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IID00794
 UniprotP27540
ProteinAryl hydrocarbon receptor nuclear translocator
GeneARNT
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
789
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 70-346 Hetero dimer : IID50364Complex
 Evidence X-RAY 5v0l A Reference
       Region 5v0l A 70-80 disorder
       Region 5v0l A 81-142 order
       Region 5v0l A 143-154 disorder
       Region 5v0l A 155-195 order
       Region 5v0l A 196-198 disorder
       Region 5v0l A 199-226 order
       Region 5v0l A 227-257 disorder
       Region 5v0l A 258-269 order
       Region 5v0l A 270-299 disorder
       Region 5v0l A 300-311 order
       Region 5v0l A 312-323 disorder
       Region 5v0l A 324-344 order
       Region 5v0l A 345-346 disorder
Seq 354-470 Monomer :
 Evidence NMR 1x0o A Reference
       Region 1x0o A 356-470 order
       Region 1x0o A 468-470 high_rmsd
 Evidence X-RAY 2b02 A Reference
       Region 2b02 A 354-464 order
       Region 2b02 A 465-470 disorder
 Evidence NMR 2k7s A Reference
       Region 2k7s A 356-470 order
       Region 2k7s A 464-470 high_rmsd
Seq 356-470 Hetero dimer : IID00629Complex
 Evidence NMR 2a24 B Reference
       Region 2a24 B 358-465 order
 Evidence X-RAY 3f1n B Reference
       Region 3f1n B 356-356 disorder
       Region 3f1n B 357-468 order
       Region 3f1n B 469-470 disorder
 Evidence X-RAY 3f1o B Reference
       Region 3f1o B 356-356 disorder
       Region 3f1o B 357-468 order
       Region 3f1o B 469-470 disorder
 Evidence X-RAY 3f1p B Reference
       Region 3f1p B 356-356 disorder
       Region 3f1p B 357-467 order
       Region 3f1p B 468-470 disorder
 Evidence X-RAY 3h7w B Reference
       Region 3h7w B 356-357 disorder
       Region 3h7w B 358-467 order
       Region 3h7w B 468-470 disorder
 Evidence X-RAY 3h82 B Reference
       Region 3h82 B 356-467 order
       Region 3h82 B 468-470 disorder
 Evidence X-RAY 4ghi B Reference
       Region 4ghi B 356-357 disorder
       Region 4ghi B 358-467 order
       Region 4ghi B 468-470 disorder
 Evidence X-RAY 4gs9 B Reference
       Region 4gs9 B 356-359 disorder
       Region 4gs9 B 360-468 order
       Region 4gs9 B 469-470 disorder
 Evidence X-RAY 4xt2 B Reference
       Region 4xt2 B 356-357 disorder
       Region 4xt2 B 358-468 order
       Region 4xt2 B 469-470 disorder
 Evidence X-RAY 4xt2 D Reference
       Region 4xt2 D 356-359 disorder
       Region 4xt2 D 360-466 order
       Region 4xt2 D 467-470 disorder
 Evidence X-RAY 5tbm B Reference
       Region 5tbm B 356-357 disorder
       Region 5tbm B 358-467 order
 Evidence X-RAY 5ufp B Reference
       Region 5ufp B 356-357 disorder
       Region 5ufp B 358-467 order
 Evidence X-RAY 6czw B Reference
       Region 6czw B 356-357 disorder
       Region 6czw B 358-467 order
       Region 6czw B 468-470 disorder
 Evidence X-RAY 6d09 B Reference
       Region 6d09 B 356-357 disorder
       Region 6d09 B 358-467 order
       Region 6d09 B 468-470 disorder
 Evidence X-RAY 6d0b B Reference
       Region 6d0b B 356-357 disorder
       Region 6d0b B 358-467 order
       Region 6d0b B 468-470 disorder
 Evidence X-RAY 6d0c B Reference
       Region 6d0c B 356-357 disorder
       Region 6d0c B 358-467 order
       Region 6d0c B 468-470 disorder
 Evidence X-RAY 6x21 B Reference
       Region 6x21 B 356-360 disorder
       Region 6x21 B 361-467 order
 Evidence X-RAY 6x28 B Reference
       Region 6x28 B 356-357 disorder
       Region 6x28 B 358-467 order
 Evidence X-RAY 6x2h B Reference
       Region 6x2h B 356-357 disorder
       Region 6x2h B 358-467 order
 Evidence X-RAY 6x37 B Reference
       Region 6x37 B 356-357 disorder
       Region 6x37 B 358-467 order
 Evidence X-RAY 6x3d B Reference
       Region 6x3d B 356-360 disorder
       Region 6x3d B 361-467 order
 Evidence X-RAY 8ck3 B Reference
       Region 8ck3 B 356-360 disorder
       Region 8ck3 B 361-467 order
       Region 8ck3 B 468-470 disorder
 Evidence X-RAY 8ck4 B Reference
       Region 8ck4 B 356-359 disorder
       Region 8ck4 B 360-467 order
       Region 8ck4 B 468-470 disorder
 Evidence X-RAY 8ck8 B Reference
       Region 8ck8 B 356-360 disorder
       Region 8ck8 B 361-467 order
       Region 8ck8 B 468-470 disorder
Seq 356-470 Hetero tetramer : Q9JJ11
 Evidence X-RAY 4lpz B Reference
       Region 4lpz B 356-360 disorder
       Region 4lpz B 361-446 order
       Region 4lpz B 447-453 disorder
       Region 4lpz B 454-464 order
       Region 4lpz B 465-470 disorder
 Evidence X-RAY 4lpz A Reference
       Region 4lpz A 356-360 disorder
       Region 4lpz A 361-446 order
       Region 4lpz A 447-454 disorder
       Region 4lpz A 455-464 order
       Region 4lpz A 465-470 disorder
Seq 356-470 Hetero heptamer : IID00629Complex,Q9JJ11
 Evidence X-RAY 4pky D Reference
       Region 4pky D 356-360 disorder
       Region 4pky D 361-449 order
       Region 4pky D 450-452 disorder
       Region 4pky D 453-464 order
       Region 4pky D 465-470 disorder
 Evidence X-RAY 4pky A Reference
       Region 4pky A 356-360 disorder
       Region 4pky A 361-448 order
       Region 4pky A 449-451 disorder
       Region 4pky A 452-464 order
       Region 4pky A 465-470 disorder
Seq 356-470 Homo dimer :
 Evidence NMR 2hv1 A Reference
       Region 2hv1 A 356-357 disorder
       Region 2hv1 A 358-465 order
       Region 2hv1 A 466-470 disorder
 Evidence NMR 2hv1 B Reference
       Region 2hv1 B 356-357 disorder
       Region 2hv1 B 358-465 order
       Region 2hv1 B 466-470 disorder
 Evidence X-RAY 4eq1 A Reference
       Region 4eq1 A 357-464 order
 Evidence X-RAY 4eq1 B Reference
       Region 4eq1 B 357-464 order
Seq 357-470 Hetero dimer : IID00085Complex
 Evidence X-RAY 4h6j B Reference
       Region 4h6j B 357-466 order
       Region 4h6j B 467-470 disorder
Seqphosphorylation
    77-77 Phosphoserine
Seqacetylation
    2-2 N-acetylalanine
 
Prediction
NeProc
Disorder 1-102,152-156,233-299,318-332,348-357,470-789
Order 103-151,157-228,300-317,333-347,358-469
ProS 56-102,233-247,254-273,282-297,299-299,329-332,348-353,692-696,759-789
AlphaFold
Disorder 1-83,143-158,227-238,240-258,271-300,315-333,345-360,466-789
Order 84-142,159-226,239-239,259-270,301-314,334-344,361-465
Pfam Hmmer
PF00010 90-143 1e-16
PF00989 163-270 1e-19
PF08447 373-467 1.2e-24
SEG 24-34 ,251-262 ,631-643 ,649-662 ,669-680 ,682-696 ,723-736 ,743-756
Function
Function in SwissProt
Required for activity of the AHR. Upon ligand binding, AHR translocates into the nucleus, where it heterodimerizes with ARNT and induces transcription by binding to xenobiotic response elements (XRE). Not required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding (PubMed:34521881). The complex initiates transcription of genes involved in the regulation of a variety of biological processes, including angiogenesis, hematopoiesis, drug and lipid metabolism, cell motility and immune modulation (Probable). The heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters and functions as a transcriptional regulator of the adaptive response to hypoxia (By similarity). The heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription (PubMed:28396409).
Biological Process
See also
Diagram with PDB data
HIF1A/EP300NMR Structures of the HIF-1alpha CTAD/p300 CH1 Complex
CITED2/EP300Structural basis for negative regulation of hypoxia-inducible factor-1alpha by CITED2