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IID00795
 UniprotP28715
ProteinDNA excision repair protein ERCC-5
GeneERCC5
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1186
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-112,750-986 Hetero tetramer :
 Evidence X-RAY 6tux B Reference
       Region 6tux B 1-39 order
       Region 6tux B 40-48 disorder
       Region 6tux B 49-97 order
       Region 6tux B 98-112 disorder
       Region 6tux B 750-752 disorder
       Region 6tux B 753-904 order
       Region 6tux B 905-910 disorder
       Region 6tux B 911-985 order
       Region 6tux B 986-986 disorder
 Evidence X-RAY 6tux A Reference
       Region 6tux A 1-99 order
       Region 6tux A 100-112 disorder
       Region 6tux A 750-752 disorder
       Region 6tux A 753-904 order
       Region 6tux A 905-907 disorder
       Region 6tux A 908-986 order
Seq 1-112,750-990 Hetero tetramer :
 Evidence X-RAY 6tus B Reference
       Region 6tus B 1-39 order
       Region 6tus B 40-41 disorder
       Region 6tus B 42-85 order
       Region 6tus B 86-112 disorder
       Region 6tus B 750-762 disorder
       Region 6tus B 763-900 order
       Region 6tus B 901-911 disorder
       Region 6tus B 912-984 order
       Region 6tus B 985-990 disorder
 Evidence X-RAY 6tus A Reference
       Region 6tus A 1-41 order
       Region 6tus A 42-49 disorder
       Region 6tus A 50-85 order
       Region 6tus A 86-112 disorder
       Region 6tus A 750-763 disorder
       Region 6tus A 764-900 order
       Region 6tus A 901-911 disorder
       Region 6tus A 912-986 order
       Region 6tus A 987-990 disorder
Seq 1-112,750-990 Hetero dimer :
 Evidence X-RAY 6tuw A Reference
       Region 6tuw A 1-38 order
       Region 6tuw A 39-46 disorder
       Region 6tuw A 47-95 order
       Region 6tuw A 96-112 disorder
       Region 6tuw A 750-751 disorder
       Region 6tuw A 752-904 order
       Region 6tuw A 905-912 disorder
       Region 6tuw A 913-985 order
       Region 6tuw A 986-990 disorder
Seq 2-85,766-987 Hetero dimer : O93634
 Evidence X-RAY 6vbh A Reference
       Region 6vbh A 2-38 order
       Region 6vbh A 39-50 disorder
       Region 6vbh A 51-85 order
       Region 6vbh A 766-902 order
       Region 6vbh A 903-910 disorder
       Region 6vbh A 911-987 order
Seq 1054-1077 Hetero trimer : IID50009Complex
 Evidence X-RAY 5ekf C Reference
       Region 5ekf C 1054-1066 disorder
       Region 5ekf C 1067-1076 order
       Region 5ekf C 1077-1077 disorder
 Evidence X-RAY 5ekf B Reference
       Region 5ekf B 1054-1068 disorder
       Region 5ekf B 1069-1074 order
       Region 5ekf B 1075-1077 disorder
Seq 1168-1186 Hetero dimer : IID50009Complex
 Evidence X-RAY 5ekg C Reference
       Region 5ekg C 1168-1169 disorder
       Region 5ekg C 1170-1178 order
       Region 5ekg C 1179-1186 disorder
 Evidence X-RAY 5ekg B Reference
       Region 5ekg B 1168-1181 disorder
       Region 5ekg B 1182-1186 order
SeqProS possible 1067-1076 Nuclear Localization Signal (NLS) Hetero trimer : IID50009Complex
       Region 5ekf B 1069-1074 order
       Region 5ekf C 1067-1076 order
SeqProS possible 1170-1186 Nuclear Localization Signal (NLS) Hetero dimer : IID50009Complex
       Region 5ekg B 1182-1186 order
       Region 5ekg C 1170-1178 order
Seqphosphorylation
    705-705 Phosphoserine
    384-384 Phosphoserine
Seqacetylation
    8-8 N6-acetyllysine
 
Prediction
NeProc
Disorder 96-117,124-178,253-728,1006-1186
Order 1-95,118-123,179-252,729-1000
ProS 96-117,124-130,135-148,156-178,253-300,318-328,341-368,383-403,431-442,467-473,553-558,590-595,630-633,652-662,680-686,725-728,1006-1024,1083-1093,1156-1170
AlphaFold
Disorder 1-1,41-49,123-162,164-165,168-169,171-186,217-221,258-341,348-349,351-732,902-911,987-1011,1044-1186
Order 2-40,50-122,163-163,166-167,170-170,187-216,222-257,342-347,350-350,733-901,912-986,1012-1043
Pfam Hmmer
PF00752 1-98 2.6e-56
PF00867 777-865 1.5e-48
SEG 104-115 ,150-167 ,352-364 ,557-565 ,642-656 ,732-757 ,1025-1042 ,1064-1079 ,1094-1109 ,1146-1154 ,1171-1185
Function
Function in SwissProt
Single-stranded structure-specific DNA endonuclease involved in DNA excision repair (PubMed:8206890, PubMed:8090225, PubMed:8078765, PubMed:7651464, PubMed:32821917, PubMed:32522879). Makes the 3'incision in DNA nucleotide excision repair (NER) (PubMed:8090225, PubMed:8078765, PubMed:32821917, PubMed:32522879). Binds and bends DNA repair bubble substrate and breaks base stacking at the single-strand/double-strand DNA junction of the DNA bubble (PubMed:32522879). Plays a role in base excision repair (BER) by promoting the binding of DNA glycosylase NTHL1 to its substrate and increasing NTHL1 catalytic activity that removes oxidized pyrimidines from DNA (PubMed:9927729). Involved in transcription-coupled nucleotide excision repair (TCR) which allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes (PubMed:16246722). Functions during the initial step of TCR in cooperation with ERCC6/CSB to recognized stalled RNA polymerase II (PubMed:16246722). Also, stimulates ERCC6/CSB binding to the DNA repair bubble and ERCC6/CSB ATPase activity (PubMed:16246722). Required for DNA replication fork maintenance and preservation of genomic stability (PubMed:26833090, PubMed:32522879). Involved in homologous recombination repair (HRR) induced by DNA replication stress by recruiting RAD51, BRCA2, and PALB2 to the damaged DNA site (PubMed:26833090). During HRR, binds to the replication fork with high specificity and stabilizes it (PubMed:32522879). Also, acts upstream of HRR, to promote the release of BRCA1 from DNA (PubMed:26833090).
Biological Process
See also
Diagram with PDB data
XPA/ERCC1Solution structure of a ERCC1-XPA heterodimer