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IID00792
 UniprotP26678
ProteinCardiac phospholamban
GenePLN
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
52
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-24 Monomer :
 Evidence NMR 1plp A Reference
       Region 1plp A 1-24 order
       Region 1plp A 20-24 high_rmsd
Seq 1-52 Homo pentamer :
 Evidence NMR 1zll E Reference
       Region 1zll E 1-52 order
 Evidence NMR 1zll D Reference
       Region 1zll D 1-52 order
 Evidence NMR 1zll C Reference
       Region 1zll C 1-52 order
 Evidence NMR 1zll B Reference
       Region 1zll B 1-52 order
 Evidence NMR 1zll A Reference
       Region 1zll A 1-52 order
 Evidence NMR 2hyn E Reference
       Region 2hyn E 1-52 order
       Region 2hyn E 1-13 high_rmsd
 Evidence NMR 2hyn D Reference
       Region 2hyn D 1-52 order
       Region 2hyn D 1-13 high_rmsd
 Evidence NMR 2hyn C Reference
       Region 2hyn C 1-52 order
       Region 2hyn C 1-13 high_rmsd
 Evidence NMR 2hyn B Reference
       Region 2hyn B 1-52 order
       Region 2hyn B 1-13 high_rmsd
 Evidence NMR 2hyn A Reference
       Region 2hyn A 1-52 order
       Region 2hyn A 1-13 high_rmsd
Seq 6-21 Hetero dimer : IID00301Complex
 Evidence X-RAY 6y40 P Reference
       Region 6y40 P 6-12 disorder
       Region 6y40 P 13-17 order
       Region 6y40 P 18-21 disorder
Seq 8-19 Hetero dimer : IID50138Complex
 Evidence X-RAY 7e0z B Reference
       Region 7e0z B 8-19 order
 Evidence X-RAY 7e11 B Reference
       Region 7e11 B 8-19 order
 Evidence X-RAY 7e12 B Reference
       Region 7e12 B 8-10 disorder
       Region 7e12 B 11-19 order
SeqProS predicted 14-17 This region is predicted to be disordered by NeProc and AlphaFold (pLDDT < 68.5). Hetero dimer : IID00301Complex
       Region 6y40 P 13-17 order
SeqProS predicted 14-19 This region is predicted to be disordered by NeProc and AlphaFold (pLDDT < 68.5). Hetero dimer : IID50138Complex
       Region 7e12 B 11-19 order
       Region 7e0z B 8-19 order
       Region 7e11 B 8-19 order
Seqphosphorylation
    16-16 Phosphoserine; by PKA and DMPK
    17-17 Phosphothreonine; by CaMK2
Seqacetylation
    1-1 N-acetylmethionine
 
Prediction
NeProc
Disorder 14-31,52-52
Order 1-13,32-51
ProS 14-31,52-52
AlphaFold
Disorder 1-1,14-23
Order 2-13,24-52
Pfam Hmmer
PF04272 1-52 1.1e-37
SEG 30-48
Function
Function in SwissProt
Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+) (PubMed:28890335). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. ATP2A2 inhibition is alleviated by PLN phosphorylation. Controls intracellular Ca(2+) levels in elongated spermatids. May play a role in germ cell differentiation (By similarity).