-RAY 6cxy C Reference
       Region 6cxy C 155-367 order
       Region 6cxy C 368-371 disorder
Seq 155-371 Hetero trimer :
 Evidence X-RAY 6vel C Reference
       Region 6vel C 155-234 order
       Region 6vel C 235-238 disorder
       Region 6vel C 239-367 order
       Region 6vel C 368-371 disorder
Seq 155-698 Hetero hexamer :
 Evidence X-RAY 7stz D Reference
       Region 7stz D 155-463 order
       Region 7stz D 464-466 disorder
       Region 7stz D 467-516 order
       Region 7stz D 517-518 disorder
       Region 7stz D 519-545 order
       Region 7stz D 546-549 disorder
       Region 7stz D 550-570 order
       Region 7stz D 571-573 disorder
       Region 7stz D 574-584 order
       Region 7stz D 585-587 disorder
       Region 7stz D 588-591 order
       Region 7stz D 592-698 disorder
 Evidence X-RAY 7stz C Reference
       Region 7stz C 155-694 order
       Region 7stz C 695-698 disorder
Seq 156-258 Hetero dimer : P0DJM0
 Evidence X-RAY 1o6s B Reference
       Region 1o6s B 156-254 order
       Region 1o6s B 255-255 disorder
 Evidence X-RAY 2omt B Reference
       Region 2omt B 156-254 order
       Region 2omt B 255-255 disorder
 Evidence X-RAY 2omu B Reference
       Region 2omu B 156-255 order
 Evidence X-RAY 2omv B Reference
       Region 2omv B 156-254 order
       Region 2omv B 255-255 disorder
 Evidence X-RAY 2omx B Reference
       Region 2omx B 156-258 order
 Evidence X-RAY 2omy B Reference
       Region 2omy B 156-254 order
 Evidence X-RAY 2omz B Reference
       Region 2omz B 156-254 order
Seqdisorder 736-781
 Evidence NMR Reference
       Region 736-781 disorder
Seq 756-773 Hetero dimer : O60716
 Evidence X-RAY 3l6x B Reference
       Region 3l6x B 756-773 order
 Evidence X-RAY 3l6y B Reference
       Region 3l6y B 756-773 order
 Evidence X-RAY 3l6y D Reference
       Region 3l6y D 756-773 order
 Evidence X-RAY 3l6y F Reference
       Region 3l6y F 756-773 order
SeqProS verified 756-773 Hetero dimer : O60716
       Region 3l6x B 756-773 order
       Region 3l6y B 756-773 order
       Region 3l6y D 756-773 order
       Region 3l6y F 756-773 order
       Region 736-781 disorder
Seqphosphorylation
    840-840 Phosphoserine
    846-846 Phosphoserine
    838-838 Phosphoserine
    793-793 Phosphoserine
    770-770 Phosphoserine
    755-755 Phosphotyrosine; by SRC
    754-754 Phosphotyrosine; by SRC
    753-753 Phosphotyrosine; by SRC
 
Prediction
NeProc
Disorder 1-23,119-145,732-765,770-799,840-856,878-882
Order 24-118,146-731,766-769,800-839,857-877
ProS 4-23,138-145,732-765,770-796,840-850
AlphaFold
Disorder 1-27,63-65,119-157,692-693,696-710,731-798,800-800,803-806,818-819,822-860,875-882
Order 28-62,66-118,158-691,694-695,711-730,799-799,801-802,807-817,820-821,861-874
Pfam Hmmer
PF00028 159-253 2.7e-18
PF00028 267-366 1.8e-30
PF00028 380-478 2.6e-22
PF00028 491-586 7.2e-16
PF00028 598-686 1.4e-15
PF01049 732-879 6.3e-97
SEG 5-21 ,284-299 ,357-371 ,464-480 ,703-731 ,753-766 ,837-853
Function
Function in SwissProt
(Microbial infection) Serves as a receptor for Listeria monocytogenes; internalin A (InlA) binds to this protein and promotes uptake of the bacteria.