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IID00793
 UniprotP27348
Protein14-3-3 protein theta
GeneYWHAQ
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
245
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-234 Hetero tetramer :
 Evidence X-RAY 2btp B Reference
       Region 2btp B 1-1 disorder
       Region 2btp B 2-69 order
       Region 2btp B 70-73 disorder
       Region 2btp B 74-205 order
       Region 2btp B 206-209 disorder
       Region 2btp B 210-230 order
       Region 2btp B 231-234 disorder
 Evidence X-RAY 2btp A Reference
       Region 2btp A 1-69 order
       Region 2btp A 70-73 disorder
       Region 2btp A 74-230 order
       Region 2btp A 231-234 disorder
Seq 1-245 Homo dimer :
 Evidence X-RAY 5iqp A Reference
       Region 5iqp A 1-230 order
       Region 5iqp A 231-245 disorder
 Evidence X-RAY 5iqp B Reference
       Region 5iqp B 1-71 order
       Region 5iqp B 72-72 disorder
       Region 5iqp B 73-230 order
       Region 5iqp B 231-245 disorder
Seq 1-245 Hetero dodecamer : IID00893Complex
 Evidence X-RAY 6bqt K Reference
       Region 6bqt K 1-1 disorder
       Region 6bqt K 2-133 order
       Region 6bqt K 134-135 disorder
       Region 6bqt K 136-230 order
       Region 6bqt K 231-245 disorder
 Evidence X-RAY 6bqt J Reference
       Region 6bqt J 1-230 order
       Region 6bqt J 231-245 disorder
 Evidence X-RAY 6bqt H Reference
       Region 6bqt H 1-71 order
       Region 6bqt H 72-72 disorder
       Region 6bqt H 73-205 order
       Region 6bqt H 206-209 disorder
       Region 6bqt H 210-230 order
       Region 6bqt H 231-245 disorder
 Evidence X-RAY 6bqt G Reference
       Region 6bqt G 1-230 order
       Region 6bqt G 231-245 disorder
 Evidence X-RAY 6bqt E Reference
       Region 6bqt E 1-230 order
       Region 6bqt E 231-245 disorder
 Evidence X-RAY 6bqt D Reference
       Region 6bqt D 1-230 order
       Region 6bqt D 231-245 disorder
 Evidence X-RAY 6bqt B Reference
       Region 6bqt B 1-69 order
       Region 6bqt B 70-72 disorder
       Region 6bqt B 73-230 order
       Region 6bqt B 231-245 disorder
 Evidence X-RAY 6bqt A Reference
       Region 6bqt A 1-230 order
       Region 6bqt A 231-245 disorder
Seq 1-245 Hetero octamer : IID00893Complex
 Evidence X-RAY 6bcr F Reference
       Region 6bcr F 1-230 order
       Region 6bcr F 231-245 disorder
 Evidence X-RAY 6bcr E Reference
       Region 6bcr E 1-231 order
       Region 6bcr E 232-245 disorder
 Evidence X-RAY 6bcr B Reference
       Region 6bcr B 1-230 order
       Region 6bcr B 231-245 disorder
 Evidence X-RAY 6bcr A Reference
       Region 6bcr A 1-230 order
       Region 6bcr A 231-245 disorder
Seq 1-245 Hetero trimer : IID00893Complex
 Evidence X-RAY 6bd2 B Reference
       Region 6bd2 B 1-230 order
       Region 6bd2 B 231-245 disorder
 Evidence X-RAY 6bd2 A Reference
       Region 6bd2 A 1-1 disorder
       Region 6bd2 A 2-230 order
       Region 6bd2 A 231-245 disorder
Seq 2-234 Hetero tetramer : IID00865Complex
 Evidence X-RAY 6kzg B Reference
       Region 6kzg B 2-231 order
       Region 6kzg B 232-234 disorder
 Evidence X-RAY 6kzg A Reference
       Region 6kzg A 2-206 order
       Region 6kzg A 207-209 disorder
       Region 6kzg A 210-230 order
       Region 6kzg A 231-234 disorder
Seq 2-234 Hetero tetramer : IID00865Complex
 Evidence X-RAY 6kzh B Reference
       Region 6kzh B 2-230 order
       Region 6kzh B 231-234 disorder
 Evidence X-RAY 6kzh A Reference
       Region 6kzh A 2-69 order
       Region 6kzh A 70-70 disorder
       Region 6kzh A 71-230 order
       Region 6kzh A 231-234 disorder
Seqphosphorylation
    92-92 Phosphoserine
    232-232 Phosphoserine
Seqacetylation
    1-1 N-acetylmethionine
    68-68 N6-acetyllysine
    49-49 N6-acetyllysine; alternate
    3-3 N6-acetyllysine
    115-115 N6-acetyllysine
 
Prediction
NeProc
Disorder 233-245
Order 1-232
ProS 233-237
AlphaFold
Disorder 233-245
Order 1-232
Pfam Hmmer
PF00244 3-236 3.9e-149
SEG 230-244
Function
Function in SwissProt
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1.
Biological Process
See also
Diagram without PDB data
CDKN1BActivation of Akt results in phosphorylation p27, which are then transported to the cytoplasm with 14-3-3.