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IID00791
 UniprotP26447
ProteinProtein S100-A4
GeneS100A4
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
101
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seqdisorder 1-93
 Evidence X-RAY 6t58 B Reference
       Region 6t58 B 1-93 disorder
Seq 1-93 Hetero trimer : IID00015Complex
 Evidence X-RAY 6t58 A Reference
       Region 6t58 A 1-2 disorder
       Region 6t58 A 3-88 order
       Region 6t58 A 89-93 disorder
Seq 1-93 Hetero trimer : P35579
 Evidence X-RAY 4eto B Reference
       Region 4eto B 1-1 disorder
       Region 4eto B 2-92 order
       Region 4eto B 93-93 disorder
 Evidence X-RAY 4eto A Reference
       Region 4eto A 1-1 disorder
       Region 4eto A 2-46 order
       Region 4eto A 47-49 disorder
       Region 4eto A 50-92 order
       Region 4eto A 93-93 disorder
Seq 1-100 Homo tetramer :
 Evidence X-RAY 7psq G Reference
       Region 7psq G 1-100 order
 Evidence X-RAY 7psq E Reference
       Region 7psq E 1-98 order
       Region 7psq E 99-100 disorder
 Evidence X-RAY 7psq C Reference
       Region 7psq C 1-91 order
       Region 7psq C 92-100 disorder
 Evidence X-RAY 7psq A Reference
       Region 7psq A 1-90 order
       Region 7psq A 91-100 disorder
Seq 1-101 Hetero trimer : P35579
 Evidence X-RAY 4cfq C Reference
       Region 4cfq C 1-1 disorder
       Region 4cfq C 2-47 order
       Region 4cfq C 48-49 disorder
       Region 4cfq C 50-88 order
 Evidence X-RAY 4cfq D Reference
       Region 4cfq D 1-84 order
       Region 4cfq D 85-88 disorder
 Evidence X-RAY 4cfq A Reference
       Region 4cfq A 1-47 order
       Region 4cfq A 48-49 disorder
       Region 4cfq A 50-87 order
       Region 4cfq A 88-88 disorder
 Evidence X-RAY 4cfq B Reference
       Region 4cfq B 1-84 order
       Region 4cfq B 85-88 disorder
 Evidence NMR 2lnk A Reference
       Region 2lnk A 1-101 order
       Region 2lnk A 94-101 high_rmsd
 Evidence NMR 2lnk B Reference
       Region 2lnk B 1-101 order
       Region 2lnk B 96-101 high_rmsd
 Evidence X-RAY 3zwh A Reference
       Region 3zwh A 1-1 disorder
       Region 3zwh A 2-94 order
       Region 3zwh A 95-101 disorder
 Evidence X-RAY 3zwh B Reference
       Region 3zwh B 1-99 order
       Region 3zwh B 100-101 disorder
 Evidence X-RAY 4cfr A Reference
       Region 4cfr A 1-1 disorder
       Region 4cfr A 2-95 order
       Region 4cfr A 96-101 disorder
 Evidence X-RAY 4cfr B Reference
       Region 4cfr B 1-100 order
       Region 4cfr B 101-101 disorder
Seq 1-101 Homo dimer :
 Evidence X-RAY 3c1v A Reference
       Region 3c1v A 1-1 disorder
       Region 3c1v A 2-94 order
       Region 3c1v A 95-101 disorder
 Evidence X-RAY 3c1v B Reference
       Region 3c1v B 1-1 disorder
       Region 3c1v B 2-98 order
       Region 3c1v B 99-101 disorder
 Evidence X-RAY 3c1v C Reference
       Region 3c1v C 1-1 disorder
       Region 3c1v C 2-94 order
       Region 3c1v C 95-101 disorder
 Evidence X-RAY 3c1v D Reference
       Region 3c1v D 1-1 disorder
       Region 3c1v D 2-98 order
       Region 3c1v D 99-101 disorder
 Evidence X-RAY 3cga A Reference
       Region 3cga A 1-3 disorder
       Region 3cga A 4-90 order
       Region 3cga A 91-101 disorder
 Evidence X-RAY 3cga B Reference
       Region 3cga B 1-3 disorder
       Region 3cga B 4-90 order
       Region 3cga B 91-101 disorder
 Evidence X-RAY 4hsz A Reference
       Region 4hsz A 1-2 disorder
       Region 4hsz A 3-92 order
       Region 4hsz A 93-93 disorder
 Evidence X-RAY 4hsz B Reference
       Region 4hsz B 1-2 disorder
       Region 4hsz B 3-92 order
       Region 4hsz B 93-93 disorder
 Evidence X-RAY 4hsz C Reference
       Region 4hsz C 1-2 disorder
       Region 4hsz C 3-92 order
       Region 4hsz C 93-93 disorder
 Evidence X-RAY 4hsz D Reference
       Region 4hsz D 1-2 disorder
       Region 4hsz D 3-92 order
       Region 4hsz D 93-93 disorder
 Evidence X-RAY 3ko0 A Reference
       Region 3ko0 A 1-1 disorder
       Region 3ko0 A 2-94 order
       Region 3ko0 A 95-101 disorder
 Evidence X-RAY 3ko0 B Reference
       Region 3ko0 B 1-1 disorder
       Region 3ko0 B 2-94 order
       Region 3ko0 B 95-101 disorder
 Evidence X-RAY 3ko0 S Reference
       Region 3ko0 S 1-1 disorder
       Region 3ko0 S 2-94 order
       Region 3ko0 S 95-101 disorder
 Evidence X-RAY 3ko0 T Reference
       Region 3ko0 T 1-1 disorder
       Region 3ko0 T 2-94 order
       Region 3ko0 T 95-101 disorder
 Evidence X-RAY 3ko0 C Reference
       Region 3ko0 C 1-1 disorder
       Region 3ko0 C 2-94 order
       Region 3ko0 C 95-101 disorder
 Evidence X-RAY 3ko0 D Reference
       Region 3ko0 D 1-1 disorder
       Region 3ko0 D 2-94 order
       Region 3ko0 D 95-101 disorder
 Evidence X-RAY 3ko0 E Reference
       Region 3ko0 E 1-1 disorder
       Region 3ko0 E 2-93 order
       Region 3ko0 E 94-101 disorder
 Evidence X-RAY 3ko0 F Reference
       Region 3ko0 F 1-1 disorder
       Region 3ko0 F 2-47 order
       Region 3ko0 F 48-50 disorder
       Region 3ko0 F 51-94 order
       Region 3ko0 F 95-101 disorder
 Evidence X-RAY 3ko0 G Reference
       Region 3ko0 G 1-1 disorder
       Region 3ko0 G 2-48 order
       Region 3ko0 G 49-51 disorder
       Region 3ko0 G 52-94 order
       Region 3ko0 G 95-101 disorder
 Evidence X-RAY 3ko0 H Reference
       Region 3ko0 H 1-1 disorder
       Region 3ko0 H 2-95 order
       Region 3ko0 H 96-101 disorder
 Evidence X-RAY 3ko0 I Reference
       Region 3ko0 I 1-1 disorder
       Region 3ko0 I 2-94 order
       Region 3ko0 I 95-101 disorder
 Evidence X-RAY 3ko0 J Reference
       Region 3ko0 J 1-1 disorder
       Region 3ko0 J 2-94 order
       Region 3ko0 J 95-101 disorder
 Evidence X-RAY 3ko0 K Reference
       Region 3ko0 K 1-1 disorder
       Region 3ko0 K 2-94 order
       Region 3ko0 K 95-101 disorder
 Evidence X-RAY 3ko0 L Reference
       Region 3ko0 L 1-1 disorder
       Region 3ko0 L 2-94 order
       Region 3ko0 L 95-101 disorder
 Evidence X-RAY 3ko0 M Reference
       Region 3ko0 M 1-1 disorder
       Region 3ko0 M 2-93 order
       Region 3ko0 M 94-101 disorder
 Evidence X-RAY 3ko0 N Reference
       Region 3ko0 N 1-1 disorder
       Region 3ko0 N 2-93 order
       Region 3ko0 N 94-101 disorder
 Evidence X-RAY 3ko0 O Reference
       Region 3ko0 O 1-1 disorder
       Region 3ko0 O 2-94 order
       Region 3ko0 O 95-101 disorder
 Evidence X-RAY 3ko0 P Reference
       Region 3ko0 P 1-1 disorder
       Region 3ko0 P 2-93 order
       Region 3ko0 P 94-101 disorder
 Evidence X-RAY 3ko0 Q Reference
       Region 3ko0 Q 1-1 disorder
       Region 3ko0 Q 2-47 order
       Region 3ko0 Q 48-53 disorder
       Region 3ko0 Q 54-95 order
       Region 3ko0 Q 96-101 disorder
 Evidence X-RAY 3ko0 R Reference
       Region 3ko0 R 1-1 disorder
       Region 3ko0 R 2-94 order
       Region 3ko0 R 95-101 disorder
 Evidence NMR 2mrd A Reference
       Region 2mrd A 1-101 order
       Region 2mrd A 1-1 high_rmsd
       Region 2mrd A 101-101 high_rmsd
 Evidence NMR 2mrd B Reference
       Region 2mrd B 1-101 order
       Region 2mrd B 1-1 high_rmsd
       Region 2mrd B 101-101 high_rmsd
 Evidence X-RAY 2q91 A Reference
       Region 2q91 A 1-1 disorder
       Region 2q91 A 2-97 order
       Region 2q91 A 98-101 disorder
 Evidence X-RAY 2q91 B Reference
       Region 2q91 B 1-1 disorder
       Region 2q91 B 2-97 order
       Region 2q91 B 98-101 disorder
 Evidence NMR 1m31 A Reference
       Region 1m31 A 1-101 order
       Region 1m31 A 1-1 high_rmsd
       Region 1m31 A 92-101 high_rmsd
 Evidence NMR 1m31 B Reference
       Region 1m31 B 1-101 order
       Region 1m31 B 1-1 high_rmsd
       Region 1m31 B 24-24 high_rmsd
       Region 1m31 B 66-66 high_rmsd
       Region 1m31 B 91-101 high_rmsd
 Evidence X-RAY 7psp A Reference
       Region 7psp A 1-96 order
       Region 7psp A 97-100 disorder
 Evidence X-RAY 7psp B Reference
       Region 7psp B 1-95 order
       Region 7psp B 96-100 disorder
Seq 1-101 Hetero tetramer : IID00700Complex
 Evidence X-RAY 5lpu D Reference
       Region 5lpu D 1-93 order
       Region 5lpu D 94-101 disorder
 Evidence X-RAY 5lpu C Reference
       Region 5lpu C 1-1 disorder
       Region 5lpu C 2-90 order
       Region 5lpu C 91-101 disorder
Seq 2-101 Homo decamer :
 Evidence X-RAY 3m0w J Reference
       Region 3m0w J 2-46 order
       Region 3m0w J 47-49 disorder
       Region 3m0w J 50-93 order
       Region 3m0w J 94-101 disorder
 Evidence X-RAY 3m0w I Reference
       Region 3m0w I 2-94 order
       Region 3m0w I 95-101 disorder
 Evidence X-RAY 3m0w H Reference
       Region 3m0w H 2-94 order
       Region 3m0w H 95-101 disorder
 Evidence X-RAY 3m0w G Reference
       Region 3m0w G 2-47 order
       Region 3m0w G 48-51 disorder
       Region 3m0w G 52-91 order
       Region 3m0w G 92-101 disorder
 Evidence X-RAY 3m0w F Reference
       Region 3m0w F 2-46 order
       Region 3m0w F 47-50 disorder
       Region 3m0w F 51-91 order
       Region 3m0w F 92-101 disorder
 Evidence X-RAY 3m0w E Reference
       Region 3m0w E 2-91 order
       Region 3m0w E 92-101 disorder
 Evidence X-RAY 3m0w D Reference
       Region 3m0w D 2-2 disorder
       Region 3m0w D 3-46 order
       Region 3m0w D 47-50 disorder
       Region 3m0w D 51-92 order
       Region 3m0w D 93-101 disorder
 Evidence X-RAY 3m0w C Reference
       Region 3m0w C 2-2 disorder
       Region 3m0w C 3-47 order
       Region 3m0w C 48-50 disorder
       Region 3m0w C 51-93 order
       Region 3m0w C 94-101 disorder
 Evidence X-RAY 3m0w B Reference
       Region 3m0w B 2-46 order
       Region 3m0w B 47-49 disorder
       Region 3m0w B 50-94 order
       Region 3m0w B 95-101 disorder
 Evidence X-RAY 3m0w A Reference
       Region 3m0w A 2-91 order
       Region 3m0w A 92-101 disorder
Seqacetylation
    35-35 N6-acetyllysine
    2-2 N-acetylalanine
    7-7 N6-acetyllysine
 
Prediction
NeProc
Disorder 93-101
Order 1-92
ProS 93-97
AlphaFold
Disorder 1-1,48-50,88-101
Order 2-47,51-87
Pfam Hmmer
PF01023 5-48 7.5e-24
Function
Function in SwissProt
Calcium-binding protein that plays a role in various cellular processes including motility, angiogenesis, cell differentiation, apoptosis, and autophagy (PubMed:16707441, PubMed:23752197, PubMed:30713770). Increases cell motility and invasiveness by interacting with non-muscle myosin heavy chain (NMMHC) IIA/MYH9 (PubMed:16707441). Mechanistically, promotes filament depolymerization and increases the amount of soluble myosin-IIA, resulting in the formation of stable protrusions facilitating chemotaxis (By similarity). Modulates also the pro-apoptotic function of TP53 by binding to its C-terminal transactivation domain within the nucleus and reducing its protein levels (PubMed:23752197). Within the extracellular space, stimulates cytokine production including granulocyte colony-stimulating factor and CCL24 from T-lymphocytes (By similarity). In addition, stimulates T-lymphocyte chemotaxis by acting as a chemoattractant complex with PGLYRP1 that promotes lymphocyte migration via CCR5 and CXCR3 receptors (PubMed:30713770, PubMed:26654597).
Biological Process
See also
Diagram with PDB data
ANXA2/S100A4Crystal structure of Annexin A2 complexed with S100A4