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IID00782
 UniprotP15056
ProteinSerine/threonine-protein kinase B-raf
GeneBRAF
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
766
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 36-110 Hetero tetramer : Q8IVT5
 Evidence X-RAY 5vyk C Reference
       Region 5vyk C 36-41 disorder
       Region 5vyk C 42-105 order
       Region 5vyk C 106-110 disorder
 Evidence X-RAY 5vyk A Reference
       Region 5vyk A 36-41 disorder
       Region 5vyk A 42-104 order
       Region 5vyk A 105-110 disorder
Seq 36-114 Monomer :
 Evidence X-RAY 5vr3 A Reference
       Region 5vr3 A 36-40 disorder
       Region 5vr3 A 41-68 order
       Region 5vr3 A 69-70 disorder
       Region 5vr3 A 71-102 order
       Region 5vr3 A 103-114 disorder
Seq 149-232 Monomer :
 Evidence NMR 5j17 A Reference
       Region 5j17 A 151-230 order
       Region 5j17 A 151-151 high_rmsd
       Region 5j17 A 230-230 high_rmsd
       Region 5j17 A 231-232 disorder
 Evidence NMR 5j18 A Reference
       Region 5j18 A 151-232 order
       Region 5j18 A 151-151 high_rmsd
       Region 5j18 A 230-232 high_rmsd
 Evidence NMR 5j2r A Reference
       Region 5j2r A 151-232 order
       Region 5j2r A 151-151 high_rmsd
       Region 5j2r A 229-232 high_rmsd
 Evidence NMR 2l05 A Reference
       Region 2l05 A 149-232 order
       Region 2l05 A 149-150 high_rmsd
       Region 2l05 A 231-232 high_rmsd
Seq 153-237 Homo dimer :
 Evidence X-RAY 3ny5 D Reference
       Region 3ny5 D 153-200 order
       Region 3ny5 D 201-204 disorder
       Region 3ny5 D 205-232 order
       Region 3ny5 D 233-237 disorder
 Evidence X-RAY 3ny5 C Reference
       Region 3ny5 C 153-201 order
       Region 3ny5 C 202-204 disorder
       Region 3ny5 C 205-235 order
       Region 3ny5 C 236-237 disorder
 Evidence X-RAY 3ny5 B Reference
       Region 3ny5 B 153-201 order
       Region 3ny5 B 202-203 disorder
       Region 3ny5 B 204-235 order
       Region 3ny5 B 236-237 disorder
 Evidence X-RAY 3ny5 A Reference
       Region 3ny5 A 153-201 order
       Region 3ny5 A 202-204 disorder
       Region 3ny5 A 205-233 order
       Region 3ny5 A 234-237 disorder
Seq 432-726 Hetero dimer : Q02750
 Evidence X-RAY 7m0t A Reference
       Region 7m0t A 445-447 disorder
       Region 7m0t A 448-721 order
       Region 7m0t A 722-723 disorder
 Evidence X-RAY 7m0u A Reference
       Region 7m0u A 445-448 disorder
       Region 7m0u A 449-722 order
       Region 7m0u A 723-723 disorder
 Evidence X-RAY 7m0v A Reference
       Region 7m0v A 445-448 disorder
       Region 7m0v A 449-722 order
       Region 7m0v A 723-723 disorder
 Evidence X-RAY 7m0w A Reference
       Region 7m0w A 445-447 disorder
       Region 7m0w A 448-721 order
       Region 7m0w A 722-723 disorder
 Evidence X-RAY 7m0x A Reference
       Region 7m0x A 445-446 disorder
       Region 7m0x A 447-722 order
       Region 7m0x A 723-723 disorder
 Evidence X-RAY 7m0y A Reference
       Region 7m0y A 445-446 disorder
       Region 7m0y A 447-721 order
       Region 7m0y A 722-723 disorder
 Evidence X-RAY 7m0z A Reference
       Region 7m0z A 445-448 disorder
       Region 7m0z A 449-721 order
       Region 7m0z A 722-723 disorder
 Evidence X-RAY 6pp9 A Reference
       Region 6pp9 A 445-446 disorder
       Region 6pp9 A 447-722 order
       Region 6pp9 A 723-723 disorder
 Evidence X-RAY 6u2g B Reference
       Region 6u2g B 432-450 disorder
       Region 6u2g B 451-602 order
       Region 6u2g B 603-610 disorder
       Region 6u2g B 611-722 order
       Region 6u2g B 723-726 disorder
 Evidence X-RAY 6v2w A Reference
       Region 6v2w A 445-446 disorder
       Region 6v2w A 447-721 order
       Region 6v2w A 722-723 disorder
Seq 432-726 Hetero tetramer : Q02750
 Evidence X-RAY 4mne B Reference
       Region 4mne B 432-448 disorder
       Region 4mne B 449-464 order
       Region 4mne B 465-468 disorder
       Region 4mne B 469-722 order
       Region 4mne B 723-726 disorder
 Evidence X-RAY 4mne C Reference
       Region 4mne C 432-448 disorder
       Region 4mne C 449-463 order
       Region 4mne C 464-468 disorder
       Region 4mne C 469-602 order
       Region 4mne C 603-609 disorder
       Region 4mne C 610-720 order
       Region 4mne C 721-726 disorder
 Evidence X-RAY 4mne F Reference
       Region 4mne F 432-448 disorder
       Region 4mne F 449-463 order
       Region 4mne F 464-469 disorder
       Region 4mne F 470-602 order
       Region 4mne F 603-611 disorder
       Region 4mne F 612-721 order
       Region 4mne F 722-726 disorder
 Evidence X-RAY 4mne G Reference
       Region 4mne G 432-448 disorder
       Region 4mne G 449-463 order
       Region 4mne G 464-468 disorder
       Region 4mne G 469-602 order
       Region 4mne G 603-610 disorder
       Region 4mne G 611-720 order
       Region 4mne G 721-726 disorder
Seq 432-727 Monomer :
 Evidence X-RAY 6b8u A Reference
       Region 6b8u A 445-448 disorder
       Region 6b8u A 449-598 order
       Region 6b8u A 599-614 disorder
       Region 6b8u A 615-627 order
       Region 6b8u A 628-630 disorder
       Region 6b8u A 631-720 order
       Region 6b8u A 721-723 disorder
 Evidence X-RAY 6b8u B Reference
       Region 6b8u B 445-446 disorder
       Region 6b8u B 447-484 order
       Region 6b8u B 485-488 disorder
       Region 6b8u B 489-596 order
       Region 6b8u B 597-615 disorder
       Region 6b8u B 616-627 order
       Region 6b8u B 628-630 disorder
       Region 6b8u B 631-720 order
       Region 6b8u B 721-723 disorder
 Evidence X-RAY 3c4c A Reference
       Region 3c4c A 444-447 disorder
       Region 3c4c A 448-596 order
       Region 3c4c A 597-613 disorder
       Region 3c4c A 614-721 order
 Evidence X-RAY 3c4c B Reference
       Region 3c4c B 444-447 disorder
       Region 3c4c B 448-595 order
       Region 3c4c B 596-613 disorder
       Region 3c4c B 614-721 order
 Evidence X-RAY 5c9c A Reference
       Region 5c9c A 432-448 disorder
       Region 5c9c A 449-486 order
       Region 5c9c A 487-488 disorder
       Region 5c9c A 489-599 order
       Region 5c9c A 600-615 disorder
       Region 5c9c A 616-720 order
       Region 5c9c A 721-726 disorder
 Evidence X-RAY 5c9c B Reference
       Region 5c9c B 432-448 disorder
       Region 5c9c B 449-597 order
       Region 5c9c B 598-615 disorder
       Region 5c9c B 616-627 order
       Region 5c9c B 628-630 disorder
       Region 5c9c B 631-720 order
       Region 5c9c B 721-726 disorder
 Evidence X-RAY 6cad A Reference
       Region 6cad A 444-448 disorder
       Region 6cad A 449-465 order
       Region 6cad A 466-466 disorder
       Region 6cad A 467-486 order
       Region 6cad A 487-488 disorder
       Region 6cad A 489-596 order
       Region 6cad A 597-613 disorder
       Region 6cad A 614-627 order
       Region 6cad A 628-631 disorder
       Region 6cad A 632-659 order
       Region 6cad A 660-660 disorder
       Region 6cad A 661-722 order
       Region 6cad A 723-723 disorder
 Evidence X-RAY 6cad B Reference
       Region 6cad B 444-448 disorder
       Region 6cad B 449-465 order
       Region 6cad B 466-467 disorder
       Region 6cad B 468-544 order
       Region 6cad B 545-545 disorder
       Region 6cad B 546-595 order
       Region 6cad B 596-613 disorder
       Region 6cad B 614-627 order
       Region 6cad B 628-631 disorder
       Region 6cad B 632-721 order
       Region 6cad B 722-723 disorder
 Evidence X-RAY 4cqe A Reference
       Region 4cqe A 448-448 disorder
       Region 4cqe A 449-466 order
       Region 4cqe A 467-468 disorder
       Region 4cqe A 469-596 order
       Region 4cqe A 597-614 disorder
       Region 4cqe A 615-628 order
       Region 4cqe A 629-630 disorder
       Region 4cqe A 631-720 order
       Region 4cqe A 721-723 disorder
 Evidence X-RAY 4cqe B Reference
       Region 4cqe B 448-465 order
       Region 4cqe B 466-468 disorder
       Region 4cqe B 469-596 order
       Region 4cqe B 597-614 disorder
       Region 4cqe B 615-626 order
       Region 4cqe B 627-630 disorder
       Region 4cqe B 631-720 order
       Region 4cqe B 721-723 disorder
 Evidence X-RAY 5csw A Reference
       Region 5csw A 442-448 disorder
       Region 5csw A 449-595 order
       Region 5csw A 596-614 disorder
       Region 5csw A 615-721 order
 Evidence X-RAY 5csw B Reference
       Region 5csw B 442-446 disorder
       Region 5csw B 447-597 order
       Region 5csw B 598-615 disorder
       Region 5csw B 616-626 order
       Region 5csw B 627-631 disorder
       Region 5csw B 632-721 order
 Evidence X-RAY 5csx A Reference
       Region 5csx A 442-447 disorder
       Region 5csx A 448-603 order
       Region 5csx A 604-613 disorder
       Region 5csx A 614-629 order
       Region 5csx A 630-631 disorder
       Region 5csx A 632-720 order
       Region 5csx A 721-721 disorder
 Evidence X-RAY 5ct7 A Reference
       Region 5ct7 A 445-448 disorder
       Region 5ct7 A 449-598 order
       Region 5ct7 A 599-614 disorder
       Region 5ct7 A 615-721 order
       Region 5ct7 A 722-723 disorder
 Evidence X-RAY 5ct7 B Reference
       Region 5ct7 B 445-448 disorder
       Region 5ct7 B 449-595 order
       Region 5ct7 B 596-614 disorder
       Region 5ct7 B 615-721 order
       Region 5ct7 B 722-723 disorder
 Evidence X-RAY 4e4x A Reference
       Region 4e4x A 432-447 disorder
       Region 4e4x A 448-605 order
       Region 4e4x A 606-612 disorder
       Region 4e4x A 613-721 order
       Region 4e4x A 722-726 disorder
 Evidence X-RAY 4e4x B Reference
       Region 4e4x B 432-447 disorder
       Region 4e4x B 448-721 order
       Region 4e4x B 722-726 disorder
 Evidence X-RAY 2fb8 A Reference
       Region 2fb8 A 445-448 disorder
       Region 2fb8 A 449-600 order
       Region 2fb8 A 601-613 disorder
       Region 2fb8 A 614-720 order
       Region 2fb8 A 721-723 disorder
 Evidence X-RAY 2fb8 B Reference
       Region 2fb8 B 445-448 disorder
       Region 2fb8 B 449-600 order
       Region 2fb8 B 601-613 disorder
       Region 2fb8 B 614-720 order
       Region 2fb8 B 721-723 disorder
 Evidence X-RAY 4g9c A Reference
       Region 4g9c A 432-447 disorder
       Region 4g9c A 448-601 order
       Region 4g9c A 602-612 disorder
       Region 4g9c A 613-723 order
       Region 4g9c A 724-726 disorder
 Evidence X-RAY 4g9c B Reference
       Region 4g9c B 432-447 disorder
       Region 4g9c B 448-600 order
       Region 4g9c B 601-612 disorder
       Region 4g9c B 613-723 order
       Region 4g9c B 724-726 disorder
 Evidence X-RAY 4g9r A Reference
       Region 4g9r A 432-447 disorder
       Region 4g9r A 448-602 order
       Region 4g9r A 603-614 disorder
       Region 4g9r A 615-721 order
       Region 4g9r A 722-726 disorder
 Evidence X-RAY 4g9r B Reference
       Region 4g9r B 432-447 disorder
       Region 4g9r B 448-601 order
       Region 4g9r B 602-614 disorder
       Region 4g9r B 615-721 order
       Region 4g9r B 722-726 disorder
 Evidence X-RAY 4h58 A Reference
       Region 4h58 A 448-601 order
       Region 4h58 A 602-613 disorder
       Region 4h58 A 614-722 order
 Evidence X-RAY 4h58 B Reference
       Region 4h58 B 448-599 order
       Region 4h58 B 600-612 disorder
       Region 4h58 B 613-722 order
 Evidence X-RAY 4h58 C Reference
       Region 4h58 C 448-448 disorder
       Region 4h58 C 449-628 order
       Region 4h58 C 629-630 disorder
       Region 4h58 C 631-722 order
 Evidence X-RAY 5hi2 A Reference
       Region 5hi2 A 444-448 disorder
       Region 5hi2 A 449-485 order
       Region 5hi2 A 491-597 order
       Region 5hi2 A 598-615 disorder
       Region 5hi2 A 616-627 order
       Region 5hi2 A 628-630 disorder
       Region 5hi2 A 631-721 order
       Region 5hi2 A 722-723 disorder
 Evidence X-RAY 5hie A Reference
       Region 5hie A 432-448 disorder
       Region 5hie A 449-485 order
       Region 5hie A 491-603 order
       Region 5hie A 604-614 disorder
       Region 5hie A 615-722 order
       Region 5hie A 723-726 disorder
 Evidence X-RAY 5hie B Reference
       Region 5hie B 432-448 disorder
       Region 5hie B 449-485 order
       Region 5hie B 491-603 order
       Region 5hie B 604-613 disorder
       Region 5hie B 614-722 order
       Region 5hie B 723-726 disorder
 Evidence X-RAY 5hie C Reference
       Region 5hie C 432-448 disorder
       Region 5hie C 449-485 order
       Region 5hie C 491-597 order
       Region 5hie C 598-613 disorder
       Region 5hie C 614-722 order
       Region 5hie C 723-726 disorder
 Evidence X-RAY 5hie D Reference
       Region 5hie D 432-448 disorder
       Region 5hie D 449-485 order
       Region 5hie D 491-597 order
       Region 5hie D 598-613 disorder
       Region 5hie D 614-722 order
       Region 5hie D 723-726 disorder
 Evidence X-RAY 3idp B Reference
       Region 3idp B 434-448 disorder
       Region 3idp B 449-597 order
       Region 3idp B 598-613 disorder
       Region 3idp B 614-720 order
       Region 3idp B 721-727 disorder
 Evidence X-RAY 3idp A Reference
       Region 3idp A 434-448 disorder
       Region 3idp A 449-599 order
       Region 3idp A 600-614 disorder
       Region 3idp A 615-628 order
       Region 3idp A 629-630 disorder
       Region 3idp A 631-720 order
       Region 3idp A 721-727 disorder
 Evidence X-RAY 3ii5 A Reference
       Region 3ii5 A 432-447 disorder
       Region 3ii5 A 448-600 order
       Region 3ii5 A 601-611 disorder
       Region 3ii5 A 612-720 order
       Region 3ii5 A 721-726 disorder
 Evidence X-RAY 3ii5 B Reference
       Region 3ii5 B 432-448 disorder
       Region 3ii5 B 449-598 order
       Region 3ii5 B 599-614 disorder
       Region 3ii5 B 615-721 order
       Region 3ii5 B 722-726 disorder
 Evidence X-RAY 5ita A Reference
       Region 5ita A 448-597 order
       Region 5ita A 598-615 disorder
       Region 5ita A 616-627 order
       Region 5ita A 628-630 disorder
       Region 5ita A 631-718 order
       Region 5ita A 719-723 disorder
 Evidence X-RAY 5ita B Reference
       Region 5ita B 448-465 order
       Region 5ita B 466-468 disorder
       Region 5ita B 469-595 order
       Region 5ita B 596-613 disorder
       Region 5ita B 614-628 order
       Region 5ita B 629-629 disorder
       Region 5ita B 630-721 order
       Region 5ita B 722-723 disorder
 Evidence X-RAY 4jvg B Reference
       Region 4jvg B 444-447 disorder
       Region 4jvg B 448-599 order
       Region 4jvg B 600-615 disorder
       Region 4jvg B 616-722 order
       Region 4jvg B 723-723 disorder
 Evidence X-RAY 4jvg A Reference
       Region 4jvg A 444-447 disorder
       Region 4jvg A 448-602 order
       Region 4jvg A 603-615 disorder
       Region 4jvg A 616-722 order
       Region 4jvg A 723-723 disorder
 Evidence X-RAY 4jvg C Reference
       Region 4jvg C 444-447 disorder
       Region 4jvg C 448-598 order
       Region 4jvg C 599-615 disorder
       Region 4jvg C 616-722 order
       Region 4jvg C 723-723 disorder
 Evidence X-RAY 4jvg D Reference
       Region 4jvg D 444-447 disorder
       Region 4jvg D 448-602 order
       Region 4jvg D 603-615 disorder
       Region 4jvg D 616-722 order
       Region 4jvg D 723-723 disorder
 Evidence X-RAY 4ksp A Reference
       Region 4ksp A 445-447 disorder
       Region 4ksp A 448-596 order
       Region 4ksp A 597-614 disorder
       Region 4ksp A 615-722 order
       Region 4ksp A 723-726 disorder
 Evidence X-RAY 4ksp B Reference
       Region 4ksp B 445-447 disorder
       Region 4ksp B 448-597 order
       Region 4ksp B 598-614 disorder
       Region 4ksp B 615-720 order
       Region 4ksp B 721-726 disorder
 Evidence X-RAY 4ksq A Reference
       Region 4ksq A 445-447 disorder
       Region 4ksq A 448-597 order
       Region 4ksq A 598-614 disorder
       Region 4ksq A 615-722 order
       Region 4ksq A 723-726 disorder
 Evidence X-RAY 4ksq B Reference
       Region 4ksq B 445-448 disorder
       Region 4ksq B 449-597 order
       Region 4ksq B 598-614 disorder
       Region 4ksq B 615-720 order
       Region 4ksq B 721-726 disorder
 Evidence X-RAY 3ppj A Reference
       Region 3ppj A 432-447 disorder
       Region 3ppj A 448-600 order
       Region 3ppj A 601-614 disorder
       Region 3ppj A 615-723 order
       Region 3ppj A 724-726 disorder
 Evidence X-RAY 3ppj B Reference
       Region 3ppj B 432-447 disorder
       Region 3ppj B 448-600 order
       Region 3ppj B 601-612 disorder
       Region 3ppj B 613-723 order
       Region 3ppj B 724-726 disorder
 Evidence X-RAY 3ppk A Reference
       Region 3ppk A 432-447 disorder
       Region 3ppk A 448-600 order
       Region 3ppk A 601-614 disorder
       Region 3ppk A 615-723 order
       Region 3ppk A 724-726 disorder
 Evidence X-RAY 3ppk B Reference
       Region 3ppk B 432-447 disorder
       Region 3ppk B 448-600 order
       Region 3ppk B 601-612 disorder
       Region 3ppk B 613-723 order
       Region 3ppk B 724-726 disorder
 Evidence X-RAY 4pp7 A Reference
       Region 4pp7 A 432-447 disorder
       Region 4pp7 A 448-605 order
       Region 4pp7 A 606-612 disorder
       Region 4pp7 A 613-721 order
       Region 4pp7 A 722-726 disorder
 Evidence X-RAY 4pp7 B Reference
       Region 4pp7 B 432-447 disorder
       Region 4pp7 B 448-721 order
       Region 4pp7 B 722-726 disorder
 Evidence X-RAY 3prf A Reference
       Region 3prf A 432-447 disorder
       Region 3prf A 448-600 order
       Region 3prf A 601-614 disorder
       Region 3prf A 615-723 order
       Region 3prf A 724-726 disorder
 Evidence X-RAY 3prf B Reference
       Region 3prf B 432-447 disorder
       Region 3prf B 448-600 order
       Region 3prf B 601-614 disorder
       Region 3prf B 615-723 order
       Region 3prf B 724-726 disorder
 Evidence X-RAY 3pri A Reference
       Region 3pri A 432-447 disorder
       Region 3pri A 448-600 order
       Region 3pri A 601-612 disorder
       Region 3pri A 613-723 order
       Region 3pri A 724-726 disorder
 Evidence X-RAY 3pri B Reference
       Region 3pri B 432-447 disorder
       Region 3pri B 448-600 order
       Region 3pri B 601-612 disorder
       Region 3pri B 613-723 order
       Region 3pri B 724-726 disorder
 Evidence X-RAY 3psb A Reference
       Region 3psb A 433-447 disorder
       Region 3psb A 448-600 order
       Region 3psb A 601-614 disorder
       Region 3psb A 615-723 order
       Region 3psb A 724-726 disorder
 Evidence X-RAY 3psb B Reference
       Region 3psb B 433-447 disorder
       Region 3psb B 448-600 order
       Region 3psb B 601-612 disorder
       Region 3psb B 613-723 order
       Region 3psb B 724-726 disorder
 Evidence X-RAY 3psd A Reference
       Region 3psd A 433-447 disorder
       Region 3psd A 448-600 order
       Region 3psd A 601-614 disorder
       Region 3psd A 615-723 order
       Region 3psd A 724-726 disorder
 Evidence X-RAY 3psd B Reference
       Region 3psd B 433-447 disorder
       Region 3psd B 448-600 order
       Region 3psd B 601-612 disorder
       Region 3psd B 613-723 order
       Region 3psd B 724-726 disorder
 Evidence X-RAY 3q4c A Reference
       Region 3q4c A 432-447 disorder
       Region 3q4c A 448-601 order
       Region 3q4c A 602-613 disorder
       Region 3q4c A 614-723 order
       Region 3q4c A 724-726 disorder
 Evidence X-RAY 3q4c B Reference
       Region 3q4c B 432-447 disorder
       Region 3q4c B 448-601 order
       Region 3q4c B 602-613 disorder
       Region 3q4c B 614-723 order
       Region 3q4c B 724-726 disorder
 Evidence X-RAY 4r5y A Reference
       Region 4r5y A 444-448 disorder
       Region 4r5y A 449-596 order
       Region 4r5y A 597-615 disorder
       Region 4r5y A 616-720 order
       Region 4r5y A 721-723 disorder
 Evidence X-RAY 4r5y B Reference
       Region 4r5y B 444-448 disorder
       Region 4r5y B 449-599 order
       Region 4r5y B 600-613 disorder
       Region 4r5y B 614-627 order
       Region 4r5y B 628-631 disorder
       Region 4r5y B 632-720 order
       Region 4r5y B 721-723 disorder
 Evidence X-RAY 4rzv A Reference
       Region 4rzv A 443-448 disorder
       Region 4rzv A 449-600 order
       Region 4rzv A 601-612 disorder
       Region 4rzv A 613-721 order
       Region 4rzv A 722-723 disorder
 Evidence X-RAY 4rzv B Reference
       Region 4rzv B 443-448 disorder
       Region 4rzv B 449-628 order
       Region 4rzv B 629-631 disorder
       Region 4rzv B 632-722 order
       Region 4rzv B 723-723 disorder
 Evidence X-RAY 3skc A Reference
       Region 3skc A 432-447 disorder
       Region 3skc A 448-596 order
       Region 3skc A 597-612 disorder
       Region 3skc A 613-723 order
       Region 3skc A 724-726 disorder
 Evidence X-RAY 3skc B Reference
       Region 3skc B 432-447 disorder
       Region 3skc B 448-723 order
       Region 3skc B 724-726 disorder
 Evidence X-RAY 3tv4 A Reference
       Region 3tv4 A 432-447 disorder
       Region 3tv4 A 448-465 order
       Region 3tv4 A 466-467 disorder
       Region 3tv4 A 468-603 order
       Region 3tv4 A 604-613 disorder
       Region 3tv4 A 614-723 order
       Region 3tv4 A 724-726 disorder
 Evidence X-RAY 3tv4 B Reference
       Region 3tv4 B 432-447 disorder
       Region 3tv4 B 448-723 order
       Region 3tv4 B 724-726 disorder
 Evidence X-RAY 3tv6 A Reference
       Region 3tv6 A 432-447 disorder
       Region 3tv6 A 448-605 order
       Region 3tv6 A 606-613 disorder
       Region 3tv6 A 614-723 order
       Region 3tv6 A 724-726 disorder
 Evidence X-RAY 3tv6 B Reference
       Region 3tv6 B 432-447 disorder
       Region 3tv6 B 448-723 order
       Region 3tv6 B 724-726 disorder
 Evidence X-RAY 5val A Reference
       Region 5val A 445-445 disorder
       Region 5val A 446-596 order
       Region 5val A 597-615 disorder
       Region 5val A 616-627 order
       Region 5val A 628-629 disorder
       Region 5val A 630-720 order
       Region 5val A 721-723 disorder
 Evidence X-RAY 5val B Reference
       Region 5val B 445-447 disorder
       Region 5val B 448-597 order
       Region 5val B 598-614 disorder
       Region 5val B 615-627 order
       Region 5val B 628-630 disorder
       Region 5val B 631-721 order
       Region 5val B 722-723 disorder
 Evidence X-RAY 5vam A Reference
       Region 5vam A 445-448 disorder
       Region 5vam A 449-605 order
       Region 5vam A 606-609 disorder
       Region 5vam A 610-721 order
       Region 5vam A 722-723 disorder
 Evidence X-RAY 5vam B Reference
       Region 5vam B 445-448 disorder
       Region 5vam B 449-598 order
       Region 5vam B 599-602 disorder
       Region 5vam B 603-605 order
       Region 5vam B 606-614 disorder
       Region 5vam B 615-721 order
       Region 5vam B 722-723 disorder
 Evidence X-RAY 4wo5 A Reference
       Region 4wo5 A 444-447 disorder
       Region 4wo5 A 448-545 order
       Region 4wo5 A 546-546 disorder
       Region 4wo5 A 547-605 order
       Region 4wo5 A 606-609 disorder
       Region 4wo5 A 610-627 order
       Region 4wo5 A 628-630 disorder
       Region 4wo5 A 631-721 order
       Region 4wo5 A 722-723 disorder
 Evidence X-RAY 4wo5 B Reference
       Region 4wo5 B 444-449 disorder
       Region 4wo5 B 450-599 order
       Region 4wo5 B 600-614 disorder
       Region 4wo5 B 615-721 order
       Region 4wo5 B 722-723 disorder
 Evidence X-RAY 4yht A Reference
       Region 4yht A 449-601 order
       Region 4yht A 602-614 disorder
       Region 4yht A 615-629 order
       Region 4yht A 630-631 disorder
       Region 4yht A 632-719 order
       Region 4yht A 720-720 disorder
 Evidence X-RAY 4yht B Reference
       Region 4yht B 449-602 order
       Region 4yht B 603-614 disorder
       Region 4yht B 615-629 order
       Region 4yht B 630-631 disorder
       Region 4yht B 632-720 order
 Evidence X-RAY 6p3d A Reference
       Region 6p3d A 448-600 order
       Region 6p3d A 601-613 disorder
       Region 6p3d A 614-721 order
 Evidence X-RAY 6xfp A Reference
       Region 6xfp A 442-448 disorder
       Region 6xfp A 449-720 order
       Region 6xfp A 721-721 disorder
Seq 432-736 Homo dimer :
 Evidence X-RAY 4dbn A Reference
       Region 4dbn A 445-447 disorder
       Region 4dbn A 448-597 order
       Region 4dbn A 598-614 disorder
       Region 4dbn A 615-721 order
       Region 4dbn A 722-726 disorder
 Evidence X-RAY 4dbn B Reference
       Region 4dbn B 445-447 disorder
       Region 4dbn B 448-604 order
       Region 4dbn B 605-614 disorder
       Region 4dbn B 615-720 order
       Region 4dbn B 721-726 disorder
 Evidence X-RAY 4e26 A Reference
       Region 4e26 A 432-447 disorder
       Region 4e26 A 448-603 order
       Region 4e26 A 604-609 disorder
       Region 4e26 A 610-723 order
       Region 4e26 A 724-726 disorder
 Evidence X-RAY 4e26 B Reference
       Region 4e26 B 432-447 disorder
       Region 4e26 B 448-602 order
       Region 4e26 B 603-613 disorder
       Region 4e26 B 614-722 order
       Region 4e26 B 723-726 disorder
 Evidence X-RAY 4ehe A Reference
       Region 4ehe A 432-447 disorder
       Region 4ehe A 448-603 order
       Region 4ehe A 604-613 disorder
       Region 4ehe A 614-723 order
       Region 4ehe A 724-726 disorder
 Evidence X-RAY 4ehe B Reference
       Region 4ehe B 432-447 disorder
       Region 4ehe B 448-723 order
       Region 4ehe B 724-726 disorder
 Evidence X-RAY 4ehg A Reference
       Region 4ehg A 432-447 disorder
       Region 4ehg A 448-600 order
       Region 4ehg A 601-614 disorder
       Region 4ehg A 615-723 order
       Region 4ehg A 724-726 disorder
 Evidence X-RAY 4ehg B Reference
       Region 4ehg B 432-447 disorder
       Region 4ehg B 448-597 order
       Region 4ehg B 598-613 disorder
       Region 4ehg B 614-723 order
       Region 4ehg B 724-726 disorder
 Evidence X-RAY 4fc0 A Reference
       Region 4fc0 A 445-447 disorder
       Region 4fc0 A 448-596 order
       Region 4fc0 A 597-614 disorder
       Region 4fc0 A 615-627 order
       Region 4fc0 A 628-630 disorder
       Region 4fc0 A 631-722 order
       Region 4fc0 A 723-726 disorder
 Evidence X-RAY 4fc0 B Reference
       Region 4fc0 B 445-447 disorder
       Region 4fc0 B 448-604 order
       Region 4fc0 B 605-614 disorder
       Region 4fc0 B 615-720 order
       Region 4fc0 B 721-726 disorder
 Evidence X-RAY 5fd2 A Reference
       Region 5fd2 A 433-447 disorder
       Region 5fd2 A 448-604 order
       Region 5fd2 A 605-613 disorder
       Region 5fd2 A 614-720 order
       Region 5fd2 A 721-726 disorder
 Evidence X-RAY 5fd2 B Reference
       Region 5fd2 B 433-448 disorder
       Region 5fd2 B 449-458 order
       Region 5fd2 B 459-468 disorder
       Region 5fd2 B 469-485 order
       Region 5fd2 B 486-496 disorder
       Region 5fd2 B 497-596 order
       Region 5fd2 B 597-613 disorder
       Region 5fd2 B 614-720 order
       Region 5fd2 B 721-726 disorder
 Evidence X-RAY 4fk3 A Reference
       Region 4fk3 A 444-447 disorder
       Region 4fk3 A 448-596 order
       Region 4fk3 A 597-613 disorder
       Region 4fk3 A 614-627 order
       Region 4fk3 A 628-630 disorder
       Region 4fk3 A 631-718 order
       Region 4fk3 A 719-723 disorder
 Evidence X-RAY 4fk3 B Reference
       Region 4fk3 B 444-447 disorder
       Region 4fk3 B 448-600 order
       Region 4fk3 B 601-613 disorder
       Region 4fk3 B 614-626 order
       Region 4fk3 B 627-630 disorder
       Region 4fk3 B 631-721 order
       Region 4fk3 B 722-723 disorder
 Evidence X-RAY 5hid A Reference
       Region 5hid A 444-448 disorder
       Region 5hid A 449-485 order
       Region 5hid A 491-598 order
       Region 5hid A 599-610 disorder
       Region 5hid A 611-722 order
       Region 5hid A 723-723 disorder
 Evidence X-RAY 5hid B Reference
       Region 5hid B 444-448 disorder
       Region 5hid B 449-485 order
       Region 5hid B 491-722 order
       Region 5hid B 723-723 disorder
 Evidence X-RAY 5jrq A Reference
       Region 5jrq A 448-603 order
       Region 5jrq A 604-615 disorder
       Region 5jrq A 616-627 order
       Region 5jrq A 628-630 disorder
       Region 5jrq A 631-719 order
       Region 5jrq A 720-723 disorder
 Evidence X-RAY 5jrq B Reference
       Region 5jrq B 448-467 order
       Region 5jrq B 468-469 disorder
       Region 5jrq B 470-600 order
       Region 5jrq B 601-616 disorder
       Region 5jrq B 617-627 order
       Region 5jrq B 628-630 disorder
       Region 5jrq B 631-657 order
       Region 5jrq B 658-664 disorder
       Region 5jrq B 665-720 order
       Region 5jrq B 721-723 disorder
 Evidence X-RAY 5jsm A Reference
       Region 5jsm A 448-601 order
       Region 5jsm A 602-613 disorder
       Region 5jsm A 614-721 order
       Region 5jsm A 722-723 disorder
 Evidence X-RAY 5jsm B Reference
       Region 5jsm B 448-603 order
       Region 5jsm B 604-615 disorder
       Region 5jsm B 616-627 order
       Region 5jsm B 628-630 disorder
       Region 5jsm B 631-721 order
       Region 5jsm B 722-723 disorder
 Evidence X-RAY 5jsm C Reference
       Region 5jsm C 448-600 order
       Region 5jsm C 601-615 disorder
       Region 5jsm C 616-661 order
       Region 5jsm C 662-662 disorder
       Region 5jsm C 663-722 order
       Region 5jsm C 723-723 disorder
 Evidence X-RAY 5jsm D Reference
       Region 5jsm D 448-487 order
       Region 5jsm D 488-489 disorder
       Region 5jsm D 490-602 order
       Region 5jsm D 603-613 disorder
       Region 5jsm D 614-627 order
       Region 5jsm D 628-630 disorder
       Region 5jsm D 631-659 order
       Region 5jsm D 660-662 disorder
       Region 5jsm D 663-721 order
       Region 5jsm D 722-723 disorder
 Evidence X-RAY 5jt2 A Reference
       Region 5jt2 A 448-604 order
       Region 5jt2 A 605-615 disorder
       Region 5jt2 A 616-625 order
       Region 5jt2 A 626-631 disorder
       Region 5jt2 A 632-660 order
       Region 5jt2 A 661-662 disorder
       Region 5jt2 A 663-719 order
       Region 5jt2 A 720-723 disorder
 Evidence X-RAY 5jt2 B Reference
       Region 5jt2 B 448-486 order
       Region 5jt2 B 487-490 disorder
       Region 5jt2 B 491-599 order
       Region 5jt2 B 600-615 disorder
       Region 5jt2 B 616-627 order
       Region 5jt2 B 628-629 disorder
       Region 5jt2 B 630-719 order
       Region 5jt2 B 720-723 disorder
 Evidence X-RAY 5jt2 C Reference
       Region 5jt2 C 448-487 order
       Region 5jt2 C 488-489 disorder
       Region 5jt2 C 490-603 order
       Region 5jt2 C 604-615 disorder
       Region 5jt2 C 616-626 order
       Region 5jt2 C 627-631 disorder
       Region 5jt2 C 632-657 order
       Region 5jt2 C 658-658 disorder
       Region 5jt2 C 659-661 order
       Region 5jt2 C 662-664 disorder
       Region 5jt2 C 665-672 order
       Region 5jt2 C 673-674 disorder
       Region 5jt2 C 675-719 order
       Region 5jt2 C 720-723 disorder
 Evidence X-RAY 5jt2 D Reference
       Region 5jt2 D 448-487 order
       Region 5jt2 D 488-489 disorder
       Region 5jt2 D 490-600 order
       Region 5jt2 D 601-615 disorder
       Region 5jt2 D 616-626 order
       Region 5jt2 D 627-630 disorder
       Region 5jt2 D 631-657 order
       Region 5jt2 D 658-674 disorder
       Region 5jt2 D 675-682 order
       Region 5jt2 D 683-683 disorder
       Region 5jt2 D 684-718 order
       Region 5jt2 D 719-723 disorder
 Evidence X-RAY 4ksp A Reference
       Region 4ksp A 445-447 disorder
       Region 4ksp A 448-596 order
       Region 4ksp A 597-614 disorder
       Region 4ksp A 615-722 order
       Region 4ksp A 723-726 disorder
 Evidence X-RAY 4ksp B Reference
       Region 4ksp B 445-447 disorder
       Region 4ksp B 448-597 order
       Region 4ksp B 598-614 disorder
       Region 4ksp B 615-720 order
       Region 4ksp B 721-726 disorder
 Evidence X-RAY 4ksq A Reference
       Region 4ksq A 445-447 disorder
       Region 4ksq A 448-597 order
       Region 4ksq A 598-614 disorder
       Region 4ksq A 615-722 order
       Region 4ksq A 723-726 disorder
 Evidence X-RAY 4ksq B Reference
       Region 4ksq B 445-448 disorder
       Region 4ksq B 449-597 order
       Region 4ksq B 598-614 disorder
       Region 4ksq B 615-720 order
       Region 4ksq B 721-726 disorder
 Evidence X-RAY 4mbj A Reference
       Region 4mbj A 432-447 disorder
       Region 4mbj A 448-605 order
       Region 4mbj A 606-612 disorder
       Region 4mbj A 613-723 order
 Evidence X-RAY 4mbj B Reference
       Region 4mbj B 432-447 disorder
       Region 4mbj B 448-723 order
 Evidence X-RAY 4mnf A Reference
       Region 4mnf A 432-448 disorder
       Region 4mnf A 449-600 order
       Region 4mnf A 601-615 disorder
       Region 4mnf A 616-720 order
       Region 4mnf A 721-736 disorder
 Evidence X-RAY 4mnf B Reference
       Region 4mnf B 432-448 disorder
       Region 4mnf B 449-600 order
       Region 4mnf B 601-615 disorder
       Region 4mnf B 616-720 order
       Region 4mnf B 721-736 disorder
 Evidence X-RAY 3q96 A Reference
       Region 3q96 A 446-448 disorder
       Region 3q96 A 449-597 order
       Region 3q96 A 598-615 disorder
       Region 3q96 A 616-627 order
       Region 3q96 A 628-630 disorder
       Region 3q96 A 631-722 order
       Region 3q96 A 723-727 disorder
 Evidence X-RAY 3q96 B Reference
       Region 3q96 B 446-448 disorder
       Region 3q96 B 449-604 order
       Region 3q96 B 605-614 disorder
       Region 3q96 B 615-720 order
       Region 3q96 B 721-727 disorder
 Evidence X-RAY 4rzw A Reference
       Region 4rzw A 443-447 disorder
       Region 4rzw A 448-596 order
       Region 4rzw A 597-614 disorder
       Region 4rzw A 615-626 order
       Region 4rzw A 627-630 disorder
       Region 4rzw A 631-720 order
       Region 4rzw A 721-723 disorder
 Evidence X-RAY 4rzw B Reference
       Region 4rzw B 443-447 disorder
       Region 4rzw B 448-595 order
       Region 4rzw B 596-614 disorder
       Region 4rzw B 615-627 order
       Region 4rzw B 628-630 disorder
       Region 4rzw B 631-721 order
       Region 4rzw B 722-723 disorder
 Evidence X-RAY 1uwh A Reference
       Region 1uwh A 448-600 order
       Region 1uwh A 601-612 disorder
       Region 1uwh A 613-723 order
 Evidence X-RAY 1uwh B Reference
       Region 1uwh B 448-600 order
       Region 1uwh B 601-612 disorder
       Region 1uwh B 613-723 order
 Evidence X-RAY 1uwj A Reference
       Region 1uwj A 448-602 order
       Region 1uwj A 603-614 disorder
       Region 1uwj A 615-723 order
 Evidence X-RAY 1uwj B Reference
       Region 1uwj B 448-601 order
       Region 1uwj B 602-614 disorder
       Region 1uwj B 615-723 order
 Evidence X-RAY 4xv1 A Reference
       Region 4xv1 A 444-448 disorder
       Region 4xv1 A 449-465 order
       Region 4xv1 A 466-468 disorder
       Region 4xv1 A 469-487 order
       Region 4xv1 A 488-488 disorder
       Region 4xv1 A 489-544 order
       Region 4xv1 A 545-546 disorder
       Region 4xv1 A 547-596 order
       Region 4xv1 A 597-613 disorder
       Region 4xv1 A 614-626 order
       Region 4xv1 A 627-630 disorder
       Region 4xv1 A 631-681 order
       Region 4xv1 A 682-683 disorder
       Region 4xv1 A 684-705 order
 Evidence X-RAY 4xv1 B Reference
       Region 4xv1 B 444-448 disorder
       Region 4xv1 B 449-464 order
       Region 4xv1 B 465-469 disorder
       Region 4xv1 B 470-600 order
       Region 4xv1 B 601-615 disorder
       Region 4xv1 B 616-626 order
       Region 4xv1 B 627-630 disorder
       Region 4xv1 B 631-705 order
 Evidence X-RAY 4xv2 A Reference
       Region 4xv2 A 444-448 disorder
       Region 4xv2 A 449-487 order
       Region 4xv2 A 488-489 disorder
       Region 4xv2 A 490-596 order
       Region 4xv2 A 597-614 disorder
       Region 4xv2 A 615-626 order
       Region 4xv2 A 627-631 disorder
       Region 4xv2 A 632-705 order
 Evidence X-RAY 4xv2 B Reference
       Region 4xv2 B 444-447 disorder
       Region 4xv2 B 448-545 order
       Region 4xv2 B 546-547 disorder
       Region 4xv2 B 548-596 order
       Region 4xv2 B 597-614 disorder
       Region 4xv2 B 615-626 order
       Region 4xv2 B 627-630 disorder
       Region 4xv2 B 631-705 order
 Evidence X-RAY 4xv3 A Reference
       Region 4xv3 A 444-447 disorder
       Region 4xv3 A 448-465 order
       Region 4xv3 A 466-468 disorder
       Region 4xv3 A 469-487 order
       Region 4xv3 A 488-489 disorder
       Region 4xv3 A 490-596 order
       Region 4xv3 A 597-613 disorder
       Region 4xv3 A 614-626 order
       Region 4xv3 A 627-630 disorder
       Region 4xv3 A 631-705 order
 Evidence X-RAY 4xv3 B Reference
       Region 4xv3 B 444-447 disorder
       Region 4xv3 B 448-464 order
       Region 4xv3 B 465-470 disorder
       Region 4xv3 B 471-521 order
       Region 4xv3 B 522-524 disorder
       Region 4xv3 B 525-585 order
       Region 4xv3 B 586-588 disorder
       Region 4xv3 B 589-595 order
       Region 4xv3 B 596-597 disorder
       Region 4xv3 B 598-600 order
       Region 4xv3 B 601-614 disorder
       Region 4xv3 B 615-625 order
       Region 4xv3 B 626-630 disorder
       Region 4xv3 B 631-705 order
 Evidence X-RAY 4xv9 A Reference
       Region 4xv9 A 442-447 disorder
       Region 4xv9 A 448-598 order
       Region 4xv9 A 599-612 disorder
       Region 4xv9 A 613-705 order
 Evidence X-RAY 8c7x A Reference
       Region 8c7x A 444-448 disorder
       Region 8c7x A 449-721 order
 Evidence X-RAY 8c7x B Reference
       Region 8c7x B 444-447 disorder
       Region 8c7x B 448-600 order
       Region 8c7x B 601-613 disorder
       Region 8c7x B 614-721 order
 Evidence X-RAY 8c7y A Reference
       Region 8c7y A 444-447 disorder
       Region 8c7y A 448-721 order
 Evidence X-RAY 8c7y B Reference
       Region 8c7y B 444-448 disorder
       Region 8c7y B 449-599 order
       Region 8c7y B 600-614 disorder
       Region 8c7y B 615-721 order
 Evidence X-RAY 3d4q A Reference
       Region 3d4q A 433-447 disorder
       Region 3d4q A 448-600 order
       Region 3d4q A 601-612 disorder
       Region 3d4q A 613-723 order
       Region 3d4q A 724-726 disorder
 Evidence X-RAY 3d4q B Reference
       Region 3d4q B 433-447 disorder
       Region 3d4q B 448-600 order
       Region 3d4q B 601-612 disorder
       Region 3d4q B 613-723 order
       Region 3d4q B 724-726 disorder
 Evidence X-RAY 8f7o A Reference
       Region 8f7o A 441-448 disorder
       Region 8f7o A 449-599 order
       Region 8f7o A 600-611 disorder
       Region 8f7o A 612-723 order
 Evidence X-RAY 8f7o B Reference
       Region 8f7o B 441-448 disorder
       Region 8f7o B 449-599 order
       Region 8f7o B 600-610 disorder
       Region 8f7o B 611-722 order
       Region 8f7o B 723-723 disorder
 Evidence X-RAY 8f7p A Reference
       Region 8f7p A 441-448 disorder
       Region 8f7p A 449-600 order
       Region 8f7p A 601-614 disorder
       Region 8f7p A 615-627 order
       Region 8f7p A 628-631 disorder
       Region 8f7p A 632-721 order
       Region 8f7p A 722-723 disorder
 Evidence X-RAY 8f7p B Reference
       Region 8f7p B 441-447 disorder
       Region 8f7p B 448-606 order
       Region 8f7p B 607-612 disorder
       Region 8f7p B 613-628 order
       Region 8f7p B 629-631 disorder
       Region 8f7p B 632-721 order
       Region 8f7p B 722-723 disorder
 Evidence X-RAY 6n0p A Reference
       Region 6n0p A 449-605 order
       Region 6n0p A 606-610 disorder
       Region 6n0p A 611-721 order
 Evidence X-RAY 6n0p B Reference
       Region 6n0p B 449-598 order
       Region 6n0p B 599-613 disorder
       Region 6n0p B 614-627 order
       Region 6n0p B 628-629 disorder
       Region 6n0p B 630-721 order
 Evidence X-RAY 6n0q A Reference
       Region 6n0q A 445-445 disorder
       Region 6n0q A 446-596 order
       Region 6n0q A 597-613 disorder
       Region 6n0q A 614-627 order
       Region 6n0q A 628-629 disorder
       Region 6n0q A 630-721 order
       Region 6n0q A 722-723 disorder
 Evidence X-RAY 6n0q B Reference
       Region 6n0q B 445-447 disorder
       Region 6n0q B 448-597 order
       Region 6n0q B 598-614 disorder
       Region 6n0q B 615-627 order
       Region 6n0q B 628-630 disorder
       Region 6n0q B 631-721 order
       Region 6n0q B 722-723 disorder
 Evidence X-RAY 6nsq A Reference
       Region 6nsq A 444-447 disorder
       Region 6nsq A 448-605 order
       Region 6nsq A 606-606 disorder
       Region 6nsq A 607-722 order
       Region 6nsq A 723-723 disorder
 Evidence X-RAY 6nsq B Reference
       Region 6nsq B 444-446 disorder
       Region 6nsq B 447-596 order
       Region 6nsq B 597-614 disorder
       Region 6nsq B 615-626 order
       Region 6nsq B 627-631 disorder
       Region 6nsq B 632-722 order
       Region 6nsq B 723-723 disorder
 Evidence X-RAY 3og7 A Reference
       Region 3og7 A 448-448 disorder
       Region 3og7 A 449-544 order
       Region 3og7 A 545-547 disorder
       Region 3og7 A 548-596 order
       Region 3og7 A 597-614 disorder
       Region 3og7 A 615-626 order
       Region 3og7 A 627-630 disorder
       Region 3og7 A 631-720 order
 Evidence X-RAY 3og7 B Reference
       Region 3og7 B 448-448 disorder
       Region 3og7 B 449-600 order
       Region 3og7 B 601-614 disorder
       Region 3og7 B 615-626 order
       Region 3og7 B 627-630 disorder
       Region 3og7 B 631-720 order
 Evidence X-RAY 7p3v A Reference
       Region 7p3v A 448-597 order
       Region 7p3v A 598-614 disorder
       Region 7p3v A 615-719 order
 Evidence X-RAY 7p3v B Reference
       Region 7p3v B 448-719 order
 Evidence X-RAY 7shv A Reference
       Region 7shv A 432-448 disorder
       Region 7shv A 449-601 order
       Region 7shv A 602-613 disorder
       Region 7shv A 614-721 order
       Region 7shv A 722-726 disorder
 Evidence X-RAY 7shv B Reference
       Region 7shv B 432-448 disorder
       Region 7shv B 449-602 order
       Region 7shv B 603-613 disorder
       Region 7shv B 614-721 order
       Region 7shv B 722-726 disorder
 Evidence X-RAY 6uuo A Reference
       Region 6uuo A 444-449 disorder
       Region 6uuo A 450-463 order
       Region 6uuo A 464-467 disorder
       Region 6uuo A 468-488 order
       Region 6uuo A 489-489 disorder
       Region 6uuo A 490-595 order
       Region 6uuo A 596-609 disorder
       Region 6uuo A 610-722 order
       Region 6uuo A 723-723 disorder
 Evidence X-RAY 6uuo B Reference
       Region 6uuo B 444-447 disorder
       Region 6uuo B 448-465 order
       Region 6uuo B 466-467 disorder
       Region 6uuo B 468-487 order
       Region 6uuo B 488-489 disorder
       Region 6uuo B 490-596 order
       Region 6uuo B 597-614 disorder
       Region 6uuo B 615-721 order
       Region 6uuo B 722-723 disorder
 Evidence X-RAY 6v2u A Reference
       Region 6v2u A 445-448 disorder
       Region 6v2u A 449-595 order
       Region 6v2u A 596-613 disorder
       Region 6v2u A 614-721 order
       Region 6v2u A 722-723 disorder
 Evidence X-RAY 6v2u B Reference
       Region 6v2u B 445-448 disorder
       Region 6v2u B 449-486 order
       Region 6v2u B 487-490 disorder
       Region 6v2u B 491-597 order
       Region 6v2u B 598-615 disorder
       Region 6v2u B 616-720 order
       Region 6v2u B 721-723 disorder
 Evidence X-RAY 6v34 A Reference
       Region 6v34 A 448-448 disorder
       Region 6v34 A 449-485 order
       Region 6v34 A 486-487 disorder
       Region 6v34 A 488-599 order
       Region 6v34 A 600-613 disorder
       Region 6v34 A 614-628 order
       Region 6v34 A 629-631 disorder
       Region 6v34 A 632-721 order
 Evidence X-RAY 6v34 B Reference
       Region 6v34 B 448-448 disorder
       Region 6v34 B 449-596 order
       Region 6v34 B 597-616 disorder
       Region 6v34 B 617-627 order
       Region 6v34 B 628-630 disorder
       Region 6v34 B 631-670 order
       Region 6v34 B 671-673 disorder
       Region 6v34 B 674-721 order
 Evidence X-RAY 6xlo A Reference
       Region 6xlo A 442-448 disorder
       Region 6xlo A 449-485 order
       Region 6xlo A 486-489 disorder
       Region 6xlo A 490-606 order
       Region 6xlo A 607-611 disorder
       Region 6xlo A 612-626 order
       Region 6xlo A 627-631 disorder
       Region 6xlo A 632-720 order
       Region 6xlo A 721-721 disorder
 Evidence X-RAY 6xlo B Reference
       Region 6xlo B 442-449 disorder
       Region 6xlo B 450-485 order
       Region 6xlo B 486-488 disorder
       Region 6xlo B 489-597 order
       Region 6xlo B 598-615 disorder
       Region 6xlo B 616-720 order
       Region 6xlo B 721-721 disorder
Seq 444-723 Homo tetramer :
 Evidence X-RAY 7k0v D Reference
       Region 7k0v D 444-448 disorder
       Region 7k0v D 449-605 order
       Region 7k0v D 606-608 disorder
       Region 7k0v D 609-722 order
       Region 7k0v D 723-723 disorder
 Evidence X-RAY 7k0v C Reference
       Region 7k0v C 444-447 disorder
       Region 7k0v C 448-606 order
       Region 7k0v C 607-614 disorder
       Region 7k0v C 615-722 order
       Region 7k0v C 723-723 disorder
 Evidence X-RAY 7k0v B Reference
       Region 7k0v B 444-448 disorder
       Region 7k0v B 449-599 order
       Region 7k0v B 600-602 disorder
       Region 7k0v B 603-607 order
       Region 7k0v B 608-611 disorder
       Region 7k0v B 612-627 order
       Region 7k0v B 628-630 disorder
       Region 7k0v B 631-722 order
       Region 7k0v B 723-723 disorder
 Evidence X-RAY 7k0v A Reference
       Region 7k0v A 444-448 disorder
       Region 7k0v A 449-599 order
       Region 7k0v A 600-608 disorder
       Region 7k0v A 609-627 order
       Region 7k0v A 628-630 disorder
       Region 7k0v A 631-722 order
       Region 7k0v A 723-723 disorder
Seq 447-735 Hetero tetramer : IID00061Complex
 Evidence X-RAY 6xag D Reference
       Region 6xag D 447-447 disorder
       Region 6xag D 448-464 order
       Region 6xag D 465-467 disorder
       Region 6xag D 468-607 order
       Region 6xag D 608-612 disorder
       Region 6xag D 613-733 order
       Region 6xag D 734-735 disorder
 Evidence X-RAY 6xag C Reference
       Region 6xag C 447-448 disorder
       Region 6xag C 449-467 order
       Region 6xag C 468-468 disorder
       Region 6xag C 469-607 order
       Region 6xag C 608-614 disorder
       Region 6xag C 615-732 order
       Region 6xag C 733-735 disorder
 Evidence X-RAY 6u2h D Reference
       Region 6u2h D 447-447 disorder
       Region 6u2h D 448-607 order
       Region 6u2h D 608-610 disorder
       Region 6u2h D 611-733 order
       Region 6u2h D 734-735 disorder
 Evidence X-RAY 6u2h C Reference
       Region 6u2h C 447-447 disorder
       Region 6u2h C 448-603 order
       Region 6u2h C 604-614 disorder
       Region 6u2h C 615-733 order
       Region 6u2h C 734-735 disorder
Seq 448-723 Homo tetramer :
 Evidence X-RAY 6p7g D Reference
       Region 6p7g D 448-448 disorder
       Region 6p7g D 449-597 order
       Region 6p7g D 598-613 disorder
       Region 6p7g D 614-627 order
       Region 6p7g D 628-630 disorder
       Region 6p7g D 631-721 order
       Region 6p7g D 722-723 disorder
 Evidence X-RAY 6p7g C Reference
       Region 6p7g C 448-448 disorder
       Region 6p7g C 449-597 order
       Region 6p7g C 598-614 disorder
       Region 6p7g C 615-721 order
       Region 6p7g C 722-723 disorder
 Evidence X-RAY 6p7g B Reference
       Region 6p7g B 448-448 disorder
       Region 6p7g B 449-721 order
       Region 6p7g B 722-723 disorder
 Evidence X-RAY 6p7g A Reference
       Region 6p7g A 448-448 disorder
       Region 6p7g A 449-597 order
       Region 6p7g A 598-613 disorder
       Region 6p7g A 614-720 order
       Region 6p7g A 721-723 disorder
SeqProS verified 721-733 Hetero tetramer : IID00061Complex
       Region 6u2h C 615-733 order
       Region 6u2h D 611-733 order
       Region 6xag C 615-732 order
       Region 6xag D 613-733 order
       Region 4mnf A 721-736 disorder
Seqphosphorylation
    753-753 Phosphothreonine; by MAPK1
    750-750 Phosphoserine
    729-729 Phosphoserine
    447-447 Phosphoserine
    446-446 Phosphoserine
    401-401 Phosphothreonine
    399-399 Phosphoserine
    365-365 Phosphoserine; by SGK1
    373-373 Phosphothreonine; by autocatalysis
    396-396 Phosphothreonine
    151-151 Phosphoserine
    333-333 Phosphoserine
Seqacetylation
    2-2 N-acetylalanine
 
Prediction
NeProc
Disorder 1-39,98-162,232-240,296-441,723-736
Order 40-97,163-231,241-295,442-722,737-766
ProS 17-24,34-39,98-108,155-162,232-240,296-301,355-394,421-424,723-736
AlphaFold
Disorder 1-42,69-69,71-74,104-154,163-164,228-233,281-448,466-468,595-615,723-766
Order 43-68,70-70,75-103,155-162,165-227,234-280,449-465,469-594,616-722
Pfam Hmmer
PF02196 155-227 7.4e-39
PF00130 235-283 3.6e-17
PF00069 457-714 1.6e-83
SEG 6-11 ,27-39 ,92-103 ,110-137 ,314-328 ,333-343 ,428-432
Function
Function in SwissProt
Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus (Probable). Phosphorylates MAP2K1, and thereby activates the MAP kinase signal transduction pathway (PubMed:21441910, PubMed:29433126). Phosphorylates PFKFB2 (PubMed:36402789). May play a role in the postsynaptic responses of hippocampal neurons (PubMed:1508179).